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  1. The aim of this study is to investigate the relationship between16-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF (vascular endothelial growth factor) expression in patients with benign and ...

    Authors: Shu-Hua Ma, Hong-Bo Le, Bao-hui Jia, Zhao-Xin Wang, Zhuang-Wei Xiao, Xiao-Ling Cheng, Wei Mei, Min Wu, Zhi-Guo Hu and Yu-Guang Li
    Citation: BMC Cancer 2008 8:186
    Content type: Research article Published on:

  3. Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to amphibole forms of asbestos, chrysotile asbestos fail to a...

    Authors: Beatriz A Cortez and Glaucia M Machado-Santelli
    Citation: BMC Cancer 2008 8:181
    Content type: Research article Published on:

  4. Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of ...

    Authors: Diana J Leeming, Inger Byrjalsen, Per Qvist, Mitsuru Koizumi, Niels Lynnerup, Michael Fregerslev, Mette G Sørensen, Claus Christiansen and Morten A Karsdal
    Citation: BMC Cancer 2008 8:180
    Content type: Research article Published on:

  5. A Disintegrin And Metalloprotease (ADAM) 9 has been implicated in tumour progression of various solid tumours, however, little is known about its role in renal cell carcinoma. We evaluated the expression of ADAM...

    Authors: Florian R Fritzsche, Kirsten Wassermann, Monika Jung, Angelika Tölle, Ilka Kristiansen, Michael Lein, Manfred Johannsen, Manfred Dietel, Klaus Jung and Glen Kristiansen
    Citation: BMC Cancer 2008 8:179
    Content type: Research article Published on:

  6. CXCR2 chemokine ligands CXCL1, CXCL5 and CXCL6 were shown to be involved in chemoattraction, inflammatory responses, tumor growth and angiogenesis. Here, we comparatively analyzed their expression profile in r...

    Authors: Claudia Rubie, Vilma Oliveira Frick, Mathias Wagner, Jochen Schuld, Stefan Gräber, Brigitte Brittner, Rainer M Bohle and Martin K Schilling
    Citation: BMC Cancer 2008 8:178
    Content type: Research article Published on:

  7. Pain is said to be one of the most feared and distressing symptoms of cancer and one that disrupts all aspects of life. The purposes of this study were: 1) to compare depression and quality of life among Irani...

    Authors: Azadeh Tavoli, Ali Montazeri, Rasool Roshan, Zahra Tavoli and Mahdiyeh Melyani
    Citation: BMC Cancer 2008 8:177
    Content type: Research article Published on:

  8. Rapamycin, an inhibitor of mammalian target of Rapamycin (mTOR), is an immunosuppressive agent that has anti-proliferative effects on some tumors. However, the role of Rapamycin-induced immune suppression on t...

    Authors: Elena V Svirshchevskaya, Jacopo Mariotti, Mollie H Wright, Natalia Y Viskova, William Telford, Daniel H Fowler and Lyuba Varticovski
    Citation: BMC Cancer 2008 8:176
    Content type: Research article Published on:

  9. Copper homeostasis proteins ATP7A and ATP7B are assumed to be involved in the intracellular transport of cisplatin. The aim of the present study was to assess the relevance of sub cellular localisation of thes...

    Authors: Ganna V Kalayda, Christina H Wagner, Irina Buß, Jan Reedijk and Ulrich Jaehde
    Citation: BMC Cancer 2008 8:175
    Content type: Research article Published on:

  10. The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the par...

    Authors: Isabel Conde, María VT Lobo, Javier Zamora, Julio Pérez, Francisco J González, Emilio Alba, Benito Fraile, Ricardo Paniagua and María I Arenas
    Citation: BMC Cancer 2008 8:174
    Content type: Research article Published on:

  11. Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor...

    Authors: Evi Michels, Jasmien Hoebeeck, Katleen De Preter, Alexander Schramm, Bénédicte Brichard, Anne De Paepe, Angelika Eggert, Geneviève Laureys, Jo Vandesompele and Frank Speleman
    Citation: BMC Cancer 2008 8:173
    Content type: Research article Published on:

  12. S100A4 is a metastasis-associated protein which has been linked to multiple cellular events, and has been identified extracellularly, in the cytoplasm and in the nucleus of tumor cells; however, the biological...

    Authors: Mads H Haugen, Kjersti Flatmark, Svein-Ole Mikalsen and Gunhild M Malandsmo
    Citation: BMC Cancer 2008 8:172
    Content type: Research article Published on:

  13. Colorectal cancer (CRC) is the second most commonly diagnosed cancer for both sexes in developed countries. This study assessed the knowledge, attitudes, and preventive practices regarding CRC of adults in Italy.

    Authors: Alessandra Sessa, Rossella Abbate, Gabriella Di Giuseppe, Paolo Marinelli and Italo F Angelillo
    Citation: BMC Cancer 2008 8:171
    Content type: Research article Published on:

  14. Resectable adenocarcinomas in the pancreatic head, by definition "periampullary", originate from ampullary, duodenal, biliary, or ductal pancreatic epithelium. Typically, periampullary adenocarcinomas have eit...

    Authors: Arne Westgaard, Svetlana Tafjord, Inger N Farstad, Milada Cvancarova, Tor J Eide, Oystein Mathisen, Ole Petter F Clausen and Ivar P Gladhaug
    Citation: BMC Cancer 2008 8:170
    Content type: Research article Published on:

  15. Cetuximab, a monoclonal antibody targeting Epidermal Growth Factor Receptor (EGFR), is currently used in metastatic colorectal cancer (mCRC), but predictive factors for therapeutic response are lacking. Mutati...

    Authors: Anthony Gonçalves, Séverine Esteyries, Brynn Taylor-Smedra, Arnaud Lagarde, Mounay Ayadi, Geneviève Monges, François Bertucci, Benjamin Esterni, Jean-Robert Delpero, Olivier Turrini, Bernard Lelong, Patrice Viens, Jean-Paul Borg, Daniel Birnbaum, Sylviane Olschwang and Frédéric Viret
    Citation: BMC Cancer 2008 8:169
    Content type: Research article Published on:

  16. Regional lymph node metastasis is an important prognostic factor in head and neck squamous cell carcinoma (HNSCC) and plays a decisive role in the choice of treatment. Here, we present an independent gene expr...

    Authors: Erik F Hensen, Maria J De Herdt, Jelle J Goeman, Jan Oosting, Vincent THBM Smit, Cees J Cornelisse and Robert J Baatenburg de Jong
    Citation: BMC Cancer 2008 8:168
    Content type: Research article Published on:

  18. Limited information is available on the effects of progestins on breast cancer progression and metastasis. Cell migration and invasion are central for these processes, and require dynamic cytoskeletal and cell...

    Authors: Xiao-Dong Fu, Maria Silvia Giretti, Lorenzo Goglia, Marina Ines Flamini, Angel Matias Sanchez, Chiara Baldacci, Silvia Garibaldi, Regine Sitruk-Ware, Andrea Riccardo Genazzani and Tommaso Simoncini
    Citation: BMC Cancer 2008 8:166
    Content type: Research article Published on:

  19. Accurate evaluation of axillary lymph node (ALN) involvement is mandatory before treatment of primary breast cancer. The aim of this study is to compare preoperative diagnostic accuracy between positron emissi...

    Authors: Shigeto Ueda, Hitoshi Tsuda, Hideki Asakawa, Jiro Omata, Kazuhiko Fukatsu, Nobuo Kondo, Tadaharu Kondo, Yukihiro Hama, Katsumi Tamura, Jiro Ishida, Yoshiyuki Abe and Hidetaka Mochizuki
    Citation: BMC Cancer 2008 8:165
    Content type: Research article Published on:

  20. The Satisfaction with Cancer Information Profile (SCIP) has previously been shown to be a valid and reliable measure responsive to changes in patient satisfaction over time. It has been suggested that the SCIP...

    Authors: Matthew C Hankins and Carrie D Llewellyn
    Citation: BMC Cancer 2008 8:164
    Content type: Research article Published on:

  21. Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment of OSCC requires the identification of molecular targets and signal...

    Authors: Sanjukta Chakraborty, SM Azeem Mohiyuddin, KS Gopinath and Arun Kumar
    Citation: BMC Cancer 2008 8:163
    Content type: Research article Published on:

  22. p53 is an important tumour suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent...

    Authors: Karen R Reed, Valerie S Meniel, Victoria Marsh, Alicia Cole, Owen J Sansom and Alan R Clarke
    Citation: BMC Cancer 2008 8:162
    Content type: Research article Published on:

  23. Viscum album (VA) preparations have been used as a complimentary therapy in cancer. In addition to their cytotoxic properties, they have also been shown to have immunostimulatory properties. In the present study...

    Authors: Sri Ramulu Elluru, Jean-Paul Duong van Huyen, Sandrine Delignat, Michel D Kazatchkine, Alain Friboulet, Srini V Kaveri and Jagadeesh Bayry
    Citation: BMC Cancer 2008 8:161
    Content type: Research article Published on:

  24. Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. ANT has been known to be a major component of the permeabi...

    Authors: Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon, Khin Chaw aYu Aung and Chul-Woo Kim
    Citation: BMC Cancer 2008 8:160
    Content type: Research article Published on:

  25. Antisense oligonucleotides against hTR (As-ODN-hTR) have shown promising results as treatment strategies for various human malignancies. All-trans retinoic acid (ATRA) is a signalling molecule with important r...

    Authors: Qin Xu, Zhiyuan Zhang, Ping Zhang and Wantao Chen
    Citation: BMC Cancer 2008 8:159
    Content type: Research article Published on:

  26. Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor, and stimulates growth in prostate cancer cells. The current study is to determine a potent...

    Authors: Kiwon Lee, Yin Liu, Jun Qin Mo, Jinsong Zhang, Zhongyun Dong and Shan Lu
    Citation: BMC Cancer 2008 8:158
    Content type: Research article Published on:

  28. Progress in lung cancer is hampered by the lack of clinically useful diagnostic markers. The goal of this study was to provide a detailed evaluation of lung cancer tumor markers indicative of molecular abnorma...

    Authors: Min Cheng, Yongyan Chen, Xiaoqing Yu, Zhigang Tian and Haiming Wei
    Citation: BMC Cancer 2008 8:156
    Content type: Research article Published on:

  29. The identification of a BRCA1 or BRCA2 mutation in familial breast cancer kindreds allows genetic testing of at risk relatives. However, considerable controversy exists regarding the cancer risks in women who tes...

    Authors: D Gareth Evans, Andrew Shenton, Emma Woodward, Fiona Lalloo, Anthony Howell and Eamonn R Maher
    Citation: BMC Cancer 2008 8:155
    Content type: Research article Published on:

  30. Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and...

    Authors: Erik Noetzel, Jürgen Veeck, Dieter Niederacher, Oliver Galm, Felicitas Horn, Arndt Hartmann, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:154
    Content type: Research article Published on:

  32. Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G...

    Authors: Véronique Ouellet, Magdalena Zietarska, Lise Portelance, Julie Lafontaine, Jason Madore, Marie-Line Puiffe, Suzanna L Arcand, Zhen Shen, Josée Hébert, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2008 8:152
    Content type: Research article Published on:

  33. Tumour hypoxia is known to be a poor prognostic indicator, predictive of increased risk of metastatic disease and reduced survival. Genomic instability has been proposed as one of the potential mechanisms for ...

    Authors: Tuula M Kalliomäki, Gordon McCallum, Sarah Jane Lunt, Peter G Wells and Richard P Hill
    Citation: BMC Cancer 2008 8:151
    Content type: Research article Published on:

  35. In the present study we analyze, in patients with breast cancer, the tumor expression of androgen receptors (AR), its relationship with clinicopathological characteristics and with the expression of several ma...

    Authors: Luis O Gonzalez, Maria D Corte, Julio Vazquez, Sara Junquera, Rosario Sanchez, Ana C Alvarez, Juan C Rodriguez, Maria L Lamelas and Francisco J Vizoso
    Citation: BMC Cancer 2008 8:149
    Content type: Research article Published on:

  36. The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as fi...

    Authors: Bhumsuk Keam, Seock-Ah Im, Sae-Won Han, Hye Seon Ham, Min A Kim, Do-Youn Oh, Se-Hoon Lee, Jee Hyun Kim, Dong-Wan Kim, Tae-You Kim, Dae Seog Heo, Woo Ho Kim and Yung-Jue Bang
    Citation: BMC Cancer 2008 8:148
    Content type: Research article Published on:

  37. The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have pre...

    Authors: Rachel Henkens, Philippe Delvenne, Mohammad Arafa, Michel Moutschen, Mustapha Zeddou, Lutz Tautz, Jacques Boniver, Tomas Mustelin and Souad Rahmouni
    Citation: BMC Cancer 2008 8:147
    Content type: Research article Published on:

  38. BRCA1 and BRCA2 are the two most important genes associated with familial breast and ovarian cancer susceptibility. In addition, PALB2 has recently been identified as a breast cancer susceptibility gene in sever...

    Authors: Katri Pylkäs, Hannele Erkko, Jenni Nikkilä, Szilvia Sólyom and Robert Winqvist
    Citation: BMC Cancer 2008 8:146
    Content type: Research article Published on:

  39. The human gene ERH (Enhancer of the Rudimentary gene Homologue) has previously been identified by in silico analysis of four million ESTs as a gene differentially expressed in breast cancer. The biological functi...

    Authors: Menelaos Zafrakas, Inge Losen, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:145
    Content type: Research article Published on:

  40. RET/PTC (rearranged in transformation/papillary thyroid carcinomas) gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma. Although it has been established tha...

    Authors: Young-Rae Kim, Hee Sun Byun, Minho Won, Kyeong Ah Park, Jin Man Kim, Byung Lyul Choi, Hyunji Lee, Jang Hee Hong, Jongsun Park, Jeong Ho Seok, Dong Wook Kim, Minho Shong, Seung-Kiel Park and Gang Min Hur
    Citation: BMC Cancer 2008 8:144
    Content type: Research article Published on:

  41. IGF binding protein-3 (IGFBP-3) regulates the bioavailability of insulin-like growth factors I and II, and has both anti-proliferative and pro-apoptotic properties. Elevated plasma IGFBP-3 has been associated ...

    Authors: Temitope O Keku, Robert S Sandler, James G Simmons, Joseph Galanko, John T Woosley, Michelle Proffitt, Oluwaseun Omofoye, Maya McDoom and Pauline K Lund
    Citation: BMC Cancer 2008 8:143
    Content type: Research article Published on:

  42. Epithelial growth factor receptor (EGFR) and KRAS mutation status have been reported as predictive markers of tumour response to EGFR inhibitors. High resolution melting (HRM) analysis is an attractive screening ...

    Authors: Hongdo Do, Michael Krypuy, Paul L Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Cancer 2008 8:142
    Content type: Research article Published on:

  43. With improved childhood cancer cure rate, long term sequelae are becoming an important factor of quality of life. Signs of cardiovascular disease are frequently found in long term survivors of cancer. Cardiac ...

    Authors: Veronika Velensek, Uros Mazic, Ciril Krzisnik, Damjan Demšar, Janez Jazbec and Berta Jereb
    Citation: BMC Cancer 2008 8:141
    Content type: Research article Published on:

  44. The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or ovarian cancer, and familial accumulation of the d...

    Authors: Eva Machackova, Lenka Foretova, Mirka Lukesova, Petra Vasickova, Marie Navratilova, Ilse Coene, Hana Pavlu, Veronika Kosinova, Jitka Kuklova and Kathleen Claes
    Citation: BMC Cancer 2008 8:140
    Content type: Research article Published on:

  45. Previous studies have found differences in the histological subtypes of lung cancers affecting males and females. Our objective was to investigate trends in the incidence of histological subtypes of lung cance...

    Authors: Victoria A Bennett, Elizabeth A Davies, Ruth H Jack, Vivian Mak and Henrik Møller
    Citation: BMC Cancer 2008 8:139
    Content type: Research article Published on:

  46. Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcr...

    Authors: Soroush Nasri, Helen More, Francesco Graziano, Annamaria Ruzzo, Emily Wilson, Anita Dunbier, Cushla McKinney, Tony Merriman, Parry Guilford, Mauro Magnani and Bostjan Humar
    Citation: BMC Cancer 2008 8:138
    Content type: Research article Published on:

  47. High incidence rates of gastrointestinal tract cancers have been reported in the Caspian region of Iran. This study aimed to: 1) describe the geographical spatial patterns of gastrointestinal tract cancer inci...

    Authors: Mohammadreza Mohebbi, Mahmood Mahmoodi, Rory Wolfe, Keramat Nourijelyani, Kazem Mohammad, Hojjat Zeraati and Akbar Fotouhi
    Citation: BMC Cancer 2008 8:137
    Content type: Research article Published on:

  48. The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease. Carbohydrate-mediated cell-...

    Authors: Soheila Korourian, Eric Siegel, Thomas Kieber-Emmons and Behjatolah Monzavi-Karbassi
    Citation: BMC Cancer 2008 8:136
    Content type: Research article Published on:

  50. Gastrointestinal stromal tumors (GIST) exhibit an unpredictable clinical course and can rapidly progress to lethality. Predictions about the biological behavior of GIST are based on a number of canonical clini...

    Authors: Dolores Di Vizio, Francesca Demichelis, Sara Simonetti, Guido Pettinato, Luigi Terracciano, Luigi Tornillo, Michael R Freeman and Luigi Insabato
    Citation: BMC Cancer 2008 8:134
    Content type: Research article Published on:

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