From: Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel
Parameters | unit | 5-FU (n = 3, Mean ± SD) | 5-FU-loaded PEG-hydrogel (n = 3, Mean ± SD) |
---|---|---|---|
Vd/F | L | 0.41 ± 0.04 | 10.60 ± 1.55 |
t1/2(a) | h | 0.21 ± 0.06 | 0.06 ± 0.03 |
t1/2 | h | 0.15 ± 0.04 | 0.87 ± 0.17* |
CLtot/F | l/h | 2.04 ± 0.51 | 8.46 ± 1.07 |
Cmax | μg/ml | 67.81 ± 15.84 | 7.47 ± 1.63 |
Tmax | h | 0.25 ± 0.00 | 0.33 ± 0.14 |
AUC0-8 day | μg·h/ml | 59.71 ± 10.58 | 14.14 ± 1.20 |
MRT | h | 0.55 ± 0.03 | 8.03 ± 4.41* |