The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis

Table 2 Association of endothelial and cytoplasmic CA II, CA IX and CA XII immunostaining with clinicopathologic variables in medulloblastomas (MB) and primitive neuroectodermal tumours (PNET).

	endothelial CA II positivity N			cytoplasmic CA II positivity N			CA IX positivity N			CA XII positivity N
Primary tumors	All	MB	PNET	All	MB	PNET	All	MB	PNET	All	MB	PNET
	33	27	6	33	27	6	35	28	7	34	27	7
Age
< 3 years	5	2	3	5	3	2	1	1	0	4*	3+	1
> 3 years	12	10	2	18	15	3	7	6	1	0	0	0
Gender
-female	6	3	3	10	7	3	1**	0++	1	1	0	1
-male	11	9	2	13	11	2	7	7	0	3	3	0
Localization
-cerebellum	12			18			7			3
-cerebrum	5			5			1			1
Total material
MIB-1	36	28	8	36	28	8	37	29	8	36	28	8
-below median	9	6	3	13	10	3	5	4	1	1	1	0
-above median	9	6	3	13	9	4	4	4	0	2	1	1
Apoptosis	37	29	8	37	29	8	39	30	9	38	29	9
-below median	8	5	3	15	11	4	5	5	0	1	1	0
-above median	10	7	3	12	9	3	4	3	1	3	2	1
Bcl-2	37	29	8	37	29	8	39	30	9	38	29	9
-negative	6	4	2	13	9	4	3	2	1	1	0	1
-positive	12	8	4	14	11	3	6	6	0	3	3	0
P53	37	29	8	37	29	8	39	30	9	38	29	9
-negative	15	6	1	23	9	1	7	4	0	3	0	0
-positive	3	6	5	4	11	6	2	4	1	1	3	1
ErbB2	37	29	8	37	29	8	39	30	9	38	29	9
-negative	8	10	5	11	10	5	6	7	0Ψ	0	2	1
-positive	10	2	1	16	2	2	3	1	1	4	1	0

ISSN: 1471-2407