Fig. 3

Panel a: apoptosis/crypt in the apparently normal mucosa (NM) of the various experimental groups. Bars represent mean + SE. n = 8, 5, 6, 4, 5, 5 in Controls, DIM CUR SU 80, DIM CUR SU 160, SU 320, DIM CUR and SU 80 groups, respectively. **: significantly different (P < 0.01) when compared with Controls. Insert of panel a: apoptosis/crypt in the NM of rats treated with a Control diet or with the same diet supplemented with SU 320 ppm for 1 or 4 months. Bars represent mean numbers + SE. n = 4 in each group. **: significantly different (P < 0.05) compared with Controls (with two-way analysis of variance for the effect of Sulindac). Panel b: proliferative activity, expressed as LI (labelling index) in the NM of the different groups. Bars are means + SE. n = 7, 5, 5, 4, 3, 4 in Controls, DIM CUR SU 80, DIM CUR SU 160, SU 320, DIM CUR and SU 80 groups, respectively