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Table 1 Growth Curve Analysis (doubling time in hrs)

From: Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

Cell Line

(+) Tet - GENE OFF

(-) Tet - GENE ON

MSU-1.1

30.2 (± 1.0)

29.8 (± 0.7)

PH3 MT

19.9 (± 0.5)

19.4 (± 0.7)

Vector Control

16.6 (± 0.5)

20.4 (± 1.2)*

Cdc42N17-C1

17.5 (± 2.0)

28.1 (± 2.0)**

Cdc42N17-C2

17.0 (± 1.7)

26.6 (± 1.2)**

Rac1N17-C1

16.3 (± 0.2)

31.2 (± 3.0)*

Rac1N17-C2

16.6 (± 0.7)

31.4 (± 1.0)**

Rac1N17/Cdc42N17

18.2 (± 0.5)

35.8 (± 1.2)*

  1. Values represent Mean ± SD
  2. *,** represent a significant difference compared to (-) Tet condition using a homoscedastic
  3. two-tailed t-test (p < 0.05, p < 0.01, respectively), N = 3 for all conditions