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  1. Considerable variation exists in diagnostic tests used for local response evaluation after chemoradiation in patients with advanced oropharyngeal cancer. The yield of invasive examination under general anesthe...

    Authors: Marjolein JE Greuter, Charlotte S Schouten, Jonas A Castelijns, Pim de Graaf, Emile FI Comans, Otto S Hoekstra, Remco de Bree and Veerle MH Coupé
    Citation: BMC Cancer 2017 17:256
    Content type: Research article Published on:

  2. Metastasis is the leading cause of death in breast cancer patients. CD73, also known as ecto-5′-nucleotidase, plays a critical role in cancer development including metastasis. The existing researches indicate ...

    Authors: Xu Yang, Shimin Pei, Huanan Wang, Yipeng Jin, Fang Yu, Bin Zhou, Hong Zhang, Di Zhang and Degui Lin
    Citation: BMC Cancer 2017 17:255
    Content type: Research article Published on:

  4. Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improv...

    Authors: Bernard Lelong, Cécile de Chaisemartin, Helene Meillat, Sandra Cournier, Jean Marie Boher, Dominique Genre, Mehdi Karoui, Jean Jacques Tuech and Jean Robert Delpero
    Citation: BMC Cancer 2017 17:253
    Content type: Study protocol Published on:

  6. Right sided colon cancer (RsCC) is proposed to be a distinct disease entity to left sided colon cancer (LsCC). We seek to confirm primary tumour location as an independent prognostic factor in locoregional col...

    Authors: Daniel Brungs, Morteza Aghmesheh, Paul de Souza, Weng Ng, Wei Chua, Martin Carolan, Philip Clingan, Emma Healey, June Rose, Tameika Tubaro and Marie Ranson
    Citation: BMC Cancer 2017 17:251
    Content type: Research article Published on:

  7. Myoepithelial carcinoma of soft tissue is a rare, malignant neoplasm that is morphologically and immunophenotypically similar to its counterpart in salivary gland. It demonstrates myoepithelial differentiation...

    Authors: Timothy M. Hoggard, Evita Henderson-Jackson, Marilyn M. Bui, Jamie Caracciolo, Jamie K. Teer, Sean Yoder, Odion Binitie, Ricardo J. Gonzalez, Andrew S. Brohl and Damon R. Reed
    Citation: BMC Cancer 2017 17:250
    Content type: Case report Published on:

  8. Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify...

    Authors: Tristan Lerbs, Savita Bisht, Sebastian Schölch, Mathieu Pecqueux, Glen Kristiansen, Martin Schneider, Bianca T. Hofmann, Thilo Welsch, Christoph Reissfelder, Nuh N. Rahbari, Johannes Fritzmann, Peter Brossart, Jürgen Weitz, Georg Feldmann and Christoph Kahlert
    Citation: BMC Cancer 2017 17:249
    Content type: Research article Published on:

  9. Tumor metastasis often occurs in hepatocellular carcinoma (HCC) and influences the patient’s prognosis, and microRNAs are reported to play key roles in tumor metastasis. This study was conducted to explore the...

    Authors: Shuzhen Chang, Binhe Chen, Xiaoyan Wang, Keqin Wu and Yuqiu Sun
    Citation: BMC Cancer 2017 17:248
    Content type: Research article Published on:

  10. UroVysion fluorescence in situ hybridization (uFISH) was reported to have superior sensitivity to urine cytology. However uFISH studies are limited by varying definitions of what is considered a positive resul...

    Authors: Hugh J. Lavery, Boriana Zaharieva, Andrew McFaddin, Nyla Heerema and Kamal S. Pohar
    Citation: BMC Cancer 2017 17:247
    Content type: Research article Published on:

  11. The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in...

    Authors: Jennifer C Melvin, Hans Garmo, Lars Holmberg, Niklas Hammar, Göran Walldius, Ingmar Jungner, Mats Lambe and Mieke Van Hemelrijck
    Citation: BMC Cancer 2017 17:246
    Content type: Research article Published on:

  12. Central nervous system (CNS) brain metastasis of advanced non-small cell lung cancer (NSCLC) patients confers a worse quality of life and prognosis. The efficacy comparison of two first-generation epidermal gr...

    Authors: Meng-Xia Li, Hao He, Zhi-Hua Ruan, Yu-Xi Zhu, Rong-Qing Li, Xiao He, Bao-Hua Lan, Zhi-Min Zhang, Guo-Dong Liu, Hua-Liang Xiao, Yan Wu, Bo Zhu, Ge Wang and Zhen-Zhou Yang
    Citation: BMC Cancer 2017 17:245
    Content type: Research article Published on:

  14. The aim of this study was to evaluate the efficacy and safety of CapeOX plus bevacizumab with a planned oxaliplatin stop-and-go strategy in Japanese patients with metastatic colorectal cancer (mCRC).

    Authors: Goro Nakayama, Kiyoshi Ishigure, Hiroyuki Yokoyama, Keisuke Uehara, Hiroshi Kojima, Akiharu Ishiyama, Naomi Hayashi, Nao Takano, Norifumi Hattori, Daisuke Kobayashi, Chie Tanaka, Masamichi Hayashi, Mitsuro Kanda, Suguru Yamada, Hiroyuki Sugimoto, Masahiko Koike…
    Citation: BMC Cancer 2017 17:243
    Content type: Research article Published on:

  15. The occurrence of Chemotherapy-induced neutropenia (CIN) was reported to be a predictor of better survival in several cancers. The objective of our study is to evaluate the relationship between the timing of C...

    Authors: Yang Chen, YanRong Wang, Yan Shi and GuangHai Dai
    Citation: BMC Cancer 2017 17:242
    Content type: Research article Published on:

  16. Triple negative breast cancer (TNBC) is a heterogeneous disease that lacks unifying molecular alterations that can guide therapy decisions. We previously identified distinct molecular subtypes of TNBC (TNBCtyp...

    Authors: Bojana Jovanović, Quanhu Sheng, Robert S. Seitz, Kasey D. Lawrence, Stephan W. Morris, Lance R. Thomas, David R. Hout, Brock L. Schweitzer, Yan Guo, Jennifer A. Pietenpol and Brian D. Lehmann
    Citation: BMC Cancer 2017 17:241
    Content type: Research article Published on:

  17. Transforming growth factor-beta (TGF-β) is associated with a higher incidence of distant metastasis and decreased survival. Whether TGF-β can be used as a prognostic indicator of colorectal cancer (CRC) remain...

    Authors: Xin-lin Chen, Zhuo-qun Chen, Shui-lian Zhu, Tian-wen Liu, Yi Wen, Yi-sheng Su, Xu-jie Xi, Yue Hu, Lei Lian and Feng-bin Liu
    Citation: BMC Cancer 2017 17:240
    Content type: Research article Published on:

  18. The defects in DNA repair genes are potentially linked to development and response to therapy in medulloblastoma. Therefore the purpose of this study was to establish the spectrum and frequency of germline varian...

    Authors: Joanna Trubicka, Tomasz Żemojtel, Jochen Hecht, Katarzyna Falana, Dorota Piekutowska- Abramczuk, Rafał Płoski, Marta Perek-Polnik, Monika Drogosiewicz, Wiesława Grajkowska, Elżbieta Ciara, Elżbieta Moszczyńska, Bożenna Dembowska-Bagińska, Danuta Perek, Krystyna H. Chrzanowska, Małgorzata Krajewska-Walasek and Maria Łastowska
    Citation: BMC Cancer 2017 17:239
    Content type: Research article Published on:

  19. A new staging system recently proposed by the IGCA has demonstrated a better capacity of stratifying different prognoses for gastric cancer than the 7th edition AJCC staging system (AJCC7). The aim of this stu...

    Authors: Ping Shu, Jing Qin, Kuntang Shen, Weidong Chen, Fenglin Liu, Yong Fang, Xuefei Wang, Hongshan Wang, Zhenbin Shen, Yihong Sun and Xinyu Qin
    Citation: BMC Cancer 2017 17:238
    Content type: Research article Published on:

  20. Although the significance of preoperative nutritional status has been investigated, there is no report regarding the relationship of their postoperative changes on outcomes in patients who underwent radical cy...

    Authors: Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Keiji Shimada, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka and Kiyohide Fujimoto
    Citation: BMC Cancer 2017 17:237
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:353

  21. Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the Merkel cell polyomavirus infection. Many mutational studies on MCC have been carried out in recent ye...

    Authors: Tuukka Veija, Virve Koljonen, Tom Bohling, Mia Kero, Sakari Knuutila and Virinder Kaur Sarhadi
    Citation: BMC Cancer 2017 17:236
    Content type: Research article Published on:

  22. Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an att...

    Authors: C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa and Kanchugarakoppal S. Rangappa
    Citation: BMC Cancer 2017 17:235
    Content type: Research article Published on:

  23. Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device “TAXIScan” was developed, which provides considerably...

    Authors: Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Masumi Itadani, Naoko Okada, Kayoko Kobiki, Masafumi Nakamura, Yoshiyuki Yamaguchi and Futoshi Kuribayashi
    Citation: BMC Cancer 2017 17:234
    Content type: Research article Published on:

  24. Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo st...

    Authors: Marcus W. Stepp, Mark A. Doll, David J. Samuelson, Mary Ann G. Sanders, J. Christopher States and David W. Hein
    Citation: BMC Cancer 2017 17:233
    Content type: Research article Published on:

  25. Clinical efficacy of the mTOR inhibitor everolimus is limited in breast cancer and regularly leads to side-effects including hyperglycemia. The AMPK inhibitor and anti-diabetic drug metformin may counteract ev...

    Authors: Gerke Ariaans, Mathilde Jalving, Emma Geertruida Elisabeth de Vries and Steven de Jong
    Citation: BMC Cancer 2017 17:232
    Content type: Research article Published on:

  26. Unexpected differences in Ki-67 values among HER2 & ER/PgR defined subgroups were found. This study aims to detect possible subdivisions beyond the conventional breast cancer types.

    Authors: Sven Kurbel, Branko Dmitrović, Ksenija Marjanović, Damir Vrbanec and Antonije Juretić
    Citation: BMC Cancer 2017 17:231
    Content type: Research article Published on:

  27. Cervical squamous cell carcinoma (CSCC) is the most frequent type among cervical cancers. Although the altered miRNA miR-30d expression and the amplified chromosome locus of MIR30D, 8q24, have been reported in...

    Authors: You Zhou, Yinghua Hao, Yuxia Li, Ruizhen Li, Ruifang Wu, Shubin Wang and Zhengyu Fang
    Citation: BMC Cancer 2017 17:230
    Content type: Research article Published on:

  28. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies today with an urgent need for novel therapeutic strategies. Biomarker analysis helps to better understand tumor biology and might ...

    Authors: Felix C. Popp, Marie Christine Popp, Yue Zhao, Christopher Betzler, Siegfried Kropf, Benjamin Garlipp, Christoph Benckert, Thomas Kalinski, Hans Lippert and Christiane J. Bruns
    Citation: BMC Cancer 2017 17:229
    Content type: Study protocol Published on:

  29. Aberrant DNA methylation profiles are a characteristic of all known cancer types, epitomized by the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). Hypermethylation has been observed at CpG ...

    Authors: Tyler McInnes, Donghui Zou, Dasari S. Rao, Francesca M. Munro, Vicky L. Phillips, John L. McCall, Michael A. Black, Anthony E. Reeve and Parry J. Guilford
    Citation: BMC Cancer 2017 17:228
    Content type: Research article Published on:

  30. Negative lymph node (NLN) count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer (RC). Since preoperative radiotherapy (Pre-RT) can signif...

    Authors: Xinxing Li, Hao Lu, Kai Xu, Haolu Wang, Xiaowen Liang and Zhiqian Hu
    Citation: BMC Cancer 2017 17:227
    Content type: Research article Published on:

  31. BMI has been suggested to impact on estrogenic activity in patients receiving anastrozole resulting in a reduced treatment efficacy in obese women. Current evidence in this regard is controversially discussed....

    Authors: A. Oberguggenberger, V. Meraner, M. Sztankay, B. Beer, G. Weigel, H. Oberacher, G. Kemmler, T. Czech, B. Holzner, L. Wildt, B. Sperner-Unterweger, M. Daniaux and M. Hubalek
    Citation: BMC Cancer 2017 17:226
    Content type: Research article Published on:

  32. Follicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid m...

    Authors: Varun V. Varadarajan, Elizabeth K. Pace, Vatsal Patel, Raja Sawhney, Robert J. Amdur and Peter T. Dziegielewski
    Citation: BMC Cancer 2017 17:225
    Content type: Case report Published on:

  34. Case management has been shown to be beneficial in phases of cancer screening and treatment. After treatment is completed, patients experience a loss of support due to reduced contact with medical professional...

    Authors: Nathalie Scherz, Irène Bachmann-Mettler, Corinne Chmiel, Oliver Senn, Nathalie Boss, Katarina Bardheci and Thomas Rosemann
    Citation: BMC Cancer 2017 17:223
    Content type: Research article Published on:

  35. ATP-binding cassette sub-family G member 2 (ABCG2) is a semi-transport protein that plays a major role in multidrug resistance. We aimed to evaluate the prognostic significance of ABCG2 expression in patients wit...

    Authors: Haofei Wang, Fangxiu Luo, Zhe Zhu, Zhaoping Xu, Xin Huang, Renyi Ma, Hongchao He, Yu Zhu, Kun Shao and Juping Zhao
    Citation: BMC Cancer 2017 17:222
    Content type: Research article Published on:

  37. Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti...

    Authors: Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, Christophe Borg, Olivier Bouché, David Ternant, Gilles Paintaud, Thierry Lecomte and William Raoul
    Citation: BMC Cancer 2017 17:220
    Content type: Research article Published on:

  38. Tumour stem cells are considered important to promote disease progression, recurrence and treatment resistance following chemotherapy in colon cancer. However, genomic analyses of colorectal cancer have mainly...

    Authors: Diana Cervantes-Madrid, Yvonne Wettergren, Peter Falk, Kent Lundholm and Annika G. Asting
    Citation: BMC Cancer 2017 17:219
    Content type: Research article Published on:

  39. Cancer-related fatigue is a common problem in persons with cancer, influencing health-related quality of life and causing a considerable challenge to society. Current evidence supports the beneficial effects o...

    Authors: Sveinung Berntsen, Neil K Aaronson, Laurien Buffart, Sussanne Börjeson, Ingrid Demmelmaier, Maria Hellbom, Pernille Hojman, Helena Igelström, Birgitta Johansson, Ronnie Pingel, Truls Raastad, Galina Velikova, Pernilla Åsenlöf and Karin Nordin
    Citation: BMC Cancer 2017 17:218
    Content type: Study protocol Published on:

  40. This study aimed to analyze the pattern of lymphogenous and hematogenous metastases in patients with stage IVb thymic carcinomas and identify prognostic factors for their survivals.

    Authors: Yu Yang, Xing-Wen Fan, Hong-Bing Wang, Yin Xu, Dou-Dou Li and Kai-Liang Wu
    Citation: BMC Cancer 2017 17:217
    Content type: Research article Published on:

  41. Former studies already revealed the anti-neoplastic properties of the anti-infective agent Taurolidine (TRD) against many tumor species in vitro and in vivo. Its anti-proliferative and cell death inducing capacit...

    Authors: M. Buchholz, B. Majchrzak-Stiller, S. Hahn, D. Vangala, R. W. Pfirrmann, W. Uhl, C. Braumann and A. M. Chromik
    Citation: BMC Cancer 2017 17:216
    Content type: Research article Published on:

  42. Multiple Myeloma (MM) is a B-cell malignancy in which clonal plasma cells progressively expand within the bone marrow (BM) as effect of complex interactions with extracellular matrix and a number of microenvir...

    Authors: S Ciavarella, A Laurenzana, S De Summa, B Pilato, A Chillà, R Lacalamita, C Minoia, F Margheri, A Iacobazzi, A Rana, F Merchionne, G Fibbi, M Del Rosso, A Guarini, S Tommasi and S Serratì
    Citation: BMC Cancer 2017 17:215
    Content type: Research article Published on:

  43. A high incidence of severe hematological adverse events during sunitinib treatment complicates decision making on dose and treatment cycle. We identified the characteristics of early-onset hematotoxicity of su...

    Authors: Renpei Kato, Yoichiro Kato, Tomohiko Matsuura, Mitsugu Kanehira, Ryo Takata and Wataru Obara
    Citation: BMC Cancer 2017 17:214
    Content type: Research article Published on:

  44. Accurate prognosticating is needed when patients are nearing the end of life to ensure appropriate treatment decisions, and facilitate palliative care provision and transitioning to terminal care. People with ...

    Authors: Elise Button, Raymond Javan Chan, Shirley Chambers, Jason Butler and Patsy Yates
    Citation: BMC Cancer 2017 17:213
    Content type: Research article Published on:

  45. We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker.

    Authors: Guntulu Ak, Yuji Tada, Hideaki Shimada, Selma Metintas, Masaaki Ito, Kenzo Hiroshima, Masatoshi Tagawa and Muzaffer Metintas
    Citation: BMC Cancer 2017 17:212
    Content type: Research article Published on:

  46. We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy (#NCT02449538).

    Authors: Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang and Ho Yeong Lim
    Citation: BMC Cancer 2017 17:211
    Content type: Research article Published on:

  47. Accurate measurement of tumor burden in breast cancer disease is essential to improve the clinical management of patients. In this study, we evaluate whether the fluctuations in the fraction of PIK3CA mutant a...

    Authors: José Angel García-Saenz, Patricia Ayllón, Marion Laig, Daniel Acosta-Eyzaguirre, Marta García-Esquinas, Myriam Montes, Julián Sanz, Miguel Barquín, Fernando Moreno, Vanesa Garcia-Barberan, Eduardo Díaz-Rubio, Trinidad Caldes and Atocha Romero
    Citation: BMC Cancer 2017 17:210
    Content type: Research article Published on:

  48. In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called ‘elective dose’ in order to achieve control of clinically occult metastases....

    Authors: Sven van den Bosch, Tim Dijkema, Martina C. Kunze-Busch, Chris H. J. Terhaard, Cornelis P. J. Raaijmakers, Patricia A. H. Doornaert, Frank J. P. Hoebers, Marije R. Vergeer, Bas Kreike, Oda B. Wijers, Wim J. G. Oyen and Johannes H. A. M. Kaanders
    Citation: BMC Cancer 2017 17:208
    Content type: Study protocol Published on:

  49. Although meningioma is a common disease, there is a lack of understanding of the underlying molecular mechanisms behind its initiation and progression. We used combined miRNA-mRNA transcriptome analysis to dis...

    Authors: Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, Aysegul Kuskucu, Cumhur Kaan Yaltirik, Oguz Ozturk, Ugur Ture and Omer Faruk Bayrak
    Citation: BMC Cancer 2017 17:207
    Content type: Research article Published on:

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