Skip to main content

Articles

Page 282 of 329

  1. Cisplatin-based chemotherapy, in combination with fluoropyrimidines or taxanes, have demonstrated efficacy against advanced gastric cancer (AGC). This retrospective study was performed with the data obtained f...

    Authors: Do Hyoung Lim, Se Hoon Park, Keon Woo Park, Jung Hun Kang, Sung Yong Oh, In Gyu Hwang, Jung Mi Kwon, Sang-Cheol Lee, Hui-Young Lee, Hyeong Su Kim, Ho Yeong Lim and Won Ki Kang
    Citation: BMC Cancer 2010 10:583
    Content type: Research article Published on:

  2. Chemotherapy-induced anemia (CIA) is responsive to treatment with erythropoiesis-stimulating agents (ESAs) such as darbepoetin alfa. Administration of ESAs on a synchronous schedule with chemotherapy administr...

    Authors: Lee Schwartzberg, Ronald Burkes, Barry Mirtsching, Timothy Rearden, Peter Silberstein, Lorrin Yee, Amy Inamoto and Tom Lillie
    Citation: BMC Cancer 2010 10:581
    Content type: Research article Published on:

  3. Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng and Zhao-You Tang
    Citation: BMC Cancer 2010 10:580
    Content type: Research article Published on:

  6. NORE1 (RASSF5) is a newly described member of the RASSF family with Ras effector function. NORE1 expression is frequently inactivated by aberrant promoter hypermethylation in many human cancers, suggesting that N...

    Authors: Chang Kyun Lee, Jin-Hee Lee, Min-Goo Lee, Seong-In Jeong, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Young Hwangbo, Jae-Jun Shim, Jae Young Jang, Kil Yeon Lee, Hyo Jong Kim and Sung-Gil Chi
    Citation: BMC Cancer 2010 10:577
    Content type: Research article Published on:

  7. Most patients with ovarian cancer are diagnosed with advanced stage disease (i.e., stage III-IV), which is associated with a poor prognosis. Differentially expressed genes (DEGs) in stage III serous ovarian carci...

    Authors: Yun-Sook Kim, Jin Hwan Do, Sumi Bae, Dong-Han Bae and Woong Shick Ahn
    Citation: BMC Cancer 2010 10:576
    Content type: Research article Published on:

  8. CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development o...

    Authors: Kefu Tang, Yang Li, Zhao Zhang, Yunmin Gu, Yuyu Xiong, Guoyin Feng, Lin He and Shengying Qin
    Citation: BMC Cancer 2010 10:575
    Content type: Research article Published on:

  9. Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Prev...

    Authors: Michelle MS Chew, Sook-Yee Gan, Alan SB Khoo and Eng-Lai Tan
    Citation: BMC Cancer 2010 10:574
    Content type: Research article Published on:

  10. An estimated 12% of females in the United States will develop breast cancer in their lifetime. Although, there are advances in treatment options including surgery and chemotherapy, breast cancer is still the s...

    Authors: Jeffrey C Miecznikowski, Dan Wang, Song Liu, Lara Sucheston and David Gold
    Citation: BMC Cancer 2010 10:573
    Content type: Research article Published on:

  11. The optimal protocol for 125I-transperineal prostatic brachytherapy (TPPB) in intermediate-risk prostate cancer (PCa) patients remains controversial. Data on the efficacy of combining androgen-deprivation therapy...

    Authors: Kenta Miki, Takayoshi Kiba, Hiroshi Sasaki, Masahito Kido, Manabu Aoki, Hiroyuki Takahashi, Keiko Miyakoda, Takushi Dokiya, Hidetoshi Yamanaka, Masanori Fukushima and Shin Egawa
    Citation: BMC Cancer 2010 10:572
    Content type: Study protocol Published on:

  12. Telomerase activation, a critical step in cell immortalization and oncogenesis, is partly regulated by alternative splicing. In this study, we aimed to use the Marek's disease virus (MDV) T-cell lymphoma model...

    Authors: Souheila Amor, Sylvie Remy, Ginette Dambrine, Yves Le Vern, Denis Rasschaert and Sylvie Laurent
    Citation: BMC Cancer 2010 10:571
    Content type: Research article Published on:

  13. Gallbladder cancer typically follows an aggressive course, with chemotherapy the standard of care for advanced disease; complete remissions are rarely encountered. The epidermal growth factor receptor (EGFR) i...

    Authors: Kabir Mody, Edward Strauss, Robert Lincer and Richard C Frank
    Citation: BMC Cancer 2010 10:570
    Content type: Case report Published on:

  14. Various studies reported remarkable high incidence rates of depression in cancer patients compared with the general population. Pancreatic cancer is still one of the malignancies with the worst prognosis and t...

    Authors: Martina Mayr and Roland M Schmid
    Citation: BMC Cancer 2010 10:569
    Content type: Debate Published on:

  15. Recent studies have suggested that the Src inhibitor dasatinib preferentially inhibits the growth of breast cancer cells of the basal-like subtype. To clarify this finding and further investigate combined anti...

    Authors: Junichi Kurebayashi, Naoki Kanomata, Takuya Moriya, Yuji Kozuka, Mika Watanabe and Hiroshi Sonoo
    Citation: BMC Cancer 2010 10:568
    Content type: Research article Published on:

  16. This phase II study investigated efficacy and safety of weekly alternating Bevacizumab (BEV)/Irinotecan (CPT-11) or Oxaliplatin (OHP) associated to weekly 5-Fluorouracil (5-FU) in first line treatment of metas...

    Authors: Gemma Bruera, Alessandra Santomaggio, Katia Cannita, Paola Lanfiuti Baldi, Marianna Tudini, Federica De Galitiis, Maria Mancini, Paolo Marchetti, Adelmo Antonucci, Corrado Ficorella and Enrico Ricevuto
    Citation: BMC Cancer 2010 10:567
    Content type: Research article Published on:

  17. The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα.

    Authors: Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi and Yoshinori Otsuki
    Citation: BMC Cancer 2010 10:566
    Content type: Research article Published on:

  18. Preclinical studies demonstrated that small chain RNA fragments accelerate the recovery of platelets numbers in animals exposed to high doses of chemotherapeutic drugs. There is anecdotal data supporting the s...

    Authors: Robert D Levin, MaryAnn Daehler, James F Grutsch, John L Hall, Digant Gupta and Christopher G Lis
    Citation: BMC Cancer 2010 10:565
    Content type: Research article Published on:

  19. Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics. The goal of this study was to investigate anatomical site-related s...

    Authors: Hye Sung Won, Myung Ah Lee, Eun-Seon Chung, Dong-Goo Kim, Young Kyoung You, Tae Ho Hong and In-Seok Lee
    Citation: BMC Cancer 2010 10:564
    Content type: Research article Published on:

  20. The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI)....

    Authors: Daniele Campa, Anika Hüsing, James D McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjønneland, Kim Overvad, Jakob Stegger, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher…
    Citation: BMC Cancer 2010 10:563
    Content type: Research article Published on:

  21. The Ras association domain family 1 (RASSF1) gene is a Ras effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative promoter selection and alternative mRNA splicing. RASSF1A is a tum...

    Authors: Mark E Reeves, Scott W Baldwin, Melissa L Baldwin, Shin-Tai Chen, Jeremy M Moretz, Robert J Aragon, Xinmin Li, Donna D Strong, Subburaman Mohan and Yousef G Amaar
    Citation: BMC Cancer 2010 10:562
    Content type: Research article Published on:

  22. Numerous studies reported genomic alterations in colorectal human tumors but few focused on rectal tumors with the specification of preoperative-treated or untreated tumors. The goals of this study were to lis...

    Authors: Benoît Romain, Agnès Neuville, Nicolas Meyer, Cécile Brigand, Serge Rohr, Anne Schneider, Marie-Pierre Gaub and Dominique Guenot
    Citation: BMC Cancer 2010 10:561
    Content type: Research article Published on:

  23. Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphobl...

    Authors: Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund and Christian Junghanss
    Citation: BMC Cancer 2010 10:560
    Content type: Research article Published on:

  24. Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of

    Authors: Emmalena Gregory-Bryson, Elizabeth Bartlett, Matti Kiupel, Schantel Hayes and Vilma Yuzbasiyan-Gurkan
    Citation: BMC Cancer 2010 10:559
    Content type: Research article Published on:

  25. The main objective of this meta-analysis was to determine the clinical benefit of concurrent chemoradiotherapy (CCRT) compared with radiation alone (RT) in the treatment of nasopharyngeal carcinoma (NPC) patie...

    Authors: Li Zhang, Chong Zhao, Bijesh Ghimire, Ming-Huang Hong, Qing Liu, Yang Zhang, Ying Guo, Yi-Jun Huang and Zhong-Zhen Guan
    Citation: BMC Cancer 2010 10:558
    Content type: Research article Published on:

  26. Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of ≤1 cm, including T1mic.

    Authors: Ji Hyun Kwon, Yu Jung Kim, Keun-Wook Lee, Do-Youn Oh, So Yeon Park, Jee Hyun Kim, Eui Kyu Chie, Sung-Won Kim, Seock-Ah Im, In-Ah Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Yung-Jue Bang and Sung Whan Ha
    Citation: BMC Cancer 2010 10:557
    Content type: Research article Published on:

  27. Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuatio...

    Authors: William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen and Zijie Sun
    Citation: BMC Cancer 2010 10:556
    Content type: Research article Published on:

  28. Polyamine metabolism has a critical role in cell death and proliferation representing a potential target for intervention in breast cancer (BC). This study investigates the expression of spermine oxidase (SMO)...

    Authors: Manuela Cervelli, Gabriella Bellavia, Emiliano Fratini, Roberto Amendola, Fabio Polticelli, Marco Barba, Rodolfo Federico, Fabrizio Signore, Giacomo Gucciardo, Rosalba Grillo, Patrick M Woster, Robert A Casero Jr and Paolo Mariottini
    Citation: BMC Cancer 2010 10:555
    Content type: Research article Published on:

  29. Many chemotherapeutic agents promote tumor cell death by activating the intrinsic pathway of apoptosis. Intrinsic apoptosis involves permeabilization of the mitochondrial outer membrane and the release of cyto...

    Authors: Sheila J Semaan and Robert W Nickells
    Citation: BMC Cancer 2010 10:554
    Content type: Research article Published on:

  30. Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. Their expression is related ...

    Authors: Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix and Jelena Anacker
    Citation: BMC Cancer 2010 10:553
    Content type: Research article Published on:

  31. Fibronectin (FN) is known to be a large multifunction glycoprotein with binding sites for many substances, including N-terminal and C-terminal heparin-binding domains. We investigated the effects of highly pur...

    Authors: Nan-Hong Tang, Yan-Lin Chen, Xiao-Qian Wang, Xiu-Jin Li, Yong Wu, Qi-Lian Zou and Yuan-Zhong Chen
    Citation: BMC Cancer 2010 10:552
    Content type: Research article Published on:

  32. Cancer health disparities affecting low-income and minority patients are well documented. Root-causes are multifactorial, including diagnostic and treatment delays, social and financial barriers, and poor comm...

    Authors: Samantha Hendren, Jennifer J Griggs, Ronald M Epstein, Sharon Humiston, Sally Rousseau, Pascal Jean-Pierre, Jennifer Carroll, Amanat M Yosha, Starlene Loader and Kevin Fiscella
    Citation: BMC Cancer 2010 10:551
    Content type: Study protocol Published on:

  33. In the last years, the transmembrane proteoglycan NG2 has gained interest as a therapeutic target for the treatment of diverse tumor types, including gliomas, because increases of its expression correlate with...

    Authors: Marta Terrile, Irene Appolloni, Filippo Calzolari, Roberto Perris, Evelina Tutucci and Paolo Malatesta
    Citation: BMC Cancer 2010 10:550
    Content type: Research article Published on:

  34. Early metastasis and infiltration are survival limiting characteristics of pancreatic ductal adenocarcinoma (PDAC). Thus, PDAC is likely to harbor alterations in metastasis suppressor genes that may provide no...

    Authors: Wolf A Mardin, Kostadin O Petrov, Andreas Enns, Norbert Senninger, Joerg Haier and Soeren T Mees
    Citation: BMC Cancer 2010 10:549
    Content type: Research article Published on:

  35. Claudin-1 is a membrane protein of tight junctions, and is associated with the development of various cancers. However, the significance of claudin-1 expression in cancer cells is not well understood. Here, we...

    Authors: Harue Akasaka, Fuyuki Sato, Satoko Morohashi, Yunyan Wu, Yang Liu, Jun Kondo, Hiroki Odagiri, Kenichi Hakamada and Hiroshi Kijima
    Citation: BMC Cancer 2010 10:548
    Content type: Research article Published on:

  36. Correlation between circulating sex steroid levels and breast cancer has been controversial, with measurement of free, or bioavailable hormone rarely available. Salivary hormone levels represent the bioavailab...

    Authors: Constantine Dimitrakakis, David Zava, Spyros Marinopoulos, Alexandra Tsigginou, Aris Antsaklis and Rebecca Glaser
    Citation: BMC Cancer 2010 10:547
    Content type: Research article Published on:

  37. Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/ca...

    Authors: Alexandra D Jensen, Anna Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2010 10:546
    Content type: Study protocol Published on:

  38. About 50% of patients with colorectal cancer are destined to develop hepatic metastases. Radical resection is the most effective treatment for patients with colorectal liver metastases offering five year survi...

    Authors: Nikol Snoeren, Emile E Voest, Andre M Bergman, Otilia Dalesio, Henk M Verheul, Rob AEM Tollenaar, Joost RM van der Sijp, Sander B Schouten, Inne HM Borel Rinkes and R van Hillegersberg
    Citation: BMC Cancer 2010 10:545
    Content type: Study protocol Published on:

  39. Germline mutations in the DNA mismatch repair genes predispose to Lynch syndrome, thus conferring a high relative risk of colorectal and endometrial cancer. The MLH1, MSH2 and MSH6 mutational spectrum reported so...

    Authors: Georgia Thodi, Florentia Fostira, Raphael Sandaltzopoulos, George Nasioulas, Anastasios Grivas, Ioannis Boukovinas, Maria Mylonaki, Christos Panopoulos, Mirjana Brankovic Magic, George Fountzilas and Drakoulis Yannoukakos
    Citation: BMC Cancer 2010 10:544
    Content type: Research article Published on:

  40. New Zealand Māori have a poorer outcome from breast cancer than non-Māori, yet prognostic data are sparse. The objective of this study was to quantify levels of prognostic factors in a cohort of self-declared ...

    Authors: Gabi U Dachs, Maiko Kano, Ekaterina Volkova, Helen R Morrin, Valerie CL Davey, Gavin C Harris, Michelle Cheale, Christopher Frampton, Margaret J Currie, J Elisabeth Wells and Bridget A Robinson
    Citation: BMC Cancer 2010 10:543
    Content type: Research article Published on:

  41. MicroRNAs (miRNAs) play an important role in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. Detection of their expression may lead to identifying novel markers for breast cancer.

    Authors: Zheng-sheng Wu, Qiang Wu, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang and Xiao-chun Xu
    Citation: BMC Cancer 2010 10:542
    Content type: Research article Published on:

  42. p27 is a cell cycle suppressor gene, whose protein is a negative regulator of cyclin/cdk complexes. p27 is also a potential target of retinoids in cancer prevention studies. In benign prostate hyperplasia (BPH...

    Authors: Winna Taylor, Amanda Mathias, Arshia Ali, Hengning Ke, Nikolay Stoynev, Anne Shilkaitis, Albert Green, Hiroaki Kiyokawa and Konstantin Christov
    Citation: BMC Cancer 2010 10:541
    Content type: Research article Published on:

  43. Activation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an importan...

    Authors: Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang and Heather E Kleiner-Hancock
    Citation: BMC Cancer 2010 10:540
    Content type: Research article Published on:

  44. Around 20% of breast cancers (BC) show ERBB2 gene amplification and overexpression of the ERBB2 tyrosine kinase receptor. They are associated with a poor prognosis but can benefit from targeted therapy. A better ...

    Authors: Fabrice Sircoulomb, Ismahane Bekhouche, Pascal Finetti, José Adélaïde, Azza Ben Hamida, Julien Bonansea, Stéphane Raynaud, Charlène Innocenti, Emmanuelle Charafe-Jauffret, Carole Tarpin, Farhat Ben Ayed, Patrice Viens, Jocelyne Jacquemier, François Bertucci, Daniel Birnbaum and Max Chaffanet
    Citation: BMC Cancer 2010 10:539
    Content type: Research article Published on:

  45. LATS2, which encodes a novel serine/threonine kinase, is known to be important in centrosome duplication and in the maintenance of genomic stability. Recently, a potential role for LATS2 in cancer has been rep...

    Authors: Yan Zhang, Chun-Fang Hu, Jing Chen, Li-Xu Yan, Yi-Xin Zeng and Jian-Yong Shao
    Citation: BMC Cancer 2010 10:538
    Content type: Research article Published on:

  46. The significance of expression of different mucins in succession of malignant transformation of colorectal polyps is not determined yet. The aim of the present study was to determine the pattern of expression ...

    Authors: Mahsa Molaei, Babak Khoshkrood Mansoori, Reza Mashayekhi, Mohsen Vahedi, Mohamad Amin Pourhoseingholi, Seyed Reza Fatemi and Mohammad Reza Zali
    Citation: BMC Cancer 2010 10:537
    Content type: Research article Published on:

  47. The mammalian target of rapamycin (mTOR) plays a key role in cellular growth and homeostasis. The purpose of our present study is to investigate the expression of activated mTOR (p-mTOR) in gastric cancer pati...

    Authors: Da-zhi Xu, Qi-rong Geng, Ying Tian, Mu-yan Cai, Xin-juan Fang, You-qing Zhan, Zhi-wei Zhou, Wei Li, Ying-bo Chen, Xiao-wei Sun, Yuan-xiang Guan, Yuan-fang Li and Tong-yu Lin
    Citation: BMC Cancer 2010 10:536
    Content type: Research article Published on:

  48. Locally advanced (pT3-4N0M0) hepatocellular carcinoma (HCC) is a heterogeneous group of tumors, which consists of four different categories, including HCC with "multiple tumors more than 5 cm", "major vascular...

    Authors: Binkui Li, Yunfei Yuan, Guihua Chen, Liru He, Yaqi Zhang, Jinqing Li, Guohui Li and Wan Yee Lau
    Citation: BMC Cancer 2010 10:535
    Content type: Research article Published on:

  49. Accurate evaluation of human epidermal growth factor receptor type-2 (HER2) status based on core needle biopsy (CNB) specimens is mandatory for identification of patients with primary breast cancer who will be...

    Authors: Hitoshi Tsuda, Masafumi Kurosumi, Shinobu Umemura, Sohei Yamamoto, Takayuki Kobayashi and Robert Yoshiyuki Osamura
    Citation: BMC Cancer 2010 10:534
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us