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Figure 5 | BMC Cancer

Figure 5

From: Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways

Figure 5

Effects of Resveratrol and treatment on apoptosis. A - Resveratrol but not IGF-1R siRNA induces apoptosis in HT-29 cells. Percentage induction of apoptosis was determined by TUNEL assay. The rate of apoptosis was expressed as a percentage of the total cells counted. Results are expressed as mean ± SE for the different treatments in both non specific siRNA and IGF-1R siRNA transfected cells. * indicates significant elevation compared to solvent control (DMSO). $indicates elevation (p < 0.05) by treatments compared to non specific siRNA control. B - Resveratrol treatment elevated cleaved PARP, a hallmark of apoptosis. Cells were treated with resveratrol (50, 100 and 150 μM) alone or IGF-1 (10 nM) for 5 minutes followed by resveratrol at different concentrations and analyzed by western blot as described in materials and methods. Similar results were obtained in duplicate experiments.

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BMC Cancer

ISSN: 1471-2407

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