Figure 1

SR/CR mice resist a broad range of lethal cancer cell lines at different doses. The percentage of SR/CR mice that were able to survive challenge with J774, MethA, EL-4, S180, B16, or LL/2 was determined empirically. Mice were monitored for at least 60 days after challenge. SR/CR C57BL/6 mice were challenged with 10e3 or 5 × 10e4 B16 or LL/2. SR/CR C57BL/6 mice were also challenged with 0.8 × 10e7, 1.6 × 10e8, 2.2 × 10e8, or 3.2 × 10e8 S180 or 2.5 × 10e7, 5 × 10e7, 10e8, or 2 × 10e8 EL-4. SR/CR BALB/c mice were challenged with 10e5, 2 × 10e5, 4 × 10e5, or 10e6 MethA or 5 × 10e4, 10e6, or 10e7 J774. WT mice uniformly died at all doses with all cell lines tested. At least 5 mice were tested for any given dose of tumor cells injected.