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  1. One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain of...

    Authors: Ceyhan Ceran, Murat Cokol, Sultan Cingoz, Ipek Tasan, Mehmet Ozturk and Tamer Yagci
    Citation: BMC Cancer 2012 12:450
  2. In non-small cell lung cancer (NSCLC), interstitial hypertension is a barrier to chemotherapy delivery, and is mediated by platelet derived growth factor receptor (PDGFR). Antagonizing PDGFR with imatinib may ...

    Authors: Julie E Bauman, Keith D Eaton, Sarah G Wallace, Laurie L Carr, Sang-Joon Lee, Dennie V Jones, Hugo Arias-Pulido, Lisa A Cerilli and Renato G Martins
    Citation: BMC Cancer 2012 12:449
  3. Chemotherapeutic bioassay for colorectal cancer (CRC) with a rat model bearing chemically-induced CRCs plays an important role in the development of new anti-tumor drugs and regimens. Although several protocol...

    Authors: Kazuto Yoshimi, Takao Hashimoto, Yusuke Niwa, Kazuya Hata, Tadao Serikawa, Takuji Tanaka and Takashi Kuramoto
    Citation: BMC Cancer 2012 12:448
  4. A 21-gene recurrence score (RS) assay may inform adjuvant systematic treatment decisions in women with early stage breast cancer. We sought to investigate the cost effectiveness of using the RS-assay versus cu...

    Authors: Malek B Hannouf, Bin Xie, Muriel Brackstone and Gregory S Zaric
    Citation: BMC Cancer 2012 12:447
  5. Research on physical activity and nutrition interventions aimed at positively impacting symptom management, treatment-related recovery and quality of life has largely excluded head and neck (HN) cancer populat...

    Authors: Lauren C Capozzi, Harold Lau, Raylene A Reimer, Margaret McNeely, Janine Giese-Davis and S Nicole Culos-Reed
    Citation: BMC Cancer 2012 12:446
  6. Breast cancer and its metastatic progression is mainly directed by epithelial to mesenchymal transition (EMT), a phenomenon supported by specific transcription factors and miRNAs.

    Authors: Elisabetta Lambertini, Andrea Lolli, Federica Vezzali, Letizia Penolazzi, Roberto Gambari and Roberta Piva
    Citation: BMC Cancer 2012 12:445
  7. Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene p53. Loss of p53 results in increased expression of CD44...

    Authors: Go J Yoshida, Yasushi Fuchimoto, Tomoo Osumi, Hiroyuki Shimada, Seiichi Hosaka, Hideo Morioka, Makio Mukai, Yohei Masugi, Michiie Sakamoto and Tatsuo Kuroda
    Citation: BMC Cancer 2012 12:444
  8. The aging of the Italian population will unavoidably lead to a growing number of persons diagnosed and living with cancer. A comprehensive description of the burden of cancer mortality among Italian elderly (6...

    Authors: Ettore Bidoli, Lucia Fratino, Silvia Bruzzone, Marilena Pappagallo, Paolo De Paoli, Umberto Tirelli and Diego Serraino
    Citation: BMC Cancer 2012 12:443
  9. Cyclophilin A (CypA) is a cytosolic protein possessing peptidyl-prolyl isomerase activity that was recently reported to be overexpressed in several cancers. Here, we explored the biology and molecular mechanis...

    Authors: Zhe Qian, Xiaoting Zhao, Mei Jiang, Wenyun Jia, Chunyan Zhang, Yue Wang, Baolan Li and Wentao Yue
    Citation: BMC Cancer 2012 12:442
  10. Very few studies examine the longitudinal prevalence of problems and the awareness or use of clinical programs by patients who report these problems. Of the studies that examine age, gender and marital status ...

    Authors: Janine Giese-Davis, Amy Waller, Linda E Carlson, Shannon Groff, Lihong Zhong, Eric Neri, Sacha M Bachor, Jassandre Adamyk-Simpson, Kate MS Rancourt, Bernie Dunlop and Barry D Bultz
    Citation: BMC Cancer 2012 12:441
  11. To reduce mortality, women with a family history of breast cancer often start mammography screening at a younger age than the general population. Breast density is high in over 50% of women younger than 50 yea...

    Authors: Sepideh Saadatmand, Emiel J T Rutgers, RobAEM Tollenaar, Hermien M Zonderland, MargreetGEM Ausems, KristienBMI Keymeulen, Margreet S Schlooz-Vries, Linetta B Koppert, Eveline A M Heijnsdijk, Caroline Seynaeve, Cees Verhoef, Jan C Oosterwijk, Inge-Marie Obdeijn, Harry J de Koning and Madeleine M A Tilanus-Linthorst
    Citation: BMC Cancer 2012 12:440
  12. Postoperative interferon-α(IFN-α) treatment delays hepatocellular carcinoma(HCC) recurrence and prolongs patient survival, and may thus be an effective form of adjuvant therapy. However, clinical observations ...

    Authors: Ju-Bo Zhang, Hui-Chuan Sun, Wei-Dong Jia, Peng-Yuan Zhuang, Yong-Bing Qian, Xiao-Dong Zhu, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu and Zhao-You Tang
    Citation: BMC Cancer 2012 12:439
  13. Integument-related toxicities are common during epidermal growth factor receptor (EGFR)-targeted therapy. Panitumumab is a fully human monoclonal antibody targeting the EGFR that significantly improves progres...

    Authors: Josef Thaler, Meinolf Karthaus, Laurent Mineur, Richard Greil, Henry Letocha, Ralf Hofheinz, Eva Fernebro, Erick Gamelin, Ana Baños and Claus-Henning Köhne
    Citation: BMC Cancer 2012 12:438
  14. Our recent studies suggested that the chromodomain helicase DNA binding protein 1-like (CHD1L) gene plays an oncogenic role in human hepatocellular carcinoma. However, the status of CHD1L protein expression in ov...

    Authors: Wei-Peng He, Juan Zhou, Mu-Yan Cai, Xiang-Shen Xiao, Yi-Ji Liao, Hsiang-Fu Kung, Xin-Yuan Guan, Dan Xie and Guo-Fen Yang
    Citation: BMC Cancer 2012 12:437
  15. DNA interstrand cross-links (ICLs) are critical lesions produced by several cancer chemotherapy agents including platinum drugs and nitrogen mustards. We have previously shown in haematological (multiple myelo...

    Authors: Victoria J Spanswick, Helen L Lowe, Claire Newton, John P Bingham, Alessia Bagnobianchi, Konstantinos Kiakos, Charles Craddock, Jonathan A Ledermann, Daniel Hochhauser and John A Hartley
    Citation: BMC Cancer 2012 12:436
  16. Data that directly associate utilization of novel systemic therapies with survival trends in metastatic breast cancer (MBC) are limited. In the setting of de novo MBC, large registry analyses cite positive tempor...

    Authors: Sumanta K Pal, Mary Dehaven, Rebecca A Nelson, Susan Onami, JoAnn Hsu, Sarah Waliany, Laura Kruper and Joanne Mortimer
    Citation: BMC Cancer 2012 12:435
  17. Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 5-deoxy-5-fluorouridine (5-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin 3...

    Authors: Laia Trigueros-Motos, Sandra Pérez-Torras, F Javier Casado, Míriam Molina-Arcas and Marçal Pastor-Anglada
    Citation: BMC Cancer 2012 12:434
  18. Metabolic genes have been associated with the function of metabolizing and detoxifying environmental carcinogens. Polymorphisms present in these genes could lead to changes in their metabolizing and detoxifyin...

    Authors: M Felicitas López-Cima, Sara M Álvarez-Avellón, Teresa Pascual, Ana Fernández-Somoano and Adonina Tardón
    Citation: BMC Cancer 2012 12:433
  19. There has been substantial increase in use of androgen deprivation therapy as adjuvant management of prostate cancer. However, this leads to a range of musculoskeletal toxicities including reduced bone mass an...

    Authors: Robert U Newton, Dennis R Taaffe, Nigel Spry, Prue Cormie, Suzanne K Chambers, Robert A Gardiner, David HK Shum, David Joseph and Daniel A Galvão
    Citation: BMC Cancer 2012 12:432
  20. The CD34+CD38- subset of AML cells is enriched for resistance to current chemotherapeutic agents and considered to contribute to disease progression and relapse in Acute Myeloid Leukaemia (AML) patients following...

    Authors: Mays Jawad, Ning Yu, Claire Seedhouse, Karuna Tandon, Nigel H Russell and Monica Pallis
    Citation: BMC Cancer 2012 12:431
  21. The survival of unresectable pancreatic cancer patients is extremely poor. The aim of this study was to examine if tumor size could predict survival length in order to optimize patient care.

    Authors: Henrik Forssell, Katrin Pröh, Michael Wester and Hans Krona
    Citation: BMC Cancer 2012 12:429
  22. The diagnosis of malignant pleural effusions (MPE) is often clinically challenging, especially if the cytology is negative for malignancy. DNA integrity index has been reported to be a marker of malignancy. Th...

    Authors: Krishna B Sriram, Vandana Relan, Belinda E Clarke, Edwina E Duhig, Morgan N Windsor, Kevin S Matar, Rishendran Naidoo, Linda Passmore, Elizabeth McCaul, Deborah Courtney, Ian A Yang, Rayleen V Bowman and Kwun M Fong
    Citation: BMC Cancer 2012 12:428
  23. Hepatoblastoma (HB) is the most common primary, malignant pediatric liver tumor in children. The treatment results for affected children have markedly improved in recent decades. However, the prognosis for hig...

    Authors: Shu-Cheng Zhang, Wei-Lin Wang, Wei-Song Cai, Kai-Lei Jiang and Zheng-Wei Yuan
    Citation: BMC Cancer 2012 12:427
  24. We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present stud...

    Authors: Siv K Bøhn, Kjell M Russnes, Amrit K Sakhi, Magne Thoresen, Marit Holden, JanØ Moskaug, Mari C Myhrstad, Ole K Olstad, Sigbjørn Smeland and Rune Blomhoff
    Citation: BMC Cancer 2012 12:426
  25. Maintenance therapy for non-small cell lung cancer (NSCLC) aims to extend disease control after first-line chemotherapy with active and well-tolerated agents. The utility of continuation maintenance therapy re...

    Authors: Nabil Mubarak, Rabab Gaafar, Samir Shehata, Tarek Hashem, Dani Abigeres, Hamdy A Azim, Gamal El-Husseiny, Hamed Al-Husaini and Zhixin Liu
    Citation: BMC Cancer 2012 12:423
  26. Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs) that might contribute to taxane response, we performed a genome-wide association stu...

    Authors: Nifang Niu, Daniel J Schaid, Ryan P Abo, Krishna Kalari, Brooke L Fridley, Qiping Feng, Gregory Jenkins, Anthony Batzler, Abra G Brisbin, Julie M Cunningham, Liang Li, Zhifu Sun, Ping Yang and Liewei Wang
    Citation: BMC Cancer 2012 12:422
  27. Exosomes are nanovesicles secreted by tumour cells which have roles in paracrine signalling during tumour progression, including tumour-stromal interactions, activation of proliferative pathways and bestowing ...

    Authors: Hamish W King, Michael Z Michael and Jonathan M Gleadle
    Citation: BMC Cancer 2012 12:421
  28. Recently, S-1, a novel 5-fluorouracil (5-FU)-based agent containing the strong dihydropyrimidine dehydrogenase (DPD) inhibitor, 5-chloro-2,4-dihydropyrimidine (CDHP) has been clinically used to treat various n...

    Authors: Hiroki Ide, Eiji Kikuchi, Masanori Hasegawa, Norihide Kozakai, Takeo Kosaka, Akira Miyajima and Mototsugu Oya
    Citation: BMC Cancer 2012 12:420
  29. Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical in...

    Authors: Anne-Laure Papa, Sudipta Basu, Poulomi Sengupta, Deboshri Banerjee, Shiladitya Sengupta and Rania Harfouche
    Citation: BMC Cancer 2012 12:419
  30. The role of Th17 cells in colorectal tumorigenesis and development still remains unclear, despite the fact that it has been established in the pathogenesis of autoimmune diseases.

    Authors: Jiansheng Wang, Kaiyu Xu, Jing Wu, Chenghua Luo, Yuchen Li, Xuebin Wu, Hong Gao, Guosheng Feng and Bao-Zhu Yuan
    Citation: BMC Cancer 2012 12:418
  31. Non-melanoma skin cancer (NMSC), comprised of basal (BCC) and squamous (SCC) cell carcinomas, is the most common cancer in Caucasians. Ultraviolet radiation (UVR) exposure is the most important environmental r...

    Authors: Michelle R Iannacone, Wei Wang, Heather G Stockwell, Kathleen O’Rourke, Anna R Giuliano, Vernon K Sondak, Jane L Messina, Richard G Roetzheim, Basil S Cherpelis, Neil A Fenske and Dana E Rollison
    Citation: BMC Cancer 2012 12:417
  32. Deregulation of the EGFR signaling pathway is one of the most frequently observed genetic abnormalities that drives cancer development. Although mutations in the downstream components of the EGFR signaling pat...

    Authors: Toshihito Suda, Takanori Hama, Shu Kondo, Yuki Yuza, Mamoru Yoshikawa, Mitsuyoshi Urashima, Takakuni Kato and Hiroshi Moriyama
    Citation: BMC Cancer 2012 12:416
  33. Carfilzomib is a next-generation proteasome inhibitor with single-agent activity in patients with relapsed and refractory multiple myeloma (R/R MM). In PX-171-003-A1, a single-arm phase 2 study of carfilzomib ...

    Authors: Roman Hájek, Richard Bryce, Sunhee Ro, Barbara Klencke and Heinz Ludwig
    Citation: BMC Cancer 2012 12:415
  34. Causes of the rapidly increasing incidence of breast cancer in Middle East and Asian countries are incompletely understood. We evaluated risk factors for postmenopausal breast cancer and estimated their attrib...

    Authors: Reza Ghiasvand, Shahram Bahmanyar, Kazem Zendehdel, Sedigheh Tahmasebi, Abdolrasoul Talei, Hans-Olov Adami and Sven Cnattingius
    Citation: BMC Cancer 2012 12:414
  35. Colorectal cancer (CRC) is one of the most commonly occurring neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease. Eicosapentae...

    Authors: Takuma Higurashi, Kunihiro Hosono, Hiroki Endo, Hirokazu Takahashi, Hiroshi Iida, Takashi Uchiyama, Akiko Ezuka, Shiori Uchiyama, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Shin Maeda, Satoshi Morita, Yutaka Natsumeda, Hajime Nagase and Atsushi Nakajima
    Citation: BMC Cancer 2012 12:413
  36. Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase act...

    Authors: Afsar Ali Mian, Anna Metodieva, Susanne Badura, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Oliver Gerhard Ottmann, Jamal Mahajna and Martin Ruthardt
    Citation: BMC Cancer 2012 12:411
  37. Recent studies suggest the potential benefits of statins as anti-cancer agents. Mechanisms by which statins induce apoptosis in cancer cells are not clear. We previously showed that simvastatin inhibit prostat...

    Authors: Anna Goc, Samith T Kochuparambil, Belal Al-Husein, Ahmad Al-Azayzih, Shuaib Mohammad and Payaningal R Somanath
    Citation: BMC Cancer 2012 12:409
  38. A subset of KIT/PDGFRA wild-type gastrointestinal stromal tumors (WT GIST) have been associated with alteration of the succinate dehydrogenase (SDH) complex II function. A recent report identified four non-syn...

    Authors: Antoine Italiano, Chun-Liang Chen, Yun-Shao Sung, Samuel Singer, Ronald P DeMatteo, Michael P LaQuaglia, Peter Besmer, Nicholas Socci and Cristina R Antonescu
    Citation: BMC Cancer 2012 12:408
  39. Ovarian cancer is a heterogeneous disease and prognosis for apparently similar cases of ovarian cancer varies. Recurrence of the disease in early stage (FIGO-stages I-II) serous ovarian cancer results in survi...

    Authors: Ingiridur Skirnisdottir, Markus Mayrhofer, Maria Rydåker, Helena Åkerud and Anders Isaksson
    Citation: BMC Cancer 2012 12:407
  40. The prognosis of human glioma is poor, and the highly invasive nature of the disease represents a major impediment to current therapeutic modalities. The oncoprotein B-cell-specific Moloney murine leukemia vir...

    Authors: Lili Jiang, Jueheng Wu, Yi Yang, Liping Liu, Libing Song, Jun Li and Mengfeng Li
    Citation: BMC Cancer 2012 12:406
  41. Numerous efficacious chemotherapy regimens may cause thrombocytopenia. Thrombopoietin receptor (TPO-R) agonists, such as eltrombopag, represent a novel approach for the treatment of chemotherapy-induced thromb...

    Authors: Connie L Erickson-Miller, Kodandaram Pillarisetti, Jennifer Kirchner, David J Figueroa, Lone Ottesen, Anne-Marie Martin, Yuan Liu, Yasser Mostafa Kamel and Conrad Messam
    Citation: BMC Cancer 2012 12:405
  42. In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes...

    Authors: W Jeffrey Petty, Mebea Aklilu, Victor A Varela, James Lovato, Paul D Savage and Antonius A Miller
    Citation: BMC Cancer 2012 12:404
  43. Disseminated tumour cells (DTCs) in the bone marrow of patients with breast cancer have been identified as an independent predictor of poor prognosis in patients with non-metastatic disease. This prospective s...

    Authors: Anna-Karin Falck, Pär-Ola Bendahl, Christian Ingvar, Jorma Isola, Per-Ebbe Jönsson, Pia Lindblom, Kristina Lövgren, Karin Rennstam, Mårten Fernö and Lisa Rydén
    Citation: BMC Cancer 2012 12:403
  44. Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellula...

    Authors: Fatima Rangwala, Kevin P Williams, Ginger R Smith, Zainab Thomas, Jennifer L Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A Morse and Gayathri R Devi
    Citation: BMC Cancer 2012 12:402
  45. The prognosis for an abnormal medical finding is affected by both early detection and adherence to the presecribed schedule for follow-up examinations. In this study, we examined the time to follow up after an...

    Authors: Hoo-Yeon Lee, Kui Son Choi, Jae Kwan Jun, Myung-Il Hahm and Eun-Cheol Park
    Citation: BMC Cancer 2012 12:400

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