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  1. Chronic inflammation is well known to be a risk factor for colon cancer. Previously we established a novel mouse model of inflammation-related colon carcinogenesis, which is useful to examine the involvement o...

    Authors: Rikako Suzuki, Shingo Miyamoto, Yumiko Yasui, Shigeyuki Sugie and Takuji Tanaka
    Citation: BMC Cancer 2007 7:84
  2. Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispos...

    Authors: Bernd Frank, Kari Hemminki, Alfons Meindl, Barbara Wappenschmidt, Christian Sutter, Marion Kiechle, Peter Bugert, Rita K Schmutzler, Claus R Bartram and Barbara Burwinkel
    Citation: BMC Cancer 2007 7:83
  3. The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk...

    Authors: Yun Bai, Liang Xu, Xiaobo Yang, Zhibin Hu, Jing Yuan, Feng Wang, Minhua Shao, Wentao Yuan, Ji Qian, Hongxia Ma, Ying Wang, Hongliang Liu, Weihong Chen, Lin Yang, Guangfu Jing, Xiang Huo…
    Citation: BMC Cancer 2007 7:81
  4. A low incidence of breast cancer in the Mediterranean basin suggests that a high consumption of Extra Virgin Olive Oil (EVOO) might confer this benefit. While the anti-HER2 oncogene effects of the main ω-9 fat...

    Authors: Javier A Menendez, Alejandro Vazquez-Martin, Ramon Colomer, Joan Brunet, Alegria Carrasco-Pancorbo, Rocio Garcia-Villalba, Alberto Fernandez-Gutierrez and Antonio Segura-Carretero
    Citation: BMC Cancer 2007 7:80
  5. Spain has one of the lowest rates of breast cancer in Europe, though estimated incidence has risen substantially in recent decades. Some years ago, the Spanish Cancer Mortality Atlas showed Spain as having a h...

    Authors: Marina Pollán, Rebeca Ramis, Nuria Aragonés, Beatriz Pérez-Gómez, Diana Gómez, Virginia Lope, Javier García-Pérez, Jose Miguel Carrasco, Maria José García-Mendizábal and Gonzalo López-Abente
    Citation: BMC Cancer 2007 7:78
  6. Adjuvant chemotherapy has been proven to be beneficial for patients with early stage non-small cell lung cancer. However, toxicity and insufficient dose delivery have been critical issues with the chemotherapy...

    Authors: Michael Kreuter, Johan Vansteenkiste, Frank Griesinger, Hans Hoffmann, Hendrik Dienemann, Paul De Leyn and Michael Thomas
    Citation: BMC Cancer 2007 7:77
  7. Most studies have found no increased risk of colon cancer associated with hormone replacement therapy (HRT), or even a decreased risk. But information about the effects of different HRT preparations is lacking.

    Authors: Jürgen C Dinger, Lothar AJ Heinemann, Sabine Möhner, Do Minh Thai and Anita Assmann
    Citation: BMC Cancer 2007 7:76
  8. Current research evidence indicates that women should return to normal use of their arm after breast cancer surgery. However, it appears some women continue to hold the view that they are supposed to protect t...

    Authors: Teresa S Lee, Sharon L Kilbreath, Gerard Sullivan, Kathryn M Refshauge and Jane M Beith
    Citation: BMC Cancer 2007 7:75
  9. Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter methylation and mutations in some oncogenes and tumor...

    Authors: Yang Liu, Weimin Gao, Jill M Siegfried, Joel L Weissfeld, James D Luketich and Phouthone Keohavong
    Citation: BMC Cancer 2007 7:74
  10. Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors. Different studies highlight the importanc...

    Authors: Stéphanie Fabre-Lafay, Florence Monville, Sarah Garrido-Urbani, Carole Berruyer-Pouyet, Christophe Ginestier, Nicolas Reymond, Pascal Finetti, Richard Sauvan, José Adélaïde, Jeannine Geneix, Eric Lecocq, Cornel Popovici, Patrice Dubreuil, Patrice Viens, Anthony Gonçalves, Emmanuelle Charafe-Jauffret…
    Citation: BMC Cancer 2007 7:73
  11. The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite instability-high (MSI-high) and BRAF mutatio...

    Authors: Shuji Ogino, Takako Kawasaki, Gregory J Kirkner, Mutsuko Ohnishi and Charles S Fuchs
    Citation: BMC Cancer 2007 7:72
  12. Waiting times for cancer patients are a national priority in the UK. Previous studies have shown variation between cancer networks in the time between diagnosis and start of radiotherapy for all cancer patient...

    Authors: Ruth H Jack, Elizabeth A Davies, David Robinson, Richard Sainsbury and Henrik Møller
    Citation: BMC Cancer 2007 7:71
  13. The intensity of the inflammation induced by Helicobacter pylori colonization is associated with the development of distal gastric cancer (GC). The host response to H. pylori has been related to genetic polymorph...

    Authors: Elvira Garza-Gonzalez, Francisco J Bosques-Padilla, Sandra I Mendoza-Ibarra, Juan P Flores-Gutierrez, Hector J Maldonado-Garza and Guillermo I Perez-Perez
    Citation: BMC Cancer 2007 7:70
  14. The high complication rates of surgically implanted port catheter systems (SIPCS) represents a major drawback in the treatment of isolated liver neoplasms by hepatic arterial infusion (HAI) of chemotherapy. In...

    Authors: Bert Hildebrandt, Maciej Pech, Annett Nicolaou, Jan M Langrehr, Jacek Kurcz, Birgit Bartels, Alexandra Miersch, Roland Felix, Peter Neuhaus, Hanno Riess, Bernd Dörken and Jens Ricke
    Citation: BMC Cancer 2007 7:69
  15. In 1996, Mexico started to register cases of childhood cancer. Here, we describe the incidence of cancer in children, residing in ten Mexican jurisdictions, who were treated by the Instituto Mexicano del Segur...

    Authors: Arturo Fajardo-Gutiérrez, Servando Juárez-Ocaña, Guadalupe González-Miranda, Virginia Palma-Padilla, Rogelio Carreón-Cruz, Manuel Carlos Ortega-Alvárez and Juan Manuel Mejía-Arangure
    Citation: BMC Cancer 2007 7:68
  16. CYYR1 is a recently identified gene located on human chromosome 21 whose product has no similarity to any known protein and is of unknown function. Analysis of expressed sequence tags (ESTs) have revealed high h...

    Authors: Lorenza Vitale, Flavia Frabetti, Shane A Huntsman, Silvia Canaider, Raffaella Casadei, Luca Lenzi, Federica Facchin, Paolo Carinci, Maria Zannotti, Domenico Coppola and Pierluigi Strippoli
    Citation: BMC Cancer 2007 7:66
  17. Evaluation of the clinical efficacy and tolerance of metronomic chemotherapy as salvage therapy in a young patient with advanced, platinum resistant, ovarian carcinoma and bad performance status.

    Authors: Riccardo Samaritani, Giacomo Corrado, Enrico Vizza and Carlo Sbiroli
    Citation: BMC Cancer 2007 7:65
  18. Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, a...

    Authors: Uma R Chandran, Changqing Ma, Rajiv Dhir, Michelle Bisceglia, Maureen Lyons-Weiler, Wenjing Liang, George Michalopoulos, Michael Becich and Federico A Monzon
    Citation: BMC Cancer 2007 7:64
  19. Bcl-2 is positively regulated by hormonal receptor pathways in breast cancer. A study was conducted to assess the prognostic significances of clinico-pathologic variables and of ER, PR, p53, c-erbB2, bcl-2, or...

    Authors: Kyung-Hun Lee, Seock-Ah Im, Do-Youn Oh, Se-Hoon Lee, Eui Kyu Chie, Wonshik Han, Dong-Wan Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Dae Seog Heo, Sung Whan Ha and Yung-Jue Bang
    Citation: BMC Cancer 2007 7:63
  20. This study evaluated the feasibility, toxicity, response rate and survival of neoadjuvant superselective intra-arterial infusion of high dose carboplatin in advanced head and neck cancer.

    Authors: Giulia Bertino, Marco Benazzo, Patrizia Gatti, Gianni Bernardo, Franco Corbella, Carmine Tinelli, Federico Zappoli and Eugenio Mira
    Citation: BMC Cancer 2007 7:62
  21. Breast cancer is a heterogeneous disease, presenting with a wide range of histologic, clinical, and genetic features. Microarray technology has shown promise in predicting outcome in these patients.

    Authors: James E Korkola, Ekaterina Blaveri, Sandy DeVries, Dan H Moore II, E Shelley Hwang, Yunn-Yi Chen, Anne LH Estep, Karen L Chew, Ronald H Jensen and Frederic M Waldman
    Citation: BMC Cancer 2007 7:61
  22. The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variati...

    Authors: Montserrat Garcia-Closas, Louise A Brinton, Jolanta Lissowska, Douglas Richesson, Mark E Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Robert Welch, Meredith Yeager, Witold Zatonski and Stephen J Chanock
    Citation: BMC Cancer 2007 7:60
  23. Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen.

    Authors: Yamei Zhou, Christina Yau, Joe W Gray, Karen Chew, Shanaz H Dairkee, Dan H Moore, Urs Eppenberger, Serenella Eppenberger-Castori and Christopher C Benz
    Citation: BMC Cancer 2007 7:59
  24. The identification of genomic signatures of colorectal cancer for risk stratification requires the study of large series of cancer patients with an extensive clinical follow-up. Multicentric clinical studies r...

    Authors: Heiko Fensterer, Bernhard Radlwimmer, Jörn Sträter, Malte Buchholz, Daniela E Aust, Catherine Julié, François Radvanyi, Bernard Nordlinger, Claudio Belluco, Eric Van Cutsem, Claus-Henning Köhne, Hans A Kestler, Carsten Schwaenen, Michelle Nessling, Manfred P Lutz, Peter Lichter…
    Citation: BMC Cancer 2007 7:58
  25. Bladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with maté drinking. We conducted an additional case-cont...

    Authors: Eduardo De Stefani, Paolo Boffetta, Hugo Deneo-Pellegrini, Pelayo Correa, Alvaro L Ronco, Paul Brennan, Gilles Ferro, Giselle Acosta and María Mendilaharsu
    Citation: BMC Cancer 2007 7:57
  26. Invasive ductal and lobular carcinomas (IDC and ILC) are the most common histological types of breast cancer. Clinical follow-up data and metastatic patterns suggest that the development and progression of the...

    Authors: Gulisa Turashvili, Jan Bouchal, Karl Baumforth, Wenbin Wei, Marta Dziechciarkova, Jiri Ehrmann, Jiri Klein, Eduard Fridman, Jozef Skarda, Josef Srovnal, Marian Hajduch, Paul Murray and Zdenek Kolar
    Citation: BMC Cancer 2007 7:55
  27. Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for d...

    Authors: Peter Laszlo Lakatos, Erika Hitre, Ferenc Szalay, Kerstin Zinober, Peter Fuszek, Laszlo Lakatos, Simon Fischer, Janos Osztovits, Orsolya Gemela, Gabor Veres, Janos Papp and Peter Ferenci
    Citation: BMC Cancer 2007 7:54
  28. Brain metastases (BM) are the most common form of intracranial cancer. The incidence of BM seems to have increased over the past decade. Recursive partitioning analysis (RPA) of data from three Radiation Thera...

    Authors: Gustavo A Viani, Marcus S Castilho, João V Salvajoli, Antonio Cassio A Pellizzon, Paulo E Novaes, Flavio S Guimarães, Maria A Conte and Ricardo C Fogaroli
    Citation: BMC Cancer 2007 7:53
  29. XIAP-associated factor 1 (XAF1) is a putative tumor suppressor that exerts its proapoptotic effects through both caspase-dependent and – independent means. Loss of XAF1 expression through promoter methylation ...

    Authors: O Cristina Micali, Herman H Cheung, Stéphanie Plenchette, Sandra L Hurley, Peter Liston, Eric C LaCasse and Robert G Korneluk
    Citation: BMC Cancer 2007 7:52
  30. Gefitinib, an oral agent of epidermal growth factor receptor tyrosine kinase inhibitor, has a certain efficacy against non-small cell lung cancer (NSCLC). Several predictive factors of gefitinib sensitivity ha...

    Authors: Hiroshi Yokouchi, Koichi Yamazaki, Ichiro Kinoshita, Jun Konishi, Hajime Asahina, Noriaki Sukoh, Masao Harada, Kenji Akie, Shigeaki Ogura, Takashi Ishida, Mitsuru Munakata, Hirotoshi Dosaka-Akita, Hiroshi Isobe and Masaharu Nishimura
    Citation: BMC Cancer 2007 7:51
  31. After two studies reporting response rates higher than 70% in HER2-positive metastatic breast cancer with weekly trastuzumab and vinorelbine, we planned a phase 2 study to test activity of the same combination...

    Authors: Ermelinda De Maio, Carmen Pacilio, Adriano Gravina, Alessandro Morabito, Francesca Di Rella, Vincenzo Labonia, Gabriella Landi, Francesco Nuzzo, Emanuela Rossi, Pasqualina Silvestro, Gerardo Botti, Maurizio Di Bonito, Maria Pia Curcio, Franca Formichelli, Franca La Vecchia, Maria Staiano…
    Citation: BMC Cancer 2007 7:50
  32. As chondrosarcomas are resistant to chemotherapy and ionizing radiation, therapeutic options are limited. Radical surgery often cannot be performed. Therefore, additional therapies such as antiangiogenesis rep...

    Authors: Frank M Klenke, Amir Abdollahi, Elisabeth Bertl, Martha-Maria Gebhard, Volker Ewerbeck, Peter E Huber and Axel Sckell
    Citation: BMC Cancer 2007 7:49
  33. Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human b...

    Authors: Emin T Elkiran, Nefsal Mar, Bilge Aygen, Ferit Gursu, Aziz Karaoglu and Suleyman Koca
    Citation: BMC Cancer 2007 7:48
  34. High risk type human papilloma viruses (HR-HPV) induce carcinomas of the uterine cervix by expressing viral oncogenes E6 and E7. Oncogene E7 of HR-HPV disrupts the pRb/E2F interaction, which negatively regulat...

    Authors: Tatiana A Ivanova, Daria A Golovina, Larisa E Zavalishina, Galina M Volgareva, Alexey N Katargin, Yulia Y Andreeva, Georgy A Frank, Fjodor L Kisseljov and Natalia P Kisseljova
    Citation: BMC Cancer 2007 7:47
  35. IL-1beta has been implicated in inflammatory episode. In view of the inflammatory nature of cancer cachexia, we determined the predictive value of IL-1B-31 T/C, -511 C/T, +3954 C/T and IL-1RN VNTR gene polymor...

    Authors: Dianliang Zhang, Hongmei Zheng, Yanbing Zhou, Xingming Tang, Baojun Yu and Jieshou Li
    Citation: BMC Cancer 2007 7:45
  36. Breast cancer is one of the most extensively studied cancers and its genetic basis is well established. Dermatoglyphic traits are formed under genetic control early in development but may be affected by enviro...

    Authors: Chintamani, Rohan Khandelwal, Aliza Mittal, Sai Saijanani, Amita Tuteja, Anju Bansal, Dinesh Bhatnagar and Sunita Saxena
    Citation: BMC Cancer 2007 7:44
  37. Cancer-cachexia induces a variety of metabolic disorders on protein turnorver, decreasing protein synthesis and increasing protein degradation. Controversly, insulin, other hormones, and branched-chain amino a...

    Authors: Gislaine Ventrucci, Maria Alice R Mello and Maria Cristina C Gomes-Marcondes
    Citation: BMC Cancer 2007 7:42
  38. The disappointing results of surgical therapy alone of ductal pancreatic cancer can only be improved using multimodal approaches. In contrast to adjuvant therapy, neoadjuvant chemoradiation is able to facilita...

    Authors: Thomas B Brunner, Gerhard G Grabenbauer, Thomas Meyer, Henriette Golcher, Rolf Sauer and Werner Hohenberger
    Citation: BMC Cancer 2007 7:41
  39. The study was designed to investigate immunocompetence in relation to cancer progression in rat and to assess the effect of the traditional Chinese anti-cancer medicine, "Shenyang" prescription, on immunity.

    Authors: Canhua Jiang, Dongxia Ye, Weiliu Qiu, Xiuli Zhang, Zhiyuan Zhang, Di He, Ping Zhang and Wantao Chen
    Citation: BMC Cancer 2007 7:40
  40. Current histo-pathological prognostic factors are not very helpful in predicting the clinical outcome of breast cancer due to the disease's heterogeneity. Molecular profiling using a large panel of genes could...

    Authors: Maïa Chanrion, Hélène Fontaine, Carmen Rodriguez, Vincent Negre, Frédéric Bibeau, Charles Theillet, Alain Hénaut and Jean-Marie Darbon
    Citation: BMC Cancer 2007 7:39
  41. Primary small cell carcinoma (SCC) of the esophagus is a rare and aggressive tumor with poor prognosis. In this study, we report the clinicopathological characteristics of 21 cases of small cell carcinoma of t...

    Authors: Jing-Ping Yun, Mei-Fang Zhang, Jin-Hui Hou, Qiu-Hong Tian, Jia Fu, Xiao-Man Liang, Qiu-Liang Wu and Tie-Hua Rong
    Citation: BMC Cancer 2007 7:38
  42. Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an infor...

    Authors: Ashokkumar A Patel, Dilipkumar Gupta, David Seligson, Eyas M Hattab, Ulysses J Balis, Thomas M Ulbright, Isaac S Kohane, Jules J Berman, John R Gilbertson, Sarah Dry, Osvaldo Schirripa, Hong Yu, Michael J Becich and Anil V Parwani
    Citation: BMC Cancer 2007 7:37
  43. Neoadjuvant chemotherapy has been considered the standard care in locally advanced breast cancer. However, about 20% of the patients do not benefit from this clinical treatment and, predictive factors of respo...

    Authors: Daniel G Tiezzi, Jurandyr M Andrade, Alfredo Ribeiro-Silva, Fábio E Zola, Heitor RC Marana and Marcelo G Tiezzi
    Citation: BMC Cancer 2007 7:36

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