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  1. Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT ...

    Authors: Arash O. Naghavi, J. M. Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J. Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E. Gloria, George Yang, Stephen A. Rosenberg, Kamran Ahmed, Marilyn M. Bui, Evita B. Henderson-Jackson, Andrew Lee…
    Citation: BMC Cancer 2024 24:437
    Content type: Study Protocol Published on:

  2. Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1–3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures ...

    Authors: Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi…
    Citation: BMC Cancer 2024 24:436
    Content type: Study Protocol Published on:

    The Correction to this article has been published in BMC Cancer 2024 24:563

  3. To establish and validate a predictive model combining pretreatment multiparametric MRI-based radiomic signatures and clinical characteristics for the risk evaluation of early rapid metastasis in nasopharyngea...

    Authors: Xiujuan Cao, Xiaowen Wang, Jian Song, Ya Su, Lizhen Wang and Yong Yin
    Citation: BMC Cancer 2024 24:435
    Content type: Research Published on:

  4. Lung adenocarcinoma, a leading cause of cancer-related mortality, demands precise prognostic indicators for effective management. The presence of spread through air space (STAS) indicates adverse tumor behavio...

    Authors: Haijun Li, Lifeng Li, Yumeng Liu, Yingke Deng, Yu Zhu, Ling Huang, Ting Long, Li Zeng, Yongqiang Shu and Dechang Peng
    Citation: BMC Cancer 2024 24:434
    Content type: Research Published on:

  5. Perineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer. However, PNI can be further subdivided according to the depth of invasion...

    Authors: Hao Chen, Chao Wang, Zexian Chen, Tianze Huang, Yanyun Lin, Junguo Chen, Bin Zhang and Xiaosheng He
    Citation: BMC Cancer 2024 24:433
    Content type: Research Published on:

  6. One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage of translation, which has been ...

    Authors: Hongkun Sun, Juanjuan Shang, Xiao Liu, Shuai Ren, Shunfeng Hu and Xin Wang
    Citation: BMC Cancer 2024 24:432
    Content type: Research Published on:

  7. Dose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances have led to the standardization of ultrahypofractionated stereotactic a...

    Authors: Elisha Fredman, Oded Icht, Assaf Moore, Dimitri Bragilovski, Jonathan Kindler, Shay Golan and Dror Limon
    Citation: BMC Cancer 2024 24:431
    Content type: Study Protocol Published on:

  8. The KEYNOTE-048 trial showed that pembrolizumab-based first-line treatment for R/M HNSCC led to improved OS in the PD-L1 CPS ≥ 1 population when compared to the EXTREME regimen. However, the R/M HNSCC real-world ...

    Authors: Alessio Cirillo, Daniele Marinelli, Umberto Romeo, Daniela Messineo, Francesca De Felice, Marco De Vincentiis, Valentino Valentini, Silvia Mezi, Filippo Valentini, Luca Vivona, Antonella Chiavassa, Bruna Cerbelli, Daniele Santini, Paolo Bossi, Antonella Polimeni, Paolo Marchetti…
    Citation: BMC Cancer 2024 24:430
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2024 24:487

  9. Prophylactic cranial irradiation (PCI) is part of standard care in limited-stage small cell lung cancer (SCLC) at present. As evidence from retrospective studies increases, the benefits of PCI for limited-stag...

    Authors: Mengyuan Chen, Runhua Li, Yue Kong, Lei Shi, Jing Wang, Yuezhen Wang, Yujin Xu, Yongling Ji and Xiao Hu
    Citation: BMC Cancer 2024 24:429
    Content type: Study Protocol Published on:

  10. This study aimed to conduct a comprehensive analysis, evaluating the prognostic significance of the baseline Advanced Lung Cancer Inflammation Index (ALI) and Gustave Roussy Immune (GRIm) Score in patients und...

    Authors: Hao Jiang, Borui Li, Min Wu, Qimei Wang and Yijin Li
    Citation: BMC Cancer 2024 24:428
    Content type: Research Published on:

  11. Although papillary thyroid cancer (PTC) patients are known to have an excellent prognosis, up to 30% of patients experience disease recurrence after initial treatment. Accurately predicting disease prognosis r...

    Authors: Hongxi Wang, Chao Zhang, Qianrui Li, Tian Tian, Rui Huang, Jiajun Qiu and Rong Tian
    Citation: BMC Cancer 2024 24:427
    Content type: Research Published on:

  12. Colorectal cancer (CRC) is the 3rd most common malignancy with the liver being the most common site of metastases. The recurrence rate of colorectal liver metastases (CRLM) after liver resection (LR) is notabl...

    Authors: Yuan Tian, Yaoqun Wang, Ningyuan Wen, Shaofeng Wang, Bei Li and Geng Liu
    Citation: BMC Cancer 2024 24:426
    Content type: Research Published on:

  13. The objective of this study was to investigate the correlation between spleen density and the prognostic outcomes of patients who underwent curative resection for colorectal cancer (CRC).

    Authors: Yunzhou Xiao, Xiaoting Wen, Yingying Ying, Xiaoyan Zhang, Luyao Li, Zhongchu Wang, Miaoguang Su and Shouliang Miao
    Citation: BMC Cancer 2024 24:425
    Content type: Research Published on:

  14. Patients from non-small cell lung cancer (NSCLC) controlled clinical trials do not always reflect real-world heterogeneous patient populations. We designed a study to describe the real-world patient characteri...

    Authors: Hozefa A. Divan, Marisa A. Bittoni, Ashok Krishna and David P. Carbone
    Citation: BMC Cancer 2024 24:424
    Content type: Research Published on:

  15. Total thyroidectomy is the main line of treatment for papillary thyroid cancer. Central lymph node dissection (CLND) is still debatable. In this study, we aimed to correlate the central lymph node status with ...

    Authors: Shadi Awny, Ahmed Abdallah, Islam H Metwally, Khaled Abdelwahab, Mohammad Zuhdy, Omar Hamdy, Ahmed M Fareed and Khalid Atallah
    Citation: BMC Cancer 2024 24:423
    Content type: Research Published on:

  16. As comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation between ≤T1 and ≥T2 gastric cancer before endoscopic intervention holds pa...

    Authors: Yuan Zhong, Yan-Yan Xiao, Jie-Yi Ye, Guo-Liang Jian and Wei-Jun Huang
    Citation: BMC Cancer 2024 24:422
    Content type: Systematic Review Published on:

  17. We designed this study based on both a physician practice survey and real-world patient data to: (1) evaluate clinical management practices in extensive-stage small cell lung cancer (ES-SCLC) among medical cen...

    Authors: Bertrand Mennecier, Jonathan Khalifa, Renaud Descourt, Laurent Greillier, Charles Naltet and Lionel Falchero
    Citation: BMC Cancer 2024 24:421
    Content type: Research Published on:

  18. Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvi...

    Authors: Yuming Gu, Qinqin Huang, Yun Wang, Haixia Wang, Zhenhua Xiang, Yu Xu, Xin Wang, Weiguo Liu and Aiju Wang
    Citation: BMC Cancer 2024 24:420
    Content type: Research Published on:

  20. This study aimed to develop and validate a machine learning (ML)-based fusion model to preoperatively predict Ki-67 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) using multip...

    Authors: Weiyue Chen, Guihan Lin, Yongjun Chen, Feng Cheng, Xia Li, Jiayi Ding, Yi Zhong, Chunli Kong, Minjiang Chen, Shuiwei Xia, Chenying Lu and Jiansong Ji
    Citation: BMC Cancer 2024 24:418
    Content type: Research Published on:

  21. Lung cancer is one of the most common type of cancer and, despite significant advances in screening and diagnosis approaches, a large proportion of patients at diagnosis still present advanced stages of the di...

    Authors: Alya Boutabba, Fadoua Missaoui, Akram Dlala, Hela Kamoun, Khalil Ben Salem, Amira Gabsi, Hadhemi Rejeb, Anne Letessier, Benoit Miotto and Raja Marrakchi
    Citation: BMC Cancer 2024 24:417
    Content type: Research Published on:

  22. Through research on the gut microbiota (GM), increasing evidence has indicated that the GM is associated with esophageal cancer (ESCA). However, the specific cause-and-effect relationship remains unclear. In t...

    Authors: Jia Li, Xuedi Gao, Xiaoming Sun, Hao Li, Jiaheng Wei, Lin Lv and Liangming Zhu
    Citation: BMC Cancer 2024 24:416
    Content type: Research Published on:

  23. Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affec...

    Authors: Bojin Zhao, Jiaheng Li, Siddharth Sinha, Zixin Qin, Si Hoi Kou, Fengxia Xiao, Huijun Lei, Tianhui Chen, Wenming Cao, Xiaofan Ding and San Ming Wang
    Citation: BMC Cancer 2024 24:415
    Content type: Research Published on:

  24. Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The ...

    Authors: Victoria Spadafora, Benjamin R. Pryce, Alexander Oles, Erin E. Talbert, Martin Romeo, Silvia Vaena, Stefano Berto, Michael C. Ostrowski, David J. Wang and Denis C. Guttridge
    Citation: BMC Cancer 2024 24:414
    Content type: Research Published on:

  25. Authors: Zaher Alwafai, Maximilian Heinz Beck, Sepideh Fazeli, Kathleen Gürtler, Christine Kunz, Juliane Singhartinger, Dominika Trojnarska, Dario Zocholl, David Johannes Krankenberg, Jens-Uwe Blohmer, Jalid Sehouli and Klaus Pietzner
    Citation: BMC Cancer 2024 24:413
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2024 24:380

  26. Tumor genomic profiling (TGP) identifies targets for precision cancer treatments, but also secondary hereditary risks. Oncologists are poorly trained to communicate the results of TGP, especially among patient...

    Authors: Michael J. Hall, Paul A. D’Avanzo, Yana Chertock, Patrick J. A. Kelly, Jesse Brajuha, Katie Singley, Caseem C. Luck and Sarah B. Bass
    Citation: BMC Cancer 2024 24:412
    Content type: Research Published on:

  27. Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical div...

    Authors: Zhiyuan Wu, Qingyun Zhang, Yiting Jin, Xinju Zhang, Yanli Chen, Can Yang, Xuemei Tang, Haowen Jiang, Xiaoyi Wang, Xinli Zhou, Feng Yu, Bing Wang and Ming Guan
    Citation: BMC Cancer 2024 24:411
    Content type: Research Published on:

  28. High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response an...

    Authors: Michèle Rouleau, Lyne Villeneuve, Eric P. Allain, Jules McCabe-Leroux, Sophie Tremblay, Flora Nguyen Van Long, Ashwini Uchil, Charles Joly-Beauparlant, Arnaud Droit and Chantal Guillemette
    Citation: BMC Cancer 2024 24:410
    Content type: Research Published on:

  29. Accurate evaluation of axillary lymph node metastasis (LNM) in breast cancer is very important. A large number of hyperplastic and dilated lymphangiogenesis cases can usually be found in the pericancerous tiss...

    Authors: Bo Li, Shaochun Dai, Qiucheng Wang, Hui Jing, Hua Shao, Lei Zhang, Ling Qin, Cong Qiao, Zhuozhong Wang and Wen Cheng
    Citation: BMC Cancer 2024 24:409
    Content type: Research Published on:

  30. Accumulating evidence indicates that aberrant non-SMC condensin II complex subunit D3 (NCAPD3) is associated with carcinogenesis of various cancers. Nevertheless, the biological role of NCAPD3 in the pathogene...

    Authors: Fan Yang, Yunfeng Zheng, Qiong Luo, Suyun Zhang, Sheng Yang and Xiangqi Chen
    Citation: BMC Cancer 2024 24:408
    Content type: Research Published on:

  31. Primary central nervous system lymphoma (PCNSL) are rare mature B-cell lymphoproliferative diseases characterized by a high incidence of MYD88 L265P and CD79B Y196 hotspot mutations. Diagnosis of PCNSL can be ...

    Authors: Yujie Zhong, Geok Wee Tan, Johanna Bult, Nick Veltmaat, Wouter Plattel, Joost Kluiver, Roelien Enting, Arjan Diepstra, Anke van den Berg and Marcel Nijland
    Citation: BMC Cancer 2024 24:407
    Content type: Research Published on:

  32. Autologous stem-cell transplantation (ASCT) remains a beneficial approach for patients with newly diagnosed multiple myeloma (NDMM) in the age of novel therapeutic agents. Nevertheless, limited real-world data...

    Authors: Yi Tao, Shiwei Jin, Dan Yang, Mengmeng Pan, Wanyan Ouyang, Yuanfang Liu, Yan Wang, Weiping Zhang and Jianqing Mi
    Citation: BMC Cancer 2024 24:406
    Content type: Research Published on:

  34. Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

    Authors: Peng-chao Zhan, Shuo Yang, Xing Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang, Qing-ya Qiu, Yu Gao, Dong-bo Lv, Li-ming Li, Cheng-long Luo, Zhi-wei Hu, Zhen Li, Pei-jie Lyu, Pan Liang and Jian-bo Gao
    Citation: BMC Cancer 2024 24:404
    Content type: Research Published on:

  35. During the last decade, twelve studies have been published investigating physical exercise interventions (PEIs) in patients with head and neck cancer (HNC) during radiotherapy (RT), chemoradiation (CRT) or bio...

    Authors: Yvette Kriellaars, Jorine Ariane Vermaire, Maaike Beugeling, Robert Poorter, Janneke Drijvers and Caroline Margina Speksnijder
    Citation: BMC Cancer 2024 24:403
    Content type: Study Protocol Published on:

  36. Among the most common forms of cancer worldwide, breast cancer posed a serious threat to women. Recent research revealed a lack of oxygen, known as hypoxia, was crucial in forming breast cancer. This research ...

    Authors: Chaoran Qiu, Wenjun Wang, Shengshan Xu, Yong Li, Jingtao Zhu, Yiwen Zhang, Chuqian Lei, Weiwen Li, Hongsheng Li and Xiaoping Li
    Citation: BMC Cancer 2024 24:402
    Content type: Research Published on:

  38. This study evaluated the clinical relevance of a set of five serum-derived circulating microRNAs (miRNAs) in colorectal cancer (CRC). Additionally, we investigated the role of miR-20a-5p released by exosomes d...

    Authors: Mahsa Ghofrani-Shahpar, Katayoon Pakravan, Ehsan Razmara, Faezeh Amooie, Mojdeh Mahmoudian, Masoumeh Heshmati and Sadegh Babashah
    Citation: BMC Cancer 2024 24:400
    Content type: Research Published on:

  41. High-risk stage III colon cancer has a considerably poorer prognosis than stage II and low-risk stage III colon cancers. Nevertheless, most guidelines recommend similar adjuvant treatment approaches for all th...

    Authors: Kyung-Ha Lee, In Jun Yang, Gi Won Ha, Jaeim Lee, Youn Young Park, Suk Hwan Lee, Jong Min Lee, Jung Hoon Bae, Eun Jung Park, Hyungjin Kim, Keun Young Kim, Sanghyung An, Ik Yong Kim and Ji Yeon Kim
    Citation: BMC Cancer 2024 24:397
    Content type: Study Protocol Published on:

  42. Emerging data suggested a favorable outcome in advanced non-small cell lung cancer (NSCLC) with chronic obstructive pulmonary disease (COPD) patients treated by immunotherapy. The objective of this study was t...

    Authors: Ao Zeng, Yanze Yin, Zhilong Xu, Abudumijiti Abuduwayiti, Fujun Yang, Mohammed Saud Shaik, Chao Wang, Keyi Chen, Chao Wang, Xinyun Fang and Jie Dai
    Citation: BMC Cancer 2024 24:396
    Content type: Research Published on:

  43. Although immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer dendritic cells (IKDCs) exhibit cytotoxicity and present antigens to r...

    Authors: Chih-Hao Fang, Wen-Fang Cheng, Ya-Fang Cheng, Keng-Li Lan and Jan-Mou Lee
    Citation: BMC Cancer 2024 24:395
    Content type: Research Published on:

  44. Bone tumors account for approximately 6% of all cancers in children. Malignant bone tumors, commonly occurring in children and adolescents, are associated with high mortality and morbidity. The overall surviva...

    Authors: Temesgen Lingerih, Sewagegn Yeshiwas, Abdulkadir Mohamedsaid and Gashaw Arega
    Citation: BMC Cancer 2024 24:394
    Content type: Research Published on:

  45. Immune checkpoint inhibitors (ICI) combined with chemotherapy are efficacious for treating advanced non-small cell lung cancer (NSCLC); however, the effectiveness of this approach in the malignant pleural effu...

    Authors: Qi Wei, Taibing Deng, Junhua Wu, Hao Zeng, Chang Qi, Sihan Tan, Yuanyuan Zhang, Qin Huang, Xin Pu, Weiguo Xu, Weimin Li, Panwen Tian and Yalun Li
    Citation: BMC Cancer 2024 24:393
    Content type: Research Published on:

  47. Breast cancer and genital cancer are known as cancers that affect people’s relationships with their partners. Women with such cancers are emotionally vulnerable and need more support from their partners. The p...

    Authors: Hamideh Zahedi, Zohreh Alizadeh-Dibazari, Mojgan Mirghafourvand, Mohammad Hasan Sahebihagh and Mina Hosseinzadeh
    Citation: BMC Cancer 2024 24:391
    Content type: Research Published on:

  49. The objective of this study was to describe real-world adjuvant therapy (AT) use by disease substage and assess determinants of treatment choice among patients with stage III melanoma.

    Authors: Eric D. Whitman, Todor I. Totev, Shan Jiang, Wilson L. da Costa Jr., Dmitri Grebennik, Hongjue Wang, Andra-Ecaterina Boca and Rajeev Ayyagari
    Citation: BMC Cancer 2024 24:389
    Content type: Research Published on:

  50. Breast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The incidence and mortality of BC are rapidly increasing, posing great challen...

    Authors: Esmatullah Esmat, Ahmed Maseh Haidary, Ramin Saadaat, Syeda Naghma Rizvi, Syeda Aleena, Mujtaba Haidari, Sayed Murtaza Sadat Hofiani, Nasrin Hussaini, Ahmadullah Hakimi, Abdullatif Khairy and Jamshid Abdul-Ghafar
    Citation: BMC Cancer 2024 24:388
    Content type: Research Published on:

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