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  1. Growth hormone (GH) mainly serves an endocrine function to regulate somatic growth, but also serves an autocrine function in lung growth and pulmonary function. Several recent studies have demonstrated the rol...

    Authors: Chia-Hung Chien, Ming-Jen Lee, Houng-Chi Liou, Horng-Huei Liou and Wen-Mei Fu
    Citation: BMC Cancer 2016 16:871
    Content type: Research article Published on:

  2. Galectin-1 (gal-1) belongs to the family of β-galactoside-binding proteins which primarily recognizes the Galβ1-4GlcNAc sequences of oligosaccharides associated with several cell surface glycoconjugates. The l...

    Authors: Pamina Geiger, Barbara Mayer, Irmi Wiest, Sandra Schulze, Udo Jeschke and Tobias Weissenbacher
    Citation: BMC Cancer 2016 16:870
    Content type: Research article Published on:

  3. Osteosarcoma (OS), which has a high potential for developing metastatic disease, is the most frequent malignant bone tumor in children and adolescents. Molecular analysis of a metastatic genetically engineered...

    Authors: Piti Techavichit, Yang Gao, Lyazat Kurenbekova, Ryan Shuck, Lawrence A. Donehower and Jason T. Yustein
    Citation: BMC Cancer 2016 16:869
    Content type: Research article Published on:

  4. Evaluate the anti-tumor activity of ozonide antimalarials using a chemoresistant neuroblastoma cell line, BE (2)-c.

    Authors: Don W. Coulter, Timothy R. McGuire, John G. Sharp, Erin M. McIntyre, Yuxiang Dong, Xiaofang Wang, Shawn Gray, Gracey R. Alexander, Nagendra K. Chatuverdi, Shantaram S. Joshi, Xiaoyu Chen and Jonathan L. Vennerstrom
    Citation: BMC Cancer 2016 16:867
    Content type: Research article Published on:

  5. Women living with HIV (WLWH) are at increased risk of persistent human papillomavirus (HPV) infection, cervical dysplasia and cervical cancer compared with women from the general population (WGP). We assessed ...

    Authors: Kristina Thorsteinsson, Merete Storgaard, Terese L. Katzenstein, Steen Ladelund, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lailoma Hashemi, Lars Nørregård Nielsen, Lisbeth Nilas, Niels Obel, Jesper Bonde and Anne-Mette Lebech
    Citation: BMC Cancer 2016 16:866
    Content type: Research article Published on:

  6. Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR...

    Authors: Nan Zhou, Chen Chu, Xin Dou, Ming Li, Song Liu, Lijing Zhu, Baorui Liu, Tingting Guo, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang and Tian Liu
    Citation: BMC Cancer 2016 16:865
    Content type: Research article Published on:

  7. The majority of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation eventually develop resistance to EGFR tyrosine kinase inhibitors (TKIs). Minimal information exist...

    Authors: Ryo Ko, Hirotsugu Kenmotsu, Masakuni Serizawa, Yasuhiro Koh, Kazushige Wakuda, Akira Ono, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Mitsuhiro Isaka, Masahiro Endo, Takashi Nakajima, Yasuhisa Ohde, Nobuyuki Yamamoto, Kazuhisa Takahashi and Toshiaki Takahashi
    Citation: BMC Cancer 2016 16:864
    Content type: Research article Published on:

  8. Tumor suppressive let-7 miRNAs are universally down-regulated in human hepatocellular carcinoma (HCC) versus normal tissues; however, the roles and related molecular mechanisms of let-7 in HCC stem cells are p...

    Authors: Bin Jin, Wei Wang, Xiang-xin Meng, Gang Du, Jia Li, Shi-zhe Zhang, Bing-hai Zhou and Zhi-hao Fu
    Citation: BMC Cancer 2016 16:863
    Content type: Research article Published on:

  9. In a large number of patients with multiple gastrointestinal adenomatous polyps, no causal germline mutation can be found. Non-genetic factors may contribute to the development of adenomatous polyps in these u...

    Authors: Lisanne Sara Rigter, Frank G. J. Kallenberg, Barbara Bastiaansen, Theo A. M. van Os, Floor E. van Leeuwen, Monique Esther van Leerdam and Evelien Dekker
    Citation: BMC Cancer 2016 16:862
    Content type: Case report Published on:

  10. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic c...

    Authors: Abram Bunya Kamiza, Fu-Hsiung Su, Wen-Chang Wang, Fung-Chang Sung, Shih-Ni Chang and Chih-Ching Yeh
    Citation: BMC Cancer 2016 16:861
    Content type: Research article Published on:

  11. Boron neutron capture therapy (BNCT) is a cellular-level particle radiation therapy that combines the selective delivery of boron compounds to tumour tissue with neutron irradiation. L-p-Boronophenylalanine (L-BP...

    Authors: Tsubasa Watanabe, Yoshihide Hattori, Youichiro Ohta, Miki Ishimura, Yosuke Nakagawa, Yu Sanada, Hiroki Tanaka, Satoshi Fukutani, Shin-ichiro Masunaga, Masahiro Hiraoka, Koji Ono, Minoru Suzuki and Mitsunori Kirihata
    Citation: BMC Cancer 2016 16:859
    Content type: Research article Published on:

  12. There are clinical situations (CS) in which the use of somatostatin analogs (SSAs) in patients with neuroendocrine tumors (NET) is controversial due to lack of evidence. A Delphi study was conducted to develop...

    Authors: Isabel Sevilla, Ángel Segura, Jaume Capdevila, Carlos López, Rocío García-Carbonero and Enrique Grande
    Citation: BMC Cancer 2016 16:858
    Content type: Research article Published on:

  13. Vorinostat, a histone deacetylase (HDAC) inhibitor, is a promising agent for cancer therapy. Combining vorinostat with cisplatin may relax the chromatin structure and facilitate the accessibility of cisplatin,...

    Authors: Chun-Hao Pan, Ying-Fang Chang, Ming-Shuo Lee, B-Chen Wen, Jen-Chung Ko, Sheng-Kai Liang and Mei-Chih Liang
    Citation: BMC Cancer 2016 16:857
    Content type: Research article Published on:

  14. Approximately 20 % of hepatocellular carcinoma (HCC) patients diagnosed in the early stages may benefit from potentially curative ablative therapies such as surgical resection, transplantation or radiofrequenc...

    Authors: Mihir Gandhi, Su Pin Choo, Choon Hua Thng, Say Beng Tan, Albert Su Chong Low, Peng Chung Cheow, Anthony Soon Whatt Goh, Kiang Hiong Tay, Richard Hoau Gong Lo, Brian Kim Poh Goh, Jen San Wong, David Chee Eng Ng, Khee Chee Soo, Wei Ming Liew and Pierce K. H. Chow
    Citation: BMC Cancer 2016 16:856
    Content type: Study protocol Published on:

  15. Human Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce. In this study, we have ...

    Authors: Asma Shabbir, Talat Mirza, Abdullah Bin Khalid, Muhammad Asif Qureshi and Sadaf Ahmed Asim
    Citation: BMC Cancer 2016 16:855
    Content type: Research article Published on:

  16. Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression of hairy and enhancer of split 1 (Hes-1) has not been investigated yet in resected specimens of CC. Notch signaling...

    Authors: Shuichi Aoki, Masamichi Mizuma, Yayoi Takahashi, Yoichi Haji, Ryo Okada, Tomoya Abe, Hideaki Karasawa, Keiichi Tamai, Takaho Okada, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose and Michiaki Unno
    Citation: BMC Cancer 2016 16:854
    Content type: Research article Published on:

  17. Emerging evidences proposed that microRNAs are associated with regulation of distinct physio-pathological processes including development of normal stem cells and carcinogenesis. In this study we aimed to inve...

    Authors: Omer Faruk Karatas, Ilknur Suer, Betul Yuceturk, Mehmet Yilmaz, Buge Oz, Gulgun Guven, Harun Cansiz, Chad J. Creighton, Michael Ittmann and Mustafa Ozen
    Citation: BMC Cancer 2016 16:853
    Content type: Research article Published on:

  18. The aims of this study were to detect HPV E6/E7 mRNA expression in women with high-risk genotypes (HPV-16, -18, -31, -33 and -45) analysing its relationship with tissue pathology and 2) 2-year follow-up of E6/...

    Authors: Nerea Fontecha, Miren Basaras, Silvia Hernáez, Daniel Andía and Ramón Cisterna
    Citation: BMC Cancer 2016 16:852
    Content type: Research article Published on:

  19. NH exchangers (NHEs) play a crucial role in regulating intra/extracellular pH, which is altered in cancer cells, and are therefore suitable targets to alter cancer cell metabolism in order to inhibit cell surv...

    Authors: Francesca Aredia, Sebastian Czaplinski, Simone Fulda and A. Ivana Scovassi
    Citation: BMC Cancer 2016 16:851
    Content type: Research article Published on:

  23. Elucidating the precise properties of cancer stem cells (CSCs) is indispensable for the development of effective therapies against tumors, because CSCs are key drivers of tumor development, metastasis and rela...

    Authors: Yoshitaka Murota, Kouichi Tabu and Tetsuya Taga
    Citation: BMC Cancer 2016 16:847
    Content type: Research article Published on:

  25. The purpose of this study is to review our results for pancreatic resection in patients with intraductal papillary mucinous neoplasm (IPMN) with and without associated carcinoma.

    Authors: Katharina Marsoner, Johannes Haybaeck, Dora Csengeri, James Elvis Waha, Jakob Schagerl, Rainer Langeder, Hans Joerg Mischinger and Peter Kornprat
    Citation: BMC Cancer 2016 16:844
    Content type: Research article Published on:

  26. The aim was to develop and evaluate a training program for physicians for communicating with breast cancer patients about complementary medicine (CM).

    Authors: Susanne Blödt, Nadine Mittring, Lena Schützler, Felix Fischer, Christine Holmberg, Markus Horneber, Adele Stapf and Claudia M. Witt
    Citation: BMC Cancer 2016 16:843
    Content type: Research article Published on:

  27. Gliomas are the most common primary brain tumors in adults and invariably carry a poor prognosis. Recent clinical studies have demonstrated the safety and compelling survival benefit when tumor treating fields...

    Authors: Jennifer Connelly, Adília Hormigo, Nimish Mohilie, Jethro Hu, Aafia Chaudhry and Nicholas Blondin
    Citation: BMC Cancer 2016 16:842
    Content type: Case report Published on:

  28. There are several indications that the composition of the tumor stroma can contribute to the malignancy of a tumor. Here we utilized expression data sets to identify metagenes that may serve as surrogate marke...

    Authors: Sofia Winslow, Kajsa Ericson Lindquist, Anders Edsjö and Christer Larsson
    Citation: BMC Cancer 2016 16:841
    Content type: Research article Published on:

  29. High-risk human papillomaviruses (HPVs) are strongly associated with the development of some malignancies. The E6 and E7 viral oncoproteins are the primary proteins responsible for cell homeostasis alteration ...

    Authors: Bruna Stuqui, André Luis Giacometti Conceição, Lara Termini, Laura Sichero, Luisa Lina Villa, Paula Rahal and Marília de Freitas Calmon
    Citation: BMC Cancer 2016 16:840
    Content type: Research article Published on:

  30. Pelvic inflammatory disease (PID) is characterized by infection and inflammation of the upper genital tract in women and is associated with health sequelae. We used a nationwide population-based retrospective ...

    Authors: Cheng-Che Shen, Li-Yu Hu, Albert C. Yang, Yung-Yen Chiang, Jeng-Hsiu Hung and Shih-Jen Tsai
    Citation: BMC Cancer 2016 16:839
    Content type: Research article Published on:

  31. Being diagnosed with cancer causes major psychological distress, yet the majority of newly diagnosed cancer patients lack psychological support. Internet interventions overcome many barriers for seeking face-t...

    Authors: Astrid Grossert, Corinne Urech, Judith Alder, Jens Gaab, Thomas Berger and Viviane Hess
    Citation: BMC Cancer 2016 16:838
    Content type: Study protocol Published on:

  32. Bladder cancer is a very heterogeneous disease as regards natural history. Environmental exposures, constitutional genetic and/or epigenetic background may affect not only the likelihood of bladder tumor occur...

    Authors: Simone Benhamou, Julia Bonastre, Karine Groussard, François Radvanyi, Yves Allory and Thierry Lebret
    Citation: BMC Cancer 2016 16:837
    Content type: Study protocol Published on:

  33. Previous studies have disclosed that serum amyloid A (SAA) is likely involved in the lung cancer pathogenesis and progression. We performed a systematic evaluation and meta-analysis to disclose the correlation...

    Authors: Rong Biaoxue, Liu Hua, Gao Wenlong and Yang Shuanying
    Citation: BMC Cancer 2016 16:836
    Content type: Research article Published on:

  34. The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to no...

    Authors: Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm and Berit Andersen
    Citation: BMC Cancer 2016 16:835
    Content type: Study protocol Published on:

  35. The survival following transarterial chemoembolization (TACE) alone is still low in unresectable hepatocellular carcinoma (HCC) with almost patients developing disease progression after treatment. There is nee...

    Authors: Ting-Shi Su, Huan-Zhen Lu, Tao Cheng, Ying Zhou, Yong Huang, Ying-Chuan Gao, Min-Yang Tang, Hua-Yan Jiang, Zu-Ping Lian, En-Cun Hou and Ping Liang
    Citation: BMC Cancer 2016 16:834
    Content type: Research article Published on:

  36. To investigate whether very low mammographic breast density (VLD), HER2, and hormone receptor status holds any prognostic significance within the different prognostic categories of the widely used Nottingham P...

    Authors: Amro Masarwah, Päivi Auvinen, Mazen Sudah, Vaiva Dabravolskaite, Otso Arponen, Anna Sutela, Sanna Oikari, Veli-Matti Kosma and Ritva Vanninen
    Citation: BMC Cancer 2016 16:833
    Content type: Research article Published on:

  37. Intake of red meat is considered a risk factor for colorectal cancer (CRC) development, and heme, the prosthetic group of myoglobin, has been suggested as a potential cause. One of the proposed molecular mecha...

    Authors: Christina Steppeler, Marianne Sødring and Jan Erik Paulsen
    Citation: BMC Cancer 2016 16:832
    Content type: Research article Published on:

  38. Although brucea javanica oil liposomes (BJOLs) have been used clinically to treat ovarian cancer, its clinical efficacy is often limited by systemic side effects due to non-specific distribution. Luteinizing h...

    Authors: Hongxia Ye, Xiaojuan Liu, Jiangchuan Sun, Shenyin Zhu, Yi Zhu and Shufang Chang
    Citation: BMC Cancer 2016 16:831
    Content type: Research article Published on:

  39. Obesity, physical inactivity and poor diet quality have been associated with increased risk of breast cancer-specific and all-cause mortality as well as treatment-related side-effects in breast cancer survivor...

    Authors: Marina M. Reeves, Caroline O. Terranova, Jane M. Erickson, Jennifer R. Job, Denise S. K. Brookes, Nicole McCarthy, Ingrid J. Hickman, Sheleigh P. Lawler, Brianna S. Fjeldsoe, Genevieve N. Healy, Elisabeth A. H. Winkler, Monika Janda, J. Lennert Veerman, Robert S. Ware, Johannes B. Prins, Theo Vos…
    Citation: BMC Cancer 2016 16:830
    Content type: Study protocol Published on:

  40. MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling...

    Authors: J. Gomez-Millan, B. Pajares, L. Perez-Villa, A. Carnero, M. Alvarez, V. De Luque, F. Rivas, J. M. Trigo, M. D. Toledo, E. Alba and J. A. Medina
    Citation: BMC Cancer 2016 16:829
    Content type: Research article Published on:

  41. Human epidermal growth factor receptor (HER)-2 is a driver gene in non-small cell lung cancer (NSCLC). The present study evaluated the mutation rate of HER-2 within the wild-type epidermal growth factor receptor ...

    Authors: Xuefei Li, Chao Zhao, Chunxia Su, Shengxiang Ren, Xiaoxia Chen and Caicun Zhou
    Citation: BMC Cancer 2016 16:828
    Content type: Research article Published on:

  42. Myoepithelial carcinoma (MEC) is a rare salivary gland tumor. Its long-term prognosis remains unknown because of the paucity of reported cases with long-term follow-up. Although some case series exist, the cli...

    Authors: Takahiro Wakasaki, Marie Kubota, Yutaka Nakashima, Eri Tomonobe, Takenao Mihara and Junichi Fukushima
    Citation: BMC Cancer 2016 16:827
    Content type: Case report Published on:

  43. Treatment options for patients with metastatic colorectal cancer (mCRC) include anti-epithelial growth factor therapies, which, in Europe, are indicated in patients with RAS wild-type tumours only and require pri...

    Authors: Annemarie Boleij, Véronique Tack, Aliki Taylor, George Kafatos, Sophie Jenkins-Anderson, Lien Tembuyser, Els Dequeker and J. Han van Krieken
    Citation: BMC Cancer 2016 16:825
    Content type: Research article Published on:

  44. Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent inducer of autophagy and its expression results in necro...

    Authors: Argentina Ornelas, Christopher R. McCullough, Zhen Lu, Niki M. Zacharias, Lindsay E. Kelderhouse, Joshua Gray, Hailing Yang, Brian J. Engel, Yan Wang, Weiqun Mao, Margie N. Sutton, Pratip K. Bhattacharya, Robert C. Bast Jr. and Steven W. Millward
    Citation: BMC Cancer 2016 16:824
    Content type: Research article Published on:

  45. Pancreatic adenocarcinoma (PDAC) incidence is increasing worldwide. Several studies have shown that lymphopenia was correlated with a poor prognosis but the potential interest to measure lymphopenia in the pre...

    Authors: Christelle d’Engremont, Dewi Vernerey, Anne-Laure Pointet, Gaël Simone, Francine Fein, Bruno Heyd, Stéphane Koch, Lucine Vuitton, Stefano Kim, Marine Jary, Najib Lamfichek, Celia Turco, Zaher Lakkis, Anne Berger, Franck Bonnetain, Julien Taieb…
    Citation: BMC Cancer 2016 16:823
    Content type: Research article Published on:

  46. Endometrial cancer is the most common cancer of the female reproductive tract.

    Authors: Anna Torres, Joanna Kozak, Agnieszka Korolczuk, Paulina Wdowiak, Ewa Domańska-Glonek, Ryszard Maciejewski and Kamil Torres
    Citation: BMC Cancer 2016 16:822
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:939

  48. CancerMath is a set of web-based prognostic tools which predict nodal status and survival up to 15 years after diagnosis of breast cancer. This study validated its performance in a Southeast Asian setting.

    Authors: Hui Miao, Mikael Hartman, Helena M. Verkooijen, Nur Aishah Taib, Hoong-Seam Wong, Shridevi Subramaniam, Cheng-Har Yip, Ern-Yu Tan, Patrick Chan, Soo-Chin Lee and Nirmala Bhoo-Pathy
    Citation: BMC Cancer 2016 16:820
    Content type: Research article Published on:

  49. Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as eff...

    Authors: Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan, Da-liu Min and Hai-yan Hu
    Citation: BMC Cancer 2016 16:818
    Content type: Research article Published on:

  50. The phase 3 MPACT trial in patients with metastatic pancreatic cancer demonstrated superior efficacy of nab-paclitaxel (nab-P) + gemcitabine (Gem) vs Gem monotherapy for all endpoints examined including overall s...

    Authors: Arndt Vogel, Josefine Römmler-Zehrer, Jack Shiansong Li, Desmond McGovern, Alfredo Romano and Michael Stahl
    Citation: BMC Cancer 2016 16:817
    Content type: Research article Published on:

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