Skip to main content

Articles

Page 216 of 329

  1. Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. Few studies have investigated polymorphisms and serum/plasma levels of IL-27 in diseases in...

    Authors: Bin Zhou, Peng Zhang, Tielong Tang, Hong Liao, Kui Zhang, Yan Pu, Peng Chen, Yaping Song and Lin Zhang
    Citation: BMC Cancer 2015 15:433
    Content type: Research article Published on:

  2. Hepsin, (also called TMPRSS1) and TMPRSS3 are type II transmembrane serine proteases (TTSPs) that are involved in cancer progression. TTSPs can remodel extracellular matrix (ECM) and, when dysregulated, promot...

    Authors: Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma and Arto Mannermaa
    Citation: BMC Cancer 2015 15:431
    Content type: Research article Published on:

  3. Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ...

    Authors: Olga Grishina, Claudia Schmoor, Konstanze Döhner, Björn Hackanson, Beate Lubrich, Annette M. May, Caroline Cieslik, Michael J. Müller and Michael Lübbert
    Citation: BMC Cancer 2015 15:430
    Content type: Study protocol Published on:

  4. Leucopenia or neutropenia during chemotherapy predicts better survival in several cancers. We aimed to assess whether leucopenia could be a biological measure of treatment and a marker of efficacy in advanced ...

    Authors: Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan and Fang-Yun Xie
    Citation: BMC Cancer 2015 15:429
    Content type: Research article Published on:

  5. The peritoneum is the second most common site of recurrence in colorectal cancer. Early detection of peritoneal carcinomatosis (PC) by imaging is difficult. Patients eventually presenting with clinically appar...

    Authors: Charlotte E L Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis J A Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer…
    Citation: BMC Cancer 2015 15:428
    Content type: Study protocol Published on:

  6. Proper functional association between mural cells and endothelial cells (EC) causes EC of blood vessels to become quiescent. Mural cells on tumor vessels exhibit decreased attachment to EC, which allows vessel...

    Authors: Mayur Choudhary, Christine Naczki, Wenhong Chen, Keith D. Barlow, L. Douglas Case and Linda J. Metheny-Barlow
    Citation: BMC Cancer 2015 15:427
    Content type: Research article Published on:

  7. Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib ...

    Authors: Kotoe Takayoshi, Kosuke Sagara, Keita Uchino, Hitoshi Kusaba, Naotaka Sakamoto, Atsushi Iguchi and Eishi Baba
    Citation: BMC Cancer 2015 15:426
    Content type: Case report Published on:

  8. Iron binding, naturally occurring protein bovine lactoferrin (bLf) has attracted attention as a safe anti-cancer agent capable of inducing apoptosis. Naturally, bLf exists partially saturated (15-20%) with Fe3+ h...

    Authors: Jessica A. Gibbons, Jagat R. Kanwar and Rupinder K. Kanwar
    Citation: BMC Cancer 2015 15:425
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:749

  9. We recently developed a clinical decision support tool, capable of estimating the likelihood of survival at 3 and 12 months following surgery for patients with operable skeletal metastases. After making it pub...

    Authors: Andrea Piccioli, M. Silvia Spinelli, Jonathan A. Forsberg, Rikard Wedin, John H. Healey, Vincenzo Ippolito, Primo Andrea Daolio, Pietro Ruggieri, Giulio Maccauro, Alessandro Gasbarrini, Roberto Biagini, Raimondo Piana, Flavio Fazioli, Alessandro Luzzati, Alberto Di Martino, Francesco Nicolosi…
    Citation: BMC Cancer 2015 15:424
    Content type: Research article Published on:

  10. Anthracycline and taxane are classes of drugs that are frequently used in the adjuvant and palliative settings of metastatic breast cancer (MBC); however, treatment failure occurs in most cases. Limited data d...

    Authors: Kun-Ming Rau, Yung-Chang Lin, Yen-Yang Chen, Jen-Shi Chen, Kuan-Der Lee, Cheng-Hsu Wang and Hsien-Kun Chang
    Citation: BMC Cancer 2015 15:423
    Content type: Research article Published on:

  11. The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explore...

    Authors: Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci and Charles P Hart
    Citation: BMC Cancer 2015 15:422
    Content type: Research article Published on:

  12. A Danish cancer pathway has been implemented for patients with serious non-specific symptoms and signs of cancer (NSSC-CPP). The initiative is one of several to improve the long diagnostic interval and the poo...

    Authors: Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen and Peter Vedsted
    Citation: BMC Cancer 2015 15:421
    Content type: Research article Published on:

  13. Primary androgen deprivation therapy (PADT) has played an important role in the treatment of prostate cancer. We sought to identify factors of PSA progression in our series of patients with localized and local...

    Authors: Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao and Kiyohide Fujimoto
    Citation: BMC Cancer 2015 15:420
    Content type: Research article Published on:

  14. Colorectal cancer is the third most common cancer and a major cause of morbidity and mortality worldwide. Adjuvant chemotherapy is considered the standard of care in patients with UICC stage III colon cancer a...

    Authors: Andreas Teufel, Michael Gerken, Janine Hartl, Timo Itzel, Stefan Fichtner-Feigl, Christian Stroszczynski, Hans Jürgen Schlitt, Ferdinand Hofstädter and Monika Klinkhammer-Schalke
    Citation: BMC Cancer 2015 15:419
    Content type: Research article Published on:

  15. Non-attendance at gynecological clinics is a major limitation of cervical cancer screening and self-collection of samples may improve this situation. Although HPV testing of self-collected vaginal samples is a...

    Authors: Cheng-Chang Chang, Rui-Lan Huang, Yu-Ping Liao, Po-Hsuan Su, Yaw-Wen Hsu, Hui-Chen Wang, Chau-Yang Tien, Mu-Hsien Yu, Ya-Wen Lin and Hung-Cheng Lai
    Citation: BMC Cancer 2015 15:418
    Content type: Research article Published on:

  16. DNA methylation regulates gene expression, through the inhibition/activation of gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can capture pivotal features of gene expres...

    Authors: Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti and Youping Deng
    Citation: BMC Cancer 2015 15:417
    Content type: Research article Published on:

  17. Pain is a prevalent and distressing symptom in patients with cancer, having an enormous impact on functioning and quality of life. Fragmentation of care, inadequate pain communication, and reluctance towards p...

    Authors: Laura MJ Hochstenbach, Annemie M Courtens, Sandra MG Zwakhalen, Maarten van Kleef and Luc P de Witte
    Citation: BMC Cancer 2015 15:416
    Content type: Study protocol Published on:

  18. Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We ...

    Authors: Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez…
    Citation: BMC Cancer 2015 15:415
    Content type: Research article Published on:

  19. Preliminary evidence suggests cancer- and chemotherapy-related autonomic nervous system (ANS) dysfunction may contribute to the increased cardiovascular (CV) morbidity- and mortality-risks in cancer survivors....

    Authors: Scott C. Adams, Ronald Schondorf, Julie Benoit and Robert D. Kilgour
    Citation: BMC Cancer 2015 15:414
    Content type: Research article Published on:

  20. Translational biomedical research relies on the availability of human tissue to explore disease aetiology and prognostic factors, with the objective of developing better targeted treatments. The establishment ...

    Authors: Jamie Bryant, Rob Sanson-Fisher, Elizabeth Fradgley, Timothy Regan, Breanne Hobden and Stephen P. Ackland
    Citation: BMC Cancer 2015 15:413
    Content type: Research article Published on:

  21. To demonstrate how assessment of life expectancy and loss in expectation of life can be used to address a wide range of research questions of public health interest pertaining to the prognosis of cancer patients.

    Authors: Therese M-L Andersson, Paul W. Dickman, Sandra Eloranta, Annika Sjövall, Mats Lambe and Paul C. Lambert
    Citation: BMC Cancer 2015 15:412
    Content type: Research article Published on:

  22. Colorectal cancer (CRC) is a leading cause of cancer death globally and new biomarkers and treatments are severely needed.

    Authors: Elena Pedraz-Cuesta, Sandra Christensen, Anders A. Jensen, Niels Frank Jensen, Lennart Bunch, Maria Unni Romer, Nils Brünner, Jan Stenvang and Stine Falsig Pedersen
    Citation: BMC Cancer 2015 15:411
    Content type: Research article Published on:

  23. An alternative approach to the traditional model of radiologists interpreting screening mammography is necessary due to the shortage of radiologists to interpret screening mammograms in many countries.

    Authors: Gabriela Torres-Mejía, Robert A. Smith, María de la Luz Carranza-Flores, Andy Bogart, Louis Martínez-Matsushita, Diana L. Miglioretti, Karla Kerlikowske, Carolina Ortega-Olvera, Ernesto Montemayor-Varela, Angélica Angeles-Llerenas, Sergio Bautista-Arredondo, Gilberto Sánchez-González, Olga G. Martínez-Montañez, Santos R. Uscanga-Sánchez, Eduardo Lazcano-Ponce and Mauricio Hernández-Ávila
    Citation: BMC Cancer 2015 15:410
    Content type: Research article Published on:

  24. The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSC...

    Authors: Pinaki Bose, Nigel T Brockton, Kelly Guggisberg, Steven C Nakoneshny, Elizabeth Kornaga, Alexander C Klimowicz, Mauro Tambasco and Joseph C Dort
    Citation: BMC Cancer 2015 15:409
    Content type: Research article Published on:

  25. Most of the blood tests aiming for breast cancer screening rely on quantification of a single or few biomarkers. The aim of this study was to evaluate the feasibility of detecting breast cancer by analyzing th...

    Authors: Udi Zelig, Eyal Barlev, Omri Bar, Itai Gross, Felix Flomen, Shaul Mordechai, Joseph Kapelushnik, Ilana Nathan, Hanoch Kashtan, Nir Wasserberg and Osnat Madhala-Givon
    Citation: BMC Cancer 2015 15:408
    Content type: Research article Published on:

  26. The objective of this work was to demonstrate that autoantibodies in breast cancer sera are not epiphenomena, and exhibit unique immunologic features resembling the rheumatic autoimmune diseases.

    Authors: Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez and Carol Peebles
    Citation: BMC Cancer 2015 15:407
    Content type: Research article Published on:

  27. To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia.

    Authors: Shih-Wei Yang, Yun-Shien Lee, Liang-Che Chang, Cheng-Cheng Hwang, Cheng-Ming Luo and Tai-An Chen
    Citation: BMC Cancer 2015 15:406
    Content type: Research article Published on:

  28. Breast cancer is the leading cause of cancer deaths in women world-wide. In low and middle income countries, where there are no population-based mammographic screening programmes, late presentation is common, ...

    Authors: Yew-Ching Teh, Gie-Hooi Tan, Nur Aishah Taib, Kartini Rahmat, Caroline Judy Westerhout, Farhana Fadzli, Mee-Hoong See, Suniza Jamaris and Cheng-Har Yip
    Citation: BMC Cancer 2015 15:405
    Content type: Research article Published on:

  29. Cancer-specific survival has changed remarkably little over the past half century, mainly because metastases that are occult at diagnosis and generally resistant to chemotherapy subsequently develop months, ye...

    Authors: Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon and Michael A. Ihnat
    Citation: BMC Cancer 2015 15:404
    Content type: Research article Published on:

  30. In metastatic breast cancer (MBC), antigen profiles of metastatic tissue and primary tumor differ in up to 20 % of patients. Reassessment of predictive markers, including human epidermal growth factor receptor...

    Authors: Markus Wallwiener, Andreas Daniel Hartkopf, Sabine Riethdorf, Juliane Nees, Martin Ronald Sprick, Birgitt Schönfisch, Florin-Andrei Taran, Jörg Heil, Christof Sohn, Klaus Pantel, Andreas Trumpp and Andreas Schneeweiss
    Citation: BMC Cancer 2015 15:403
    Content type: Research article Published on:

  31. Epithelioid hemangioendothelioma is a rare vascular tumor of borderline or low-grade malignancy. The lungs and liver are the two common primary organs affected. Metastatic disease was reported in more than 100...

    Authors: Valeriya Semenisty, Inna Naroditsky, Zohar Keidar and Gil Bar-Sela
    Citation: BMC Cancer 2015 15:402
    Content type: Case report Published on:

  32. Accumulating evidence suggests that breast cancer involves tumour-initiating cells (TICs), which play a role in initiation, metastasis, therapeutic resistance and relapse of the disease. Emerging drugs that ta...

    Authors: Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong and Jiri Neuzil
    Citation: BMC Cancer 2015 15:401
    Content type: Research article Published on:

  33. Leptomeningeal metastasis of melanoma is a devastating complication with a grave prognosis, and there are no known effective standard treatments. Although selective BRAF inhibitors have demonstrated a signific...

    Authors: Dae Won Kim, Edelyn Barcena, Urvi N Mehta, Michelle L Rohlfs, Ashok J Kumar, Marta Penas-Prado and Kevin B Kim
    Citation: BMC Cancer 2015 15:400
    Content type: Case report Published on:

  34. CTCs expressing variable levels of epithelial and mesenchymal markers in breast cancer have previously been reported. However, no information exists for keratin expression levels of CTCs in association with di...

    Authors: Hara Polioudaki, Sofia Agelaki, Rena Chiotaki, Eleni Politaki, Dimitris Mavroudis, Alexios Matikas, Vassilis Georgoulias and Panayiotis A Theodoropoulos
    Citation: BMC Cancer 2015 15:399
    Content type: Research article Published on:

  35. Hyperemesis gravidarum is a serious condition affecting 0.8–2.3 % of pregnant women and can be regarded as a restricted period of famine. Research concerning potential long-term consequences of the condition f...

    Authors: Kathrine F. Vandraas, Åse V. Vikanes, Nathalie C. Støer, Rebecca Troisi, Olof Stephansson, Henrik T. Sørensen, Siri Vangen, Per Magnus, Andrej M. Grjibovski and Tom Grotmol
    Citation: BMC Cancer 2015 15:398
    Content type: Research article Published on:

  38. The oncogenic PI3K/Akt/mTOR pathway is frequently activated in HCC. Data on the mTOR inhibitor, temsirolimus, is limited in HCC patients with concomitant chronic liver disease. The objectives of this study wer...

    Authors: Winnie Yeo, Stephen L Chan, Frankie KF Mo, Cheuk M Chu, Joyce WY Hui, Joanne HM Tong, Anthony WH Chan, Jane Koh, Edwin P Hui, Herbert Loong, Kirsty Lee, Leung Li, Brigette Ma, Ka F To and Simon CH Yu
    Citation: BMC Cancer 2015 15:395
    Content type: Research article Published on:

  39. A care pathway is defined as patient-focused global care that addresses temporal (effective and coordinated management throughout the illness) and spatial issues (treatment is provided near the health territor...

    Authors: Sandrine Baffert, Huong Ly Hoang, Anne Brédart, Bernard Asselain, Séverine Alran, Hélène Berseneff, Cyrille Huchon, Caroline Trichot, Aline Combes, Karine Alves, Martin Koskas, Thuy Nguyen, Aurélie Roulot, Roman Rouzier and Delphine Héquet
    Citation: BMC Cancer 2015 15:394
    Content type: Study protocol Published on:

  40. Previous studies assessing second primary malignancies (SPMs) after uterine cancer have been conducted in Western populations with conflicting results. This study aimed to define the incidence and risk of SPMs...

    Authors: Kuan-Der Lee, Chao-Yu Chen, Huei-Jean Huang, Ting-Yao Wang, David Teng, Shih-Hao Huang, Chyong-Huey Lai and Min-Chi Chen
    Citation: BMC Cancer 2015 15:393
    Content type: Research article Published on:

  41. Liver Transplantation (LT) is treatment of choice for patients with hepatocellular carcinoma (HCC) within MILAN Criteria. Tumour progression and subsequent dropout from waiting list have significant impact on ...

    Authors: Katrin Hoffmann, Tom Ganten, Daniel Gotthardtp, Boris Radeleff, Utz Settmacher, Otto Kollmar, Silvio Nadalin, Irini Karapanagiotou-Schenkel, Christof von Kalle, Dirk Jäger, Markus W Büchler and Peter Schemmer
    Citation: BMC Cancer 2015 15:392
    Content type: Research article Published on:

  42. NBPF1 (Neuroblastoma Breakpoint Family, member 1) was originally identified in a neuroblastoma patient on the basis of its disruption by a chromosomal translocation t(1;17)(p36.2;q11.2). Considering this genetic ...

    Authors: Vanessa Andries, Karl Vandepoele, Katrien Staes, Geert Berx, Pieter Bogaert, Gert Van Isterdael, Daisy Ginneberge, Eef Parthoens, Jonathan Vandenbussche, Kris Gevaert and Frans van Roy
    Citation: BMC Cancer 2015 15:391
    Content type: Research article Published on:

  43. Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase that serves as active link between extracellular signals and the primary response of gene expression. However, the involvement of MSK1 in malig...

    Authors: Binbin Li, Zheng Wan, Guoliang Huang, Zunnan Huang, Xiangning Zhang, Dan Liao, Shengqun Luo and Zhiwei He
    Citation: BMC Cancer 2015 15:390
    Content type: Research article Published on:

  44. Emerging data have suggested that cell surface GRP78 is a multifunctional receptor and has been linked to proliferative and antiapoptotic signaling cascades. Activated α2−macroglobin (α2M*) is a natural circulati...

    Authors: Song Zhao, Hongdan Li, Qingjun Wang, Chang Su, Guan Wang, Huijuan Song, Liang Zhao, Zhidong Luan and Rongjian Su
    Citation: BMC Cancer 2015 15:389
    Content type: Research article Published on:

  45. Fever and neutropenia (FN) is a common complication of pediatric cancer treatment, but hospital utilization patterns for this condition are not well described.

    Authors: Emily L. Mueller, Kelly J. Walkovich, Rajen Mody, Achamyeleh Gebremariam and Matthew M. Davis
    Citation: BMC Cancer 2015 15:388
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2017 17:668

  46. The monocarboxylate transporter-1 (MCT1) represents a novel target in rational anticancer drug design while AZD3965 was developed as an inhibitor of this transporter and is undergoing Phase I clinical trials (

    Authors: Stephen Kershaw, Jeffrey Cummings, Karen Morris, Jonathan Tugwood and Caroline Dive
    Citation: BMC Cancer 2015 15:387
    Content type: Technical advance Published on:

  47. Glasgow Prognostic Score (GPS) has been reported as a powerful prognostic tool for patients with advanced non–small cell lung cancer (NSCLC). The aim of this study was to assess the relationship between GPS an...

    Authors: Ai-Gui Jiang, Hong-Lin Chen and Hui-Yu Lu
    Citation: BMC Cancer 2015 15:386
    Content type: Research article Published on:

  48. In airways, a proliferative effect is played directly by cholinergic agonists through nicotinic and muscarinic receptors activation. How tumors respond to aberrantly activated cholinergic signalling is a key q...

    Authors: Ana Cristina Castillo-González, Susana Nieto-Cerón, Juan Pablo Pelegrín-Hernández, María Fernanda Montenegro, José Antonio Noguera, María Fuensanta López-Moreno, José Neptuno Rodríguez-López, Cecilio J Vidal, Diego Hellín-Meseguer and Juan Cabezas-Herrera
    Citation: BMC Cancer 2015 15:385
    Content type: Research article Published on:

  49. The aim of the trial was to compare two active adjuvant chemotherapy regimens in patients with early stage colorectal cancer (CRC).

    Authors: Dimitrios Pectasides, Vasilios Karavasilis, George Papaxoinis, Georgia Gourgioti, Thomas Makatsoris, Georgia Raptou, Eleni Vrettou, Joseph Sgouros, Epaminontas Samantas, George Basdanis, Pavlos Papakostas, Dimitrios Bafaloukos, Vassiliki Kotoula, Haralambos P. Kalofonos, Chrisoula D. Scopa, George Pentheroudakis…
    Citation: BMC Cancer 2015 15:384
    Content type: Research article Published on:

  50. Despite progress in identifying genes associated with breast cancer, many more risk loci exist. Genome-wide association analyses in genetically-homogeneous populations, such as that of Sardinia (Italy), could ...

    Authors: Grazia Palomba, Angela Loi, Eleonora Porcu, Antonio Cossu, Ilenia Zara, Mario Budroni, Mariano Dei, Sandra Lai, Antonella Mulas, Nina Olmeo, Maria Teresa Ionta, Francesco Atzori, Gianmauro Cuccuru, Maristella Pitzalis, Magdalena Zoledziewska, Nazario Olla…
    Citation: BMC Cancer 2015 15:383
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us