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Table 2 Percentages of patients showing positive immunohistochemical reactions to NAIP, Survivin and XIAP in normal prostate (NP), benign prostatic hyperplasia (BPH), prostatic carcinoma (PC) average optical densities of immunostaining in positive patients.

From: Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

 

NAIP

SURVIVIN

XIAP

Prostates (no.)

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Normal (20)

0

---

0

---

20

6.96 ± 1.6a

BPH (35)

60.6

11.23 ± 2.9a

9.1

8.4 ± 1.51a

27.27

13.42 ± 0.59b

PIN

      

   Low grade PIN (12)

0

----

0

---

25

9.6 ± 1.21c

   High grade PIN (15)

60

18.49 ± 2.02b

20

17.46 ± 1.57b

33.3

16.93 ± 1.73d

PC

      

   Low Gleason (21)

56.52

17.4 ± 1.96b

21.7

17.48 ± 1.53b

17.39

17.79 ± 1.55d

   Medium Gleason (51)

58.82

18.25 ± 2.02b

13.72

17.66 ± 1.6b

39.21

16.64 ± 1.31d

   High Gleason (21)

66.6

17.28 ± 2.46b

28.57

21.59 ± 1.35c

23.8

16.38 ± 1.03d

  1. Average optical densities were evaluated only in patients showing positive immunoreactions. Statistical analysis refers to each antibody separately. Values denoted by different superscripts are significantly different from each other. Significance was determined by the one way ANOVA test at p ≤ 0.05, by multiple pairwise comparisons (GraphPad PRISMA 3.0 computer program).