MCM2 - a promising marker for premalignant lesions of the lung: a cohort study

BMC Cancer

Table 1 Percentage and intensity of staining for MCM2 and Ki-67 in normal bronchial mucosa and premalignant lesions

Type of	Number of	% Cells Positive	% Cells Positive	Mean	Mean
Specimen	Specimens	for MCM2	for Ki-67	Intensity for	Intensity
		Mean (Range)	Mean (Range)	MCM2^a	for Ki-67^a
Normal Mucosa	7	11^b,e (5-20)	3^b,f (1-5)	1.6ⁱ (1.0-2.0)	1.6ⁱ (1.0-2.5)
Metaplasia	21	39^c,e (7-90)	14^c,f (1-60)	2.3ⁱ (1.0-3.0)	2.3ⁱ (1.0-3.0)
Dysplasia	7	64^d,e,g (40-100)	34^d,f (7-40)	2.6ⁱ (2.0-3.0)	2.8ⁱ (2.0-3.0)
CIS	6	39^e,g (5-60)	17^f,h (3-60)	2.4ⁱ (2.0-3.0)	2.3ⁱ (1.0-3.0)
Combined data	41	39^c(5-100)	16^c (1-60)	2.2 (1.0 - 3.0)	2.3 (1.0-3.0)

^a The intensity of stain ranges from 0 (absent) to 3 (strong). ^b p-value < 0.016 for the paired difference t-test and Wilcoxon sign rank test. ^c p-value < 0.001 for the paired difference t-test and Wilcoxon sign rank test. ^d p-value < 0.034 for the paired difference t-test and <0.063 for the Wilcoxon sign-rank test. ^e p-value <0.010 for the ANOVA and Kruskal-Wallis tests of differences in MCM2 category means. ^f p-value <0.001 for the ANOVA and Kruskal-Wallis tests of differences in Ki-67 category means. ^g p-value <0.080 for the independent samples t-test between dysplasia and CIS within MCM2. ^h p-value <0.117 for the independent samples t-test between dysplasia and CIS within Ki67. ⁱ p-value <0.004 for the ANOVA and Kruskal-Wallis tests of differences in MCM2 and Ki-67 category means.

ISSN: 1471-2407