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  1. Disease and treatment related events, can adversely affect the quality of life of patients with cancer. The purpose of this study was to translate and validate a gastric cancer specific health related quality ...

    Authors: Sanamber Sadighi, Ali Montazeri, Zahra Sedighi, Mohammad Ali Mohagheghi and Hossein Froutan
    Citation: BMC Cancer 2009 9:305
    Content type: Research article Published on:

  2. Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma of childhood including two major histological subtypes, alveolar (ARMS) and embryonal (ERMS) RMS. Like other human malignancies RMS possesses high meta...

    Authors: Valentina Masola, Claudio Maran, Evelyne Tassone, Angelica Zin, Angelo Rosolen and Maurizio Onisto
    Citation: BMC Cancer 2009 9:304
    Content type: Research article Published on:

  3. K-RAS wild type colorectal tumors show an improved response rate to anti-EGFR monoclonal antibodies. Nevertheless 70% to 40% of these patients still does not seem to benefit from this therapeutic approach. FIS...

    Authors: Mario Scartozzi, Italo Bearzi, Alessandra Mandolesi, Chiara Pierantoni, Fotios Loupakis, Alberto Zaniboni, Francesca Negri, Antonello Quadri, Fausto Zorzi, Eva Galizia, Rossana Berardi, Tommasina Biscotti, Roberto Labianca, Gianluca Masi, Alfredo Falcone and Stefano Cascinu
    Citation: BMC Cancer 2009 9:303
    Content type: Research article Published on:

  4. Recent studies have demonstrated that a molecular subtype of glioblastoma is characterized by overexpression of extracellular matrix (ECM)/mesenchymal components and shorter survival. Specifically, gene expres...

    Authors: Sonja Mertsch, Leon J Schurgers, Kathrin Weber, Werner Paulus and Volker Senner
    Citation: BMC Cancer 2009 9:302
    Content type: Research article Published on:

  5. The nitroreductase/5-(azaridin-1-yl)-2,4-dinitrobenzamide (NTR/CB1954) enzyme/prodrug system is considered as a promising candidate for anti-cancer strategies by gene-directed enzyme prodrug therapy (GDEPT) an...

    Authors: Maik Grohmann, Nils Paulmann, Sebastian Fleischhauer, Jakob Vowinckel, Josef Priller and Diego J Walther
    Citation: BMC Cancer 2009 9:301
    Content type: Research article Published on:

  6. NSCLC exhibits considerable heterogeneity in its sensitivity to chemotherapy and similar heterogeneity is noted in vitro in a variety of model systems. This study has tested the hypothesis that the molecular b...

    Authors: Sharon Glaysher, Dennis Yiannakis, Francis G Gabriel, Penny Johnson, Marta E Polak, Louise A Knight, Zoe Goldthorpe, Katharine Peregrin, Mya Gyi, Paul Modi, Joe Rahamim, Mark E Smith, Khalid Amer, Bruce Addis, Matthew Poole, Ajit Narayanan…
    Citation: BMC Cancer 2009 9:300
    Content type: Research article Published on:

  7. Electroporation is a versatile method for in vitro or in vivo delivery of different molecules into cells. However, no study so far has analysed the effects of electric pulses used in electrochemotherapy (ECT puls...

    Authors: Vid Mlakar, Vesna Todorovic, Maja Cemazar, Damjan Glavac and Gregor Sersa
    Citation: BMC Cancer 2009 9:299
    Content type: Research article Published on:

  8. The transcription factor GLI1, a member of the GLI subfamily of Krüppel-like zinc finger proteins is involved in signal transduction within the hedgehog pathway. Aberrant hedgehog signalling has been implicate...

    Authors: Anette ten Haaf, Nuran Bektas, Sonja von Serenyi, Inge Losen, Elfriede Christel Arweiler, Arndt Hartmann, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2009 9:298
    Content type: Research article Published on:

  10. Interpretation of comparative health-related quality of life (HRQOL) studies following different prostate cancer treatments is often difficult due to differing patient ages. Furthermore, age-related changes ca...

    Authors: Michael Pinkawa, Karin Fischedick, Bernd Gagel, Marc D Piroth, Branka Asadpour, Jens Klotz, Holger Borchers, Gerhard Jakse and Michael J Eble
    Citation: BMC Cancer 2009 9:296
    Content type: Research article Published on:

  11. The PORPUS-P is a short questionnaire for measuring prostate-specific quality of life (QoL), which was designed in Canada for use in prostate cancer (PC) patients. We aimed to generate a German version and com...

    Authors: Annika Waldmann, Volker Rohde, Karen Bremner, Murray Krahn, Thomas Kuechler and Alexander Katalinic
    Citation: BMC Cancer 2009 9:295
    Content type: Research article Published on:

  12. Different publications show an increased incidence of neoplasms in renal transplant patients. The objective of this study is to determine the incidence of cancer in the recipients of renal transplants performe...

    Authors: Salvador Pita-Fernandez, Francisco Valdes-Cañedo, Sonia Pertega-Diaz, Maria Teresa Seoane-Pillado and Rocio Seijo-Bestilleiro
    Citation: BMC Cancer 2009 9:294
    Content type: Study protocol Published on:

  13. Melanoma is the most aggressive form of skin cancer, and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have been uniformly disappointing. A Br...

    Authors: Fernando SF Guimarães, Ana PR Abud, Simone M Oliveira, Carolina C Oliveira, Beatriz César, Lucas F Andrade, Lucélia Donatti, Juarez Gabardo, Edvaldo S Trindade and Dorly F Buchi
    Citation: BMC Cancer 2009 9:293
    Content type: Research article Published on:

  14. Tumour infiltrating lymphocytes (TIL) are generally considered to represent a host immune response directed against tumour antigens. TIL are also increasingly recognised as possible prognostic parameters. Howe...

    Authors: Dominik Pretscher, Luitpold V Distel, Gerhard G Grabenbauer, Michael Wittlinger, Maike Buettner and Gerald Niedobitek
    Citation: BMC Cancer 2009 9:292
    Content type: Research article Published on:

  15. Thrombospondin1 (THBS1), cystene-rich protein 61 (Cyr61) and connective tissue growth factor (CTGF) are all involved in the transforming growth factor-beta (TGF-β) signal pathway, which plays an important role...

    Authors: Zhu-Qing Zhou, Wei-Hua Cao, Jian-Jun Xie, Jing Lin, Zhong-Ying Shen, Qing-Ying Zhang, Jin-Hui Shen, Li-Yan Xu and En-Min Li
    Citation: BMC Cancer 2009 9:291
    Content type: Research article Published on:

  17. Transcription factor Snail1 has a central role in induction of epithelial-mesenchymal transition (EMT). The aim of the present study was to elucidate the expression of Snail1 protein during epithelial ovarian ...

    Authors: Hanna Tuhkanen, Ylermi Soini, Veli-Matti Kosma, Maarit Anttila, Reijo Sironen, Kirsi Hämäläinen, Laura Kukkonen, Ismo Virtanen and Arto Mannermaa
    Citation: BMC Cancer 2009 9:289
    Content type: Research article Published on:

  18. The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing su...

    Authors: Li-Chu Sun, Koung-Shing Chu, Su-Chen Cheng, Chien-Yu Lu, Chao-Hung Kuo, Jan-Sing Hsieh, Ying-Ling Shih, Shun-Jen Chang and Jaw-Yuan Wang
    Citation: BMC Cancer 2009 9:288
    Content type: Research article Published on:

  19. Surface enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) analysis on serum samples was reported to be able to detect colorectal cancer (CRC) from normal or control patie...

    Authors: Qi Wang, Jing Shen, Zhen-fu Li, Jian-zheng Jie, Wen-yue Wang, Jin Wang, Zhong-tao Zhang, Zhi-xia Li, Li Yan and Jin Gu
    Citation: BMC Cancer 2009 9:287
    Content type: Research article Published on:

  20. Colorectal cancer survivors may suffer from a range of ongoing psychosocial and physical problems that negatively impact on quality of life. This paper presents the study protocol for a novel telephone-deliver...

    Authors: Anna L Hawkes, Kenneth I Pakenham, Kerry S Courneya, Sara Gollschewski, Peter Baade, Louisa G Gordon, Brigid M Lynch, Joanne F Aitken and Suzanne K Chambers
    Citation: BMC Cancer 2009 9:286
    Content type: Study protocol Published on:

  21. Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment for ductal carcinoma in situ (DCIS). However, it is unknown whether a neoadjuvant (preoperative) anti-estrogen approach ...

    Authors: Yunn-Yi Chen, Sandy DeVries, Joseph Anderson, Juan Lessing, Rebecca Swain, Koei Chin, Veronica Shim, Laura J Esserman, Frederic M Waldman and E Shelley Hwang
    Citation: BMC Cancer 2009 9:285
    Content type: Research article Published on:

  23. Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast cancer syndromes, where specific interventions can be proposed ...

    Authors: Patricia Ashton-Prolla, Juliana Giacomazzi, Aishameriane V Schmidt, Fernanda L Roth, Edenir I Palmero, Luciane Kalakun, Ernestina S Aguiar, Susana M Moreira, Erica Batassini, Vanessa Belo-Reyes, Lavinia Schuler-Faccini, Roberto Giugliani, Maira Caleffi and Suzi Alves Camey
    Citation: BMC Cancer 2009 9:283
    Content type: Research article Published on:

  24. Despite identification of the major genes and pathways involved in the development of colorectal cancer (CRC), it has become obvious that several steps in these pathways might be bypassed by other as yet unkno...

    Authors: Vid Mlakar, Gašper Berginc, Metka Volavšek, Zdravko Štor, Miran Rems and Damjan Glavač
    Citation: BMC Cancer 2009 9:282
    Content type: Research article Published on:

  25. Current chemotherapy of human cancers focuses on the DNA damage pathway to induce a p53-mediated cellular response leading to either G1 arrest or apoptosis. However, genotoxic treatments may induce mutations a...

    Authors: Valentina Turinetto, Paola Porcedda, Luca Orlando, Mario De Marchi, Antonio Amoroso and Claudia Giachino
    Citation: BMC Cancer 2009 9:281
    Content type: Research article Published on:

  26. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in survival signaling. FAK has been shown to be overexpressed in breast cancer tumors at early stages of tumorigenesis.

    Authors: Vita M Golubovskaya, Min Zheng, Li Zhang, Jian-Liang Li and William G Cance
    Citation: BMC Cancer 2009 9:280
    Content type: Research article Published on:

  27. Activator protein 2 gamma (AP-2γ) is a member of the transcription factor activator protein-2 (AP-2) family, which is developmentally regulated and plays a role in human neoplasia. AP-2γ has been found to be o...

    Authors: He Ailan, Xiao Xiangwen, Ren Daolong, Gan Lu, Ding Xiaofeng, Qiao Xi, Hu Xingwang, Liu Rushi, Zhang Jian and Xiang Shuanglin
    Citation: BMC Cancer 2009 9:279
    Content type: Research article Published on:

  28. Recently published data showed discrepancies beteween P53 cDNA and DNA sequencing in glioblastomas. We hypothesised that similar discrepancies may be observed in other human cancers.

    Authors: Malgorzata Szybka, Magdalena Zakrzewska, Piotr Rieske, Grazyna Pasz-Walczak, Dominika Kulczycka-Wojdala, Izabela Zawlik, Robert Stawski, Dorota Jesionek-Kupnicka, Pawel P Liberski and Radzislaw Kordek
    Citation: BMC Cancer 2009 9:278
    Content type: Research article Published on:

  29. There have been few prospective observational studies which recruited older newly-diagnosed cancer patients, and of these only some have reported information on the number needed to screen to recruit their stu...

    Authors: Martine TE Puts, Johanne Monette, Veronique Girre, Christina Wolfson, Michele Monette, Gerald Batist and Howard Bergman
    Citation: BMC Cancer 2009 9:277
    Content type: Research article Published on:

  30. Decreased expression of the interferon-stimulated, putative tumour suppressor gene XAF1 has been shown to play a role during the onset, progression and treatment failure in various malignancies. However, littl...

    Authors: Carsten Kempkensteffen, Florian Rudolf Fritzsche, Manfred Johannsen, Steffen Weikert, Stefan Hinz, Manfred Dietel, Marc-Oliver Riener, Holger Moch, Klaus Jung, Hans Krause, Kurt Miller and Glen Kristiansen
    Citation: BMC Cancer 2009 9:276
    Content type: Research article Published on:

  31. Cervical cancer and infection with human immunodeficiency virus (HIV) are both important public health problems in South Africa (SA). The aim of this study was to determine the prevalence of cervical squamous ...

    Authors: Jennifer R Moodley, Deborah Constant, Margaret Hoffman, Anna Salimo, Bruce Allan, Ed Rybicki, Inga Hitzeroth and Anna-Lise Williamson
    Citation: BMC Cancer 2009 9:275
    Content type: Research article Published on:

  32. It is well recognized that colorectal cancer does not frequently metastasize to bone. The aim of this retrospective study was to establish whether colorectal cancer ever bypasses other organs and metastasizes ...

    Authors: Eira S Roth, David T Fetzer, Bruce J Barron, Usha A Joseph, Isis W Gayed and David Q Wan
    Citation: BMC Cancer 2009 9:274
    Content type: Research article Published on:

  33. Concomitant chemotherapy and radiotherapy (chemoradiation; CRT) is the standard treatment for locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). CRT improves local control and ove...

    Authors: Pol M Specenier, Joost Weyler, Carl Van Laer, Danielle Van den Weyngaert, Jan Van den Brande, Manon T Huizing, Sevilay Altintas and Jan B Vermorken
    Citation: BMC Cancer 2009 9:273
    Content type: Research article Published on:

  34. Bone metastases are a common cause of skeletal morbidity in patients with advanced cancer. The pattern of skeletal morbidity is complex, and the number of skeletal complications is influenced by the duration o...

    Authors: Pierre P Major, Richard J Cook, Allan Lipton, Matthew R Smith, Evangelos Terpos and Robert E Coleman
    Citation: BMC Cancer 2009 9:272
    Content type: Research article Published on:

  35. Non-alcoholic fatty liver disease (NAFLD) has a prevalence of over 20% in Western societies. Affected individuals are at risk of developing both cirrhosis and hepatocellular cancer (HCC). Presently there is no...

    Authors: Joe Gray, Dipankar Chattopadhyay, Gary S Beale, Gillian L Patman, Luca Miele, Barry P King, Stephen Stewart, Mark Hudson, Christopher P Day, Derek M Manas and Helen L Reeves
    Citation: BMC Cancer 2009 9:271
    Content type: Research article Published on:

  38. Loss of heterozygosity of chromosome 10q26 has been shown to be associated with the aggressiveness of astrocytic tumors (or astrocytomas), but the responsible gene(s) residing in this region has not been fully...

    Authors: Jingmei Liu, Huimei Lu, Hiroko Ohgaki, Adrian Merlo and Zhiyuan Shen
    Citation: BMC Cancer 2009 9:268
    Content type: Research article Published on:

  40. Neuroblastoma (NB) is the principal tumor of the sympathetic nervous system in children under one year of age. The incidence in developed countries is greater than that in developing countries. The aim of this...

    Authors: Servando Juárez-Ocaña, Virginia Palma-Padilla, Guadalupe González-Miranda, Alicia Georgina Siordia-Reyes, Enrique López-Aguilar, Martha Aguilar-Martínez, Juan Manuel Mejía-Aranguré, Rogelio Carreón-Cruz, Mario Enrique Rendón-Macías and Arturo Fajardo-Gutiérrez
    Citation: BMC Cancer 2009 9:266
    Content type: Research article Published on:

  41. Needle core biopsy, often in conjunction with ultrasonic or stereotactic guided techniques, is frequently used to diagnose breast carcinoma in women. Confocal scanning laser microscopy (CSLM) is a technology t...

    Authors: Linda M Schiffhauer, J Neil Boger, Thomas A Bonfiglio, James M Zavislan, Margarita Zuley and Christi Alessi Fox
    Citation: BMC Cancer 2009 9:265
    Content type: Research article Published on:

  42. Most patients with ductal pancreatic adenocarcinoma are diagnosed with locally advanced (unresectable) or metastatic disease. The aim of this study was to evaluate the prognostic significance of DNA ploidy in ...

    Authors: Nikolas Tsavaris, Nicolaos Kavantzas, Kostantinos Tsigritis, Ioannis D Xynos, Nikitas Papadoniou, Andreas Lazaris, Christos Kosmas, George Agrogiannis, Anna Dokou, Evangelos Felekouras, Efstathios Antoniou, Aris Polyzos, John Sarantonis, Heracles Tsipras, Gavrilos Karatzas, Alexandros Papalambros…
    Citation: BMC Cancer 2009 9:264
    Content type: Research article Published on:

  43. Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl peptidase inhibitor with immunostimulatory properties.

    Authors: Robert M Eager, C Casey Cunningham, Neil N Senzer, Joe Stephenson Jr, Stephen P Anthony, Steven J O'Day, Gary Frenette, Anna C Pavlick, Barry Jones, Margaret Uprichard and John Nemunaitis
    Citation: BMC Cancer 2009 9:263
    Content type: Research article Published on:

  44. Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions) are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring s...

    Authors: Lorenzo Anasagasti-Angulo, Yanelda Garcia-Vega, Silvia Barcelona-Perez, Pedro Lopez-Saura and Iraldo Bello-Rivero
    Citation: BMC Cancer 2009 9:262
    Content type: Research article Published on:

  45. The development and progression of liver cancer may involve abnormal changes in DNA methylation, which lead to the activation of certain proto-oncogenes, such as c-myc, as well as the inactivation of certain tumo...

    Authors: Yan-ping Du, Jun-sheng Peng, Ai Sun, Zhi-hong Tang, Wen-hua Ling and Hui-lian Zhu
    Citation: BMC Cancer 2009 9:261
    Content type: Database Published on:

  46. Oral squamous cell carcinoma could be preceded by clinically evident oral potentially malignant disorders (OPMDs). Transformation of OPMDs to cancer has been studied in several population groups. It is difficu...

    Authors: Pei-Shan Ho, Pai-Li Chen, Saman Warnakulasuriya, Tien-Yu Shieh, Yun-Kwan Chen and I-Yueh Huang
    Citation: BMC Cancer 2009 9:260
    Content type: Research article Published on:

  47. Breast cancer is a major problem in the United States leading to tens of thousands of deaths each year. Although citrus auraptene suppresses cancer in numerous rodent models, its role in breast cancer preventi...

    Authors: Prasad Krishnan, Karen J Yan, David Windler, Jesse Tubbs, Robert Grand, Benjamin DL Li, C Marcelo Aldaz, Jerry McLarty and Heather E Kleiner-Hancock
    Citation: BMC Cancer 2009 9:259
    Content type: Research article Published on:

  48. The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is critical for designing therapeutic modalities for...

    Authors: Divya Khaitan, Umesh T Sankpal, Babette Weksler, Edward A Meister, Ignacio A Romero, Pierre-Olivier Couraud and Nagendra S Ningaraj
    Citation: BMC Cancer 2009 9:258
    Content type: Research article Published on:

  49. Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence...

    Authors: Federico Canzian, Rudolf Kaaks, David G Cox, Katherine D Henderson, Brian E Henderson, Christine Berg, Sheila Bingham, Heiner Boeing, Julie Buring, Eugenia E Calle, Stephen Chanock, Francoise Clavel-Chapelon, Laure Dossus, Heather Spencer Feigelson, Christopher A Haiman, Susan E Hankinson…
    Citation: BMC Cancer 2009 9:257
    Content type: Research article Published on:

  50. Smokeless tobacco is an alternative for smokers who want to quit but require nicotine. Reliable evidence on its effects is needed. Boffetta et al. and ourselves recently reviewed the evidence on cancer, based ...

    Authors: Peter N Lee and Jan Hamling
    Citation: BMC Cancer 2009 9:256
    Content type: Correspondence Published on:

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