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  1. Hepato-pulmonary metastasis of colorectal cancer (CRC) is a rare disease with poor prognosis. This study aims to establish a highly efficient nomogram model to predict overall survival (OS) and cancer-specific...

    Authors: Shenghe Deng, Zhenxing Jiang, Yinghao Cao, Junnan Gu, Fuwei Mao, Yifan Xue, Le Qin, Ke Liu, Jiliang Wang, Ke Wu and Kailin Cai
    Citation: BMC Cancer 2022 22:643
  2. Malignant pleural mesothelioma, a tumor arising from the membrane covering the lungs and the inner side of the ribs, is a cancer in which genetic alterations of genes encoding proteins that act on or are part ...

    Authors: Loreley Calvet, Odette Dos-Santos, Emmanuel Spanakis, Véronique Jean-Baptiste, Jean-Christophe Le Bail, Armelle Buzy, Pascal Paul, Christophe Henry, Sandrine Valence, Colette Dib, Jack Pollard, Sukhvinder Sidhu, Jürgen Moll, Laurent Debussche and Iris Valtingojer
    Citation: BMC Cancer 2022 22:639
  3. Recurrent esophageal cancer is associated with dismal prognosis. There is no consensus about the role of surgical treatments in patients with limited recurrences. This study aimed to evaluate the role of surgi...

    Authors: Ping-Chung Tsai, Hung-Che Chien, Po-Kuei Hsu, Jung-Jyh Hung, Chien-Sheng Huang, Wen-Hu Hsu and Han-Shui Hsu
    Citation: BMC Cancer 2022 22:637
  4. Aberrant methylation of EphA7 has been reported in the process of carcinogenesis but not in cervical cancer. Therefore, an integration study was performed to explore the association between EphA7 hypermethylat...

    Authors: Wenfan Zhang, Huiling Cao, Jinhao Yang, Jing Zhao, Zheng Liang, Xiaodong Kang and Rong Wang
    Citation: BMC Cancer 2022 22:636
  5. The prognosis of Borrmann type III advanced gastric cancer (AGC) is known to vary significantly among patients. This study aimed to determine which differentially expressed genes (DEGs) are directly related to...

    Authors: Yufei Wang, Tianyi Fang, Yimin Wang, Xin Yin, Lei Zhang, Xinghai Zhang, Daoxu Zhang, Yao Zhang, Xibo Wang, Hao Wang and Yingwei Xue
    Citation: BMC Cancer 2022 22:635
  6. Semaphorins have been found to play important roles in multiple malignancy-related processes. However, the role of Semaphorin 4B (SEMA4B) in lung cancer remains unclear. Here, we aimed to explore the biologica...

    Authors: Jun Jiang, Yuan Lu, Fang Zhang, Tao Pan, Zhipei Zhang, Yi Wan, Xinling Ren and Rui Zhang
    Citation: BMC Cancer 2022 22:632
  7. Non-muscle invasive bladder cancer can be controlled by transurethral resection of bladder (TURB), but suffers from frequent recurrences in 60–70% of cases. Although, recurrence interval after TURB influences ...

    Authors: Seung-hwan Jeong, Jang Hee Han, Chang Wook Jeong, Hyeon Hoe Kim, Cheol Kwak, Hyeong Dong Yuk and Ja Hyeon Ku
    Citation: BMC Cancer 2022 22:631
  8. The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results that have been translated into regulatory approval, supportin...

    Authors: David J. Barnes, Peter Dutton, Øyvind Bruland, Hans Gelderblom, Ade Faleti, Claudia Bühnemann, Annemiek van Maldegem, Hannah Johnson, Lisa Poulton, Sharon Love, Gesa Tiemeier, Els van Beelen, Karin Herbschleb, Caroline Haddon, Lucinda Billingham, Kevin Bradley…
    Citation: BMC Cancer 2022 22:629
  9. Eukaryotic translation elongation factors 1 δ (EEF1D), has garnered much attention with regards to their role in the drug resistance of cancers. In this paper, we investigated the effects and mechanisms of inc...

    Authors: Qia Xu, Yun Liu, Shenyi Wang, Jing Wang, Liwei Liu, Yin Xu and Yide Qin
    Citation: BMC Cancer 2022 22:628
  10. Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers and is challenging to treat due to a lack of effective targeted therapies. Previous studies in TNBC cell lines showed in vitro growth i...

    Authors: Nanda Kumar Yellapu, Thuc Ly, Mihaela E. Sardiu, Dong Pei, Danny R. Welch, Jeffery A. Thompson and Devin C. Koestler
    Citation: BMC Cancer 2022 22:627
  11. Epidermal growth factor receptor (EGFR) activation is associated with increased production of interleukin 6 (IL6), which is intensified by radiotherapy (RT) induced inflammatory response. Elevated IL6 levels i...

    Authors: Lucas Maahs, Ahmed I. Ghanem, Radhika Gutta, Amy Tang, Swarn Arya, Zaid Al Saheli, Haythem Ali, Steven Chang, Samantha Tam, Vivian Wu, Farzan Siddiqui and Jawad Sheqwara
    Citation: BMC Cancer 2022 22:626
  12. Tropomyosin receptor kinase (TRK) fusion proteins resulting from neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare primary oncogenic drivers in a wide array of tumors. Larotrectinib is a first-in...

    Authors: James C. H. Yang, Marcia S. Brose, Gilberto Castro, Edward S. Kim, Ulrik N. Lassen, Serge Leyvraz, Alberto Pappo, Fernando López-Ríos, John A. Reeves, Marc Fellous, Frédérique Penault-Llorca, Erin R. Rudzinski, Ghazaleh Tabatabai, Gilles Vassal, Alexander Drilon and Jonathan Trent
    Citation: BMC Cancer 2022 22:625
  13. Current guidelines consider T-DM1 the standard 2nd line therapy for HER2 positive metastatic breast cancer (MBC) patients following trastuzumab (T) + pertuzumab (P) and taxane 1st line treatment. Despite this, th...

    Authors: Claudia Omarini, Federico Piacentini, Isabella Sperduti, Krisida Cerma, Monica Barbolini, Fabio Canino, Cecilia Nasso, Christel Isca, Federica Caggia, Massimo Dominici and Luca Moscetti
    Citation: BMC Cancer 2022 22:623
  14. Polyploid giant cancer cells (PGCCs) have been observed in epithelial ovarian tumors. They can resist antimitotic drugs, thus participating in tumor maintenance and recurrence. Although their origin remains un...

    Authors: Lucile Yart, Daniel Bastida-Ruiz, Mathilde Allard, Pierre-Yves Dietrich, Patrick Petignat and Marie Cohen
    Citation: BMC Cancer 2022 22:622
  15. Treatment of cancer patients in certified cancer centers, that meet specific quality standards in term of structures and procedures of medical care, is a national treatment goal in Germany. However, convincing...

    Authors: Martin Roessler, Jochen Schmitt, Christoph Bobeth, Michael Gerken, Kees Kleihues-van Tol, Christoph Reissfelder, Bettina M. Rau, Marius Distler, Pompiliu Piso, Christian Günster, Monika Klinkhammer-Schalke, Olaf Schoffer and Veronika Bierbaum
    Citation: BMC Cancer 2022 22:621
  16. Cholangiocarcinoma (CHOL) is a malignant tumor that originates in the extrahepatic bile duct and can extend from the hilar region to the lower end of the common bile duct. The prognosis of CHOL patients is par...

    Authors: Huaqiang Zhu, Haini Zhao, Jianlu Wang, Shuchao Zhao, Chaoqun Ma, Dongliang Wang, Hengjun Gao, Faji Yang, Qingqiang Ni, Hongguang Li, Xu Zhou, Chunqing Zhang and Jun Lu
    Citation: BMC Cancer 2022 22:620
  17. An imbalance of intracellular iron metabolism can lead to the occurrence of ferroptosis. Ferroptosis can be a factor in the remodeling of the immune microenvironment and can affect the efficacy of cancer immun...

    Authors: Xiao-Fen Li, Wen-Fen Fu, Jie Zhang and Chuan-Gui Song
    Citation: BMC Cancer 2022 22:619
  18. Breast cancer and lung cancer are the top two malignancies in the female population and the number of patients with breast cancer and subsequent primary lung cancer has increased significantly in recent years....

    Authors: Yan Wang, Wenpeng Song, Sicheng Zhou, Shuai Chang, Junke Chang, Jie Tian, Liming Zhang, Jue Li and Guowei Che
    Citation: BMC Cancer 2022 22:618
  19. The CheckMate 025 trial established nivolumab monotherapy as one of the standards of care in previously treated advanced or metastatic renal cell carcinoma (aRCC). However, supporting real-world data is lackin...

    Authors: T. Waddell, K. Fife, R. Griffiths, A. Sharma, P. Dhokia, L. Groves, M. Hurst, C. Tsang, D. Sugrue, S. McKenna, J. Houghton and R. Carroll
    Citation: BMC Cancer 2022 22:617
  20. Cisplatin-based concurrent chemoradiotherapy has been identified as the primary and standard treatment for locally advanced nasopharyngeal carcinoma (NPC). However, the side effects of cisplatin affect the com...

    Authors: Zhiru Li, Chao Li, Dong Yang, Junmei Song, Ting Liu, Ziyan Zhou, Lifang Zhou and Min Kang
    Citation: BMC Cancer 2022 22:616
  21. To investigate the feasibility, safety, and clinical application value of single photon emission computed tomography/computed tomography (SPECT/CT)-guided bone marrow biopsy (BMB) in breast cancer (BC) patient...

    Authors: Xiaomin Li, Caixia An and Wanchun Zhang
    Citation: BMC Cancer 2022 22:614
  22. A malignancy of the liver, hepatocellular carcinoma (HCC) is among the most common and second-leading causes of cancer-related deaths worldwide. A reliable prognosis model for guidance in choosing HCC therapie...

    Authors: Chunting Zeng, Linmeng Zhang, Chanhua Luo, Chen Yang, Xiaowen Huang, Linfeng Fan, Jiarong Li, Fengsheng Chen and Zelong Luo
    Citation: BMC Cancer 2022 22:613
  23. Glioblastoma (GBM) has a high incidence rate, invasive growth, and easy recurrence, and the current therapeutic effect is less than satisfying. Pyroptosis plays an important role in morbidity and progress of G...

    Authors: Min-Rui Ding, Yan-Jie Qu, Xiao Peng, Jin-Fang Chen, Meng-Xue Zhang, Tong Zhang, Bing Hu and Hong-Mei An
    Citation: BMC Cancer 2022 22:611
  24. The management of melanoma patients with metastatic melanoma in the sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstr...

    Authors: Saveria Tropea, Paolo Del Fiore, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Simone Ribero, Pietro Quaglino, Virginia Caliendo, Lorenzo Borgognoni, Serena Sestini, Giuseppe Giudice, Eleonora Nacchiero, Corrado Caracò, Adriana Cordova, Nicola Solari, Dario Piazzalunga…
    Citation: BMC Cancer 2022 22:610
  25. Although pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the skeleton, disseminated tumor cells have been detected in bone marrow samples from patients with this disease. The prognostic value of...

    Authors: Oddmund Nordgård, Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Karin Hestnes Edland, Nicolay Bore Neverdahl, Dmitrij Fostenes, Herish Garresori, Nils Glenjen, Rune Smaaland and Bjørnar Gilje
    Citation: BMC Cancer 2022 22:609
  26. The multidisciplinary treatment including induction chemotherapy plus conversion surgery (CS) has attracted attention as a new strategy to improve the outcome of metastatic gastric cancer (MGC). However, it is...

    Authors: Jun Kinoshita, Sachio Fushida, Takahisa Yamaguchi, Hideki Moriyama, Hiroto Saito, Mari Shimada, Shiro Terai, Koichi Okamoto, Keishi Nakamura, Itasu Ninomiya, Shintaro Yagi and Noriyuki Inaki
    Citation: BMC Cancer 2022 22:608
  27. Anal cancer is primarily treated using concurrent chemoradiotherapy (CRT), with conformal techniques such as intensity modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) now being the standard tec...

    Authors: Stelios Theophanous, Robert Samuel, John Lilley, Ann Henry, David Sebag-Montefiore, Alexandra Gilbert and Ane L. Appelt
    Citation: BMC Cancer 2022 22:607
  28. Central lymph node status in papillary thyroid microcarcinoma (PTMC) plays an important role in treatment decision-making clinically, however, it is not easy to predict central lymph node metastasis (CLNM). Th...

    Authors: Qian-wen Luo, Shan Gao, Xiao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han, Yun-peng Wang, Quan-lin Guan and Tao Gong
    Citation: BMC Cancer 2022 22:606

    The Correction to this article has been published in BMC Cancer 2022 22:698

  29. Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecu...

    Authors: Krisztina A. Szigeti, Alexandra Kalmár, Orsolya Galamb, Gábor Valcz, Barbara K. Barták, Zsófia B. Nagy, Sára Zsigrai, Ildikó Felletár, Árpád V. Patai, Tamás Micsik, Márton Papp, Eszter Márkus, Zsolt Tulassay, Peter Igaz, István Takács and Béla Molnár
    Citation: BMC Cancer 2022 22:605
  30. Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, ...

    Authors: Lucy Gately, Katharine Drummond, Mark Rosenthal, Rosemary Harrup, Anthony Dowling, Andrew Gogos, Zarnie Lwin, Ian Collins, David Campbell, Elizabeth Ahern, Claire Phillips, Hui K. Gan, Iwan Bennett, Oliver M. Sieber and Peter Gibbs
    Citation: BMC Cancer 2022 22:604
  31. This study aims to evaluate the incidence of and identify risk factors for gastrointestinal (GI) and genitourinary (GU) fistula or perforation formation with or without bevacizumab in patients with recurrent c...

    Authors: Woo Yeon Hwang, Suk-Joon Chang, Hee Seung Kim, Nam Kyeong Kim, Tae Hun Kim, Yeorae Kim, Tae Wook Kong, Eun Ji Lee, Soo Jin Park, Seung Hyuk Shim, Joo-Hyuk Son, Dong Hoon Suh and Eun Jung Yang
    Citation: BMC Cancer 2022 22:603
  32. There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a high frequency of ci...

    Authors: Mohammad A. Al-Mterin, Khaled Murshed, Alhasan Alsalman, Ala Abu-Dayeh and Eyad Elkord
    Citation: BMC Cancer 2022 22:601
  33. With the aim of obtaining more uniformity and quality in the treatment of corpus uteri cancer in Belgium, the EFFECT project has prospectively collected detailed information on the real-world clinical care off...

    Authors: Joren Vanbraband, Nancy Van Damme, Gauthier Bouche, Geert Silversmit, Anke De Geyndt, Eric de Jonge, Gerd Jacomen, Frédéric Goffin, Hannelore Denys and Frédéric Amant
    Citation: BMC Cancer 2022 22:600
  34. The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structur...

    Authors: Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith and Mousa Alreshidi
    Citation: BMC Cancer 2022 22:599
  35. Tumor heterogeneity has frequently been observed in gastric cancer (GC), but the correlation between patients’ clinico-pathologic features and the tumoral heterogeneity of GC-associated molecules is unclear. W...

    Authors: Gen Tsujio, Koji Maruo, Yurie Yamamoto, Tomohiro Sera, Atsushi Sugimoto, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira and Masakazu Yashiro
    Citation: BMC Cancer 2022 22:598
  36. Osimertinib is a standard first-line treatment for advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Although malignant pleural effusion (PE) is a common cli...

    Authors: Hiroshi Nokihara, Hirokazu Ogino, Atsushi Mitsuhashi, Kensuke Kondo, Ei Ogawa, Ryohiko Ozaki, Yohei Yabuki, Hiroto Yoneda, Kenji Otsuka and Yasuhiko Nishioka
    Citation: BMC Cancer 2022 22:597
  37. Part of papillary thyroid microcarcinoma (PTMC) has a high risk of tumor invasion and metastasis, which may occur in the regional lymph node metastasis or distant metastasis, severely threatening the life of p...

    Authors: Xiuhe Zou, Qian Zhou, Yan Nie, Junhe Gou, Jing Yang, Jingqiang Zhu, Zhihui Li and Yanping Gong
    Citation: BMC Cancer 2022 22:595
  38. NOSTRIN, abundantly expressed in colon, was reported to be anti-angiogenic, anti-invasive and anti-inflammatory. NOSTRIN expression was inversely related to survival of pancreatic ductal adeno-carcinoma patien...

    Authors: Madhurima Paul, Tamal Kanti Gope, Priyanka Das and Rupasri Ain
    Citation: BMC Cancer 2022 22:594
  39. Prior studies reported survival benefits from early initiation of adjuvant chemotherapy for stage III colon cancer, but this evidence was derived from studies that may be sensitive to time-related biases. Ther...

    Authors: Yan Lu, Aaron W. Gehr, Rachel J. Meadows, Bassam Ghabach, Latha Neerukonda, Kalyani Narra and Rohit P. Ojha
    Citation: BMC Cancer 2022 22:593
  40. The aim of the study was to enhance colorectal cancer prognostication by integrating single nucleotide polymorphism (SNP) and gene expression (GE) microarrays for genomic and transcriptional alteration detecti...

    Authors: Ming-Hung Shen, Chi-Jung Huang, Thien-Fiew Ho, Chih-Yi Liu, Ying-Yih Shih, Ching-Shui Huang and Chi-Cheng Huang
    Citation: BMC Cancer 2022 22:590

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