Figure 9

Enforced expression of merlin increases total merlin and the predominant, lower molecular weight, hypophosphorylated form of p-merlin (lane 2), and these effects are potentiated in virally-infected CD44s-Separate cells (lane 3). This effect is minimal in CD44s-Fusion cells (lane 4). Merlin overexpression also markedly increases CD44 total (Figure 2). Together, findings suggest that CD44s-merlin binding reduces degradation of both molecules.