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  1. The aim of the present study was to determine the feasibility of detecting sentinel lymph node (SLN) metastases using interstitial magnetic resonance (MR) lymphography in patients with cervical cancer. MR data...

    Authors: Ying Hong, Luojun Xiang, Yali Hu, Zhengyang Zhou, Haiping Yu and Bing Zhu
    Citation: BMC Cancer 2012 12:360
    Content type: Research article Published on:

  2. In ovarian cancer, massive intraperitoneal dissemination is due to exfoliated tumor cells in ascites. Tumor-initiating cells (TICs or cancer stem cells) and cells showing epithelial-mesenchymal-transition (EMT...

    Authors: My Wintzell, Elisabet Hjerpe, Elisabeth Åvall Lundqvist and Maria Shoshan
    Citation: BMC Cancer 2012 12:359
    Content type: Research article Published on:

  3. Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing ...

    Authors: Massimiliano Monticone, Antonio Daga, Simona Candiani, Francesco Romeo, Valentina Mirisola, Silvia Viaggi, Ilaria Melloni, Simona Pedemonte, Gianluigi Zona, Walter Giaretti, Ulrich Pfeffer and Patrizio Castagnola
    Citation: BMC Cancer 2012 12:358
    Content type: Research article Published on:

  4. AMP-activated protein kinase (AMPK) has recently been considered as a potential target for cancer therapy. However, the expression status of various subunits of the heterotrimeric AMPK in human cancers is rarely...

    Authors: Cuilan Li, Vincent WS Liu, Pui M Chiu, David W Chan and Hextan YS Ngan
    Citation: BMC Cancer 2012 12:357
    Content type: Research article Published on:

  5. More than half of patients with colorectal cancer will develop metastatic disease either evident at the time of initial diagnosis or during their course of disease. Besides multidisciplinary management further...

    Authors: Alexander Stein, Gabriel Glockzin, Andreas Wienke, Dirk Arnold, Thomas Edelmann, Bert Hildebrandt, Stephan Hollerbach, Gerald Illerhaus, Alfred Königsrainer, Michael Richter, Hans J Schlitt and Hans-Joachim Schmoll
    Citation: BMC Cancer 2012 12:356
    Content type: Study protocol Published on:

  6. Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibitio...

    Authors: Zohreh Ghoreishi, Ali Esfahani, Abolghasem Djazayeri, Mahmoud Djalali, Banafsheh Golestan, Hormoz Ayromlou, Shahriar Hashemzade, Mohammad Asghari Jafarabadi, Vahid Montazeri, Seyed Ali Keshavarz and Masoud Darabi
    Citation: BMC Cancer 2012 12:355
    Content type: Research article Published on:

  9. Development of breast cancer is a multistage process influenced by hormonal and environmental factors as well as by genetic background. The search for genes underlying this malignancy has recently been highly ...

    Authors: Emma Samuelson, Sara Karlsson, Karolina Partheen, Staffan Nilsson, Claude Szpirer and Afrouz Behboudi
    Citation: BMC Cancer 2012 12:352
    Content type: Research article Published on:

  10. It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons...

    Authors: Julie Gentil, Tienhan Sandrine Dabakuyo, Samiratou Ouedraogo, Marie-Laure Poillot, Olivier Dejardin and Patrick Arveux
    Citation: BMC Cancer 2012 12:351
    Content type: Research article Published on:

  11. Overexpression of the human epidermal growth factor receptor (HER) 2 is associated with poor prognosis and shortened survival in breast cancer patients. HER2 is a potent activator of several signaling pathways...

    Authors: Elisabet Tina, Breezy Malakkaran Lindqvist, Marike Gabrielson, Zelmina Lubovac, Pia Wegman and Sten Wingren
    Citation: BMC Cancer 2012 12:350
    Content type: Research article Published on:

  12. To evaluate the value of KRAS codon 13 mutations in patients with advanced colorectal cancer (advanced CRC) treated with oxaliplatin and fluoropyrimidines.

    Authors: Anke Reinacher-Schick, Karsten Schulmann, Dominik P Modest, Nina Bruns, Ulrich Graeven, Malgorzata Jaworska, Richard Greil, Rainer Porschen, Dirk Arnold, Wolff Schmiegel and Andrea Tannapfel
    Citation: BMC Cancer 2012 12:349
    Content type: Research article Published on:

  13. MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several...

    Authors: Xiang-hua Liu, Kai-hua Lu, Ke-ming Wang, Ming Sun, Er-bao Zhang, Jin-song Yang, Dan-dan Yin, Zhi-li Liu, Jing Zhou, Zhi-jun Liu, Wei De and Zhao-xia Wang
    Citation: BMC Cancer 2012 12:348
    Content type: Research article Published on:

  14. We evaluated the association between a KRAS mutational status and various clinicopathologic features including the metastatic pattern in patients with metastatic or recurrent colorectal cancer (MRCRC). The con...

    Authors: Mi-Jung Kim, Hye Seung Lee, Jee Hyun Kim, Yu Jung Kim, Ji Hyun Kwon, Jeong-Ok Lee, Soo-Mee Bang, Kyoung Un Park, Duck-Woo Kim, Sung-Bum Kang, Jae-Sung Kim, Jong Seok Lee and Keun-Wook Lee
    Citation: BMC Cancer 2012 12:347
    Content type: Research article Published on:

  15. The identification of circulating tumour cells (CTCs) in peripheral blood is a useful approach to estimate prognosis, monitor disease progression, and measure treatment effects in various malignancies. However...

    Authors: Hiroaki Ito, Haruhiro Inoue, Norimasa Sando, Satoshi Kimura, Keigo Gohda, Jun Sato, Katsuhiro Murakami, Shun Ito, Noriko Odaka, Hitoshi Satodate and Shin-ei Kudo
    Citation: BMC Cancer 2012 12:346
    Content type: Research article Published on:

  16. Near infrared (NIR) photoimmunotherapy (PIT) is a new type of cancer treatment based on a monoclonal antibody (mAb)-NIR phthalocyanine dye, (IR700) conjugate. In vitro cancer-specific cell death occurs during NIR...

    Authors: Makoto Mitsunaga, Takahito Nakajima, Kohei Sano, Gabriela Kramer-Marek, Peter L Choyke and Hisataka Kobayashi
    Citation: BMC Cancer 2012 12:345
    Content type: Research article Published on:

  17. The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histol...

    Authors: Sara Karami, Joanne S Colt, Kendra Schwartz, Faith G Davis, Julie J Ruterbusch, Stella S Munuo, Sholom Wacholder, Patricia A Stewart, Barry I Graubard, Nathanial Rothman, Wong-Ho Chow and Mark P Purdue
    Citation: BMC Cancer 2012 12:344
    Content type: Research article Published on:

  18. C-reactive protein (CRP) and Serum amyloid A protein (SAA) increases with systemic inflammation and are related to worse survival for breast cancer survivors. This study examines the association between percen...

    Authors: Anne Dee, Roberta McKean-Cowdin, Marian L Neuhouser, Cornelia Ulrich, Richard N Baumgartner, Anne McTiernan, Kathy Baumgartner, Catherine M Alfano, Rachel Ballard-Barbash and Leslie Bernstein
    Citation: BMC Cancer 2012 12:343
    Content type: Research article Published on:

  19. BRCA1 (B), ERCC1 (E), RRM1 (R) and TYMS (T) mRNA expression has been extensively studied with respect to NSCLC patient outcome upon various chemotherapy agents. However, these markers have not been introduced ...

    Authors: Vassiliki Kotoula, Dimitrios Krikelis, Vasilios Karavasilis, Triantafillia Koletsa, Anastasia G Eleftheraki, Despina Televantou, Christos Christodoulou, Stefanos Dimoudis, Ippokratis Korantzis, Dimitrios Pectasides, Konstantinos N Syrigos, Paris A Kosmidis and George Fountzilas
    Citation: BMC Cancer 2012 12:342
    Content type: Research article Published on:

  20. Versican is detected in the interstitial tissues at the invasive margins of breast carcinoma, is predictive of relapse, and negatively impacts overall survival rates. The versican G3 domain is important in bre...

    Authors: William Weidong Du, Ling Fang, Weining Yang, Wang Sheng, Yaou Zhang, Arun Seth, Burton B Yang and Albert J Yee
    Citation: BMC Cancer 2012 12:341
    Content type: Research article Published on:

  21. Hepatic resection is currently still the best choice of therapeutic strategies for liver cancer, but the long-term survival rate after surgery is unsatisfactory. Most patients develop intra- and/or extrahepati...

    Authors: Feng Xiaobin, Zheng Shuguo, Zhou Jian, Qiu Yudong, Liang Lijian, Ma Kuansheng, Li Xiaowu, Xia Feng, Yi Dong, Wang Shuguang, Bie Ping and Dong Jiahong
    Citation: BMC Cancer 2012 12:340
    Content type: Study protocol Published on:

  22. A cancer diagnosis is 2.9 times more likely to occur during the adolescent and young adult years than in younger children. This spike in incidence coincides with a life stage characterised by psychological vul...

    Authors: Ursula M Sansom-Daly, Claire E Wakefield, Richard A Bryant, Phyllis Butow, Susan Sawyer, Pandora Patterson, Antoinette Anazodo, Kate Thompson and Richard J Cohn
    Citation: BMC Cancer 2012 12:339
    Content type: Study protocol Published on:

  23. A significant number of cancers are caused by defects in p21 causing functional defects in p21 or p53 tumour-suppressor proteins. This has led to many therapeutic approaches including restoration by gene thera...

    Authors: Christina A Kousparou, Efthymia Yiacoumi, Mahendra P Deonarain and Agamemnon A Epenetos
    Citation: BMC Cancer 2012 12:338
    Content type: Research article Published on:

  24. C-reactive protein (CRP) is considered a useful serum marker for patients with RCC. However, its clinical utility in advanced metastatic renal cell carcinoma (AM-RCC), particularly in deciding whether to perfo...

    Authors: Hiroki Ito, Koichi Shioi, Takayuki Murakami, Akitoshi Takizawa, Futoshi Sano, Takashi Kawahara, Nobuhiko Mizuno, Kazuhide Makiyama, Noboru Nakaigawa, Takeshi Kishida, Takeshi Miura, Yoshinobu Kubota and Masahiro Yao
    Citation: BMC Cancer 2012 12:337
    Content type: Research article Published on:

  25. Maspin, a putative tumor suppressor that is down-regulated in breast and prostate cancer, has been associated with decreased cell motility. Snail transcription factor is a zinc finger protein that is increased...

    Authors: Corey L Neal, Veronica Henderson, Bethany N Smith, Danielle McKeithen, Tisheeka Graham, Baohan T Vo and Valerie A Odero-Marah
    Citation: BMC Cancer 2012 12:336
    Content type: Research article Published on:

  26. Bladder cancer results from complex interactions between many genetic and environment factors. The polymorphism Ser326Cys in hOGG1 gene has been reported to be associated with bladder cancer in some studies, thou...

    Authors: Changwei Ji, Zhao Liu, Huimei Chen, Hongqian Guo and Changjian Liu
    Citation: BMC Cancer 2012 12:335
    Content type: Research article Published on:

  27. Diffusion-weighted (DW) imaging has shown potential to differentiate between malignant and benign breast lesions. However, different b values have been used with varied sensitivity and specificity. This study ...

    Authors: Xin Chen, Xi-Jing He, Rui Jin, You-Min Guo, Xian Zhao, Hua-Feng Kang, Li-Ping Mo and Qian Wu
    Citation: BMC Cancer 2012 12:334
    Content type: Research article Published on:

  28. The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopo...

    Authors: Ane Kongsgaard Rud, Marius Lund-Iversen, Gisle Berge, Odd Terje Brustugun, Steinar K Solberg, Gunhild M Mælandsmo and Kjetil Boye
    Citation: BMC Cancer 2012 12:333
    Content type: Research article Published on:

  29. Resistance to apoptosis is a hallmark of cancer and proteins regulating apoptosis have been proposed as prognostic markers in several malignancies. However, the prognostic impact of apoptotic markers has not b...

    Authors: Pinaki Bose, Alexander C Klimowicz, Elizabeth Kornaga, Stephanie K Petrillo, T Wayne Matthews, Shamir Chandarana, Anthony M Magliocco, Nigel T Brockton and Joseph C Dort
    Citation: BMC Cancer 2012 12:332
    Content type: Research article Published on:

  31. Hyperfibrinogenemia is a common problem associated with various carcinomas, and is accompanied by hypercoagulablity. In advanced non-small-cell lung cancer (NSCLC) it remains unclear whether or not chemotherap...

    Authors: Jun Zhao, Mingfang Zhao, Bo Jin, Ping Yu, Xuejun Hu, Yuee Teng, Jingdong Zhang, Ying Luo, Lingyun Zhang, Shuang Zheng, Qiyin Zhou, Heming Li, Yunpeng Liu and Xiujuan Qu
    Citation: BMC Cancer 2012 12:330
    Content type: Research article Published on:

  32. Aldehyde dehydrogenases belong to a superfamily of detoxifying enzymes that protect cells from carcinogenic aldehydes. Of the superfamily, ALDH1A1 has gained most attention because current studies have shown t...

    Authors: Yu-Ting Saw, Junzheng Yang, Shu-Kay Ng, Shubai Liu, Surendra Singh, Margit Singh, William R Welch, Hiroshi Tsuda, Wing-Ping Fong, David Thompson, Vasilis Vasiliou, Ross S Berkowitz and Shu-Wing Ng
    Citation: BMC Cancer 2012 12:329
    Content type: Research article Published on:

  33. Correct detection of bone metastases in patients with esophageal squamous cell carcinoma is pivotal for prognosis and selection of an appropriate treatment regimen. Whole-body bone scan for staging is not rout...

    Authors: Shau-Hsuan Li, Yung-Cheng Huang, Wan-Ting Huang, Wei-Che Lin, Chien-Ting Liu, Wan-Yu Tien and Hung-I Lu
    Citation: BMC Cancer 2012 12:328
    Content type: Research article Published on:

  34. Bevacizumab, a humanized antibody to vascular endothelial growth factor (VEGF), shows clinical activity against human cancer, with its addition to standard chemotherapy having been found to improve outcome in ...

    Authors: Masayuki Takeda, Isamu Okamoto, Takeharu Yamanaka, Kazuhiko Nakagawa and Yoichi Nakanishi
    Citation: BMC Cancer 2012 12:327
    Content type: Study protocol Published on:

  35. Surgery is often advocated in patients with resectable pulmonary metastases from colorectal cancer (CRC). Our study aims to evaluate peri-operative chemotherapy in patients with metastastic CRC undergoing pulm...

    Authors: Eliza A Hawkes, George Ladas, David Cunningham, Andrew G Nicholson, Katharina Wassilew, Yolanda Barbachano, Gihan Ratnayake, Sheela Rao and Ian Chau
    Citation: BMC Cancer 2012 12:326
    Content type: Research article Published on:

  36. We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it wou...

    Authors: Jan Dominik Kuhlmann, Heidi Schwarzenbach, Pauline Wimberger, Micaela Poetsch, Rainer Kimmig and Sabine Kasimir-Bauer
    Citation: BMC Cancer 2012 12:325
    Content type: Research article Published on:

  37. Prostate cancer is the most commonly diagnosed non-melanoma cancer among men. Androgen deprivation therapy (ADT) has been the core therapy for men with advanced prostate cancer. It is only in recent years that...

    Authors: C Ellen Lee, Andrea Kilgour and YK James Lau
    Citation: BMC Cancer 2012 12:324
    Content type: Study protocol Published on:

  38. Although global hypomethylation of leukocyte DNA has been associated with an increased risk of several sites of cancer, including breast cancer, determinants of global methylation level among healthy individua...

    Authors: Motoki Iwasaki, Hiroe Ono, Aya Kuchiba, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida and Shoichiro Tsugane
    Citation: BMC Cancer 2012 12:323
    Content type: Research article Published on:

  39. To evaluate efficacy in patients with brain metastasis (BM) on entry into the lapatinib expanded access program (LEAP).

    Authors: Jungsil Ro, Sohee Park, Sung- Bae Kim, Tae You Kim, Young Hyuk Im, Sun Young Rha, Joo Seop Chung, Hanlim Moon and Sergio Santillana
    Citation: BMC Cancer 2012 12:322
    Content type: Research article Published on:

  40. Cell division cycle associated 3 (CDCA3), part of the Skp1-cullin-F-box (SCF) ubiquitin ligase, refers to a trigger of mitotic entry and mediates destruction of the mitosis inhibitory kinase. Little is known a...

    Authors: Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, Hiroaki Takatori, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa and Hiroki Bukawa
    Citation: BMC Cancer 2012 12:321
    Content type: Research article Published on:

  41. Germline BRCA1 and BRCA2 mutation testing offered shortly after a breast cancer diagnosis to inform women’s treatment choices - treatment-focused genetic testing ‘TFGT’ - has entered clinical practice in speciali...

    Authors: Kaaren J Watts, Bettina Meiser, Gillian Mitchell, Judy Kirk, Christobel Saunders, Michelle Peate, Jessica Duffy, Patrick J Kelly, Margaret Gleeson, Kristine Barlow-Stewart, Belinda Rahman, Michael Friedlander and Kathy Tucker
    Citation: BMC Cancer 2012 12:320
    Content type: Study protocol Published on:

  42. Although blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blo...

    Authors: Nuh N Rahbari, Ulrich Bork, Ulf Hinz, Albrecht Leo, Johanna Kirchberg, Moritz Koch, Markus W Büchler and Jürgen Weitz
    Citation: BMC Cancer 2012 12:319
    Content type: Research article Published on:

  43. Multiple myeloma (MM) is at present an incurable malignancy, characterized by apoptosis-resistant tumor cells. Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an ...

    Authors: Lina Y Dimberg, Anna Dimberg, Karolina Ivarsson, Mårten Fryknäs, Linda Rickardson, Gerard Tobin, Simon Ekman, Rolf Larsson, Urban Gullberg, Kenneth Nilsson, Fredrik Öberg and Helena Jernberg Wiklund
    Citation: BMC Cancer 2012 12:318
    Content type: Research article Published on:

  44. Studies have revealed both higher cancer survival in the US than in Germany and substantial improvement of cancer survival in the past in these countries. This population-based study aims at comparing most rec...

    Authors: Bernd Holleczek and Hermann Brenner
    Citation: BMC Cancer 2012 12:317
    Content type: Research article Published on:

  45. S100A9 was originally discovered as a factor secreted by inflammatory cells. Recently, S100A9 was found to be associated with several human malignancies. The purpose of this study is to investigate S100A9 expr...

    Authors: Biao Fan, Lian-Hai Zhang, Yong-ning Jia, Xi-Yao Zhong, Yi-Qiang Liu, Xiao-Jing Cheng, Xiao-Hong Wang, Xiao-Fang Xing, Ying Hu, Ying-Ai Li, Hong Du, Wei Zhao, Zhao-Jian Niu, Ai-Ping Lu, Ji-You Li and Jia-Fu Ji
    Citation: BMC Cancer 2012 12:316
    Content type: Research article Published on:

  47. Thromboembolism (TE) and infection are two common complications of central venous line (CVL). Thrombotic CVL-dysfunction is a common, yet less studied, complication of CVL. Two retrospective studies have repor...

    Authors: Jacqueline Halton, Kim Nagel, Leonardo R Brandão, Mariana Silva, Paul Gibson, Anthony Chan, Kay Blyth, Kim Hicks, Nagina Parmar, Leslie Paddock, Stephanie Willing, Lehana Thabane and Uma Athale
    Citation: BMC Cancer 2012 12:314
    Content type: Study protocol Published on:

  48. Soft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported i...

    Authors: Jiro Ichikawa, Seiichi Matsumoto, Takashi Shimoji, Taisuke Tanizawa, Tabu Gokita, Keiko Hayakawa, Kaoru Aoki, Saori Ina and Hiroaki Kanda
    Citation: BMC Cancer 2012 12:313
    Content type: Case report Published on:

  49. Although treatment regimen have improved in the last few years, prostate cancer patients following a radical prostatectomy still experience severe disease- and treatment-related side effects, including urinary...

    Authors: Eva M Zopf, Moritz Braun, Stefan Machtens, Jürgen Zumbé, Wilhelm Bloch and Freerk T Baumann
    Citation: BMC Cancer 2012 12:312
    Content type: Study protocol Published on:

  50. The NeoAzure study has demonstrated that the use of the bisphosphonate zoledronic acid (Zol) in the neoadjuvant setting increases the rate of complete response in primary breast cancer and therefore indicates ...

    Authors: Tanja Fehm, Manfred Zwirner, Diethelm Wallwiener, Harald Seeger and Hans Neubauer
    Citation: BMC Cancer 2012 12:308
    Content type: Research article Published on:

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