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  1. As supplement to KRAS mutational analysis, BRAF and PIK3CA mutations as well as expression of PTEN may account for additional non-responders to anti-EGFR-MoAbs treatment. The aim of the present study was to inves...

    Authors: Karen-Lise G Spindler, Niels Pallisgaard, Jan Lindebjerg, Sanne K Frifeldt and Anders Jakobsen
    Citation: BMC Cancer 2011 11:107
    Content type: Research article Published on:

  2. Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to pr...

    Authors: Sumiya Ishigami, Shinichi Ueno, Yuka Nishizono, Masataka Matsumoto, Hiroshi Kurahara, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Kita Yoshiaki, Yuko Kijima, Masaki Kitazono and Shoji Natsugoe
    Citation: BMC Cancer 2011 11:106
    Content type: Research article Published on:

  3. Multikinase inhibitors (MKIs) sunitinib and sorafenib have become a standard of care for metastatic renal cell carcinoma (mRCC). This study assessed safety and treatment patterns for these agents in a real-wor...

    Authors: Camillo Porta, Chiara Paglino, Ilaria Imarisio, Cinzia Canipari, Kristina Chen, Maureen Neary and Mei Sheng Duh
    Citation: BMC Cancer 2011 11:105
    Content type: Research article Published on:

  4. The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been repor...

    Authors: Keke Zhou, Dezhi Hu, Juan Lu, Weiwei Fan, Hongliang Liu, Hongyan Chen, Gong Chen, Qingyi Wei, Guhong Du, Ying Mao, Daru Lu and Liangfu Zhou
    Citation: BMC Cancer 2011 11:104
    Content type: Research article Published on:

  5. The adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer. In this study we further investigate the relationship of PINCH...

    Authors: Jasmine Lööf, Johan Rosell, Charlotte Bratthäll, Siv Doré, Hans Starkhammar, Hong Zhang and Xiao-Feng Sun
    Citation: BMC Cancer 2011 11:103
    Content type: Research article Published on:

  6. DNA methylation in the SHOX2 locus was previously used to reliably detect lung cancer in a group of critical controls, including 'cytologically negative' samples with no visible tumor cell content, at a high spec...

    Authors: Katja U Schneider, Dimo Dietrich, Michael Fleischhacker, Gunda Leschber, Johannes Merk, Frank Schäper, Henk R Stapert, Erik R Vossenaar, Sabine Weickmann, Volker Liebenberg, Christoph Kneip, Anke Seegebarth, Fikret Erdogan, Gudrun Rappold and Bernd Schmidt
    Citation: BMC Cancer 2011 11:102
    Content type: Research article Published on:

  7. In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer devel...

    Authors: Kamel Rouissi, Islem Ben Bahria, Karim Bougatef, Raja Marrakchi, Nejla Stambouli, Khouloud Hamdi, Mohamed Cherif, Mohamed Riadh Ben Slama, Mohamed Sfaxi, Fethi Ben Othman, Mohamed Chebil, Amel Benammar Elgaaied and Slah Ouerhani
    Citation: BMC Cancer 2011 11:101
    Content type: Research article Published on:

  8. Recently EBUS-TBNA, which has a sensitivity of 94.6%, specificity of 100% and diagnostic accuracy rate of 96.3% as previously reported, has been widely used for patients with mediastinal and hilar lymphadenopa...

    Authors: Ting Ye, Hong Hu, Xiaoyang Luo and Haiquan Chen
    Citation: BMC Cancer 2011 11:100
    Content type: Research article Published on:

  9. It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs. The current study was designed to investigate whether resv...

    Authors: Xiao-Fang Niu, Bao-Qin Liu, Zhen-Xian Du, Yan-Yan Gao, Chao Li, Ning Li, Yifu Guan and Hua-Qin Wang
    Citation: BMC Cancer 2011 11:99
    Content type: Research article Published on:

  10. Considerable variation in intravenous 5-fluorouracil (5-FU) metabolism can occur due to the wide range of dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can affect both tolerability and efficacy....

    Authors: Patrice Cellier, Bernard Leduc, Laurent Martin, Brigitte Vié, Christian Chevelle, Véronique Vendrely, Augustin Salemkour, Christian Carrie, Gilles Calais, Pascal Burtin, Loïc Campion, Michèle Boisdron-Celle, Alain Morel, Virginie Berger and Erick Gamelin
    Citation: BMC Cancer 2011 11:98
    Content type: Research article Published on:

  11. CXCL12 has been widely reported to play a biologically relevant role in tumor growth and spread. In epithelial ovarian cancer (EOC), CXCL12 enhances tumor angiogenesis and contributes to the immunosuppressive ...

    Authors: Véronique Machelon, Françoise Gaudin, Sophie Camilleri-Broët, Salam Nasreddine, Laurence Bouchet-Delbos, Eric Pujade-Lauraine, Jerôme Alexandre, Laurence Gladieff, Fernando Arenzana-Seisdedos, Dominique Emilie, Sophie Prévot, Philippe Broët and Karl Balabanian
    Citation: BMC Cancer 2011 11:97
    Content type: Research article Published on:

  13. We aimed to validate prognostic scores for survival in patients undergoing chemotherapy for advanced or metastatic cancer after first-line treatment.

    Authors: Olivier Trédan, Isabelle Ray-Coquard, Gisèle Chvetzoff, Paul Rebattu, Agathe Bajard, Sylvie Chabaud, David Pérol, Chadi Saba, Florent Quiblier, Jean-Yves Blay and Thomas Bachelot
    Citation: BMC Cancer 2011 11:95
    Content type: Research article Published on:

  14. Lymphoedema is a common and troublesome condition that develops following breast cancer treatment. The aim of this study is to analyze the effectiveness of Manual Lymphatic Drainage in the treatment of postmas...

    Authors: Marta López Martín, Miguel A Hernández, Cristina Avendaño, Francisco Rodríguez and Helena Martínez
    Citation: BMC Cancer 2011 11:94
    Content type: Study protocol Published on:

  15. The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targ...

    Authors: Genni M Newnham, Matthew Conron, SueAnne McLachlan, Alexander Dobrovic, Hongdo Do, Jason Li, Kenneth Opeskin, Natalie Thompson, Gavin M Wright and David M Thomas
    Citation: BMC Cancer 2011 11:93
    Content type: Research article Published on:

  16. The Mayo Lung Project (MLP), a randomized controlled clinical trial of lung cancer screening conducted between 1971 and 1986 among male smokers aged 45 or above, demonstrated an increase in lung cancer surviva...

    Authors: Lu Shi, Haijun Tian, William J McCarthy, Barbara Berman, Shinyi Wu and Rob Boer
    Citation: BMC Cancer 2011 11:92
    Content type: Research article Published on:

  17. Folic acid may affect the development of human cancers. However, few studies have evaluated the consumption of diet folate in the prognosis of patients with esophageal squamous cell carcinoma (ESCC).

    Authors: Cheng Lu, Hui Xie, Fengliang Wang, Hongbing Shen and Jianming Wang
    Citation: BMC Cancer 2011 11:91
    Content type: Research article Published on:

  18. Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. Here, we r...

    Authors: Renhua Guo, Xiaofen Chen, Tongshan Wang, Zhiyuan Zhang, Jin Sun and Yongqian Shu
    Citation: BMC Cancer 2011 11:90
    Content type: Case report Published on:

  19. The importance of changes in tumour-associated stroma for tumour initiation and progression has been established. Endosialin is expressed in fibroblasts and pericytes of blood vessels in several types of tumou...

    Authors: Zhi-Yong Zhang, Hong Zhang, Gunnar Adell and Xiao-Feng Sun
    Citation: BMC Cancer 2011 11:89
    Content type: Research article Published on:

  20. The purpose of this study was to assess the expression levels for TβRI, TβRII, and TβRIII in epithelial layers of oral premalignant lesions (oral leukoplakia, OLK) and oral squamous cell carcinoma (OSCC), as w...

    Authors: Wenxia Meng, Qingjie Xia, Lanyan Wu, Sixiu Chen, Xin He, Lin Zhang, Qinghong Gao and Hongmei Zhou
    Citation: BMC Cancer 2011 11:88
    Content type: Research article Published on:

  21. The optimal treatment of early stage follicular Lymphoma is a matter of debate. Radiation therapy has frequently been applied with a curative approach beside watchful waiting. Involved field, extended field an...

    Authors: Mathias Witzens-Harig, Manfred Hensel, Michael Unterhalt and Klaus Herfarth
    Citation: BMC Cancer 2011 11:87
    Content type: Study protocol Published on:

  22. By using cDNA microarray analysis, we identified a G protein-coupled receptor, GPR39, that is significantly up-regulated in ESCC. The aim of this study is to investigate the role of GPR39 in human esophageal canc...

    Authors: Fajun Xie, Haibo Liu, Ying-Hui Zhu, Yan-Ru Qin, Yongdong Dai, Tingting Zeng, Leilei Chen, Changjun Nie, Hong Tang, Yan Li, Li Fu and Xin-Yuan Guan
    Citation: BMC Cancer 2011 11:86
    Content type: Research article Published on:

  23. Malignant melanoma is a rare disease in Asia, and knowledge on its characteristics and clinical outcome in Asian patients is limited. The purpose of this observational study was to determine the clinical prese...

    Authors: Zhihong Chi, Siming Li, Xinan Sheng, Lu Si, Chuanliang Cui, Mei Han and Jun Guo
    Citation: BMC Cancer 2011 11:85
    Content type: Research article Published on:

  24. Fibroblast growth factor receptor 4 (FGFR4) displays multiple biological activities, including mitogenic and angiogenic activity, and plays important roles in the etiology and progression of prostate cancer. Gly3...

    Authors: Bin Xu, Na Tong, Shu Q Chen, Li X Hua, Zeng J Wang, Zheng D Zhang and Ming Chen
    Citation: BMC Cancer 2011 11:84
    Content type: Research article Published on:

  26. Cancer stem cells (CSCs) play an important role in the development and recurrence of malignant tumors including glioma. Notch signaling, an evolutionarily conserved pathway mediating direct cell-cell interacti...

    Authors: Yi-Yang Hu, Min-Hua Zheng, Gang Cheng, Liang Li, Liang Liang, Fang Gao, Ya-Ning Wei, Luo-An Fu and Hua Han
    Citation: BMC Cancer 2011 11:82
    Content type: Research article Published on:

  27. Pregnane X receptor (PXR) is a key transcription factor that regulates drug metabolizing enzymes such as cytochrome P450 (CYP) 3A4, and plays important roles in intestinal first-pass metabolism. Although there...

    Authors: Wataru Habano, Toshie Gamo, Jun Terashima, Tamotsu Sugai, Koki Otsuka, Go Wakabayashi and Shogo Ozawa
    Citation: BMC Cancer 2011 11:81
    Content type: Research article Published on:

  28. Cervical cancer is the most common cancer among Indian women. This cancer has well defined pre-cancerous stages and evolves over 10-15 years or more. This study was undertaken to identify differentially expres...

    Authors: Thangarajan Rajkumar, Kesavan Sabitha, Neelakantan Vijayalakshmi, Sundersingh Shirley, Mayil Vahanan Bose, Gopisetty Gopal and Ganesharaja Selvaluxmy
    Citation: BMC Cancer 2011 11:80
    Content type: Research article Published on:

  30. The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatou...

    Authors: Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim and Dae-Ghon Kim
    Citation: BMC Cancer 2011 11:78
    Content type: Research article Published on:

  31. One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO in...

    Authors: María S Domínguez-Sánchez, Carmen Sáez, Miguel A Japón, Andrés Aguilera and Rosa Luna
    Citation: BMC Cancer 2011 11:77
    Content type: Research article Published on:

  32. Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from a...

    Authors: Yoichiro Okubo, Kazutoshi Shibuya, Atsushi Namiki, Kazuhisa Takamura, Noriaki Kameda, Tetsuo Nemoto, Aki Mitsuda, Megumi Wakayama, Minoru Shinozaki, Nobuyuki Hiruta, Kanako Kitahara, Takao Ishiwatari and Junichi Yamazaki
    Citation: BMC Cancer 2011 11:76
    Content type: Case report Published on:

  33. To evaluate whether weekly schedules of docetaxel-based chemotherapy were superior to 3-weekly ones in terms of quality of life in locally advanced or metastatic breast cancer.

    Authors: Francesco Nuzzo, Alessandro Morabito, Adriano Gravina, Francesca Di Rella, Gabriella Landi, Carmen Pacilio, Vincenzo Labonia, Emanuela Rossi, Ermelinda De Maio, Maria Carmela Piccirillo, Giuseppe D'Aiuto, Renato Thomas, Massimo Rinaldo, Gerardo Botti, Maurizio Di Bonito, Massimo Di Maio…
    Citation: BMC Cancer 2011 11:75
    Content type: Research article Published on:

  34. To study whether and how c-MYC expression determines response to radio- and chemotherapy in childhood medulloblastoma (MB).

    Authors: André O von Bueren, Christoph Oehler, Tarek Shalaby, Katja von Hoff, Martin Pruschy, Burkhardt Seifert, Nicolas U Gerber, Monika Warmuth-Metz, Duncan Stearns, Charles G Eberhart, Rolf D Kortmann, Stefan Rutkowski and Michael A Grotzer
    Citation: BMC Cancer 2011 11:74
    Content type: Research article Published on:

  35. Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT.

    Authors: Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa and Veli-Matti Kosma
    Citation: BMC Cancer 2011 11:73
    Content type: Research article Published on:

  36. The role of surgery in the management of patients with advanced gastrointestinal stromal tumors (GIST) in the era of imatinib mesylate (IM) remains debated. We analyzed the outcome of patients with non metasta...

    Authors: Aurore Blesius, Philippe A Cassier, François Bertucci, Jerome Fayette, Isabelle Ray-Coquard, Binh Bui, Antoine Adenis, Maria Rios, Didier Cupissol, David Pérol, Jean-Yves Blay and Axel Le Cesne
    Citation: BMC Cancer 2011 11:72
    Content type: Research article Published on:

  38. Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent leading to the establishment of particle therapy in this indication. However, even modern techniques leave sp...

    Authors: Alexandra D Jensen, Anna Nikoghosyan, Axel Hinke, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:70
    Content type: Study protocol Published on:

  39. Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular p...

    Authors: Yi Zhang, Rachel M Gonzalez and Richard C Zangar
    Citation: BMC Cancer 2011 11:69
    Content type: Research article Published on:

  40. In principle, the elimination of malignancies by oncolytic virotherapy could proceed by different mechanisms - e.g. tumor cell specific oncolysis, destruction of the tumor vasculature or an anti-tumoral immuno...

    Authors: Stephanie Weibel, Viktoria Raab, Yong A Yu, Andrea Worschech, Ena Wang, Francesco M Marincola and Aladar A Szalay
    Citation: BMC Cancer 2011 11:68
    Content type: Research article Published on:

  41. Treatment options for patients with advanced hepatocellular carcinoma (HCC) are often limited. In most cases, they are not amenable to local therapies including surgery or radiofrequency ablation. The multi-ki...

    Authors: Stephanie E Combs, Daniel Habermehl, Tom Ganten, Jan Schmidt, Lutz Edler, Iris Burkholder, Oliver Jäkel, Thomas Haberer and Jürgen Debus
    Citation: BMC Cancer 2011 11:67
    Content type: Study protocol Published on:

  42. Epigenetic mechanisms such as DNA methylation and histone modifications are important regulators of gene expression and are frequently involved in silencing tumor suppressor genes.

    Authors: Helena Carén, Anna Djos, Maria Nethander, Rose-Marie Sjöberg, Per Kogner, Camilla Enström, Staffan Nilsson and Tommy Martinsson
    Citation: BMC Cancer 2011 11:66
    Content type: Research article Published on:

  43. Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and...

    Authors: Jette Bornholdt, Stine Friis, Sine Godiksen, Steen S Poulsen, Eric Santoni-Rugiu, Hanne C Bisgaard, Inger MB Lothe, Tone Ikdahl, Kjell M Tveit, Egil Johnson, Elin H Kure and Lotte K Vogel
    Citation: BMC Cancer 2011 11:65
    Content type: Research article Published on:

  44. Although preoperative radiotherapy (RT) is widely used as the initial treatment for locally advanced rectal cancer (RC) in the neoadjuvant setting, factors determining clinical response have not been adequatel...

    Authors: Joji Kitayama, Koji Yasuda, Kazushige Kawai, Eiji Sunami and Hirokazu Nagawa
    Citation: BMC Cancer 2011 11:64
    Content type: Research article Published on:

  45. Tumor hypoxia is linked to poor prognosis, but identification and quantification of tissue hypoxia remains a challenge. The hypoxia-specificity of HIF-1α target genes in vivo has been questioned due to the con...

    Authors: Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen and Jens Overgaard
    Citation: BMC Cancer 2011 11:63
    Content type: Research article Published on:

  47. Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remai...

    Authors: Xiaoqin Yuan, Xinjian Lin, Gerald Manorek and Stephen B Howell
    Citation: BMC Cancer 2011 11:61
    Content type: Research article Published on:

  48. The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined.

    Authors: Vikram Deshpande, Afamefuna Nduaguba, Stephanie M Zimmerman, Sarah M Kehoe, Laura E MacConaill, Gregory Y Lauwers, Cristina Ferrone, Nabeel Bardeesy, Andrew X Zhu and Aram F Hezel
    Citation: BMC Cancer 2011 11:60
    Content type: Research article Published on:

  50. Histone modifications in tumorigenesis are increasingly recognized as important epigenetic factors leading to cancer. Increased phosphorylation levels of histone H3 as a result of aurora B and pMSK1 overexpres...

    Authors: Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu and Jan-Gowth Chang
    Citation: BMC Cancer 2011 11:58
    Content type: Research article Published on:

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