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  1. Despite the clinical significance of liver metastases, the difference between molecular and cellular changes in primary colorectal cancers (CRC) and matched liver metastases is poorly understood.

    Authors: Ja-Rang Lee, Chae Hwa Kwon, Yuri Choi, Hye Ji Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh and Do Youn Park
    Citation: BMC Cancer 2016 16:539
    Content type: Research article Published on:

  3. The increasingly complex programs of contemporary cancer therapy emphasize the need for biological indicators of both therapeutic response and adverse effects. One example is combined-modality treatment aimed ...

    Authors: Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark and Anne Hansen Ree
    Citation: BMC Cancer 2016 16:536
    Content type: Research article Published on:

  4. Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then ex...

    Authors: Sandra Fernandes Martins, Ricardo Amorim, Marta Viana-Pereira, Céline Pinheiro, Ricardo Filipe Alves Costa, Patrícia Silva, Carla Couto, Sara Alves, Sara Fernandes, Sónia Vilaça, Joaquim Falcão, Herlander Marques, Fernando Pardal, Mesquita Rodrigues, Ana Preto, Rui Manuel Reis…
    Citation: BMC Cancer 2016 16:535
    Content type: Research article Published on:

  5. Due to the steadily increasing number of cancer patients worldwide the early diagnosis and treatment of cancer is a major field of research. The diagnosis of cancer is mostly performed by an experienced pathol...

    Authors: Thomas W. Bocklitz, Firas Subhi Salah, Nadine Vogler, Sandro Heuke, Olga Chernavskaia, Carsten Schmidt, Maximilian J. Waldner, Florian R. Greten, Rolf Bräuer, Michael Schmitt, Andreas Stallmach, Iver Petersen and Jürgen Popp
    Citation: BMC Cancer 2016 16:534
    Content type: Research Article Published on:

  6. Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (...

    Authors: Linh Nguyen, Theodora Fifis and Christopher Christophi
    Citation: BMC Cancer 2016 16:533
    Content type: Research article Published on:

  7. Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, ce...

    Authors: Ming-Feng Chen, S. Joseph Huang, Chao-Cheng Huang, Pei-Shan Liu, Kun-I Lin, Ching-Wen Liu, Wen-Chuan Hsieh, Li-Yen Shiu and Chang-Han Chen
    Citation: BMC Cancer 2016 16:532
    Content type: Research article Published on:

  8. The use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mTOR-mediated pro-survival signaling in colorectal carcinoma (CRC) cell lines with KRAS or BRAF mutation has been shown to indu...

    Authors: Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes and Anne Hansen Ree
    Citation: BMC Cancer 2016 16:531
    Content type: Research article Published on:

  9. Prostate cancer (PC) is a major health concern for men worldwide, with an estimated lifetime risk of ~14 %. A recent comprehensive analysis of mutational processes revealed ageing and mismatch repair as the on...

    Authors: Lynne Kerr, Matthew J. Rewhorn, Mark Longmuir, Sioban Fraser, Shaun Walsh, Nicola Andrew and Hing Y. Leung
    Citation: BMC Cancer 2016 16:529
    Content type: Research article Published on:

  10. Adequate prediction of survival plays an important role in treatment decisions for patients with spinal bone metastases (SBM). Several prognostic factors are already used in daily clinical practice, but factor...

    Authors: Robert J. Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief and German Bone Research Group
    Citation: BMC Cancer 2016 16:528
    Content type: Research article Published on:

  11. One of the most prevalent long-term consequences of surviving breast cancer is fear of cancer recurrence (FCR), which is associated with higher (mental) healthcare costs and lower surveillance rates. The major...

    Authors: Sanne Jasperine van Helmondt, Marije Liesbeth van der Lee and Jolanda de Vries
    Citation: BMC Cancer 2016 16:527
    Content type: Study protocol Published on:

  12. This study was initiated to investigate the difference in HER2 status between tumor tissue and circulating tumor cells (CTCs), as well as the predictive value of CTC HER2 status for predicting the outcomes of ...

    Authors: Shaohua Zhang, Lei Li, Tao Wang, Li Bian, Haixu Hu, Chunhong Xu, Bing Liu, Yi Liu, Massimo Cristofanilli and Zefei Jiang
    Citation: BMC Cancer 2016 16:526
    Content type: Research article Published on:

  13. Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients...

    Authors: Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Yasuhito Iseki and Kosei Hirakawa
    Citation: BMC Cancer 2016 16:525
    Content type: Research article Published on:

  14. Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. Attaining these objectives will be...

    Authors: Jing-Hung Wang, Aaron N. Endsley, Carol E. Green and A. C. Matin
    Citation: BMC Cancer 2016 16:524
    Content type: Research article Published on:

  15. Pharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liqui...

    Authors: Karoline Freeman, Mark P. Saunders, Olalekan A. Uthman, Sian Taylor-Phillips, Martin Connock, Rachel Court, Tara Gurung, Paul Sutcliffe and Aileen Clarke
    Citation: BMC Cancer 2016 16:523
    Content type: Research article Published on:

  16. The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course of the disease in breast cancer (BC). Therefore, reassessment of these markers at the time of disease progressi...

    Authors: Bahriye Aktas, Sabine Kasimir-Bauer, Volkmar Müller, Wolfgang Janni, Tanja Fehm, Diethelm Wallwiener, Klaus Pantel and Mitra Tewes
    Citation: BMC Cancer 2016 16:522
    Content type: Research article Published on:

  17. We recently demonstrated the cytotoxicity of liquid crystal precursors (hereafter referred to as “mesogenic compounds”) in the human non-small cell lung cancer (NSCLC) cell line A549 which carry wild-type p53....

    Authors: Saori Fukushi, Hironori Yoshino, Atsushi Yoshizawa and Ikuo Kashiwakura
    Citation: BMC Cancer 2016 16:521
    Content type: Research article Published on:

  18. Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of...

    Authors: Floortje K. Ploos van Amstel, Judith B. Prins, Winette T. A. van der Graaf, Marlies E. W. J. Peters and Petronella B. Ottevanger
    Citation: BMC Cancer 2016 16:520
    Content type: Study protocol Published on:

  19. Neoadjuvant chemoradiotherapy (NACRT) followed by surgical resection is the standard therapy for locally advanced rectal cancer. However, tumor response following NACRT varies, ranging from pathologic complete...

    Authors: Laura del Puerto-Nevado, Juan Pablo Marin-Arango, Maria Jesus Fernandez-Aceñero, David Arroyo-Manzano, Javier Martinez-Useros, Aurea Borrero-Palacios, Maria Rodriguez-Remirez, Arancha Cebrian, Teresa Gomez del Pulgar, Marlid Cruz-Ramos, Cristina Carames, Begoña Lopez-Botet and Jesús Garcia-Foncillas
    Citation: BMC Cancer 2016 16:519
    Content type: Research article Published on:

  20. Authors: Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar and Thierry Andre
    Citation: BMC Cancer 2016 16:518
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2016 16:412

  21. In an effort to reduce the risk of breast cancer-related arm lymphedema, patients are commonly advised to avoid heavy lifting, impacting activities of daily living and resistance exercise prescription. This ad...

    Authors: Kira Bloomquist, Sandi Hayes, Lis Adamsen, Tom Møller, Karl Bach Christensen, Bent Ejlertsen and Peter Oturai
    Citation: BMC Cancer 2016 16:517
    Content type: Study protocol Published on:

  22. Noninvasive prognostic tools for esophageal squamous cell carcinoma (ESCC) are urgently needed. Serum lipids and lipoproteins are used for the prognosis of certain diseases; however, the prognostic value of se...

    Authors: Xue-Ping Wang, Xiao-Hui Li, Lin Zhang, Jian-Hua Lin, Hao Huang, Ting Kang, Min-Jie Mao, Hao Chen and Xin Zheng
    Citation: BMC Cancer 2016 16:516
    Content type: Research article Published on:

  23. Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6–8 cycles of NAC has become the stand...

    Authors: Yaewon Yang, Seock-Ah Im, Bhumsuk Keam, Kyung‑Hun Lee, Tae‑Yong Kim, Koung Jin Suh, Han Suk Ryu, Hyeong-Gon Moon, Sae‑Won Han, Do‑Youn Oh, Wonshik Han, Tae‑You Kim, In Ae Park and Dong-Young Noh
    Citation: BMC Cancer 2016 16:515
    Content type: Research article Published on:

  24. The chemokine CXCL12 and its corresponding receptor CXCR4 are key players in the development of several cancers. Therefore, we hypothesized that there is a functional causality between CXCL12 expression and tu...

    Authors: Yusuke Uchi, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori and Yuko Kitagawa
    Citation: BMC Cancer 2016 16:514
    Content type: Research article Published on:

  25. Rectal cancer surgery is accompanied with high morbidity and poor long term functional outcome. Screening programs have shown a shift towards more early staged cancers. Patients with early rectal cancer can po...

    Authors: W. A. A. Borstlap, P. J. Tanis, T. W. A. Koedam, C. A. M. Marijnen, C. Cunningham, E. Dekker, M. E. van Leerdam, G. Meijer, N. van Grieken, I. D. Nagtegaal, C. J. A. Punt, M. G. W. Dijkgraaf, J. H. De Wilt, G. Beets, E. J. de Graaf, A. A. W van Geloven…
    Citation: BMC Cancer 2016 16:513
    Content type: Study protocol Published on:

  26. Primary melanocytic neoplasms are rare in the pediatric age. Among them, the pattern of neoplastic meningitis represents a peculiar diagnostic challenge since neuroradiological features may be subtle and cereb...

    Authors: Giulia Angelino, Maria Debora De Pasquale, Luigi De Sio, Annalisa Serra, Luca Massimi, Rita De Vito, Antonio Marrazzo, Laura Lancella, Andrea Carai, Manila Antonelli, Felice Giangaspero, Marco Gessi, Laura Menchini, Laura Scarciolla, Daniela Longo and Angela Mastronuzzi
    Citation: BMC Cancer 2016 16:512
    Content type: Case report Published on:

  27. Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis. Most metastatic or unresectable cases are incurable. Novel antitumor agents and precise prognostication are needed for SS patients. The p...

    Authors: Akira Maekawa, Kenichi Kohashi, Masaaki Kuda, Kunio Iura, Takeaki Ishii, Makoto Endo, Tetsuya Nakatsura, Yukihide Iwamoto and Yoshinao Oda
    Citation: BMC Cancer 2016 16:511
    Content type: Research article Published on:

  28. High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many fals...

    Authors: Sarah Preisler, Matejka Rebolj, Ditte Møller Ejegod, Elsebeth Lynge, Carsten Rygaard and Jesper Bonde
    Citation: BMC Cancer 2016 16:510
    Content type: Research article Published on:

  29. In treatment-refractory liver dominant metastatic colorectal cancer, the role of liver directed therapies still is unclear. We sought to determine a prognostic score for Y90 radioembolization in these patients.

    Authors: Robert Damm, Ricarda Seidensticker, Gerhard Ulrich, Leonie Breier, Ingo G. Steffen, Max Seidensticker, Benjamin Garlipp, Konrad Mohnike, Maciej Pech, Holger Amthauer and Jens Ricke
    Citation: BMC Cancer 2016 16:509
    Content type: Research article Published on:

  30. Colorectal cancer (CRC) is closely linked to Wnt signalling, with 94 % of cases exhibiting a Wnt related mutation. ROR2 is a receptor tyrosine kinase that is thought to repress β-catenin dependent Wnt signalli...

    Authors: Sean S. Q. Ma, Sameer Srivastava, Estelle Llamosas, Nicholas J. Hawkins, Luke B. Hesson, Robyn L. Ward and Caroline E. Ford
    Citation: BMC Cancer 2016 16:508
    Content type: Research article Published on:

  31. Occult invasive cervical cancer (OICC) is sometimes incidentally found in surgical specimens after a simple hysterectomy (SH). This study was aimed at identifying a subset of patients with OICC who have a favo...

    Authors: Huimin Bai, Dongyan Cao, Fang Yuan, Huilan Wang, Jie Chen, Yue Wang, Keng Shen and Zhenyu Zhang
    Citation: BMC Cancer 2016 16:507
    Content type: Research article Published on:

  32. This study was carried out to determine the prognostic significance of preoperative peripheral epithelial cell adhesion molecule- positive (EpCAM +) circulating tumor cell (CTC) and T ...

    Authors: Yan Zhou, Beili Wang, Jiong Wu, Chunyan Zhang, Yiwen Zhou, XinRong Yang, Jian Zhou, Wei Guo and Jia Fan
    Citation: BMC Cancer 2016 16:506
    Content type: Research article Published on:

  33. We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment.

    Authors: Young Ho Yun, Young Ae Kim, Jin Ah Sim, Ae Sun Shin, Yoon Jung Chang, Jongmog Lee, Moon Soo Kim, Young Mog Shim and Jae lll Zo
    Citation: BMC Cancer 2016 16:505
    Content type: Research article Published on:

  34. Platinum-based chemotherapy is emerging as the first line of treatment for castration resistant prostate cancer. Among the family of platinum (IV)-based compounds, a member known as CPA-7 inhibits the growth o...

    Authors: Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang and Xiaoyi Huang
    Citation: BMC Cancer 2016 16:504
    Content type: Research article Published on:

  35. Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality tr...

    Authors: Jens Hoeppner, Florian Lordick, Thomas Brunner, Torben Glatz, Peter Bronsert, Nadine Röthling, Claudia Schmoor, Dietmar Lorenz, Christian Ell, Ulrich T. Hopt and J. Rüdiger Siewert
    Citation: BMC Cancer 2016 16:503
    Content type: Study protocol Published on:

  36. The multifunctional β-galactoside-binding protein galectin-3 is found in many distinct subcellular compartments including the cell nucleus. Expression and distribution of galectin-3 between the cell nucleus an...

    Authors: Katharina Fritsch, Marco Mernberger, Andrea Nist, Thorsten Stiewe, Alexander Brehm and Ralf Jacob
    Citation: BMC Cancer 2016 16:502
    Content type: Research article Published on:

  37. To report the results of combined chemoradiation (CCRT) with cisplatin versus carboplatin in locally advanced cervical carcinoma.

    Authors: Ekkasit Tharavichitkul, Vicharn Lorvidhaya, Pimkhuan Kamnerdsupaphon, Vimol Sukthomya, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkoch Supawongwattana, Nantaka Pukanhaphan, Razvan Galalae and Imjai Chitapanarux
    Citation: BMC Cancer 2016 16:501
    Content type: Research article Published on:

  38. Two-thirds of U.S. adult women are overweight or obese. High body mass index (BMI) and adult weight gain are risk factors for a number of chronic diseases, including postmenopausal breast cancer. The higher po...

    Authors: Jessica A. Martinez, Pavani Chalasani, Cynthia A. Thomson, Denise Roe, Maria Altbach, Jean-Philippe Galons, Alison Stopeck, Patricia A. Thompson, Diana Evelyn Villa-Guillen and H-H. Sherry Chow
    Citation: BMC Cancer 2016 16:500
    Content type: Study protocol Published on:

  39. Patients with advanced stage non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) often experience multidimensional impairments, affecting quality of life during their course of disease. In lung...

    Authors: Joachim Wiskemann, Simone Hummler, Christina Diepold, Melanie Keil, Ulrich Abel, Karen Steindorf, Philipp Beckhove, Cornelia M. Ulrich, Martin Steins and Michael Thomas
    Citation: BMC Cancer 2016 16:499
    Content type: Study protocol Published on:

  40. The 2010 guidelines of the French National Cancer Institute (INCa) classify patients with endometrial cancer into three risk groups for lymph node invasion and recurrence on the basis of MRI and histological a...

    Authors: Noemie Body, Vincent Lavoué, Olivier De Kerdaniel, Fabrice Foucher, Sébastien Henno, Aurélie Cauchois, Bruno Laviolle, Marc Leblanc and Jean Levêque
    Citation: BMC Cancer 2016 16:498
    Content type: Research article Published on:

  41. Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of...

    Authors: N. J. O’Farrell, R. Feighery, S. L. Picardo, N. Lynam-Lennon, M. Biniecka, S. A. McGarrigle, J. J. Phelan, F. MacCarthy, D. O’Toole, E. J. Fox, N. Ravi, J. V. Reynolds and J. O’Sullivan
    Citation: BMC Cancer 2016 16:497
    Content type: Research article Published on:

  42. EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is li...

    Authors: Sonoko Atsumi, Chisato Nosaka, Hayamitsu Adachi, Tomoyuki Kimura, Yoshihiko Kobayashi, Hisashi Takada, Takumi Watanabe, Shun-ichi Ohba, Hiroyuki Inoue, Manabu Kawada, Masakatsu Shibasaki and Masabumi Shibuya
    Citation: BMC Cancer 2016 16:496
    Content type: Research article Published on:

  43. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy that exhibits distinct geographical and ethnic prevalence. Although the contemporary therapeutic approach of radio...

    Authors: Chartia Ching-Mei Cheung, Samantha Wei-Man Lun, Grace Tin-Yun Chung, Chit Chow, Carman Lo, Kwong-Wai Choy and Kwok-Wai Lo
    Citation: BMC Cancer 2016 16:495
    Content type: Research article Published on:

  44. Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases which are involved in angiogenesis, tumor invasion and metastatic formation. Up to date, the prognostic relevance of MMPs in s...

    Authors: Fee Klupp, Lena Neumann, Christoph Kahlert, Johannes Diers, Niels Halama, Clemens Franz, Thomas Schmidt, Moritz Koch, Juergen Weitz, Martin Schneider and Alexis Ulrich
    Citation: BMC Cancer 2016 16:494
    Content type: Research article Published on:

  45. Mantle cell lymphoma (MCL) is an aggressive disease with short median survival. Molecularly, MCL is defined by the t(11;14) translocation leading to overexpression of the CCND1 gene. However, recent data show tha...

    Authors: Venera Kuci Emruli, Roger Olsson, Fredrik Ek and Sara Ek
    Citation: BMC Cancer 2016 16:493
    Content type: Research article Published on:

  46. The purpose of this retrospective study was to evaluate the efficacy of incorporating trans-arterial radioembolization (TARE) with systemic chemotherapy in the treatment of liver-dominant metastatic pancreatic...

    Authors: Alexander Y. Kim, Keith Unger, Hongkun Wang and Michael J. Pishvaian
    Citation: BMC Cancer 2016 16:492
    Content type: Research article Published on:

  47. Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard care of patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC), development of acquired ...

    Authors: Ren Zhao, Shun Zhou, Bing Xia, Cui-ying Zhang, Ping Hai, Hong Zhe and Yan-yang Wang
    Citation: BMC Cancer 2016 16:491
    Content type: Research article Published on:

  48. Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression ...

    Authors: Igor Snapkov, Carl Otto Öqvist, Yngve Figenschau, Per Kogner, John Inge Johnsen and Baldur Sveinbjørnsson
    Citation: BMC Cancer 2016 16:490
    Content type: Research article Published on:

  49. Molecules Interacting with CasL (MICAL1), a multidomain flavoprotein monoxygenase, is strongly involved in the mechanisms that promote cancer cell proliferation and survival. Activation of MICAL1 causes an up-...

    Authors: Wenjie Deng, Yueyuan Wang, Luo Gu, Biao Duan, Jie Cui, Yujie Zhang, Yan Chen, Shixiu Sun, Jing Dong and Jun Du
    Citation: BMC Cancer 2016 16:489
    Content type: Research article Published on:

  50. mTOR inhibition of aromatase inhibitor (AI)-resistant breast cancer is currently under evaluation in the clinic. Everolimus/RAD001 (Afinitor®) has had limited efficacy as a solo agent but is projected to becom...

    Authors: Asona Lui, Jacob New, Joshua Ogony, Sufi Thomas and Joan Lewis-Wambi
    Citation: BMC Cancer 2016 16:487
    Content type: Research article Published on:

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