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  1. Previous population-based studies have demonstrated an association between metformin use and improved survival among diabetic patients with cancer. We sought to analyze the effects of diabetes and its treatmen...

    Authors: Oscar Arrieta, Edgar Varela-Santoyo, Enrique Soto-Perez-de-Celis, Roberto Sánchez-Reyes, Martha De la Torre-Vallejo, Saé Muñiz-Hernández and Andrés F. Cardona
    Citation: BMC Cancer 2016 16:633
    Content type: Research article Published on:

  2. Pancreatic cancer is poorly characterized at genetic and non-genetic levels. The current study evaluates in a large cohort of patients the prognostic relevance of molecular subtypes and key transcription facto...

    Authors: Rekin’s Janky, Maria Mercedes Binda, Joke Allemeersch, Anke Van den broeck, Olivier Govaere, Johannes V. Swinnen, Tania Roskams, Stein Aerts and Baki Topal
    Citation: BMC Cancer 2016 16:632
    Content type: Research article Published on:

  3. The preferred chemotherapy method for gastric cancer continues to be matter of debate. We performed a meta-analysis to comparing prognosis and safety between perioperative chemotherapy and adjuvant chemotherap...

    Authors: Jun-hua Zhao, Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Bin Ma, Yu-chong Yang and Zhen-ning Wang
    Citation: BMC Cancer 2016 16:631
    Content type: Research article Published on:

  4. Recent epidemiological studies indicate the rate of gastrointestinal (GI) malignancies among younger patients is increasing, mainly due to colorectal cancer. There is a paucity of data regarding the magnitude ...

    Authors: G. Perl, S. Nordheimer, S. Lando, C. Benedict, B. Brenner, S. Perry, G. Shmoisman, O. Purim, L. Amit, S. M. Stemmer and I. Ben-Aharon
    Citation: BMC Cancer 2016 16:630
    Content type: Research article Published on:

  5. Melanotic neuroectodermal tumor of infancy (MNTI) is exceptionally rare and occurs predominantly in the head and neck (92.8 % cases). The patient reported here is only the eighth case of MNTI presenting in an ...

    Authors: David J. Barnes, Edward Hookway, Nick Athanasou, Takeshi Kashima, Udo Oppermann, Simon Hughes, Daniel Swan, Dietrich Lueerssen, John Anson and A. Bassim Hassan
    Citation: BMC Cancer 2016 16:629
    Content type: Case report Published on:

  6. Overexpression the KCNJ3, a gene that encodes subunit 1 of G-protein activated inwardly rectifying K+ channel (GIRK1) in the primary tumor has been found to be associated with reduced survival times and increased...

    Authors: S. Rezania, S. Kammerer, C. Li, B. Steinecker-Frohnwieser, A. Gorischek, T. T. J. DeVaney, S. Verheyen, C. A. Passegger, N. Ghaffari Tabrizi-Wizsy, H. Hackl, D. Platzer, A. H. Zarnani, E. Malle, S. W. Jahn, T. Bauernhofer and W. Schreibmayer
    Citation: BMC Cancer 2016 16:628
    Content type: Research article Published on:

  7. Circulating cell-free DNA (cfDNA) is emerging as a surrogate sample type for mutation analyses. To improve the clinical utility of cfDNA, we developed a sensitive peptide nucleic acid (PNA)-based method for an...

    Authors: Ji-Youn Han, Jae-Jin Choi, Jin Young Kim, You Lim Han and Geon Kook Lee
    Citation: BMC Cancer 2016 16:627
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:803

  8. Variable degrees of differentiation in hepatocellular carcinoma(HCC)under Edmondson-Steiner grading system has been proven to be an independent prognostic indicator for HCC. Up till now, there has been no effe...

    Authors: Zhenpeng Peng, Mengjie Jiang, Huasong Cai, Tao Chan, Zhi Dong, Yanji Luo, Zi-Ping Li and Shi-Ting Feng
    Citation: BMC Cancer 2016 16:625
    Content type: Research article Published on:

  9. High expression levels of Inhibitors of Apoptosis Proteins (IAPs) have been correlated with poor cancer prognosis and block the cell death pathway by interfering with caspase activation. SMAC-mimetics are smal...

    Authors: Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa and Alexander Pintzas
    Citation: BMC Cancer 2016 16:624
    Content type: Research article Published on:

  10. Cyclophosphamide (CPA) can activate immunogenic tumor cell death, which induces immune-based tumor ablation and long-term anti-tumor immunity in a syngeneic C57BL/6 (B6) mouse GL261 glioma model when CPA is gi...

    Authors: Junjie Wu, Marie Jordan and David J. Waxman
    Citation: BMC Cancer 2016 16:623
    Content type: Research article Published on:

  11. The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown.

    Authors: Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk and Joachim Reischl
    Citation: BMC Cancer 2016 16:622
    Content type: Research article Published on:

  12. The radiopharmaceutical 131I-meta-iodobenzylguanidine (131I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from 131I-MIBG is likely to be obtained by its combination with ...

    Authors: Donna L. Nile, Colin Rae, Iain J. Hyndman, Mark N. Gaze and Robert J. Mairs
    Citation: BMC Cancer 2016 16:621
    Content type: Research article Published on:

  13. As with many anti-cancer drugs, the topoisomerase II inhibitor etoposide is considered safe for administration to women in the second and third trimesters of pregnancy, but assessment of effects on the develop...

    Authors: Agnes Stefansdottir, Zoe C. Johnston, Nicola Powles-Glover, Richard A. Anderson, Ian R. Adams and Norah Spears
    Citation: BMC Cancer 2016 16:482
    Content type: Research article Published on:

  14. Current evidence indicates sub-optimal incidence of fertility preservation (FP) in eligible patients. We present herein our designated multidisciplinary program for FP in pediatric and adolescent population an...

    Authors: Irit Ben-Aharon, R. Abir, G. Perl, J. Stein, G. Gilad, H. Toledano, S. Elitzur, G. Avrahami, A. Ben-Haroush, G. Oron, E. Freud, D. Kravarusic, M. Ben-Arush, G. Herzel, I. Yaniv, S. M. Stemmer…
    Citation: BMC Cancer 2016 16:620
    Content type: Research article Published on:

  15. Anthracyclines, as the most effective therapy, are the cornerstone of advanced stage sarcoma treatment. However, anthracyclines can also contribute to myocardial dysfunction and congestive heart failure, ultim...

    Authors: Markus K. Schuler, Sebastian Gerdes, Antje West, Stephan Richter, Christoph Busemann, Leopold Hentschel, Felicitas Lenz, Hans-Georg Kopp, Gerhard Ehninger, Peter Reichardt and Daniel Pink
    Citation: BMC Cancer 2016 16:619
    Content type: Research article Published on:

  16. The minor allele of two caspase 8 polymorphisms, namely CASP8 -652 6N InsDel (rs3834129) and CASP8 Asp302His (rs1045485), were repeatedly associated with reduced breast cancer susceptibility. Contrarily, the pres...

    Authors: J. D. Kuhlmann, A. Bankfalvi, K. W. Schmid, R. Callies, R. Kimmig, P. Wimberger, W. Siffert and H. S. Bachmann
    Citation: BMC Cancer 2016 16:618
    Content type: Research article Published on:

  17. Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown.

    Authors: Swathi Ramakrishnan, ShengYu Ku, Eric Ciamporcero, Kiersten Marie Miles, Kris Attwood, Sreenivasulu Chintala, Li Shen, Leigh Ellis, Paula Sotomayor, Wendy Swetzig, Ray Huang, Dylan Conroy, Ashley Orillion, Gokul Das and Roberto Pili
    Citation: BMC Cancer 2016 16:617
    Content type: Research article Published on:

  19. Due to lack of a targeted therapy for the triple-negative breast cancer (TNBC) patients, it is important to explore this aggressive breast cancer type in more detail and to establish novel therapeutic approach...

    Authors: Michaela C. Huber, Rebecca Mall, Herbert Braselmann, Annette Feuchtinger, Sara Molatore, Katrin Lindner, Axel Walch, Eva Gross, Manfred Schmitt, Natalie Falkenberg and Michaela Aubele
    Citation: BMC Cancer 2016 16:615
    Content type: Research article Published on:

  20. Circulating tumor cells (CTCs) have shown prognostic relevance in many cancer types. However, the majority of current CTC capture methods rely on positive selection techniques that require a priori knowledge a...

    Authors: Weiqiang Chen, Steven G. Allen, Ajaya Kumar Reka, Weiyi Qian, Shuo Han, Jianing Zhao, Liwei Bao, Venkateshwar G. Keshamouni, Sofia D. Merajver and Jianping Fu
    Citation: BMC Cancer 2016 16:614
    Content type: Research article Published on:

  21. Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we ...

    Authors: Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim and Je-Jung Lee
    Citation: BMC Cancer 2016 16:613
    Content type: Research article Published on:

  22. Thrombocytosis has been associated with poor ovarian cancer prognosis. However, comparisons of thresholds to define thrombocytosis and evaluation of relevant timing of platelet measurement has not been previou...

    Authors: Gabriella D. Cozzi, Jacob M. Samuel, Jason T. Fromal, Spencer Keene, Marta A. Crispens, Dineo Khabele and Alicia Beeghly-Fadiel
    Citation: BMC Cancer 2016 16:612
    Content type: Research article Published on:

  23. Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely u...

    Authors: Patrick Grossmann, David A. Gutman, William D. Dunn Jr, Chad A. Holder and Hugo J. W. L. Aerts
    Citation: BMC Cancer 2016 16:611
    Content type: Research article Published on:

  26. Association between cancer survival and socioeconomic status has been reported in various countries but it has never been studied in Portugal. We aimed here to study the role of education and socioeconomic dep...

    Authors: Luís Antunes, Denisa Mendonça, Maria José Bento and Bernard Rachet
    Citation: BMC Cancer 2016 16:608
    Content type: Research article Published on:

  27. Prostate cancer (PCa) is the most commonly diagnosed malignancy reported to Australian cancer registries with numerous studies from individual registries summarizing diagnostic and treatment characteristics. T...

    Authors: Rasa Ruseckaite, Kerri Beckmann, Michael O’Callaghan, David Roder, Kim Moretti, Jeremy Millar and Sue Evans
    Citation: BMC Cancer 2016 16:607
    Content type: Research article Published on:

  28. The response to neoadjuvant chemotherapy has been proven to predict long-term clinical benefits for patients. Our research is to construct a nomogram to predict pathological complete response of human epiderma...

    Authors: Xi Jin, Yi-Zhou Jiang, Sheng Chen, Ke-Da Yu, Ding Ma, Wei Sun, Zhi-Min Shao and Gen-Hong Di
    Citation: BMC Cancer 2016 16:606
    Content type: Research article Published on:

  29. MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 in CRC and the mechanism underlying that function is still unclear.

    Authors: Chenli Li, Lingxu Zhao, Yuan Chen, Tiantian He, Xiaowan Chen, Jiating Mao, Chunmei Li, Jianxin Lyu and Qing H. Meng
    Citation: BMC Cancer 2016 16:605
    Content type: Research article Published on:

  30. Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This s...

    Authors: Anaïs Balbous, Ulrich Cortes, Karline Guilloteau, Pierre Rivet, Baptiste Pinel, Mathilde Duchesne, Julie Godet, Odile Boissonnade, Michel Wager, René Jean Bensadoun, Jean-Claude Chomel and Lucie Karayan-Tapon
    Citation: BMC Cancer 2016 16:604
    Content type: Research article Published on:

  31. Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment of a minor subgroup of non-small cell lung cancer (NSCLC) patients. Although fluorescence in situ hybridization (FISH) is ...

    Authors: Johanna S. M. Mattsson, Hans Brunnström, Verena Jabs, Karolina Edlund, Karin Jirström, Stephanie Mindus, Linnéa la Fleur, Fredrik Pontén, Mats G. Karlsson, Christina Karlsson, Hirsh Koyi, Eva Brandén, Johan Botling, Gisela Helenius, Patrick Micke and Maria A. Svensson
    Citation: BMC Cancer 2016 16:603
    Content type: Research article Published on:

  32. The S6 Kinase (S6K) proteins are some of the main downstream effectors of the mammalian Target Of Rapamycin (mTOR) and act as key regulators of protein synthesis and cell growth. S6K is overexpressed in a vari...

    Authors: Camila L. Amaral, Lidia B. Freitas, Rodrigo E. Tamura, Mariana R. Tavares, Isadora C. B. Pavan, Marcio C. Bajgelman and Fernando M. Simabuco
    Citation: BMC Cancer 2016 16:602
    Content type: Research article Published on:

  33. Lymphedema is a prevalent long-term effect of breast cancer treatment that is associated with reduced quality of life. More recent observational data suggest that the addition of night-time compression to day-...

    Authors: Margaret L. McNeely, Kristin L. Campbell, Marc Webster, Urve Kuusk, Karen Tracey and John Mackey
    Citation: BMC Cancer 2016 16:601
    Content type: Study protocol Published on:

  35. The screening of ROS proto-oncogene 1, receptor tyrosine kinase(ROS1) fusion rearrangement might be potentially beneficial for an effective therapy against non-small cell lung cancer (NSCLC). However, the thre...

    Authors: Jieyu Wu, Yunen Lin, Xinming He, Haihong Yang, Ping He, Xinge Fu, Guangqiu Li and Xia Gu
    Citation: BMC Cancer 2016 16:599
    Content type: Research article Published on:

  36. Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin’s lymphoma. Bortezomib is the first product to be approved for the treatment of patients with previously untreated MCL, for whom haematop...

    Authors: Marjolijn van Keep, Kerry Gairy, Divyagiri Seshagiri, Pushpike Thilakarathne and Dawn Lee
    Citation: BMC Cancer 2016 16:598
    Content type: Research article Published on:

  37. Germ cell neoplasia in situ (GCNIS), is preinvasive stage of testicular germ cell tumours (TGCTs). Fibrillins, which are integral components of microfibrils are suggested to be involved in cancer pathogenesis ...

    Authors: Z. Cierna, M. Mego, I. Jurisica, K. Machalekova, M. Chovanec, V. Miskovska, D. Svetlovska, K. Kalavska, K. Rejlekova, K. Kajo, J. Mardiak and P. Babal
    Citation: BMC Cancer 2016 16:597
    Content type: Research article Published on:

  40. We previously identified CK1α as a novel tumor suppressor in melanoma and reported that the loss of CK1α leads to increased proliferation and invasive growth of melanoma cells by strong activation of the Wnt/β...

    Authors: Tobias Sinnberg, Jun Wang, Birgit Sauer and Birgit Schittek
    Citation: BMC Cancer 2016 16:594
    Content type: Research article Published on:

  41. Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor...

    Authors: Quan Lin, Guo-ping Cai, Kai-Yan Yang, Li Yang, Cheng-Shui Chen and Yu-Ping Li
    Citation: BMC Cancer 2016 16:593
    Content type: Case report Published on:

  42. In the lung, melanoma is mostly arranged as patterns of multiple nodules, solitary nodules, or miliary invasions. Very rarely, it also displays a “crazy paving” pattern (also described as a “paving stone,” “fl...

    Authors: Yikuan Feng, Jianping Zhao, Qun Yang, Weining Xiong, Guohua Zhen, Yongjian Xu, Zhenxiang Zhang and Huilan Zhang
    Citation: BMC Cancer 2016 16:592
    Content type: Case report Published on:

  43. Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstr...

    Authors: David Bernal-Estévez, Ramiro Sánchez, Rafael E. Tejada and Carlos Parra-López
    Citation: BMC Cancer 2016 16:591
    Content type: Research article Published on:

  44. Liver biopsies in pediatric hematopoietic stem cell transplantation (HSCT) patients are as and effective when performed at bedside in the Bone Marrow Transplant Unit (BMTU) than in the Day Surgery Unit (DSU), ...

    Authors: Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol and Aurelio Sonzogni
    Citation: BMC Cancer 2016 16:590
    Content type: Research article Published on:

  45. Radiation recall gastritis is rare but can be induced after concurrent chemoradiation for pancreatic cancer. We report a patient with pancreatic cancer who developed radiation-recall gastritis related to a com...

    Authors: Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak and Jun Suk Kim
    Citation: BMC Cancer 2016 16:588
    Content type: Case report Published on:

  46. Prostate cancer is one of the most common male cancers worldwide. Active Surveillance (AS) has been developed to allow men with lower risk disease to postpone or avoid the adverse side effects associated with ...

    Authors: Eimear Ruane-McAteer, Joe O’Sullivan, Sam Porter, Lionne Venderbos and Gillian Prue
    Citation: BMC Cancer 2016 16:586
    Content type: Study protocol Published on:

  47. HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01–0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated wi...

    Authors: Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux and Béatrice Weber
    Citation: BMC Cancer 2016 16:573
    Content type: Case report Published on:

  48. Imatinib-resistant chronic myeloid leukemia (CML) patients receiving second-line tyrosine kinase inhibitor (TKI) therapy with dasatinib or nilotinib have a higher risk of disease relapse and progression and no...

    Authors: Simona Soverini, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Manuela Mancini, Luana Bavaro, Katerina Machova Polakova, Jana Linhartova, Alessandra Iurlo, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Michele Cavo, Michele Baccarani and Giovanni Martinelli
    Citation: BMC Cancer 2016 16:572
    Content type: Technical advance Published on:

  49. Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into diffe...

    Authors: Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie and Shuxin Huang
    Citation: BMC Cancer 2016 16:571
    Content type: Research article Published on:

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