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  1. Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated...

    Authors: Oliver F Bathe, Scot Dowden, Francis Sutherland, Elijah Dixon, Charles Butts, David Bigam, Barb Walley, Dean Ruether and Scott Ernst
    Citation: BMC Cancer 2004 4:32
    Content type: Study protocol Published on:

  2. A novel member of the Wnt signalling pathway, Chibby, was recently identified. This protein inhibits Wnt/β-catenin mediated transcriptional activation by competing with Lef-1 (the transcription factor and targ...

    Authors: Sophie Gad, David Teboul, Astrid Lièvre, Nicolas Goasguen, Anne Berger, Philippe Beaune and Pierre Laurent-Puig
    Citation: BMC Cancer 2004 4:31
    Content type: Research article Published on:

  3. North central China has some of the highest rates of esophageal squamous cell carcinoma in the world with cumulative mortality surpassing 20%. Mitochondrial DNA (mtDNA) accumulates more mutations than nuclear ...

    Authors: Christian C Abnet, Konrad Huppi, Ana Carrera, David Armistead, Keith McKenney, Nan Hu, Ze-Zong Tang, Philip R Taylor and Sanford M Dawsey
    Citation: BMC Cancer 2004 4:30
    Content type: Research article Published on:

  4. Serum leptin level is associated with appetite and energy expenditure in healthy individuals. We aimed to evaluate the serum leptin concentration and the other factors which may be associated with weight loss ...

    Authors: F Fusun Bolukbas, Hasan Kilic, Cengiz Bolukbas, Mahmut Gumus, Mehmet Horoz, Nazım S Turhal and Birsel Kavakli
    Citation: BMC Cancer 2004 4:29
    Content type: Research article Published on:

  5. The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable signal transduction events. Withi...

    Authors: Christina L Addison, John A Belperio, Marie D Burdick and Robert M Strieter
    Citation: BMC Cancer 2004 4:28
    Content type: Research article Published on:

  6. Recent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous studies have shown that tumorous tissues have higher 5α-reductase (5αR) and lower 3α-hydroxyste...

    Authors: Michael J Lewis, John P Wiebe and J Godfrey Heathcote
    Citation: BMC Cancer 2004 4:27
    Content type: Research article Published on:

  8. Based on the site of breakpoint in t(9;22) (q34;q11), bcr-abl fusion in leukemia patients is associated with different types of transcript proteins. In this study we have seen the association of HLA genes with di...

    Authors: Shailendra Mundhada, Rajyalakshmi Luthra and Pedro Cano
    Citation: BMC Cancer 2004 4:25
    Content type: Research article Published on:

  9. Signaling networks promoting cell growth and proliferation are frequently deregulated in cancer. Tumors often are highly dependent on such signaling pathways and may become hypersensitive to downregulation of ...

    Authors: Boris W Kramer, Rudolf Götz and Ulf R Rapp
    Citation: BMC Cancer 2004 4:24
    Content type: Research article Published on:

  10. Therapeutic options to effectively inhibit growth and spread of neuroendocrine gastrointestinal tumors are still limited. As both meta-iodobenzylguanidine (MIBG) and interferon-γ (IFNγ) cause antineoplastic ef...

    Authors: Michael Höpfner, Andreas P Sutter, Alexander Huether, Gudrun Ahnert-Hilger and Hans Scherübl
    Citation: BMC Cancer 2004 4:23
    Content type: Research article Published on:

  11. Patients with cancer must make frequent visits to the clinic not only for chemotherapy but also for the management of treatment-related adverse effects. Neutropenia, the most common dose-limiting toxicity of m...

    Authors: Barry V Fortner, Kurt Tauer, Ling Zhu, Theodore A Okon, Kelley Moore, Davis Templeton and Lee Schwartzberg
    Citation: BMC Cancer 2004 4:22
    Content type: Research article Published on:

  13. DNA microarray profiling performed on clinical tissue specimens can potentially provide significant information regarding human cancer biology. Biopsy cores, the typical source of human tumor tissue, however, ...

    Authors: Elizabeth M Goley, Soni J Anderson, Cynthia Ménard, Eric Chuang, Xing Lü, Philip J Tofilon and Kevin Camphausen
    Citation: BMC Cancer 2004 4:20
    Content type: Research article Published on:

  15. Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adh...

    Authors: David L Crowe and Arthur Ohannessian
    Citation: BMC Cancer 2004 4:18
    Content type: Research article Published on:

  19. Surveillance colonoscopy is commonly recommended following potentially curative surgery for colorectal cancer. We determined factors associated with patients undergoing a least one colonoscopy within five year...

    Authors: Robert J Hilsden, Heather E Bryant, Lloyd R Sutherland, Penny MA Brasher and Anthony LA Fields
    Citation: BMC Cancer 2004 4:14
    Content type: Research article Published on:

  21. Most of the steps involved in the initiation and progression of Hürthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown.

    Authors: Valdemar Máximo, Ana Preto, Ana Crespo, Ana Sofia Rocha, José Carlos Machado, Paula Soares and Manuel Sobrinho-Simões
    Citation: BMC Cancer 2004 4:12
    Content type: Research article Published on:

  22. Fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluoro-2'deoxyuridine (FUDR) are among the most effective chemotherapeutic agents for treatment of metastatic colorectal cancer (CRC). Increased expression...

    Authors: Massimo Libra, Patrick M Navolanic, Renato Talamini, Erica Cecchin, Franca Sartor, Salvatore Tumolo, Sara Masier, Salvatore Travali, Mauro Boiocchi and Giuseppe Toffoli
    Citation: BMC Cancer 2004 4:11
    Content type: Research article Published on:

  24. Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer. Polymorphisms in DNA repa...

    Authors: Alice J Sigurdson, Michael Hauptmann, Nilanjan Chatterjee, Bruce H Alexander, Michele Morin Doody, Joni L Rutter and Jeffery P Struewing
    Citation: BMC Cancer 2004 4:9
    Content type: Research article Published on:

  28. Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy is the choice of treatment for advanced stages of the disease. The prognosis is poor, wi...

    Authors: Pulivarthi H Rao, Hugo Arias-Pulido, Xin-Yan Lu, Charles P Harris, Hernan Vargas, Fang F Zhang, Gopeshwar Narayan, Achim Schneider, Mary Beth Terry and Vundavalli VVS Murty
    Citation: BMC Cancer 2004 4:5
    Content type: Research article Published on:

  29. Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death. Publicly accessible databases conta...

    Authors: Ping Qiu, Luquan Wang, Mitch Kostich, Wei Ding, Jason S Simon and Jonathan R Greene
    Citation: BMC Cancer 2004 4:4
    Content type: Research article Published on:

  30. A case of Primitive Neuroectodermal Tumor (PNET) of the kidney in a 27-year-old woman is presented. Few cases are reported in the literature with a variable, nonspecific presentation and an aggressive behaviou...

    Authors: Giorgio Pomara, Francesco Cappello, Maria G Cuttano, Francesca Rappa, Girolamo Morelli, Pierantonio Mancini and Cesare Selli
    Citation: BMC Cancer 2004 4:3
    Content type: Case report Published on:

  31. Although sentinel node biopsy (SNB) is becoming the standard approach for axillary staging in patients with small breast cancer, criteria for patient selection and some technical aspects of the procedure have ...

    Authors: Giorgio Zavagno, Gian Luca De Salvo, Dario Casara, Paola Del Bianco, Domenico Rubello, Fabrizio Meggiolaro, Carlo Riccardo Rossi, Mariaelena Pierobon and Mario Lise
    Citation: BMC Cancer 2004 4:2
    Content type: Research article Published on:

  32. Kaposi's sarcoma (KS) is a mesenchymal tumour associated with human herpesvirus-8 infection. However, the incidence of human herpesvirus-8 infection is far higher than the prevalence of KS, suggesting that vir...

    Authors: Thierry Simonart
    Citation: BMC Cancer 2004 4:1
    Content type: Debate Published on:

  33. Dysregulation of apoptosis, specifically overexpression of soluble Fas (sFas), has been proposed to play a role in the development of ovarian cancer. The main objective of the present study was to evaluate ser...

    Authors: Arslan Akhmedkhanov, Eva Lundin, Seth Guller, Annekatrin Lukanova, Andrea Micheli, Yuehong Ma, Yelena Afanasyeva, Anne Zeleniuch-Jacquotte, Vittorio Krogh, Per Lenner, Paola Muti, Sabina Rinaldi, Rudolf Kaaks, Franco Berrino, Göran Hallmans and Paolo Toniolo
    Citation: BMC Cancer 2003 3:33
    Content type: Research article Published on:

  34. Patients with advanced (incurable) tumours usually experience a diverse burden of symptoms. Although many symptom assessment instruments are available, we examined whether these addressed tumour-related symptoms.

    Authors: Margherita J Barresi, Bruce Shadbolt, Don Byrne and Robin Stuart-Harris
    Citation: BMC Cancer 2003 3:32
    Content type: Research article Published on:

  35. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number o...

    Authors: Marc E Lenburg, Louis S Liou, Norman P Gerry, Garrett M Frampton, Herbert T Cohen and Michael F Christman
    Citation: BMC Cancer 2003 3:31
    Content type: Research article Published on:

  37. The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factor...

    Authors: Mary Beth Terry, Alfred I Neugut, Mahesh Mansukhani, Jerome Waye, Noam Harpaz and Hanina Hibshoosh
    Citation: BMC Cancer 2003 3:29
    Content type: Research article Published on:

  38. Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effect...

    Authors: Antonio González-Pérez, Luis A García Rodríguez and Ruy López-Ridaura
    Citation: BMC Cancer 2003 3:28
    Content type: Research article Published on:

  39. Morphologic criteria which might help to support the need for a preventive strategy for early detection of rectal cancer were analysed. Population-based data on rectal adenomas with high-grade dysplastic chang...

    Authors: René Scheiden, Julien Sand, Joseph Weber, Philippe Turk, Yolande Wagener and Catherine Capesius
    Citation: BMC Cancer 2003 3:27
    Content type: Technical advance Published on:

  40. A systematic review was conducted to evaluate the literature regarding the impact of follow-up on colorectal cancer patient survival and, in a second phase, recommendations were developed.

    Authors: Alvaro Figueredo, R Bryan Rumble, Jean Maroun, Craig C Earle, Bernard Cummings, Robin McLeod, Lisa Zuraw and Caroline Zwaal
    Citation: BMC Cancer 2003 3:26
    Content type: Research article Published on:

  41. Tocopherols are lipid soluble antioxidants that exist as eight structurally different isoforms. The intake of γ-tocopherol is higher than α-tocopherol in the average US diet. The clinical results of the effect...

    Authors: Sharon E Campbell, William L Stone, Sarah G Whaley, Min Qui and Koyamangalath Krishnan
    Citation: BMC Cancer 2003 3:25
    Content type: Research article Published on:

  44. Estrogen signaling plays a critical role in a number of normal physiological processes and has important implications in the treatment of breast cancer. The p160 nuclear receptor coactivator, AIB1 (amplified in b...

    Authors: Sarah L Anzick, David O Azorsa, S Stoney Simons Jr and Paul S Meltzer
    Citation: BMC Cancer 2003 3:22
    Content type: Research article Published on:

  47. We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared ...

    Authors: Sanjay Sharma, Michael H Neale, Federica Di Nicolantonio, Louise A Knight, Pauline A Whitehouse, Stuart J Mercer, Bernard R Higgins, Alan Lamont, Richard Osborne, Andrew C Hindley, Christian M Kurbacher and Ian A Cree
    Citation: BMC Cancer 2003 3:19
    Content type: Research article Published on:

  48. Breast and cervical cancer continue to represent major health challenges for African American women. among Caucasian women. The underlying reasons for this disparity are multifactorial and include lack of educ...

    Authors: Thelma C Hurd, Paola Muti, Deborah O Erwin and Sharita Womack
    Citation: BMC Cancer 2003 3:18
    Content type: Research article Published on:

  50. To determine whether the dose-volume histograms (DVH's) for the rectum and bladder constructed using biological-effective dose (BED-DVH's) better correlate with late gastrointestinal (GI) and genitourinary (GU...

    Authors: Ashesh B Jani, Christopher M Hand, Charles A Pelizzari, John C Roeske, Lani Krauz and Srinivasan Vijayakumar
    Citation: BMC Cancer 2003 3:16
    Content type: Research article Published on:

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