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  1. Vinca alkaloids are an important class of anticancer agents and semisynthetic vinca alkaloids are developed to improve the therapeutic index of this class of drugs. In the present study, a direct comparison wa...

    Authors: Cindy Simoens, Filip Lardon, Bea Pauwels, Christel MJ De Pooter, Hilde AJ Lambrechts, Greet GO Pattyn, Fabienne Breillout and Jan B Vermorken
    Citation: BMC Cancer 2008 8:65
    Content type: Research article Published on:

  2. Immunohistochemical studies of lymphatic vessels have been limited by a lack of specific markers. Recently, the novel D2-40 antibody, which selectively marks endothelium of lymphatic vessels, was released. The...

    Authors: Vanessa FZ Marinho, Konradin Metze, Fernanda SF Sanches, Gislene FS Rocha and Helenice Gobbi
    Citation: BMC Cancer 2008 8:64
    Content type: Research article Published on:

  3. Several epidemiologic studies have examined the association between physical activity and pancreatic cancer risk; however, the results of these studies are not consistent.

    Authors: Brook A Calton, Rachael Z Stolzenberg-Solomon, Steven C Moore, Arthur Schatzkin, Catherine Schairer, Demetrius Albanes and Michael F Leitzmann
    Citation: BMC Cancer 2008 8:63
    Content type: Research article Published on:

  4. In recent years, preoperative volume reduction of locally advanced breast cancers, resulting in higher rates of breast-conserving surgery (BCS), has become increasingly important also in postmenopausal women. ...

    Authors: Ute E Krainick-Strobel, Werner Lichtenegger, Diethelm Wallwiener, Augustinus H Tulusan, Fritz Jänicke, Gunther Bastert, Ludwig Kiesel, Birgit Wackwitz and Stefan Paepke
    Citation: BMC Cancer 2008 8:62
    Content type: Research article Published on:

  5. We present two melting curve analysis (MCA)-based semiquantitative real time PCR techniques to detect the promoter methylation status of genes. The first, MCA-MSP, follows the same principle as standard MSP bu...

    Authors: Aiala Lorente, Wolf Mueller, Edurne Urdangarín, Paula Lázcoz, Andreas von Deimling and Javier S Castresana
    Citation: BMC Cancer 2008 8:61
    Content type: Technical advance Published on:

  6. Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the susceptibility to lung cancer patients you...

    Authors: Albert Rosenberger, Thomas Illig, Katrin Korb, Norman Klopp, Vera Zietemann, Gabi Wölke, Eckart Meese, Gerhard Sybrecht, Florian Kronenberg, Matthias Cebulla, Maria Degen, Peter Drings, Andreas Gröschel, Nikolaus Konietzko, Karsten grosse Kreymborg, Karl Häußinger…
    Citation: BMC Cancer 2008 8:60
    Content type: Research article Published on:

  7. Germline inactivating mutations in BRCA1 and BRCA2 underlie a major proportion of the inherited predisposition to breast and ovarian cancer. These mutations are usually detected by DNA sequencing. Cost-effective ...

    Authors: Elena A Takano, Gillian Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Cancer 2008 8:59
    Content type: Technical advance Published on:

  8. Arsenic trioxide (As2O3) exhibits promising anticarcinogenic activity in acute promyelocytic leukemic patients and induces apoptosis in various tumor cells in vitro. Here, we investigated the effect of the natura...

    Authors: Tseng-Hsi Lin, Hsing-Chun Kuo, Fen-Pi Chou and Fung-Jou Lu
    Citation: BMC Cancer 2008 8:58
    Content type: Research article Published on:

  9. Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape of cancer. B7-H1 is an inhibitory molecule that binds to PD-1 on T lymphocytes, while FOXP3 is a ma...

    Authors: Hazem Ghebeh, Eman Barhoush, Asma Tulbah, Naser Elkum, Taher Al-Tweigeri and Said Dermime
    Citation: BMC Cancer 2008 8:57
    Content type: Research article Published on:

  10. To determine the incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel.

    Authors: Martine Berliere, Florence Dalenc, Nathalie Malingret, Anita Vindevogel, Philippe Piette, Henry Roche, Jacques Donnez, Michel Symann, Joseph Kerger and Jean-Pascal Machiels
    Citation: BMC Cancer 2008 8:56
    Content type: Research article Published on:

  11. We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of...

    Authors: Kaidi Mikhitarian, Renee Hebert Martin, Megan Baker Ruppel, William E Gillanders, Rana Hoda, Del H Schutte, Kathi Callahan, Michael Mitas and David J Cole
    Citation: BMC Cancer 2008 8:55
    Content type: Research article Published on:

  12. Single nucleotide polymorphisms (SNPs) are the most frequent type of genetic variation in the human genome, and are of interest for the study of susceptibility to and protection from diseases. The haplotype at...

    Authors: Rikke D Hansen, Mette Sørensen, Anne Tjønneland, Kim Overvad, Håkan Wallin, Ole Raaschou-Nielsen and Ulla Vogel
    Citation: BMC Cancer 2008 8:54
    Content type: Research article Published on:

  13. Cancer in the sinonasal tract is rare, but persons who have been occupationally exposed to wood dust have a substantially increased risk. It has been estimated that approximately 3.6 million workers are expose...

    Authors: Jette Bornholdt, Johnni Hansen, Torben Steiniche, Michael Dictor, Annemarie Antonsen, Henrik Wolff, Vivi Schlünssen, Reetta Holmila, Danièle Luce, Ulla Vogel, Kirsti Husgafvel-Pursiainen and Håkan Wallin
    Citation: BMC Cancer 2008 8:53
    Content type: Research article Published on:

  14. MDM4 is a negative regulator of p53 and cooperates with MDM2 in the cellular response to DNA damage. It is unknown, however, whether MDM4 gene alterations play some role in the inherited component of breast cance...

    Authors: Scarlett Reincke, Lina Govbakh, Bettina Wilhelm, Haiyan Jin, Natalia Bogdanova, Michael Bremer, Johann H Karstens and Thilo Dörk
    Citation: BMC Cancer 2008 8:52
    Content type: Research article Published on:

  15. Chemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially i...

    Authors: Ruoping Tang, Anne-Marie Faussat, Jean-Yves Perrot, Zora Marjanovic, Simy Cohen, Thomas Storme, Hamid Morjani, Ollivier Legrand and Jean-Pierre Marie
    Citation: BMC Cancer 2008 8:51
    Content type: Research article Published on:

  16. Early relapse in colorectal cancer (CRC) patients is attributed mainly to the higher malignant entity (such as an unfavorable genotype, deeper tumor invasion, lymph node metastasis and advance cancer stage) an...

    Authors: Ming-Yii Huang, Wei-Yu Fang, Su-Chen Lee, Tian-Lu Cheng, Jaw-Yuan Wang and Shiu-Ru Lin
    Citation: BMC Cancer 2008 8:50
    Content type: Research article Published on:

  17. Epidemiologic studies suggest that long term low dose celecoxib use significantly lowers breast cancer risk. We previously demonstrated that 400 mg celecoxib taken twice daily for 2 weeks lowered circulating p...

    Authors: Edward R Sauter, Wenyi Qin, John E Hewett, Rachel L Ruhlen, John T Flynn, George Rottinghaus and Yin-Chieh Chen
    Citation: BMC Cancer 2008 8:49
    Content type: Research article Published on:

  18. It has been suggested that a small population of cells with unique self-renewal properties and malignant potential exists in solid tumors. Such "cancer stem cells" have been isolated by flow cytometry, followe...

    Authors: Heike Immervoll, Dag Hoem, Per Øystein Sakariassen, Ole Johnny Steffensen and Anders Molven
    Citation: BMC Cancer 2008 8:48
    Content type: Research article Published on:

  19. Activation of peroxisome proliferator-activated receptors γ (PPARγ) induces diverse effects on cancer cells. The thiazolidinediones (TZDs), such as troglitazone and ciglitazone, are PPARγ agonists exhibiting a...

    Authors: Gabriela Magenta, Ximena Borenstein, Romina Rolando and María Adela Jasnis
    Citation: BMC Cancer 2008 8:47
    Content type: Research article Published on:

  20. Previous reports showed that mast cells can typically be found in the peritumoral stroma of cervix carcinomas as well as in many other cancers. Both histamine and TNF-α are potent preformed mast cell mediators...

    Authors: Nicolae-Costin Diaconu, Jaana Rummukainen, Mikko Mättö, Anita Naukkarinen, Rauno J Harvima, Jukka Pelkonen and Ilkka T Harvima
    Citation: BMC Cancer 2008 8:46
    Content type: Research article Published on:

  22. Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome. The National Cancer Institute (NCI) has recommended the Revised Bethesda guidelines for screening HNPCC. There has been a gr...

    Authors: Hei-Ying Jin, Xiufang Liu, Vicky Ka Ming Li, Yijiang Ding, Bolin Yang, Jianxiang Geng, Rensheng Lai, Shuqing Ding, Min Ni and Ronghua Zhao
    Citation: BMC Cancer 2008 8:44
    Content type: Research article Published on:

  23. The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression. This study was pe...

    Authors: Nhu-An Pham, Joerg Schwock, Vladimir Iakovlev, Greg Pond, David W Hedley and Ming-Sound Tsao
    Citation: BMC Cancer 2008 8:43
    Content type: Research article Published on:

  24. FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been repo...

    Authors: Nuran Bektas, Anette ten Haaf, Jürgen Veeck, Peter Johannes Wild, Juliane Lüscher-Firzlaff, Arndt Hartmann, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:42
    Content type: Research article Published on:

  25. IBC (Inflammatory Breast cancer) is a rare form of breast cancer with a particular phenotype. New molecular targets are needed to improve the treatment of this rapidly fatal disease. Given the role of NF-κB-re...

    Authors: Florence Lerebours, Sophie Vacher, Catherine Andrieu, Marc Espie, Michel Marty, Rosette Lidereau and Ivan Bieche
    Citation: BMC Cancer 2008 8:41
    Content type: Research article Published on:

  26. Over expression of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs, abbreviated as OAcSGP) has been demonstrated as a disease-associated antigen on the lymphoblasts of childhood acute lymphoblastic leukaemia (AL...

    Authors: Suchandra Chowdhury, Suman Bandyopadhyay, Chandan Mandal, Sarmila Chandra and Chitra Mandal
    Citation: BMC Cancer 2008 8:40
    Content type: Research article Published on:

  27. Gelsolin-like actin-capping protein (CapG) is a ubiquitous gelsolin-family actin-modulating protein involved in cell signalling, receptor-mediated membrane ruffling, phagocytosis, and motility. CapG has genera...

    Authors: Hitomi Nomura, Katsuhiro Uzawa, Takashi Ishigami, Yukinao Kouzu, Hirofumi Koike, Katsunori Ogawara, Masashi Siiba, Hiroki Bukawa, Hidetaka Yokoe, Hitoshi Kubosawa and Hideki Tanzawa
    Citation: BMC Cancer 2008 8:39
    Content type: Research article Published on:

  29. Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the ...

    Authors: Malene Herbsleb, Ole F Christensen, Thomas Thykjaer, Carsten Wiuf, Michael Borre, Torben F Ørntoft and Lars Dyrskjøt
    Citation: BMC Cancer 2008 8:37
    Content type: Research article Published on:

  30. In women with duct carcinoma in-situ (DCIS) receiving breast conservation therapy (BCT), in-breast recurrences are seen in approximately 10%, but cannot be accurately predicted using clinical and histological ...

    Authors: Swati Kulkarni, Deepa B Patil, Leslie K Diaz, Elizabeth L Wiley, Monica Morrow and Seema A Khan
    Citation: BMC Cancer 2008 8:36
    Content type: Research article Published on:

  31. The Comunitat Valenciana (CV) is a tourist region on the Mediterranean coast of Spain with a high rate of retirement migration. Lung cancer in women is the cancer mortality cause that has increased most in the...

    Authors: Oscar Zurriaga, Hermelinda Vanaclocha, Miguel A Martinez-Beneito and Paloma Botella-Rocamora
    Citation: BMC Cancer 2008 8:35
    Content type: Research article Published on:

  32. This study was performed in order to determine whether monocyte in vitro function is associated with presence, stage and prognosis of head and neck squamous cell carcinoma (HNSCC) disease.

    Authors: John-Helge Heimdal, Kenneth Kross, Beate Klementsen, Jan Olofsson and Hans Jørgen Aarstad
    Citation: BMC Cancer 2008 8:34
    Content type: Research article Published on:

  33. Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island met...

    Authors: Takako Kawasaki, Katsuhiko Nosho, Mutsuko Ohnishi, Yuko Suemoto, Jonathan N Glickman, Andrew T Chan, Gregory J Kirkner, Mari Mino-Kenudson, Charles S Fuchs and Shuji Ogino
    Citation: BMC Cancer 2008 8:33
    Content type: Research article Published on:

  34. TP53 is one of major tumour suppressor genes being essential in preservation of genome integrity. Two very common polymorphisms have been demonstrated to contribute to cancer susceptibility and tumour behaviour....

    Authors: Sandra Costa, Daniela Pinto, Deolinda Pereira, Helena Rodrigues, Jorge Cameselle-Teijeiro, Rui Medeiros and Fernando Schmitt
    Citation: BMC Cancer 2008 8:32
    Content type: Research article Published on:

  35. The incidence of ovarian cancer increases sharply with age, and many elderly patients have coexisting diseases. If patients with comorbidities are diagnosed with advanced stages, this would explain the poor su...

    Authors: Mette S Tetsche, Claus Dethlefsen, Lars Pedersen, Henrik T Sorensen and Mette Norgaard
    Citation: BMC Cancer 2008 8:31
    Content type: Research article Published on:

  36. Neuroblastoma is a severe pediatric tumor, histologically characterised by a variety of cellular phenotypes. One of the pharmacological approaches to neuroblastoma is the treatment with retinoic acid. The mech...

    Authors: Elio Messi, Maria C Florian, Claudio Caccia, Mariarosa Zanisi and Roberto Maggi
    Citation: BMC Cancer 2008 8:30
    Content type: Research article Published on:

  37. Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extrem...

    Authors: Hua Chen, Qiang Huang, Jun Dong, De-Zhong Zhai, Ai-Dong Wang and Qing Lan
    Citation: BMC Cancer 2008 8:29
    Content type: Research article Published on:

  38. Inflammatory breast cancer (IBC) is a distinct and aggressive form of locally-advanced breast cancer with high metastatic potential. In Tunisia, IBC is associated with a high death rate. Among the major molecu...

    Authors: Azza Ben Hamida, Intidhar S Labidi, Karima Mrad, Emmanuelle Charafe-Jauffret, Saïda Ben Arab, Benjamin Esterni, Luc Xerri, Patrice Viens, François Bertucci, Daniel Birnbaum and Jocelyne Jacquemier
    Citation: BMC Cancer 2008 8:28
    Content type: Research article Published on:

  39. Taxane-platinum therapy (TP) has replaced platinum-based therapy (PC or PAC, DNA damaging chemotherapy) in the postoperative treatment of ovarian cancer patients; however, it is not always effective. TP53 prot...

    Authors: Jolanta Kupryjanczyk, Ewa Kraszewska, Izabela Ziolkowska-Seta, Radoslaw Madry, Agnieszka Timorek, Janina Markowska, Jerzy Stelmachow and Mariusz Bidzinski
    Citation: BMC Cancer 2008 8:27
    Content type: Research article Published on:

  40. To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT.

    Authors: Laurent Quero, Pierre Mongiat-Artus, Vincent Ravery, Claude Maylin, François Desgrandchamps and Christophe Hennequin
    Citation: BMC Cancer 2008 8:26
    Content type: Research article Published on:

  41. The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain – bikunin, encoded by AMBP – and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITI...

    Authors: Alexander Hamm, Juergen Veeck, Nuran Bektas, Peter J Wild, Arndt Hartmann, Uwe Heindrichs, Glen Kristiansen, Tamra Werbowetski-Ogilvie, Rolando Del Maestro, Ruth Knuechel and Edgar Dahl
    Citation: BMC Cancer 2008 8:25
    Content type: Research article Published on:

  42. Patients with advanced cancer suffer from cachexia, which is characterised by a marked weight loss, and is invariably associated with the presence of tumoral and humoral factors which are mainly responsible fo...

    Authors: Claudia L Yano, Gislaine Ventrucci, William N Field, Michael J Tisdale and Maria Cristina C Gomes-Marcondes
    Citation: BMC Cancer 2008 8:24
    Content type: Research article Published on:

  43. Osteosarcoma is the most frequent bone tumor in childhood and adolescence. Patients with primary metastatic disease have a poor prognosis. It is therefore important to better characterize the biology of this t...

    Authors: Irene von Luettichau, Stephan Segerer, Alexandra Wechselberger, Mike Notohamiprodjo, Michaela Nathrath, Markus Kremer, Anna Henger, Roghieh Djafarzadeh, Stefan Burdach, Ralf Huss and Peter J Nelson
    Citation: BMC Cancer 2008 8:23
    Content type: Research article Published on:

  44. Bone tumours are comparatively rare tumours and delays in diagnosis and treatment are common. The purpose of this study was to analyse sociodemographic risk factors for bone tumour patients in order to identif...

    Authors: Christoph Schnurr, Mathias Pippan, Hartmut Stuetzer, Karl S Delank, Joern WP Michael and Peer Eysel
    Citation: BMC Cancer 2008 8:22
    Content type: Research article Published on:

  45. Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histo...

    Authors: Maddalena T Tilli, Angela R Parrish, Ion Cotarla, Laundette P Jones, Michael D Johnson and Priscilla A Furth
    Citation: BMC Cancer 2008 8:21
    Content type: Research article Published on:

  46. Quantitative real-time RT-PCR (RT-qPCR) has become a valuable molecular technique in basic and translational biomedical research, and is emerging as an equally valuable clinical tool. Correlation of inter-samp...

    Authors: Maria B Lyng, Anne-Vibeke Lænkholm, Niels Pallisgaard and Henrik J Ditzel
    Citation: BMC Cancer 2008 8:20
    Content type: Research article Published on:

  47. Melanoma progression occurs through three major stages: radial growth phase (RGP), confined to the epidermis; vertical growth phase (VGP), when the tumor has invaded into the dermis; and metastasis. In this wo...

    Authors: Josane F Sousa and Enilza M Espreafico
    Citation: BMC Cancer 2008 8:19
    Content type: Research article Published on:

  48. In a previously published pilot study we explored the performance of microarrays in predicting clinical behaviour of ovarian tumours. For this purpose we performed microarray analysis on 20 patients and estima...

    Authors: Olivier Gevaert, Frank De Smet, Toon Van Gorp, Nathalie Pochet, Kristof Engelen, Frederic Amant, Bart De Moor, Dirk Timmerman and Ignace Vergote
    Citation: BMC Cancer 2008 8:18
    Content type: Research article Published on:

  49. Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethyla...

    Authors: Joshua Z Press, Alessandro De Luca, Niki Boyd, Sean Young, Armelle Troussard, Yolanda Ridge, Pardeep Kaurah, Steve E Kalloger, Katherine A Blood, Margaret Smith, Paul T Spellman, Yuker Wang, Dianne M Miller, Doug Horsman, Malek Faham, C Blake Gilks…
    Citation: BMC Cancer 2008 8:17
    Content type: Research article Published on:

  50. To investigate the neuropsychological outcome of children treated with surgery and posterior fossa irradiation for localized infratentorial ependymoma.

    Authors: Katja von Hoff, Virginie Kieffer, Jean-Louis Habrand, Chantal Kalifa, Georges Dellatolas and Jacques Grill
    Citation: BMC Cancer 2008 8:15
    Content type: Research article Published on:

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