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  1. Sunitinib is a protein tyrosine kinase-inhibitor targeting VEGFR, c-kit and PDGFR. It has been approved for the treatment of metastatic renal-cell carcinoma and gastrointestinal stromal tumors. Although it has...

    Authors: Loukas F Kontovinis, Konstantinos T Papazisis, Panagiota Touplikioti, Charalambos Andreadis, Despoina Mouratidou and Alexandros H Kortsaris
    Citation: BMC Cancer 2009 9:82
    Content type: Research article Published on:

  2. Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more ma...

    Authors: Stacey L Fossey, Albert T Liao, Jennifer K McCleese, Misty D Bear, Jiayuh Lin, Pui-Kai Li, William C Kisseberth and Cheryl A London
    Citation: BMC Cancer 2009 9:81
    Content type: Research article Published on:

  3. ADAM33 protein is a member of the family of transmembrane glycoproteins composed of multidomains. ADAM family members have different activities, such as proteolysis and adhesion, making them good candidates to...

    Authors: Gerusa G Seniski, Anamaria A Camargo, Daniela F Ierardi, Edneia AS Ramos, Mariana Grochoski, Enilze SF Ribeiro, Iglenir J Cavalli, Fabio O Pedrosa, Emanuel M de Souza, Silvio M Zanata, Fabrício F Costa and Giseli Klassen
    Citation: BMC Cancer 2009 9:80
    Content type: Research article Published on:

  4. The metastasis of cancer cells and leukocyte extravasation into inflamed tissues share common features. Specialized carbohydrates modified with sialyl Lewis x (sLex) antigens on leukocyte membranes are ligands fo...

    Authors: Catherine A St Hill, Mariya Farooqui, Gregory Mitcheltree, H Evin Gulbahce, Jose Jessurun, Qing Cao and Bruce Walcheck
    Citation: BMC Cancer 2009 9:79
    Content type: Research article Published on:

  5. The proinflammatory cytokine interleukin-1 (IL-1) is known to play an important role in the carcinogenesis of breast cancer. Although IL-1 gene polymorphisms were reported to be associated with increased risk ...

    Authors: Christoph Grimm, Eva Kantelhardt, Georg Heinze, Stephan Polterauer, Robert Zeillinger, Heinz Kölbl, Alexander Reinthaller and Lukas Hefler
    Citation: BMC Cancer 2009 9:78
    Content type: Research article Published on:

  6. The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect clini...

    Authors: Anne Margrete Øyan, Nina Ånensen, Trond Hellem Bø, Laila Stordrange, Inge Jonassen, Øystein Bruserud, Karl-Henning Kalland and Bjørn Tore Gjertsen
    Citation: BMC Cancer 2009 9:77
    Content type: Research article Published on:

  7. Breast cancer is the leading female malignancy in Nigeria. Screening for early detection has led to reduction in mortality from the disease. It is known that attitudes of physicians and motivation by community...

    Authors: Nasiru A Ibrahim and Olumuyiwa O Odusanya
    Citation: BMC Cancer 2009 9:76
    Content type: Research article Published on:

  8. Inhibitor of differentiation 2 (Id2) is a critical factor for cell proliferation and differentiation in normal vertebrate development. Most of the biological function of Id2 has been ascribed to its helix-loop-he...

    Authors: Yuanguang Meng, Chenglei Gu, Zhiqiang Wu, Yali Zhao, Yiling Si, Xiaobing Fu and Weidong Han
    Citation: BMC Cancer 2009 9:75
    Content type: Research article Published on:

  9. Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is s...

    Authors: David Sarrió, José Palacios, Marta Hergueta-Redondo, Gonzalo Gómez-López, Amparo Cano and Gema Moreno-Bueno
    Citation: BMC Cancer 2009 9:74
    Content type: Research article Published on:

  10. In the course of surveillance of gastric cancer recurrence after curative resection, contrast CT scan is used in general. However, new findings from CT scan are not always confirmatory for the recurrence. In t...

    Authors: Sung Hoon Sim, Yu Jung Kim, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Won Jun Kang, Seock-Ah Im, Tae-You Kim, Woo Ho Kim, Dae Seog Heo and Yung-Jue Bang
    Citation: BMC Cancer 2009 9:73
    Content type: Research article Published on:

  11. Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis. Topoisomerase IIα (topoIIα), located at chromosome 17q21-22, is consi...

    Authors: Shin-ichiro Maruya, Takashi Shirasaki, Takahiko Nagaki, Seiji Kakehata, Hidekachi Kurotaki, Hiroki Mizukami and Hideichi Shinkawa
    Citation: BMC Cancer 2009 9:72
    Content type: Research article Published on:

  12. Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies. Besides sharing common growth features with other types ...

    Authors: Jean-Louis Boulay, Urs Stiefel, Elisabeth Taylor, Béatrice Dolder, Adrian Merlo and Frank Hirth
    Citation: BMC Cancer 2009 9:71
    Content type: Research article Published on:

  13. A positive family history of chronic diseases including cancer can be used as an index of genetic and shared environmental influences. The tumours studied have several putative risk factors in common including...

    Authors: Helen H McDuffie, Punam Pahwa, Chandima P Karunanayake, John J Spinelli and James A Dosman
    Citation: BMC Cancer 2009 9:70
    Content type: Research article Published on:

  14. Carboxypeptidase 4 (CPA4) is a zinc-dependent metallocarboxypeptidase on chromosome 7q32 in a region linked to prostate cancer aggressiveness. CPA4 is involved in the histone hyperacetylation pathway and may modu...

    Authors: Phillip L Ross, Iona Cheng, Xin Liu, Mine S Cicek, Peter R Carroll, Graham Casey and John S Witte
    Citation: BMC Cancer 2009 9:69
    Content type: Research article Published on:

  15. Limited information is available regarding the effect of age on choice of surgical and oncological treatment for rectal cancer. The objective of this study was to assess the influence of age on treatment and o...

    Authors: Bärbel Jung, Lars Påhlman, Robert Johansson and Erik Nilsson
    Citation: BMC Cancer 2009 9:68
    Content type: Research article Published on:

  16. The prerequisite for the potential use of the bacterial toxin verotoxin-1 in the treatment of breast cancer was investigated by first determining the expression of its receptor Gb3 (CD77) in clinical breast ca...

    Authors: David Johansson, Eldina Kosovac, Jasmin Moharer, Ingrid Ljuslinder, Thomas Brännström, Anders Johansson and Parviz Behnam-Motlagh
    Citation: BMC Cancer 2009 9:67
    Content type: Research article Published on:

  17. Advanced pancreatic cancer has a poor prognosis, and the current standard of care (gemcitabine based chemotherapy) provides a small survival advantage. However the drawback is the accompanying systemic toxicit...

    Authors: Asma Sultana, Susannah Shore, Michael GT Raraty, Sobhan Vinjamuri, Jonathan E Evans, Catrin Tudur Smith, Steven Lane, Seema Chauhan, Lorraine Bosonnet, Conall Garvey, Robert Sutton, John P Neoptolemos and Paula Ghaneh
    Citation: BMC Cancer 2009 9:66
    Content type: Research article Published on:

  18. Caveolin-1 is the main component of caveolae membrane structures and has different roles during tumorigenesis in different cancer types with varying expression profiles, indicating that the role of caveolin-1 ...

    Authors: Murat Cokakli, Esra Erdal, Deniz Nart, Funda Yilmaz, Ozgul Sagol, Murat Kilic, Sedat Karademir and Nese Atabey
    Citation: BMC Cancer 2009 9:65
    Content type: Research article Published on:

  19. Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker f...

    Authors: Shi-qian Zhang, Hao Yu and Lin-lin Zhang
    Citation: BMC Cancer 2009 9:64
    Content type: Research article Published on:

  20. The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism...

    Authors: Luke H Stockwin, Sherry X Yu, Howard Stotler, Melinda G Hollingshead and Dianne L Newton
    Citation: BMC Cancer 2009 9:63
    Content type: Research article Published on:

  21. Germline mutations in BRCA1 or BRCA2 genes have been demonstrated to increase the risk of developing breast cancer. Conversely, the impact of BRCA mutations on prognosis and survival of breast cancer patients is ...

    Authors: Mario Budroni, Rosaria Cesaraccio, Vincenzo Coviello, Ornelia Sechi, Daniela Pirino, Antonio Cossu, Francesco Tanda, Marina Pisano, Grazia Palomba and Giuseppe Palmieri
    Citation: BMC Cancer 2009 9:62
    Content type: Research article Published on:

  22. The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in ...

    Authors: Zi-Ke Qin, Jian-An Yang, Yun-lin Ye, Xing Zhang, Li-Hua Xu, Fang-Jian Zhou, Hui Han, Zuo-Wei Liu, Li-Bing Song and Mu-Sheng Zeng
    Citation: BMC Cancer 2009 9:61
    Content type: Research article Published on:

  23. A germ line single nucleotide polymorphism (SNP) in the first intron of the gene encoding MDM2 at position 309, an important modulator of p53, has been described. BRCA1/2 mutation have been associated with inc...

    Authors: Hovav Nechushtan, Tamar Hamburger, Susan Mendelson, Luna Kadouri, Nir Sharon, Eli Pikarsky and Tamar Peretz
    Citation: BMC Cancer 2009 9:60
    Content type: Research article Published on:

  24. The COOH terminal peptide of Pro-collagen type I (PICP, also called C3) is chemotactic for endothelial melanoma and breast cancer cells. PICP induces the expression of Metalloproteinases-2 and -9, of Vascular ...

    Authors: Davide Visigalli, Daniela Palmieri, Antonella Strangio, Simonetta Astigiano, Ottavia Barbieri, Gianluigi Casartelli, Antonio Zicca and Paola Manduca
    Citation: BMC Cancer 2009 9:59
    Content type: Research article Published on:

  25. Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Ther...

    Authors: Shigeru Iida, Reiko Kuni-Kamochi, Katsuhiro Mori, Hirofumi Misaka, Miho Inoue, Akira Okazaki, Kenya Shitara and Mitsuo Satoh
    Citation: BMC Cancer 2009 9:58
    Content type: Research article Published on:

  26. The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activi...

    Authors: Miikka Korja, Anne Jokilammi, Toivo T Salmi, Hannu Kalimo, Tarja-Terttu Pelliniemi, Jorma Isola, Immo Rantala, Hannu Haapasalo and Jukka Finne
    Citation: BMC Cancer 2009 9:57
    Content type: Research article Published on:

  27. The proteasome inhibitor bortezomib has shown impressive clinical activity alone and in combination with conventional and other novel agents for the treatment of multiple myeloma (MM) and some solid cancers. A...

    Authors: Zhen-Xian Du, Hai-Yan Zhang, Xin Meng, Yifu Guan and Hua-Qin Wang
    Citation: BMC Cancer 2009 9:56
    Content type: Research article Published on:

  28. We previously found that r-hu-IFNγ exerts a potent anti-tumor effect on human nasopharyngeal carcinoma xenografts in vivo. Considering the fact that the clinical use of recombinant IFNγ is limited by its short ha...

    Authors: Jiangxue Wu, Xia Xiao, Hongyun Jia, Jiemin Chen, Yinghui Zhu, Peng Zhao, Huanxin Lin and Wenlin Huang
    Citation: BMC Cancer 2009 9:55
    Content type: Research article Published on:

  29. Although features of variable differentiation in glioblastoma cell cultures have been reported, a comparative analysis of differentiation properties of normal neural GFAP positive progenitors, and those shown ...

    Authors: Piotr Rieske, Ewa Golanska, Magdalena Zakrzewska, Sylwester Piaskowski, Krystyna Hulas-Bigoszewska, Magdalena Wolańczyk, Malgorzata Szybka, Monika Witusik-Perkowska, Dariusz J Jaskolski, Krzysztof Zakrzewski, Wojciech Biernat, Barbara Krynska and Pawel P Liberski
    Citation: BMC Cancer 2009 9:54
    Content type: Research article Published on:

  30. Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML) and Ph+ acute lymphoblastic leukaemia (ALL). However, most advanced-phase CML and Ph+...

    Authors: Patricia Mambou Gwanmesia, Annette Romanski, Kerstin Schwarz, Biserka Bacic, Martin Ruthardt and Oliver G Ottmann
    Citation: BMC Cancer 2009 9:53
    Content type: Research article Published on:

  32. Oncoprotein HCCR-1 functions as a negative regulator of the p53 and contributes breast tumorigenesis. The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast ...

    Authors: Seon-Ah Ha, Youn Soo Lee, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Hong Namkoong, Hae Joo Kim, Sang Min Jung, Yu Sun Lee, Yeun Jun Chung, Sang Seol Jung and Jin Woo Kim
    Citation: BMC Cancer 2009 9:51
    Content type: Research article Published on:

  33. The additional use of radiotherapy has changed the treatment of locally advanced rectal cancer (LARC) dramatically. But a major achievement has been the development of total mesorectal excision (TME) as a surg...

    Authors: Robert Siegel, Susen Burock, Klaus-Dieter Wernecke, Albrecht Kretzschmar, Manfred Dietel, Volker Loy, Stephan Koswig, Volker Budach and Peter M Schlag
    Citation: BMC Cancer 2009 9:50
    Content type: Study protocol Published on:

  34. Housekeeping genes are routinely used as endogenous references to account for experimental differences in gene expression assays. However, recent reports show that they could be de-regulated in different disea...

    Authors: Li-Yun Fu, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Cai Wu, Yue Zhao, Hai-Jun Zhou, Ning Ren, Qin-Hai Ye and Lun-Xiu Qin
    Citation: BMC Cancer 2009 9:49
    Content type: Research article Published on:

  35. The development of breast cancer is multifactorial. Hormonal, environmental factors and genetic predisposition, among others, could interact in the presentation of breast carcinoma. Human leukocyte antigen (HL...

    Authors: David Cantú de León, Delia Pérez-Montiel, Verónica Villavicencio, Alejandro García Carranca, Alejandro Mohar Betancourt, Victor Acuña-Alonzo, Alberto López-Tello, Gilberto Vargas-Alarcón, Rodrigo Barquera, Neng Yu, Edmond J Yunis and Julio Granados
    Citation: BMC Cancer 2009 9:48
    Content type: Research article Published on:

  36. Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the fac...

    Authors: Harue Tada, Satoshi Teramukai, Masanori Fukushima and Hiroshi Sasaki
    Citation: BMC Cancer 2009 9:47
    Content type: Research article Published on:

  38. The bone-tumor microenvironment encompasses unique interactions between the normal cells of the bone and marrow cavity and the malignant cells from a primary or metastasized cancer. A multitude of paracrine fa...

    Authors: Katherine R Schiller, Marion R Zillhardt, Jeremy Alley, Dori L Borjesson, Alvin J Beitz and Laura J Mauro
    Citation: BMC Cancer 2009 9:45
    Content type: Research article Published on:

  39. Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficul...

    Authors: Cinzia Lavarino, Nai-Kong V Cheung, Idoia Garcia, Gema Domenech, Carmen de Torres, Miguel Alaminos, Jose Rios, William L Gerald, Brian Kushner, Mike LaQuaglia and Jaume Mora
    Citation: BMC Cancer 2009 9:44
    Content type: Research article Published on:

  40. Only a limited number of studies have performed comprehensive investigations of coding variation in relation to breast cancer risk. Given the established role of estrogens in breast cancer, we hypothesized tha...

    Authors: Christopher A Haiman, Rachel R Garcia, Chris Hsu, Lucy Xia, Helen Ha, Xin Sheng, Loic Le Marchand, Laurence N Kolonel, Brian E Henderson, Michael R Stallcup, Geoffrey L Greene and Michael F Press
    Citation: BMC Cancer 2009 9:43
    Content type: Research article Published on:

  42. Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeut...

    Authors: Srinivas Koduru, Srinivasan Sowmyalakshmi, Raj Kumar, Rohini Gomathinayagam, Jürgen Rohr and Chendil Damodaran
    Citation: BMC Cancer 2009 9:41
    Content type: Research article Published on:

  44. Evidence suggests that truth telling and honest disclosure of cancer diagnosis could lead to improved outcomes in cancer patients. To examine such findings in Iran, this trial aimed to study the various dimens...

    Authors: Ali Montazeri, Azadeh Tavoli, Mohammad Ali Mohagheghi, Rasool Roshan and Zahra Tavoli
    Citation: BMC Cancer 2009 9:39
    Content type: Research article Published on:

  45. Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patie...

    Authors: Louise A Knight, Christian M Kurbacher, Sharon Glaysher, Augusta Fernando, Ralf Reichelt, Susanne Dexel, Uwe Reinhold and Ian A Cree
    Citation: BMC Cancer 2009 9:38
    Content type: Research article Published on:

  46. A frequent manifestation of advanced lung cancer is malnutrition, timely identification and treatment of which can lead to improved patient outcomes. Bioelectrical impedance analysis (BIA) is an easy-to-use an...

    Authors: Digant Gupta, Carolyn A Lammersfeld, Pankaj G Vashi, Jessica King, Sadie L Dahlk, James F Grutsch and Christopher G Lis
    Citation: BMC Cancer 2009 9:37
    Content type: Research article Published on:

  47. Bowel cancer is common and a major cause of death. The NHS is currently rolling out a national bowel cancer screening programme that aims to cover the entire population by 2010. The programme will be based on ...

    Authors: Sue Wilson, Taina Taskila, Tariq Ismail, Deborah D Stocken, Ashley Martin, Val Redman, Michael Wakelam, Ian Perry and Richard Hobbs
    Citation: BMC Cancer 2009 9:36
    Content type: Study protocol Published on:

  48. The purpose of this study has been to establish the level of RCAS1 – a membrane protein expressed in various cancer cells and able to induce apoptosis of CTLs and NK cells in pharyngeal and laryngeal cancer an...

    Authors: Magdalena Dutsch-Wicherek, Romana Tomaszewska, Agata Lazar, Lukasz Wicherek and Jacek Skladzien
    Citation: BMC Cancer 2009 9:35
    Content type: Research article Published on:

  50. A consensus on the most reliable staging system for hepatocellular carcinoma (HCC) is still lacking but the most used is a revised Barcelona Clinic Liver Cancer (BCLC) system, adopted by the American Associati...

    Authors: Fabio Farinati, Adriana Sergio, Anna Baldan, Anna Giacomin, Maria Anna Di Nolfo, Paolo Del Poggio, Luisa Benvegnu, Gianludovico Rapaccini, Marco Zoli, Franco Borzio, Edoardo G Giannini, Eugenio Caturelli and Franco Trevisani
    Citation: BMC Cancer 2009 9:33
    Content type: Research article Published on:

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