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  1. There is increasing evidence that the toll-like receptor 3 (TLR3) is an interesting target for anti-cancer therapy. Unfortunately, most laboratory investigations about the impact of TLR3 stimulation on human m...

    Authors: Luc Friboulet, Claire Gourzones, Sai Wah Tsao, Yannis Morel, Carine Paturel, Stéphane Témam, Catherine Uzan and Pierre Busson
    Citation: BMC Cancer 2010 10:327
  2. Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lup...

    Authors: Giuseppe Bifulco, Vincenzo D Mandato, Roberto Piccoli, Pierluigi Giampaolino, Chiara Mignogna, Michele D Mignogna, Luigi Costagliola and Carmine Nappi
    Citation: BMC Cancer 2010 10:324
  3. The role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function.

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding
    Citation: BMC Cancer 2010 10:323
  4. The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause disseminat...

    Authors: Ferdinando Marandino, Carmine Zoccali, Nicola Salducca, Mirella Marino and Paolo Visca
    Citation: BMC Cancer 2010 10:322
  5. The breast is a rare extranodal site of non-Hodgkin lymphoma, and primary breast lymphoma (PBL) has been arbitrarily defined as disease localized to one or both breasts with or without regional lymph nodes inv...

    Authors: Ho-Young Yhim, Hye Jin Kang, Yoon Hee Choi, Seok Jin Kim, Won Seog Kim, Yee Soo Chae, Jin Seok Kim, Chul Won Choi, Sung Yong Oh, Hyeon Seok Eom, Jeong-A Kim, Jae Hoon Lee, Jong-Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Jung Sung…
    Citation: BMC Cancer 2010 10:321
  6. Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α (HIF-1α) and glucose transporter-1 (Glut-1). Hypoxic conditions have also been associated with overexpression of angiogenic factors,...

    Authors: Mariusz Koda, Luiza Kanczuga-Koda, Mariola Sulkowska, Eva Surmacz and Stanislaw Sulkowski
    Citation: BMC Cancer 2010 10:320
  7. We have identified a set of genes whose relative mRNA expression levels in various solid tumors can be used to robustly distinguish cancer from matching normal tissue. Our current feature set consists of 113 g...

    Authors: Joseph Irgon, C Chris Huang, Yi Zhang, Dmitri Talantov, Gyan Bhanot and Sándor Szalma
    Citation: BMC Cancer 2010 10:319
  8. Two mature microRNAs (miRNAs), hsa-miR-125a-3p and hsa-miR-125a-5p (collectively referred to as hsa-miR-125a-3p/5p), are derived from 3' and 5' ends of pre-miR-125a, respectively. Although impaired regulation ...

    Authors: Lili Jiang, Qin Huang, Siyang Zhang, Qingfu Zhang, Jihong Chang, Xueshan Qiu and Enhua Wang
    Citation: BMC Cancer 2010 10:318
  9. The product of CDKN2A, p16 is an essential regulator of the cell cycle controlling the entry into the S-phase. Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiatio...

    Authors: Antal Csepregi, Matthias PA Ebert, Christoph Röcken, Regine Schneider-Stock, Juliane Hoffmann, Hans-Ulrich Schulz, Albert Roessner and Peter Malfertheiner
    Citation: BMC Cancer 2010 10:317
  10. Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. In our previous work, we constructed t...

    Authors: Christian A Merkel, Rafael B da Silva Soares, Anna Carolina V de Carvalho, Daniela B Zanatta, Marcio C Bajgelman, Paula Fratini, Eugenia Costanzi-Strauss and Bryan E Strauss
    Citation: BMC Cancer 2010 10:316
  11. Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding ...

    Authors: Lorna W Harries, John RB Perry, Paul McCullagh and Malcolm Crundwell
    Citation: BMC Cancer 2010 10:315
  12. The onset and the development of neoplastic disease may be influenced by many physiological, biological and immunological factors. The nervous, endocrine and immune system might act as an integrated unit to ma...

    Authors: Gianluigi Mazzoccoli, Gianluigi Vendemiale, Angelo De Cata, Stefano Carughi and Roberto Tarquini
    Citation: BMC Cancer 2010 10:314
  13. The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydr...

    Authors: Jennifer Gjerde, Jürgen Geisler, Steinar Lundgren, Dagfinn Ekse, Jan Erik Varhaug, Gunnar Mellgren, Vidar M Steen and Ernst A Lien
    Citation: BMC Cancer 2010 10:313
  14. Telomerase expression is one of the characteristics of gastric cancer (GC) cells and telomerase activity is frequently up-regulated by a variety of mechanisms during GC development. Therefore, we hypothesized ...

    Authors: Xianli He, Qing Qiao, Naijian Ge, Jing Nan, Shuqun Shen, Zizhong Wang, Yefa Yang and Guoqiang Bao
    Citation: BMC Cancer 2010 10:312
  15. Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively consi...

    Authors: Takahisa Nakayama, Zhi-Qiang Ling, Ken-ichi Mukaisho, Takanori Hattori and Hiroyuki Sugihara
    Citation: BMC Cancer 2010 10:311
  16. The incidence of invasive cervical cancer in HIV-positive women is higher than in the general population. There is evidence that HIV-positive women do not participate sufficiently in cervical cancer screening ...

    Authors: Luigino Dal Maso, Silvia Franceschi, Mauro Lise, Priscilla Sassoli de' Bianchi, Jerry Polesel, Florio Ghinelli, Fabio Falcini and Alba C Finarelli
    Citation: BMC Cancer 2010 10:310
  17. The role of peri-operative chemotherapy in patients with resected stage IV colorectal cancer (CRC) remains to be defined. This study was aimed at evaluating the effectiveness of peri-operative chemotherapy in ...

    Authors: Martina Wieser, Stefan Sauerland, Dirk Arnold, Wolff Schmiegel and Anke Reinacher-Schick
    Citation: BMC Cancer 2010 10:309
  18. We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery.

    Authors: Hao Zhang, Caigang Liu, Di Wu, Yi Meng, Ruonan Song, Ping Lu and Shubao Wang
    Citation: BMC Cancer 2010 10:308
  19. Hypoxia inducible factor 1α (HIF-1α) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27kip1, which is generally reduced in e...

    Authors: Laura MS Seeber, Nicole Horrée, Petra van der Groep, Elsken van der Wall, René HM Verheijen and Paul J van Diest
    Citation: BMC Cancer 2010 10:307
  20. 14-3-3epsilon regulates a wide range of biological processes, including cell cycle control, proliferation, and apoptosis, and plays a significant role in neurogenesis and the formation of malignant tumours. Ho...

    Authors: Xing-Hua Che, Hong Chen, Zhen-Ming Xu, Chao Shang, Kai-Lai Sun and Wei-Neng Fu
    Citation: BMC Cancer 2010 10:306
  21. Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.

    Authors: Jin-xiang Cheng, Bo-lin Liu, Xiang Zhang, Wei Lin, Yong-qiang Zhang, Wei-ping Liu, Jian-ning Zhang, Hong Lin, Rui Wang and Hong Yin
    Citation: BMC Cancer 2010 10:305
  22. Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (...

    Authors: Masakazu Yashiro, Kosei Hirakawa and C Richard Boland
    Citation: BMC Cancer 2010 10:303
  23. Cholangiocarcinoma (CC) is a malignant neoplasm of the bile ducts or the gallbladder. Targeting of growth factor receptors showed therapeutic potential in palliative settings for many solid tumors. The aim of ...

    Authors: Ling Xu, Martin Hausmann, Wolfgang Dietmaier, Silvia Kellermeier, Theresa Pesch, Manuela Stieber-Gunckel, Elisabeth Lippert, Frank Klebl and Gerhard Rogler
    Citation: BMC Cancer 2010 10:302
  24. Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known.

    Authors: Hong Wei Yang, Lata G Menon, Peter M Black, Rona S Carroll and Mark D Johnson
    Citation: BMC Cancer 2010 10:301
  25. The development and progression of colorectal cancer has been extensively studied and the genes responsible have been well characterized. However the correlation between the SMAD4 gene mutations with KRAS mutant ...

    Authors: A Syed Sameer, Nissar A Chowdri, Nidda Syeed, Mujeeb Z Banday, Zaffar A Shah and Mushtaq A Siddiqi
    Citation: BMC Cancer 2010 10:300
  26. Patients with gastric cancer in China have worse outcome and poorer prognosis. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. The intratumoral and peritumoral lymphat...

    Authors: Xiao-Lei Wang, Jian-Ping Fang, Ru-Yong Tang and Xi-Mei Chen
    Citation: BMC Cancer 2010 10:299
  27. The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast ...

    Authors: Hichame Id Boufker, Laurence Lagneaux, Mehdi Najar, Martine Piccart, Ghanem Ghanem, Jean-Jacques Body and Fabrice Journé
    Citation: BMC Cancer 2010 10:298
  28. The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts ...

    Authors: Imke Müller, Frank Wischnewski, Klaus Pantel and Heidi Schwarzenbach
    Citation: BMC Cancer 2010 10:297
  29. Previous studies have shown that the ADIPOR1, ADORA1, BTG2 and CD46 genes differ significantly between long-term survivors of breast cancer and deceased patients, both in levels of gene expression and DNA copy nu...

    Authors: Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Parris, Donal J Brennan, Karin Jirström, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2010 10:296
  30. Pancreatic cancer is still associated with devastating prognosis. Real progress in treatment options has still not been achieved. Therefore new models are urgently needed to investigate this deadly disease. As...

    Authors: Tatyana Kalinina, Cenap Güngör, Sabrina Thieltges, Maren Möller-Krull, Eva Maria Murga Penas, Daniel Wicklein, Thomas Streichert, Udo Schumacher, Viacheslav Kalinin, Ronald Simon, Benjamin Otto, Judith Dierlamm, Heidi Schwarzenbach, Katharina E Effenberger, Maximilian Bockhorn, Jakob R Izbicki…
    Citation: BMC Cancer 2010 10:295
  31. Metastasis is a multi-step process that is responsible for the majority of deaths in cancer patients. Current treatments are not effective in targeting metastasis. The molecular chaperone hsp90α is secreted fr...

    Authors: Jessica McCready, Jessica D Sims, Doug Chan and Daniel G Jay
    Citation: BMC Cancer 2010 10:294
  32. Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We h...

    Authors: Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari and Caroline A Lamb
    Citation: BMC Cancer 2010 10:293
  33. Chronic gastro-oesophageal reflux disease and excessive body fat are considered principal causes of Barrett's oesophagus (a metaplastic change in the cells lining the oesophagus) and its neoplastic progression...

    Authors: Brooke M Winzer, Jennifer D Paratz, Marina M Reeves and David C Whiteman
    Citation: BMC Cancer 2010 10:292
  34. Molecularly targeted drugs inhibit aberrant signaling within oncogenic pathways. Identifying the predominant pathways at work within a tumor is a key step towards tailoring therapies to the patient. Clinical s...

    Authors: Yogesh M Kulkarni, Vivian Suarez and David J Klinke II
    Citation: BMC Cancer 2010 10:291
  35. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Early diagnosis is critical for guiding the therapeutic management of ESCC. It is imperative to find more effective biomarkers ...

    Authors: Xi Zhu, Ming Ding, Mei-Lan Yu, Ming-Xiang Feng, Li-Jie Tan and Fu-Kun Zhao
    Citation: BMC Cancer 2010 10:290
  36. Diabetes is associated with an increased risk of several malignancies. Both diabetic patients and patients with cancer have an increase in platelet reactivity and platelet activation has recently emerged as a ...

    Authors: Chris E Holmes, Maria E Ramos-Nino and Benjamin Littenberg
    Citation: BMC Cancer 2010 10:289
  37. Decreased expression of the angiogenesis inhibitor ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) has previously been reported during prostate cancer progression. The aim of this study was...

    Authors: Heléne Gustavsson, Tajana Tešan, Karin Jennbacken, Kouji Kuno, Jan-Erik Damber and Karin Welén
    Citation: BMC Cancer 2010 10:288
  38. Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one ...

    Authors: Till Krech, Margarethe Thiede, Ellen Hilgenberg, Reinhold Schäfer and Karsten Jürchott
    Citation: BMC Cancer 2010 10:287
  39. Epigenetic aberrations and a CpG island methylator phenotype have been shown to be associated with poor outcomes in children with neuroblastoma (NB). Seven cancer related genes (THBS-1, CASP8, HIN-1, TIG-1, BLU, ...

    Authors: Qiwei Yang, Yufeng Tian, Kelly R Ostler, Alexandre Chlenski, Lisa J Guerrero, Helen R Salwen, Lucy A Godley and Susan L Cohn
    Citation: BMC Cancer 2010 10:286
  40. We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution...

    Authors: Darren R Brenner, Rayjean J Hung, Ming-Sound Tsao, Frances A Shepherd, Michael R Johnston, Steven Narod, Warren Rubenstein and John R McLaughlin
    Citation: BMC Cancer 2010 10:285
  41. Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. We have recently showed the implica...

    Authors: Kaouther Snoussi, Wijden Mahfoudh, Noureddine Bouaouina, Meriem Fekih, Hedi Khairi, Ahmed N Helal and Lotfi Chouchane
    Citation: BMC Cancer 2010 10:283
  42. The alkylating agent Dacarbazine (DTIC) has been used in the treatment of melanoma for decades, but when used as a monotherapy for cancer only moderate response rates are achieved. Recently, the clinical use o...

    Authors: Thilakavathy Thangasamy, Sivanandane Sittadjody, Geoffrey C Mitchell, Erin E Mendoza, Vijayababu M Radhakrishnan, Kirsten H Limesand and Randy Burd
    Citation: BMC Cancer 2010 10:282
  43. The rates of chemotherapy-induced amenorrhea (CIA) associated with docetaxel-based regimens reported by previous studies are discordant. For navelbine-based chemotherapies, rates of CIA have seldom been reported.

    Authors: Wen-Bin Zhou, Hong Yin, Xiao-An Liu, Xiao-Ming Zha, Lin Chen, Jun-Cheng Dai, Ai-di Tao, Ling Chen, Jing-Jing Ma, Li-Jun Ling and Shui Wang
    Citation: BMC Cancer 2010 10:281
  44. Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tum...

    Authors: Javier del Rey, Esther Prat, Immaculada Ponsa, Josep Lloreta, Antoni Gelabert, Ferran Algaba, Jordi Camps and Rosa Miró
    Citation: BMC Cancer 2010 10:280
  45. Genetic testing for hereditary colorectal cancer (HCRC) had significant psychological consequences for test recipients. This prospective longitudinal study investigated the factors that predict psychological r...

    Authors: Samuel MY Ho, Judy WC Ho, George A Bonanno, Annie TW Chu and Emily MS Chan
    Citation: BMC Cancer 2010 10:279
  46. Overall survival (OS) is the gold standard for the demonstration of a clinical benefit in cancer trials. Replacement of OS by a surrogate endpoint allows to reduce trial duration. To date, few surrogate endpoi...

    Authors: Nicolas Methy, Laurent Bedenne and Franck Bonnetain
    Citation: BMC Cancer 2010 10:277
  47. Epigallocatechin-3-gallate (EGCG), one of the major catechins in green tea, is a potential chemopreventive agent for various cancers. The aim of this study was to examine the effect of EGCG on the expression o...

    Authors: Phan LCHB Tran, Soo-A Kim, Hong Seok Choi, Jung-Hoon Yoon and Sang-Gun Ahn
    Citation: BMC Cancer 2010 10:276
  48. It is uncertain whether smoking is related to colorectal cancer risk. Cytochrome P-450 CYP1A1, glutathione-S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are important enzymes in the metabolis...

    Authors: Hoirun Nisa, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya…
    Citation: BMC Cancer 2010 10:274

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