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  1. Functional inactivation of the tumor suppressor Smad4 in colorectal and pancreatic carcinogenesis occurs coincident with the transition to invasive growth. Breaking the basement membrane (BM) barrier, a prereq...

    Authors: Dirk Zboralski, Miriam Böckmann, Marc Zapatka, Sabine Hoppe, Anna Schöneck, Stephan A Hahn, Wolff Schmiegel and Irmgard Schwarte-Waldhoff
    Citation: BMC Cancer 2008 8:215
    Content type: Research article Published on:

  2. Breast Cancer is the most commonly diagnosed cancer among Sri Lankan women. Germline mutations in the susceptibility genes BRCA1 and BRCA2 in hereditary breast/ovarian cancer, though low in prevalence, are highly...

    Authors: Wasanthi De Silva, Eric H Karunanayake, Kamani H Tennekoon, Marie Allen, Indrani Amarasinghe, Preethika Angunawala and Mohamed H Ziard
    Citation: BMC Cancer 2008 8:214
    Content type: Research article Published on:

  3. After total mesorectal excision (TME) for rectal cancer around 10% of patients develops local recurrences within the pelvis. One reason for recurrence might be spillage of cancer cells during surgery. This pil...

    Authors: Annette Torgunrud Kristensen, Johan N Wiig, Stein G Larsen, Karl-Erik Giercksky and Per O Ekstrøm
    Citation: BMC Cancer 2008 8:213
    Content type: Research article Published on:

  4. PTX is one of the most widely used drug in oncology due to its high efficacy against solid tumors and several hematological cancers. PTX is administered in a formulation containing 1:1 Cremophor® EL (polyethoxyla...

    Authors: Luisa Vicari, Teresa Musumeci, Ignazio Giannone, Luana Adamo, Concetta Conticello, Ruggero De Maria, Rosario Pignatello, Giovanni Puglisi and Massimo Gulisano
    Citation: BMC Cancer 2008 8:212
    Content type: Research article Published on:

  5. In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytologica...

    Authors: Yasmin Adam, Cyril J van Gelderen, Guy de Bruyn, James A McIntyre, Diane A Turton and Neil A Martinson
    Citation: BMC Cancer 2008 8:211
    Content type: Research article Published on:

  6. Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity...

    Authors: Hiroshi Makino, Hiroyuki Uetake, Kathleen Danenberg, Peter V Danenberg and Kenichi Sugihara
    Citation: BMC Cancer 2008 8:210
    Content type: Research article Published on:

  7. The vinka-alkaloyd vinorelbine is a potentially valuable treatment in patients with HER2-positive, trastuzumab-resistant advanced breast cancer. We sought to document the clinical activity of vinorelbine-based...

    Authors: Filippo Montemurro, Stefania Redana, Franco Nolè, Michela Donadio, Maria Elena Jacomuzzzi, Giorgio Valabrega, Giuseppe Viale, Anna Sapino and Massimo Aglietta
    Citation: BMC Cancer 2008 8:209
    Content type: Research article Published on:

  8. Conjugated linoleic acid (CLA), a naturally occurring fatty acid found in ruminant products such as milk and beef, has been shown to possess anti-cancer activities in in vivo animal models and in vitro cell cultu...

    Authors: Li-Shu Wang, Yi-Wen Huang, Suling Liu, Pearlly Yan and Young C Lin
    Citation: BMC Cancer 2008 8:208
    Content type: Research article Published on:

  9. Prostate cancer is the most common male cancer in the Western world but is highly heterogeneous in disease progression and outcomes. Consequently, the most substantial morbidity may actually arise from the adv...

    Authors: Suzanne K Chambers, Megan Ferguson, RA Gardiner, David Nicol, Louisa Gordon, Stefano Occhipinti and Joanne Aitken
    Citation: BMC Cancer 2008 8:207
    Content type: Study protocol Published on:

  10. Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1α and...

    Authors: Christian Moser, Sven A Lang, Akira Mori, Claus Hellerbrand, Hans J Schlitt, Edward K Geissler, William E Fogler and Oliver Stoeltzing
    Citation: BMC Cancer 2008 8:206
    Content type: Research article Published on:

  11. DLC2, a unique RhoGAP, has been recently identified as a tumor suppressor gene in hepatocellular carcinoma (HCC). However, the expression of DLC2 protein, and its relationship with RhoA in clinical hepatocellu...

    Authors: Li Xiaorong, Wu Wei, Qian Liyuan and Yang Kaiyan
    Citation: BMC Cancer 2008 8:205
    Content type: Research article Published on:

  12. Molecular analyses of the c-kit and PDGFRα genes have contributed greatly to our understanding of the development of gastrointestinal stromal tumors (GISTs), but little is known about their malignant potential. T...

    Authors: Ursula Pauser, Nina Schmedt auf der Günne, Günter Klöppel, Hartmut Merz and Alfred C Feller
    Citation: BMC Cancer 2008 8:204
    Content type: Research article Published on:

  13. An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast ...

    Authors: Geertruida H de Bock, Catharina E Jacobi, Caroline Seynaeve, Elly MM Krol-Warmerdam, Jannet Blom, Christi J van Asperen, Cees J Cornelisse, Jan GM Klijn, Peter Devilee, Rob AEM Tollenaar, Cecile TM Brekelmans and Johannes C van Houwelingen
    Citation: BMC Cancer 2008 8:203
    Content type: Research article Published on:

  14. Infection with high-risk human papillomavirus is an important factor associated with cervical cancer, and the distribution of HPV types varies greatly worldwide. Determination of type-specific HPV prevalence c...

    Authors: En-qi Wu, Guo-nan Zhang, Xiang-hui Yu, Yuan Ren, Ying Fan, Yong-ge Wu, Wei Kong and Xiao Zha
    Citation: BMC Cancer 2008 8:202
    Content type: Research article Published on:

  16. The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies. Despite knowing the at risk populations ...

    Authors: Gary Beale, Dipankar Chattopadhyay, Joe Gray, Stephen Stewart, Mark Hudson, Christopher Day, Paolo Trerotoli, Gianluigi Giannelli, Derek Manas and Helen Reeves
    Citation: BMC Cancer 2008 8:200
    Content type: Research article Published on:

  18. Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, ma...

    Authors: Yoonseok Kam, Cherise Guess, Lourdes Estrada, Brandy Weidow and Vito Quaranta
    Citation: BMC Cancer 2008 8:198
    Content type: Technical advance Published on:

  19. HO-1 participates in the degradation of heme. Its products can exert unique cytoprotective effects. Numerous tumors express high levels of HO-1 indicating that this enzyme might be a potential therapeutic targ...

    Authors: Dominika Nowis, Marek Bugajski, Magdalena Winiarska, Jacek Bil, Angelika Szokalska, Pawel Salwa, Tadeusz Issat, Halina Was, Alicja Jozkowicz, Jozef Dulak, Tomasz Stoklosa and Jakub Golab
    Citation: BMC Cancer 2008 8:197
    Content type: Research article Published on:

  20. hRad9 is a cell cycle checkpoint gene that is up-regulated in breast cancer. We have previously shown that the mRNA up-regulation correlated with tumor size and local recurrence. Immunohistochemical studies were...

    Authors: Vivian Chan, US Khoo, MS Wong, Ken Lau, Dacita Suen, George Li, Ava Kwong and TK Chan
    Citation: BMC Cancer 2008 8:196
    Content type: Research article Published on:

  21. Patients with acute myeloid leukemia (AML) are often neutropenic as a result of their disease. Furthermore, these patients typically experience profound neutropenia following induction and/or consolidation che...

    Authors: Jorge Sierra, Jeffrey Szer, Jeannine Kassis, Richard Herrmann, Mario Lazzarino, Xavier Thomas, Stephen J Noga, Nigel Baker, Roger Dansey and Alberto Bosi
    Citation: BMC Cancer 2008 8:195
    Content type: Research article Published on:

  22. Cathepsin B and L (CATB, CATL), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 play an important role in colorectal cancer invasion. The tumor marker utility and prognostic relevance of the...

    Authors: László Herszényi, Fabio Farinati, Romilda Cardin, Gábor István, László D Molnár, István Hritz, Massimo De Paoli, Mario Plebani and Zsolt Tulassay
    Citation: BMC Cancer 2008 8:194
    Content type: Research article Published on:

  23. Variant translocations t(9;22) occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60–80% of patients in blast crisis (BC). Here, we report on a CML patient in blast crisis ...

    Authors: An De Weer, Bruce Poppe, Barbara Cauwelier, Andre Carlier, Jan Dierick, Bruno Verhasselt, Jan Philippé, Nadine Van Roy and Frank Speleman
    Citation: BMC Cancer 2008 8:193
    Content type: Research article Published on:

  24. Recent meta-analyses have found a survival advantage with gemcitabine based combinations over single agent gemcitabine in patients with advanced pancreatic cancer. There is paucity of evidence in the form of d...

    Authors: Asma Sultana, Paula Ghaneh, David Cunningham, Naureen Starling, John P Neoptolemos and Catrin Tudur Smith
    Citation: BMC Cancer 2008 8:192
    Content type: Research article Published on:

  25. TGFβ has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT). Some evidence suggests that these effects may be int...

    Authors: Sharon Sheahan, Christopher O Bellamy, Stephen N Hartland, David J Harrison and Sandrine Prost
    Citation: BMC Cancer 2008 8:191
    Content type: Research article Published on:

  26. Kaposi sarcoma (KS) is a multifocal, vascular lesion of low-grade malignant potential that presents most frequently in mucocutaneous sites. KS also commonly involves lymph nodes and visceral organs. This artic...

    Authors: Liron Pantanowitz and Bruce J Dezube
    Citation: BMC Cancer 2008 8:190
    Content type: Review Published on:

  27. Signaling downstream of Ras is mediated by three major pathways, Raf/ERK, phosphatidylinositol 3 kinase (PI3K), and Ral guanine nucleotide exchange factor (RalGEF). Ras signal transduction pathways play an imp...

    Authors: Michael D Oberst, Stacey J Beberman, Liu Zhao, Juan Juan Yin, Yvona Ward and Kathleen Kelly
    Citation: BMC Cancer 2008 8:189
    Content type: Research article Published on:

  28. A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports...

    Authors: Masashi Ishikawa, Takayuki Miyauchi and Yutaka Kashiwagi
    Citation: BMC Cancer 2008 8:188
    Content type: Research article Published on:

  29. Mortality from colorectal cancer is mainly due to metastatic liver disease. Improved understanding of the molecular events underlying metastasis is crucial for the development of new methods for early detectio...

    Authors: Donia P Macartney-Coxson, Kylie A Hood, Hong-jun Shi, Teresa Ward, Anna Wiles, Rosemary O'Connor, David A Hall, Rod A Lea, Janice A Royds, Richard S Stubbs and Serena Rooker
    Citation: BMC Cancer 2008 8:187
    Content type: Research article Published on:

  30. The aim of this study is to investigate the relationship between16-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF (vascular endothelial growth factor) expression in patients with benign and ...

    Authors: Shu-Hua Ma, Hong-Bo Le, Bao-hui Jia, Zhao-Xin Wang, Zhuang-Wei Xiao, Xiao-Ling Cheng, Wei Mei, Min Wu, Zhi-Guo Hu and Yu-Guang Li
    Citation: BMC Cancer 2008 8:186
    Content type: Research article Published on:

  31. Syndecan-1 is a transmembrane proteoglycan with important roles in cell-cell and cell-extracellular matrix adhesion and as a growth factor co-receptor. Syndecan-1 is highly expressed by normal epithelial cells...

    Authors: Yosuke Hashimoto, Marek Skacel and Josephine C Adams
    Citation: BMC Cancer 2008 8:185
    Content type: Research article Published on:

  33. Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recu...

    Authors: David Lindgren, Sigurdur Gudjonsson, Kowan Ja Jee, Fredrik Liedberg, Sonja Aits, Anna Andersson, Gunilla Chebil, Åke Borg, Sakari Knuutila, Thoas Fioretos, Wiking Månsson and Mattias Höglund
    Citation: BMC Cancer 2008 8:183
    Content type: Research article Published on:

  34. Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas.

    Authors: Anxun Wang, Bin Zhang, Hongzhang Huang, Leitao Zhang, Donglin Zeng, Qian Tao, Jianguang Wang and Chaobin Pan
    Citation: BMC Cancer 2008 8:182
    Content type: Research article Published on:

  35. Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to amphibole forms of asbestos, chrysotile asbestos fail to a...

    Authors: Beatriz A Cortez and Glaucia M Machado-Santelli
    Citation: BMC Cancer 2008 8:181
    Content type: Research article Published on:

  36. Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of ...

    Authors: Diana J Leeming, Inger Byrjalsen, Per Qvist, Mitsuru Koizumi, Niels Lynnerup, Michael Fregerslev, Mette G Sørensen, Claus Christiansen and Morten A Karsdal
    Citation: BMC Cancer 2008 8:180
    Content type: Research article Published on:

  37. A Disintegrin And Metalloprotease (ADAM) 9 has been implicated in tumour progression of various solid tumours, however, little is known about its role in renal cell carcinoma. We evaluated the expression of ADAM...

    Authors: Florian R Fritzsche, Kirsten Wassermann, Monika Jung, Angelika Tölle, Ilka Kristiansen, Michael Lein, Manfred Johannsen, Manfred Dietel, Klaus Jung and Glen Kristiansen
    Citation: BMC Cancer 2008 8:179
    Content type: Research article Published on:

  38. CXCR2 chemokine ligands CXCL1, CXCL5 and CXCL6 were shown to be involved in chemoattraction, inflammatory responses, tumor growth and angiogenesis. Here, we comparatively analyzed their expression profile in r...

    Authors: Claudia Rubie, Vilma Oliveira Frick, Mathias Wagner, Jochen Schuld, Stefan Gräber, Brigitte Brittner, Rainer M Bohle and Martin K Schilling
    Citation: BMC Cancer 2008 8:178
    Content type: Research article Published on:

  39. Pain is said to be one of the most feared and distressing symptoms of cancer and one that disrupts all aspects of life. The purposes of this study were: 1) to compare depression and quality of life among Irani...

    Authors: Azadeh Tavoli, Ali Montazeri, Rasool Roshan, Zahra Tavoli and Mahdiyeh Melyani
    Citation: BMC Cancer 2008 8:177
    Content type: Research article Published on:

  40. Rapamycin, an inhibitor of mammalian target of Rapamycin (mTOR), is an immunosuppressive agent that has anti-proliferative effects on some tumors. However, the role of Rapamycin-induced immune suppression on t...

    Authors: Elena V Svirshchevskaya, Jacopo Mariotti, Mollie H Wright, Natalia Y Viskova, William Telford, Daniel H Fowler and Lyuba Varticovski
    Citation: BMC Cancer 2008 8:176
    Content type: Research article Published on:

  41. Copper homeostasis proteins ATP7A and ATP7B are assumed to be involved in the intracellular transport of cisplatin. The aim of the present study was to assess the relevance of sub cellular localisation of thes...

    Authors: Ganna V Kalayda, Christina H Wagner, Irina Buß, Jan Reedijk and Ulrich Jaehde
    Citation: BMC Cancer 2008 8:175
    Content type: Research article Published on:

  42. The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the par...

    Authors: Isabel Conde, María VT Lobo, Javier Zamora, Julio Pérez, Francisco J González, Emilio Alba, Benito Fraile, Ricardo Paniagua and María I Arenas
    Citation: BMC Cancer 2008 8:174
    Content type: Research article Published on:

  43. Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor...

    Authors: Evi Michels, Jasmien Hoebeeck, Katleen De Preter, Alexander Schramm, Bénédicte Brichard, Anne De Paepe, Angelika Eggert, Geneviève Laureys, Jo Vandesompele and Frank Speleman
    Citation: BMC Cancer 2008 8:173
    Content type: Research article Published on:

  44. S100A4 is a metastasis-associated protein which has been linked to multiple cellular events, and has been identified extracellularly, in the cytoplasm and in the nucleus of tumor cells; however, the biological...

    Authors: Mads H Haugen, Kjersti Flatmark, Svein-Ole Mikalsen and Gunhild M Malandsmo
    Citation: BMC Cancer 2008 8:172
    Content type: Research article Published on:

  45. Colorectal cancer (CRC) is the second most commonly diagnosed cancer for both sexes in developed countries. This study assessed the knowledge, attitudes, and preventive practices regarding CRC of adults in Italy.

    Authors: Alessandra Sessa, Rossella Abbate, Gabriella Di Giuseppe, Paolo Marinelli and Italo F Angelillo
    Citation: BMC Cancer 2008 8:171
    Content type: Research article Published on:

  46. Resectable adenocarcinomas in the pancreatic head, by definition "periampullary", originate from ampullary, duodenal, biliary, or ductal pancreatic epithelium. Typically, periampullary adenocarcinomas have eit...

    Authors: Arne Westgaard, Svetlana Tafjord, Inger N Farstad, Milada Cvancarova, Tor J Eide, Oystein Mathisen, Ole Petter F Clausen and Ivar P Gladhaug
    Citation: BMC Cancer 2008 8:170
    Content type: Research article Published on:

  47. Cetuximab, a monoclonal antibody targeting Epidermal Growth Factor Receptor (EGFR), is currently used in metastatic colorectal cancer (mCRC), but predictive factors for therapeutic response are lacking. Mutati...

    Authors: Anthony Gonçalves, Séverine Esteyries, Brynn Taylor-Smedra, Arnaud Lagarde, Mounay Ayadi, Geneviève Monges, François Bertucci, Benjamin Esterni, Jean-Robert Delpero, Olivier Turrini, Bernard Lelong, Patrice Viens, Jean-Paul Borg, Daniel Birnbaum, Sylviane Olschwang and Frédéric Viret
    Citation: BMC Cancer 2008 8:169
    Content type: Research article Published on:

  48. Regional lymph node metastasis is an important prognostic factor in head and neck squamous cell carcinoma (HNSCC) and plays a decisive role in the choice of treatment. Here, we present an independent gene expr...

    Authors: Erik F Hensen, Maria J De Herdt, Jelle J Goeman, Jan Oosting, Vincent THBM Smit, Cees J Cornelisse and Robert J Baatenburg de Jong
    Citation: BMC Cancer 2008 8:168
    Content type: Research article Published on:

  50. Accurate evaluation of axillary lymph node (ALN) involvement is mandatory before treatment of primary breast cancer. The aim of this study is to compare preoperative diagnostic accuracy between positron emissi...

    Authors: Shigeto Ueda, Hitoshi Tsuda, Hideki Asakawa, Jiro Omata, Kazuhiko Fukatsu, Nobuo Kondo, Tadaharu Kondo, Yukihiro Hama, Katsumi Tamura, Jiro Ishida, Yoshiyuki Abe and Hidetaka Mochizuki
    Citation: BMC Cancer 2008 8:165
    Content type: Research article Published on:

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