Physical measurements and tests |
   Height, weight, and body mass index |
   Body composition |
   Resting and exercise heart rate |
   Resting and exercise blood pressure |
   Resting and exercise 12-lead ECG |
   Peak and submaximal oxygen consumption |
   Ventilatory threshold |
Mechanistic physiological measurements |
   Resting and exercise echocardiogram |
   Skeletal muscle function (fiber type distribution, oxidative capacity, and muscular strength) |
   Pulmonary function |
   Hemoglobin concentration |
   Resting and exercise oxygen saturation |
   Each intervention (exercise or attention control) session: heart rate, blood pressure, oxygen saturation, RPE |
Patient-reported outcomes (questionnaire-based) |
   Medications |
   Quality of life |
   Fatigue |
   Dyspnea |
   Depression |
   Adverse events (Common Terminology Criteria for Adverse Events; CTCAE v.4.0) |
Substudies |
   Genetic studies to examine differences to exercise stimulus |
   Predictors of exercise adherence |
   Pilot studies for exercise-induced changes in peripheral gene expression |