Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates

Table 2 Univariate and multivariate analysis of clinical-pathological parameters associated with low survival rates.

Parameters	Analysis (Pvalue)
	Univariate	Multivariate
Histological diagnosis (MC)	0.05*	0.18
Size (>5 cm)	0.03*	0.18
Lymph node metastasis (Yes)	0.003*	0.09
Pulmonary metastasis (Yes)	< 0.0001*	0.39
Histological grade (II-III)	0.007*	0.42
Inflammatory distribution (multifocal)	0.04*	0.07
Inflammatory intensity (moderate/intense)	0.71	ND
Lymphocytic infiltrate ((600 lymphocytes)	0.002*	0.02*
% of CD4 ⁺ ((66.7%), CD8 ⁺ T-cells (<33.3%)	0.12	ND

* Selected for multivariate analysis. ND = not done. The end point was the animal death or discharge during the follow-up period

ISSN: 1471-2407