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  1. The aim of this study is to compare the cost-effectiveness of screening with stool DNA testing with that of screening with other tools (annual fecal occult blood testing, flexible sigmoidoscopy every 5 years, ...

    Authors: Grace Hui-Min Wu, Yi-Ming Wang, Amy Ming-Fang Yen, Jau-Min Wong, Hsin-Chih Lai, Jane Warwick and Tony Hsiu-Hsi Chen
    Citation: BMC Cancer 2006 6:136
  2. Cervical cancer and infection with human immunodeficiency virus (HIV) are both major public health problems in South Africa. The aim of this study was to determine the risk of cervical pre-cancer and cancer am...

    Authors: Jennifer R Moodley, Margaret Hoffman, Henri Carrara, Bruce R Allan, Diane D Cooper, Lynn Rosenberg, Lynette E Denny, Samuel Shapiro and Anna-Lise Williamson
    Citation: BMC Cancer 2006 6:135
  3. COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expres...

    Authors: Pradeep Bhandari, Adrian C Bateman, Raj L Mehta, Bernard SF Stacey, Penny Johnson, Ian A Cree, Federica Di Nicolantonio and Praful Patel
    Citation: BMC Cancer 2006 6:134
  4. The implementation of combined radiochemotherapy (RCHT) with temozolomide (TMZ) has lead to a significant increase in overall survival times in patients with Glioblastoma multiforme (GBM), however, outcome sti...

    Authors: Stephanie E Combs, Steffen Heeger, Renate Haselmann, Lutz Edler, Jürgen Debus and Daniela Schulz-Ertner
    Citation: BMC Cancer 2006 6:133
  5. Expression of folylpoly-γ-glutamate synthetase (FPGS) gene is two- to three-fold higher in B-precursor ALL (Bp- ALL) than in T-lineage ALL (T-ALL) and correlates with intracellular accumulation of methotrexate...

    Authors: Guy J Leclerc, Gilles M Leclerc, Ting Ting Hsieh Kinser and Julio C Barredo
    Citation: BMC Cancer 2006 6:132
  6. Germline mutations in RET are responsible for multiple endocrine neoplasia type 2 (MEN2), an autosomal dominantly inherited cancer syndrome that is characterized by medullary thyroid carcinoma (MTC), pheochromocy...

    Authors: Christian A Koch, Frederieke M Brouwers, Alexander O Vortmeyer, Andrea Tannapfel, Steven K Libutti, Zhengping Zhuang, Karel Pacak, Hartmut PH Neumann and Ralf Paschke
    Citation: BMC Cancer 2006 6:131
  7. Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the tre...

    Authors: Daniele Martarelli, Alfonso Catalano, Antonio Procopio, Sara Orecchia, Roberta Libener and Giorgio Santoni
    Citation: BMC Cancer 2006 6:130
  8. Bortezomib (Velcade®), a dipeptide boronate proteasome inhibitor, is a novel anti-cancer agent registered for multiple myeloma (MM). It has also shown promising clinical activity in non-small cell lung cancer (NS...

    Authors: Jens Voortman and Giuseppe Giaccone
    Citation: BMC Cancer 2006 6:129
  9. Low-dose Cisplatin and Interferon alpha treatment of solid tumors rarely has been associated with severe hypocalcaemia. To the authors knowledge the phenomenon has not been reported previously in patients with...

    Authors: Katrin Hoffmann, Angela Marten, Katja Lindel, Stefan Fritz, Dirk Jager, Markus W Buchler and Jan Schmidt
    Citation: BMC Cancer 2006 6:128
  10. Leiomyomatosis peritonealis disseminata (LPD) is a rare disease in which multiple smooth muscle or smooth muscle-like nodules develop subperitoneally in any part of the abdominal cavity. No reports of multiple...

    Authors: Carmine Nappi, Attilio Di Spiezio Sardo, Vincenzo Dario Mandato, Giuseppe Bifulco, Elisa Merello, Antonio Savanelli, Chiara Mignogna, Valeria Capra and Maurizio Guida
    Citation: BMC Cancer 2006 6:127
  11. Elderly patients have been often excluded from or underrepresented in the study populations of combination chemotherapy trials. The primary end point of this study was to determine the response rate and the to...

    Authors: D Santini, F Graziano, V Catalano, M Di Seri, E Testa, AM Baldelli, P Giordani, A La Cesa, B Spalletta, B Vincenzi, A Russo, M Caraglia, V Virzi, S Cascinu and G Tonini
    Citation: BMC Cancer 2006 6:125
  12. In previous analyses we identified therapy-induced upregulation of the CDK inhibitor p21CIP/WAF-1 and consequently decreased tumor cell proliferation or loss of Bax as adverse factors for survival in rectal cance...

    Authors: Isrid Sturm, Beate Rau, Peter M Schlag, Peter Wust, Bert Hildebrandt, Hanno Riess, Steffen Hauptmann, Bernd Dörken and Peter T Daniel
    Citation: BMC Cancer 2006 6:124
  13. Conflicting data exist about the prevalence of HER-2/neu overexpression in colorectal cancer ranging from 0 to 83 %. In our study we tried to clarify the extent of expression and its relationship to clinicopat...

    Authors: B Schuell, T Gruenberger, W Scheithauer, Ch Zielinski and F Wrba
    Citation: BMC Cancer 2006 6:123
  14. Even today, treatment of Stage III NSCLC still poses a serious challenge. So far, surgical resection is the treatment of choice. Patients whose tumour is not resectable or who are unfit to undergo surgery are ...

    Authors: AD Jensen, MW Münter, H Bischoff, R Haselmann, C Timke, R Krempien, F Sterzing, S Nill, S Heeger, A Hoess, U Haberkorn, PE Huber, M Steins, M Thomas, J Debus and KK Herfarth
    Citation: BMC Cancer 2006 6:122
  15. Unresectable biliary tract carcinoma is known to demonstrate a poor prognosis. We conducted a single arm phase II study of LFP therapy (5-FU (5-fluorourasil) continuous infusion (CVI) and Low-dose consecutive ...

    Authors: Kazuma Kobayashi, Akihito Tsuji, Sojiro Morita, Tadashi Horimi, Tetsuhiko Shirasaka and Takashi Kanematsu
    Citation: BMC Cancer 2006 6:121
  16. Advances in molecular biology and growing requirements from biomarker validation studies have generated a need for tissue banks to provide quality-controlled tissue samples with standardized clinical annotatio...

    Authors: Ashokkumar A Patel, John R Gilbertson, Anil V Parwani, Rajiv Dhir, Milton W Datta, Rajnish Gupta, Jules J Berman, Jonathan Melamed, Andre Kajdacsy-Balla, Jan Orenstein and Michael J Becich
    Citation: BMC Cancer 2006 6:120
  17. Phytopharmacological studies of different Calendula extracts have shown anti-inflamatory, anti-viral and anti-genotoxic properties of therapeutic interest. In this study, we evaluated the in vitro cytotoxic anti-...

    Authors: Eva Jiménez-Medina, Angel Garcia-Lora, Laura Paco, Ignacio Algarra, Antonia Collado and Federico Garrido
    Citation: BMC Cancer 2006 6:119
  18. Solitary plasmacytoma (SP) of the bone is a rare plasma-cell neoplasm. There are no conclusive data in the literature on the optimal radiation therapy (RT) dose in SP. Therefore, in this large retrospective st...

    Authors: David Knobel, Abderrahim Zouhair, Richard W Tsang, Philip Poortmans, Yazid Belkacémi, Michel Bolla, Fazilet Dinçbas Oner, Christine Landmann, Bernard Castelain and Mahmut Ozsahin
    Citation: BMC Cancer 2006 6:118
  19. Primary pancreatic lymphomas (PPL) are rare tumours of the pancreas. Symptoms, imaging and tumour markers can mimic pancreatic adenocarcinoma, but they are much more amenable to treatment. Treatment for PPL re...

    Authors: Peter S Grimison, Melvin T Chin, Michelle L Harrison and David Goldstein
    Citation: BMC Cancer 2006 6:117
  20. Breast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. Many studies have shown that the cancer risks associated with individu...

    Authors: Venüs Ümmiye Onay, Laurent Briollais, Julia A Knight, Ellen Shi, Yuanyuan Wang, Sean Wells, Hong Li, Isaac Rajendram, Irene L Andrulis and Hilmi Ozcelik
    Citation: BMC Cancer 2006 6:114
  21. Therapeutic regulation of PPARδ activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARδ) activity...

    Authors: Karen R Reed, Owen J Sansom, Anthony J Hayes, Andreas J Gescher, Jeffrey M Peters and Alan R Clarke
    Citation: BMC Cancer 2006 6:113
  22. Prostate cancer that has recurred after local therapy or disseminated distantly is usually treated with androgen deprivation therapy; however, most men will eventually experience disease progression within 12 ...

    Authors: Eric Winquist, Tricia Waldron, Scott Berry, D Scott Ernst, Sébastien Hotte and Himu Lukka
    Citation: BMC Cancer 2006 6:112
  23. The poly Q polymorphism in AIB1 (amplified in breast cancer) gene is usually assessed by fragment length analysis which does not reveal the actual sequence variation. The purpose of this study is to investigate t...

    Authors: Lee-Jun C Wong, Pu Dai, Jyh-Feng Lu, Mary Ann Lou, Robert Clarke and Viktor Nazarov
    Citation: BMC Cancer 2006 6:111
  24. Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study i...

    Authors: Minglei Guo, Jinjun Li, Dafang Wan and Jianren Gu
    Citation: BMC Cancer 2006 6:109
  25. ACTH overproduction within the pituitary gland or ectopically leads to hypercortisolism. Here, we report the first case of Cushing' syndrome caused by an ectopic ACTH-secreting neuroendocrine carcinoma of the ...

    Authors: Mathias Fasshauer, Thomas Lincke, Helmut Witzigmann, Regine Kluge, Andrea Tannapfel, Michael Moche, Michael Buchfelder, Stephan Petersenn, Juergen Kratzsch, Ralf Paschke and Christian A Koch
    Citation: BMC Cancer 2006 6:108
  26. New cancer therapeutic strategies must be investigated that enhance prostate cancer treatment while minimizing associated toxicities. We have previously shown that genistein, the major isoflavone found in soy,...

    Authors: Julian J Raffoul, Yu Wang, Omer Kucuk, Jeffrey D Forman, Fazlul H Sarkar and Gilda G Hillman
    Citation: BMC Cancer 2006 6:107
  27. SSeCKS is a major protein kinase C substrate with kinase scaffolding and metastasis-suppressor activity whose expression is severely downregulated in Src- and Ras-transformed fibroblast and epithelial cells an...

    Authors: Yongzhong Liu, Lingqiu Gao and Irwin H Gelman
    Citation: BMC Cancer 2006 6:105
  28. Mathematical models of cancer relevant processes are being developed at an increasing rate. Conceptual frameworks are needed to support new treatment designs based on such models.

    Authors: Tomas Radivoyevitch, Kenneth A Loparo, Robert C Jackson and W David Sedwick
    Citation: BMC Cancer 2006 6:104
  29. Twenty years after the nuclear accident in Chernobyl (Eastern Europe), there is still a controversial debate concerning a possible effect of the radioactive iodines, especially I-131, on the increase of thyroi...

    Authors: René Scheiden, Marc Keipes, Carlo Bock, Walter Dippel, Nelly Kieffer and Catherine Capesius
    Citation: BMC Cancer 2006 6:102
  30. While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive. Our study aimed to ...

    Authors: Tatiana Burjanivova, Jozef Madzo, Katerina Muzikova, Claus Meyer, Bjoern Schneider, Felix Votava, Rolf Marschalek, Jan Stary, Jan Trka and Jan Zuna
    Citation: BMC Cancer 2006 6:100
  31. Searches for differentially expressed genes in tumours have made extensive use of array technology. Most samples have been obtained from tumour biopsies or from established tumour-derived cell lines. Here we c...

    Authors: Mariana Fernandez-Cobo, James F Holland and Beatriz GT Pogo
    Citation: BMC Cancer 2006 6:99
  32. A critical choice facing breast cancer patients is which surgical treatment – mastectomy or breast conserving surgery (BCS) – is most appropriate. Several studies have investigated factors that impact the type...

    Authors: Michael A Martin, Ramona Meyricke, Terry O'Neill and Steven Roberts
    Citation: BMC Cancer 2006 6:98
  33. We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated with reduced survival. To investi...

    Authors: Yu Liang, Andrew W Bollen, Ken D Aldape and Nalin Gupta
    Citation: BMC Cancer 2006 6:97
  34. Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mu...

    Authors: Jane Fridlyand, Antoine M Snijders, Bauke Ylstra, Hua Li, Adam Olshen, Richard Segraves, Shanaz Dairkee, Taku Tokuyasu, Britt Marie Ljung, Ajay N Jain, Jane McLennan, John Ziegler, Koei Chin, Sandy Devries, Heidi Feiler, Joe W Gray…
    Citation: BMC Cancer 2006 6:96
  35. Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear. In cervical cance...

    Authors: Martin Dreilich, Michael Bergqvist, Martin Moberg, Daniel Brattström, Inger Gustavsson, Stefan Bergström, Alkwin Wanders, Patrik Hesselius, Gunnar Wagenius and Ulf Gyllensten
    Citation: BMC Cancer 2006 6:94
  36. The roles of mitochondria in energy metabolism, the generation of ROS, aging, and the initiation of apoptosis have implicated their importance in tumorigenesis. In this study we aim to establish the mutation s...

    Authors: Duan-Jun Tan, Julia Chang, Ling-Ling Liu, Ren-Kui Bai, Yu-Fen Wang, Kun-Tu Yeh and Lee-Jun C Wong
    Citation: BMC Cancer 2006 6:93
  37. A considerable proportion of estrogen receptor (ER)-positive breast cancer recurs despite tamoxifen treatment, which is a serious problem commonly encountered in clinical practice. We tried to find novel progn...

    Authors: Wonshik Han, Mi-Ryung Han, Jason Jongho Kang, Ji-Yeon Bae, Ji Hyun Lee, Young Ju Bae, Jeong Eon Lee, Hyuk-Jae Shin, Ki-Tae Hwang, Sung-Eun Hwang, Sung-Won Kim and Dong-Young Noh
    Citation: BMC Cancer 2006 6:92
  38. Ribosomal proteins are the components of ribosome, which also exhibit various secondary functions in DNA repair, apoptosis, drug resistance and proliferation. In our previous study of microarray, ribosomal pro...

    Authors: Hui Wang, Li-Na Zhao, Kai-Zong Li, Rui Ling, Xiao-Jun Li and Ling Wang
    Citation: BMC Cancer 2006 6:91
  39. WT1 is a tumor suppressor gene responsible for Wilms' tumor. WT1 reactivity is limited to ovarian serous carcinomas. Recent studies have shown that WT1 plays an important role in the progression of disease and...

    Authors: Wirote Netinatsunthorn, Jitti Hanprasertpong, Chavaboon Dechsukhum, Roengsak Leetanaporn and Alan Geater
    Citation: BMC Cancer 2006 6:90
  40. Epigenetic changes during ageing and their relationship with cancer are under the focus of intense research. RASSF1A and NORE1A are novel genes acting in concert in the proapoptotic pathway of the RAS signalling....

    Authors: Sonia Di Gioia, Paolo Bianchi, Annarita Destro, Fabio Grizzi, Alberto Malesci, Luigi Laghi, Massimo Levrero, Alberto Morabito and Massimo Roncalli
    Citation: BMC Cancer 2006 6:89
  41. Mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2), two members of the secretoglobin superfamily, are known to be co-expressed in breast cancer, where their proteins form a covalent complex. Based on the relative...

    Authors: Menelaos Zafrakas, Beate Petschke, Andreas Donner, Florian Fritzsche, Glen Kristiansen, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2006 6:88
  42. Hematopoietic stem cell transplantation is being increasingly used in cancer therapy. Diffuse alveolar hemorrhage, an early complication of stem cell transplant, results from bacterial, viral and fungal infect...

    Authors: Sachin Gupta, Amit Jain, Tina V Fanning, Daniel R Couriel, Carlos A Jimenez and Georgie A Eapen
    Citation: BMC Cancer 2006 6:87

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