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Figure 7 | BMC Cancer

Figure 7

From: Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways

Figure 7

Suppressed human colon cancer cell proliferation and elevated apoptosis by resveratrol involves multiple molecular targets. Effects of resveratrol (R; 150 μM) and/or IGF-1 (I; 10 nM) on expression of A, β-catenin; B, sp1; C, MDM2 and p53; D, FKHRL1, p27 and cyclin D1; in HT-29 cells. HT-29 cells were treated with IGF-1 and/or resveratrol for 24 h. Whole cell lysates were analyzed by western blotting as described in materials and methods. Blots were incubated with the indicated antibodies. Band intensities normalized to loading control were indicated on top of the respective band (A, B). Similar results were obtained in duplicate experiments.

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BMC Cancer

ISSN: 1471-2407

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