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  1. The association between the combination of platelet count and neutrophil–lymphocyte ratio (COP-NLR) at the time of adverse events during sunitinib treatment and prognosis is unclear, and prognostic models comb...

    Authors: Miki Takenaka Sato, Ayuki Ida, Yuki Kanda, Kaori Takano, Masayuki Ohbayashi, Noriko Kohyama, Jun Morita, Kohzo Fuji, Haruaki Sasaki, Yoshio Ogawa and Mari Kogo
    Citation: BMC Cancer 2022 22:1214
  2. Urothelial carcinoma (UC) is the ninth most commonly diagnosed cancer worldwide, with a 3.8/1 male to female ratio. Platinum-based chemotherapy is the first line standard of care for fit patients with advanced...

    Authors: Elodie Coquan, Bénédicte Clarisse, Justine Lequesne, Pierre-Emmanuel Brachet, Zoé Nevière, Emeline Meriaux, Isabelle Bonnet, Marie Castera, Nicolas Goardon, Jeremy Boutrois, Romain Travers, Florence Joly, Jean-Michel Grellard and Antoine Thiery-Vuillemin
    Citation: BMC Cancer 2022 22:1213
  3. Nutritional support, including nutritional counseling and oral nutritional supplements (ONS), has been recommended as a first-line strategy in patients with non-small cell lung cancer (NSCLC). Evidence on the ...

    Authors: Riccardo Caccialanza, Emanuele Cereda, Francesco Agustoni, Catherine Klersy, Amanda Casirati, Elisabetta Montagna, Simona Carnio, Silvia Novello, Michele Milella, Sara Pilotto, Ilaria Trestini, Lucio Buffoni, Alessandra Ferrari and Paolo Pedrazzoli
    Citation: BMC Cancer 2022 22:1212
  4. Vast amounts of rapidly accumulating biological data related to cancer and a remarkable progress in the field of artificial intelligence (AI) have paved the way for precision oncology. Our recent contribution ...

    Authors: Manali Singha, Limeng Pu, Brent A. Stanfield, Ifeanyi K. Uche, Paul J. F. Rider, Konstantin G. Kousoulas, J. Ramanujam and Michal Brylinski
    Citation: BMC Cancer 2022 22:1211
  5. We aimed to elucidate the temporal and spatial characteristics of tumor evolution in an oral squamous cell carcinoma (OSCC) mouse model with higher burden of lymphatic metastasis through high-throughput sequen...

    Authors: Yong Cao, Hao Dong, Guangyu Li, Huiping Wei, Cheng Xie, Yangjuan Tuo, Nian Chen and Dahai Yu
    Citation: BMC Cancer 2022 22:1209
  6. Exosomes are a new way of the communication between the tumor cell and macrophage in the micro-environment. The macrophage can be induced to different phenotypes according to the different tumors. In the prese...

    Authors: Jingting Wang, Nan Wang, Zeyu Zheng, Yanlu Che, Masanobu Suzuki, Satoshi Kano, Jianguang Lu, Peng Wang, Yanan Sun and Akihiro Homma
    Citation: BMC Cancer 2022 22:1208
  7. In recent years, benchmarking and assessment methods to improve the quality of care have become increasingly important. Such approaches allow for a uniform assessment, comparisons between centers or over time,...

    Authors: Marcin Ziętek, Jędrzej Wierzbicki, Edyta Pawlak, Adam Maciejczyk and Rafał Matkowski
    Citation: BMC Cancer 2022 22:1207
  8. Previous studies confirmed that ground-glass nodules (GGNs) with certain CT manifestations had a higher probability of malignancy. However, differentiating patchy ground-glass opacities (GGOs) and GGNs has not...

    Authors: Zhang-rui Liang, Min Ye, Fa-jin Lv, Bin-jie Fu, Rui-yu Lin, Wang-jia Li and Zhi-gang Chu
    Citation: BMC Cancer 2022 22:1206
  9. It would be very helpful to stratify patients and direct patient selection if risk factors for quality of life were identified in a particular population. Nonetheless, it is still challenging to forecast the h...

    Authors: Yue Li, Ze Long, Xiuju Wang, Mingxing Lei, Chunzi Liu, Xiaolin Shi and Yaosheng Liu
    Citation: BMC Cancer 2022 22:1205
  10. Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a c...

    Authors: Jiyue Wu, Qing Bi, Xiang Zheng, Huawei Cao, Changzhen Hao, Zejia Sun and Wei Wang
    Citation: BMC Cancer 2022 22:1204
  11. The long-term oncologic outcomes after laparoscopic and open procedures for patients with intermediate‑ and high‑risk endometrial cancer (EC) remain unclear. Accordingly, laparoscopy cannot still be recommende...

    Authors: Xing Zhou, Sitian Wei, Qingchun Shao, Jun Zhang, Rong Zhao, Rui Shi, Wei Zhang, Kejun Dong, Wan Shu and Hongbo Wang
    Citation: BMC Cancer 2022 22:1203
  12. Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, particularly in women with oestrogen receptor-positive (ER +) disease. The aim of this...

    Authors: J. M. Saxton, K. Pickering, S. Wane, H. Humphreys, H. Crank, A. S. Anderson, H. Cain, J. Cohen, R. J. Copeland, J. Gray, J. Hargreaves, R. J. Q. McNally and C. Wilson
    Citation: BMC Cancer 2022 22:1202
  13. Triple-negative breast cancer (TNBC) is a heterogenous subtype involving different patterns of behavior and clinical course, demanding a complex, individualized sequence of treatment. The knowledge and attitud...

    Authors: Ruffo Freitas-Junior, Vilmar Marques de Oliveira, Antonio Luiz Frasson, Francisco Pimentel Cavalcante, Fabio Postiglione Mansani, André Mattar, Felipe Pereira Zerwes, Adriana Magalhães de Oliveira Freitas, Alessandra Borba Anton de Souza, Andrea P. Damin, Annamaria Massahud Rodrigues dos Santos, Carlos Alberto Ruiz, Clécio Ênio Murta de Lucena, Eduardo Camargo Millen, Fábio Bagnoli, Felipe Andrade…
    Citation: BMC Cancer 2022 22:1201
  14. In our previous study, N end of the Circumsporozoite protein (CSP I-plus) modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed, which had antiangiogenic capability and bound ...

    Authors: Xueqin Chen, Yan Wang, Hancong Liu, Jingjing Zhang, Jie Wang, Xiaobao Jin and Yan Ma
    Citation: BMC Cancer 2022 22:1200
  15. Lung cancer is the third most frequent tumor and the main cause of death by tumor in Spain. Although the incidence and mortality are still significantly higher in men than in women, the disparity between the s...

    Authors: Abraham Galindo-Utrero, Jesús María San-Román-Montero, Ruth Gil-Prieto and Ángel Gil-de-Miguel
    Citation: BMC Cancer 2022 22:1199
  16. The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer.

    Authors: Tzu-Lin Yeh, Min-Shu Hsu, Hsin-Yin Hsu, Ming-Chieh Tsai, Jing-Rong Jhuang, Chun-Ju Chiang, Wen-Chung Lee and Kuo-Liong Chien
    Citation: BMC Cancer 2022 22:1198
  17. The prognostic value of pretreatment and preoperative fibrinogen plasma levels and the modified Glasgow prognostic score (mGPS) in stage III/N2 non-small cell lung cancer (NSCLC) patients who receive neoadjuva...

    Authors: Katharina Sinn, Berta Mosleh, Michael Grusch, Walter Klepetko, Konrad Hoetzenecker, Thomas Klikovits, Daniela Gompelmann and Mir Alireza Hoda
    Citation: BMC Cancer 2022 22:1197
  18. While an important surgical landmark of the dentate line has been established for locally advanced lower rectal cancer (LALRC), the prognostic significance of dentate line invasion (DLI) has not been well defi...

    Authors: Maxiaowei Song, Hongzhi Wang, Lin Wang, Shuai Li, Yangzi Zhang, Jianhao Geng, Xianggao Zhu, Yongheng Li, Yong Cai and Weihu Wang
    Citation: BMC Cancer 2022 22:1196
  19. Early detection of bladder cancer (BCa) offers patients a favorable outcome and avoids the need for cystectomy. Development of an accurate and sensitive noninvasive BCa diagnostic test is imperative. DNA methy...

    Authors: Tae Jeong Oh, Eunkyung Lim, Bo-Ram Bang, Justin Junguek Lee, Yong Gil Na, Ju Hyun Shin, Jae Sung Lim, Ki Hak Song and Sungwhan An
    Citation: BMC Cancer 2022 22:1195
  20. The relative contributions of genetic and environmental factors versus unavoidable stochastic risk factors to the variation in cancer risk among tissues have become a widely-discussed topic. Some claim that th...

    Authors: Xinhui Liu, Jifeng Yang, Hongkai Li, Qing Wang, Yuanyuan Yu, Xiaoru Sun, Shucheng Si, Lei Hou, Lu Liu, Fan Yang, Ran Yan, Yifan Yu, Zhentao Fu, Zilong Lu, Dejin Li, Hao Xue…
    Citation: BMC Cancer 2022 22:1194
  21. The incidence of primary liver tumors, hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma (ICC), and combined HCC/ICC (cHCC/CC) is increasing. For ICC, targeted therapy exists only for a ...

    Authors: Ihtzaz Ahmed Malik, Mansi Rajput, Rieke Werner, Dorothea Fey, Niloofar Salehzadeh, Christine A. F. von Arnim and Jörg Wilting
    Citation: BMC Cancer 2022 22:1193
  22. The real-world experience of Swiss chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) is largely unknown, in particular with regard to achievement of response per European L...

    Authors: Nathan Cantoni, Roberto Sommavilla, Patrick Seitz, Elisabeth Kulenkampff, Stefan Kahn, Jean-François Lambert, Adrian Schmidt, Reinhard Zenhaeusern and Stefan Balabanov
    Citation: BMC Cancer 2022 22:1192
  23. Synchronous multiple primary esophageal squamous cell carcinoma (S-MPESCC) refers to more than one primary esophageal carcinoma detected in a solitary patient at the time of initial presentation. The purpose o...

    Authors: Yueyang Yang, Peng Tang, Mingquan Ma, Hongdian Zhang, Haitong Wang, Kai Zhu, Wanyi Xiao, Lei Gong and Zhentao Yu
    Citation: BMC Cancer 2022 22:1191
  24. Umbilical cord blood transplantation (UCBT) from unrelated donors is one of the successful treatments for acute leukemia in childhood. The most frequent side effect of UCBT is peri-engraftment syndrome (PES), ...

    Authors: Xin-Yu Li, Li-Ping Zhan, Dian-Dian Liu, Xia-Wei Han, Han Chen, Zheng-Zhou Wu, Yin Wang, Li-Ping Que, Xiao-Jun Wu, Su Liu, Kai-Mei Wang, Shao-Liang Huang, Jian-Pei Fang, Ke Huang and Hong-Gui Xu
    Citation: BMC Cancer 2022 22:1190
  25. Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, notably in women with oestrogen-receptor positive disease. The aim of this qualitative...

    Authors: Saxton JM, Pickering K, Wane S, Crank H, Anderson AS, Cain H, Cohen J, Copeland RJ, Gray J, Hargreaves J, McNally RJQ and Wilson C
    Citation: BMC Cancer 2022 22:1189
  26. The aim of this study is to explore the expression and clinical relevance of CAF-associated markers, EZH2 and FOXM1 in gastric samples.

    Authors: Hui Sun, Xin Wang, Xiaoyan Zhang, Xu Wang, Cong Tan, Weiwei Weng, Meng Zhang, Shujuan Ni, Lei Wang, Dan Huang, Midie Xu and Weiqi Sheng
    Citation: BMC Cancer 2022 22:1188
  27. Obesity plays an important role in the development and progression of breast cancer via various oncogenic pathways. However, the biological mechanisms underlying this relationship are not fully understood. Mor...

    Authors: Dorothy Meyer, Belén Pastor-Villaescusa, Sophie Michel, Hans Hauner and Dagmar Hauner
    Citation: BMC Cancer 2022 22:1187
  28. An increasing number of studies have demonstrated that CX3CL1 is involved in the development of tumors and may thus be considered a new potential therapeutic target for them. However, the function of CX3CL1 in...

    Authors: Qiming Gong, Zhiting Guo, Wenjuan Sun, Xiuri Du, Yan Jiang and Fahui Liu
    Citation: BMC Cancer 2022 22:1184
  29. The C-reactive protein to albumin ratio (CAR) is associated with poor prognosis in various cancers. However, its value in thymic epithelial tumors remains to be elucidated, we aimed to evaluate the prognostic ...

    Authors: Yang-Yu Huang, Xuan Liu, Shen-Hua Liang, Yu Hu and Guo-Wei Ma
    Citation: BMC Cancer 2022 22:1183
  30. Gut microbiome has been linked to a regulatory role in cancer progression. However, whether broad-spectrum antibiotics (ATB) associated gut microbiome dysbiosis contributes to an impaired T cell immune functio...

    Authors: Ke Xu, Jixu Cai, Jun Xing, Xu Li, Beishou Wu, Zhuxian Zhu and Ziqiang Zhang
    Citation: BMC Cancer 2022 22:1182
  31. Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and ...

    Authors: Tingting Geng, Miao Li, Rong Chen, Shuangyu Yang, Guoquan Jin, Tinabo Jin and Fulin Chen
    Citation: BMC Cancer 2022 22:1181
  32. Circumferential resection margin (CRM) is very important in esophageal cancer, but its diagnostic criteria has not been unified. The College of American Pathologists (CAP) and the Royal College of Pathologists...

    Authors: Zhaoyang Yang, Hua Lin, Zhen Wang, Lulu Rong, Xuchen Zhang, Lin Wang, Jianjun Qin, Xuemin Xue, Yin Li and Liyan Xue
    Citation: BMC Cancer 2022 22:1180
  33. Postoperative radiotherapy (PORT) could be useful for pN1 breast cancer patients who have undergone breast-conserving surgery (BCS) or mastectomy. However, the value of regional nodal irradiation (RNI) for BCS...

    Authors: Tae Hoon Lee, Ji Hyun Chang, Bum-Sup Jang, Jae Sik Kim, Tae Hyun Kim, Won Park, Yong Bae Kim, Su Ssan Kim, Wonshik Han, Han-Byoel Lee and Kyung Hwan Shin
    Citation: BMC Cancer 2022 22:1179
  34. Accurately predicting the prognosis of patients with spontaneously ruptured hepatocellular carcinoma (HCC) is crucial for effective clinical management. The aim of the present study was to establish and evalua...

    Authors: Peng Wang, Shuping Yang, Chao Li, Xiangjun Han, Duo Hong and Haibo Shao
    Citation: BMC Cancer 2022 22:1177
  35. Induction or adjuvant therapies are not always beneficial for thoracic esophageal squamous cell carcinoma (ESCC) patients, and it is thus important to identify patients at high risk for postoperative ESCC recu...

    Authors: Hayato Kaida, Takushi Yasuda, Osamu Shiraishi, Hiroaki Kato, Yutaka Kimura, Kohei Hanaoka, Minoru Yamada, Yuko Matsukubo, Masakatsu Tsurusaki, Kazuhiro Kitajima, Satoshi Hattori and Kazunari Ishii
    Citation: BMC Cancer 2022 22:1176
  36. For the first-line treatment of KRAS mutant non-small cell lung cancer (NSCLC) patients, immunotherapy or platinum-based chemotherapy are the main treatment method. Here, we investigated the clinical efficacy ...

    Authors: Yanxia Liu, Yuan Gao, Ying Wang, Cong Zhao, Zhiyun Zhang, Baolan Li and Tongmei Zhang
    Citation: BMC Cancer 2022 22:1175
  37. For patients with acute myeloid leukaemia (AML), the only potentially curative treatment is intensive chemotherapy (IC). This is highly toxic, particularly for patients > 60 years, potentially leading to prolo...

    Authors: Richard Dillon, Shanna Maycock, Aimee Jackson, Sonia Fox, Sylvie Freeman, Charles Craddock, Catherine Thomas, Emma Homer, Jane Leahy, Anna Mamwell, Nicola Potter, Nigel Russell, Andrew Wei, Hans Beier Ommen, Claire Hemmaway, Steve Knapper…
    Citation: BMC Cancer 2022 22:1174
  38. The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis. In this study, we examine the relationship between niacin intake and ...

    Authors: Hongan Ying, Lijie Gao, Nansheng Liao, Xijuan Xu, Wenfeng Yu and Weiwen Hong
    Citation: BMC Cancer 2022 22:1173
  39. To investigate the expression of programmed death ligand-1 (PD-L1) and the levels of CD8+ tumor-infiltrating lymphocytes (TILs) in meningioma as well as determine the association between their levels and the clin...

    Authors: Yaochuan Zhang, Xiaoliang Wang, Mengwu Shi, Yifu Song, Juanhan Yu and Sheng Han
    Citation: BMC Cancer 2022 22:1171
  40. There is no consensus on the role of serum dehydroepiandrosterone (DHEA) concentrations in the detection of prostate cancer. This study examined the effectiveness of serum DHEA in predicting candidate patients...

    Authors: Yasuhide Miyoshi, Takashi Kawahara and Hiroji Uemura
    Citation: BMC Cancer 2022 22:1169
  41. The goal of research was to investigate the possible relations between serum concentrations of IL-6 and TGF-β1, individual and clinical characteristics, and adverse effects of radiotherapy in patients with pro...

    Authors: Katarina Kopčalić, Ivana Z. Matić, Irina Besu, Vesna Stanković, Zoran Bukumirić, Tatjana P. Stanojković, Aleksandar Stepanović and Marina Nikitović
    Citation: BMC Cancer 2022 22:1167
  42. Intrahepatic cholangiocarcinoma (ICC), originating from the bile ducts, is the second most common primary liver malignancy, and its incidence has recently increased. H2A.Z, a highly conserved H2A variant, is e...

    Authors: Qi Wang, Yongqiang Qi, Fei Xiong, Da Wang, Bing Wang and Yongjun Chen
    Citation: BMC Cancer 2022 22:1166
  43. Ureteral reconstruction is required after surgical resection of the tumor invading the urinary tract in ovarian cancer with low incidence. There are no currently reported surgical outcomes of ureteral reconstr...

    Authors: Ji Hyun Kim, Dong-eun Lee, Hyeong In Ha, Jae Young Jung, Sung Han Kim, Hyung Ho Lee, Ho Kyung Seo, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park and Myong Cheol Lim
    Citation: BMC Cancer 2022 22:1163

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