Table 3 Correlation between the IL-6, VEGF, CRP, and clinicopathological parameters
| Â | VEGF pg/ml | IL-6 pg/ml | CRP mg/dL | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Mean | Median (range) | p | Mean | Median (range) | p | Mean | Median (range) | p |
Sex | |||||||||
   Male | 656 | 567 (131-3242) | 0048 | 13.12 | 5.03 (1.02-139.17) | 0.019 | 1.24 | 0.25 (0.01-18.40) | 0.827 |
   Female | 567 | 469 (123-2001) |  | 16.14 | 7.71 (1.25-90.06) |  | 0.83 | 0.16 (0.00-8.41) |  |
Age | |||||||||
   < 60 | 634 | 569 (123-1620) | 0.363 | 15.31 | 5.61 (1.02-90.06) | 0.854 | 1.15 | 0.17 (0.02-8.41) | 0.610 |
   ≥ 60 | 593 | 494 (131-3242) |  | 13.70 | 6.63 (1.58-139.17) |  | 0.98 | 0.24 (0.00-18.40) |  |
CEA | |||||||||
   ≤ 5 | 583 | 493 (123-32.42) | 0.038 | 12.98 | 5.70 (1.02-94.11) | 0.255 | 1.14 | 0.20 (0.01-18.40) | 0.824 |
   > 5 | 680 | 635 (131-1619) |  | 18.91 | 8.0 (1.58-139.17) |  | 0.80 | 0.25 (0.02-6.97) |  |
Primary tumor | |||||||||
   pT1 | 452 | 422 (123-892) | 0.540 | 18.60 | 3.93 (2.18-94.11) | 0.549 | 1.02 | 0.16 (0.01-6.22) | 0.905 |
   pT2 | 565 | 471 (139-1585) |  | 14.78 | 7.74 (1.02-70.96) |  | 0.67 | 0.33 (0.02-3.43) |  |
   pT3 | 639 | 546 (126-3242) |  | 13.35 | 6.02 (1.25-139.17) |  | 1.17 | 0.24 (0.00-18.40) |  |
   pT4 | 606 | 567 (174-1216) |  | 17.00 | 6.05 (3.44-88.96) |  | 0.77 | 0.53 (0.03-2.29) |  |
Regional Lymph nodes | |||||||||
   N0 | 652 | 539 (123-3242) | 0.557 | 13.32 | 6.49 (1.02-94.11) | 0.533 | 1.04 | 0.26 (0.01-10.09) | 0.432 |
   N1 | 579 | 562 (139-1098) |  | 8.53 | 5.66 (1.49-30.02) |  | 1.23 | 0.13 (0.00-18.40 |  |
   N2 | 560 | 432 (156-1620) |  | 27.92 | 6.31 (1.25-139.17) |  | 0.79 | 0.20 (0.02-7.83) |  |
Lymph node ratio | |||||||||
   pNr1 0.01-0.11 | 634 | 558 (123-3242) | 0.215 | 11.89 | 5.58 (1.02-94.11) | 0.242 | 1.16 | 0.25 (0.0-18.40) | 0.352 |
   pNr2 0.12-0.24 | 495 | 495 (145-1619) |  | 20.86 | 6.31 (1.91-90.06) |  | 0.76 | 0.11 (0.00-6.97) |  |
   pNr3 0.25-0.92 | 446 | 430 (156-1068) |  | 26.10 | 10.15 (1.25-139.17) |  | 0.54 | 0.17 (0.04-2.18) |  |
Size | |||||||||
   < 5 cm | 550 | 463 (123-3242) | 0.012 | 10.58 | 5.15 (1.02-76.79) | 0.129 | 1.32 | 1.15 (0.00-18.40) | 0.739 |
   ≥ 5 cm | 655 | 577 (126-2001) |  | 12.28 | 7.15 (1.25-139.17) |  | 0.84 | 0.25 (0.01-8.41) |  |
Stage | |||||||||
   Stage I | 547 | 471 (123-1586) | 0.320 | 17.60 | 5.52 (1.02-94.11) | 0.907 | 0.88 | 0.16 (0.01-6.22) | 0.681 |
   Stage II | 711 | 573 (126-3242) |  | 10.94 | 10.94 (1.58-93.08) |  | 1.13 | 0.28 (0.01-10.09) |  |
   Stage III | 553 | 495 (139-1620) |  | 15.67 | 5.97 (1.25-139.47) |  | 1.07 | 0.13 (0.00-18.40) |  |
Differentiation | |||||||||
   Well | 644 | 495 (123-3242) | 0.234 | 12.07 | 5.49 (1.02-94.11) | 0.275 | 0.75 | 0.25 (0.01-6.97) | 0.957 |
   Moderate | 541 | 511 (133-1620) |  | 18.07 | 7.45 (1.49-139.17) |  | 1.60 | 0.15 (0.00-18.40) |  |
   Poor | 531 | 520 (174-1083) |  | 7.45 | 8.42 (2.65-11.88) |  | 0.28 | 0.20 (0.00-0.54) |  |
   Mucinous | 805 | 663 (448-1258) |  | 13.35 | 8.30 (1.25-39.03) |  | 0.52 | 0.18 (0.02-1.60) |  |