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  1. The metastatic disease rather than the primary tumor itself is responsible for death in most solid tumors, including breast cancer. The role of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMP...

    Authors: Rita CS Figueira, Luciana R Gomes, João S Neto, Fabricio C Silva, Ismael DCG Silva and Mari C Sogayar
    Citation: BMC Cancer 2009 9:20
    Content type: Research article Published on:

  2. Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation indu...

    Authors: Michelle S Cotroneo, Jill D Haag, Nicholas R Stapel, Jordy L Waller, Stephan Woditschka and Michael N Gould
    Citation: BMC Cancer 2009 9:19
    Content type: Research article Published on:

  3. Ewing sarcoma family of tumors (ESFT), characterized by t(11;22)(q24;q12), is one of the most common tumors of bone in children and young adults. In addition to EWS/FLI1 gene fusion, copy number changes are known...

    Authors: Suvi Savola, Arto Klami, Abhishek Tripathi, Tarja Niini, Massimo Serra, Piero Picci, Samuel Kaski, Diana Zambelli, Katia Scotlandi and Sakari Knuutila
    Citation: BMC Cancer 2009 9:17
    Content type: Research article Published on:

  4. Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary r...

    Authors: Chen-yu Liu, Yi-Hsiang Hsu, Ming-Tsang Wu, Pi-Chen Pan, Chi-Kung Ho, Li Su, Xin Xu, Yi Li and David C Christiani
    Citation: BMC Cancer 2009 9:15
    Content type: Research article Published on:

  5. We explored the heterogeneity of philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL) in a study of the effect of early features on prognosis in children. Here we report the long-term result...

    Authors: Virginie Gandemer, Marie-Francoise Auclerc, Yves Perel, Jean-Pierre Vannier, Edouard Le Gall, Francois Demeocq, Claudine Schmitt, Christophe Piguet, Jean-Louis Stephan, Odile Lejars, Marianne Debre, Philippe Jonveaux, Jean-Michel Cayuela, Sylvie Chevret, Guy Leverger and Andre Baruchel
    Citation: BMC Cancer 2009 9:14
    Content type: Study protocol Published on:

  6. It has been suggested that the single nucleotide polymorphism 309 (SNP309, T -> G) in the promoter region of the MDM2 gene is important for tumor development; however, with regards to breast cancer, inconsiste...

    Authors: Ying-Fang Sun, Jyh-Der Leu, Su-Mei Chen, I-Feng Lin and Yi-Jang Lee
    Citation: BMC Cancer 2009 9:13
    Content type: Research article Published on:

  7. Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, pr...

    Authors: Sanjay Sachdev, Yahao Bu and Irwin H Gelman
    Citation: BMC Cancer 2009 9:12
    Content type: Research article Published on:

  8. The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling.

    Authors: Cherry L Estilo, Pornchai O-charoenrat, Simon Talbot, Nicholas D Socci, Diane L Carlson, Ronald Ghossein, Tijaana Williams, Yoshihiro Yonekawa, Yegnanarayana Ramanathan, Jay O Boyle, Dennis H Kraus, Snehal Patel, Ashok R Shaha, Richard J Wong, Joseph M Huryn, Jatin P Shah…
    Citation: BMC Cancer 2009 9:11
    Content type: Research article Published on:

  9. With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulati...

    Authors: André O von Bueren, Tarek Shalaby, Christoph Oehler-Jänne, Lucia Arnold, Duncan Stearns, Charles G Eberhart, Alexandre Arcaro, Martin Pruschy and Michael A Grotzer
    Citation: BMC Cancer 2009 9:10
    Content type: Research article Published on:

  10. p75NTR has been used to isolate esophageal and corneal epithelial stem cells. In the present study, we investigated the expression of p75NTR in esophageal squamous cell carcinoma (ESCC) and explored the biologica...

    Authors: Sheng-Dong Huang, Yang Yuan, Xiao-Hong Liu, De-Jun Gong, Chen-Guang Bai, Feng Wang, Jun-Hui Luo and Zhi-Yun Xu
    Citation: BMC Cancer 2009 9:9
    Content type: Research article Published on:

  11. YKL-40 (chitinase-3-like-1) is a member of "mammalian chitinase-like proteins". The protein is expressed in many types of cancer cells and the highest plasma YKL-40 levels have been found in patients with meta...

    Authors: Estrid VS Høgdall, Merete Ringsholt, Claus K Høgdall, Ib Jarle Christensen, Julia S Johansen, Susanne K Kjaer, Jan Blaakaer, Lene Ostenfeld-Møller, Paul A Price and Lise H Christensen
    Citation: BMC Cancer 2009 9:8
    Content type: Research article Published on:

  13. Esophageal squamous cell carcinoma (ESCC) is the sixth most frequent neoplasia in Brazil. It is usually associated with a poor prognosis because it is often at an advanced stage when diagnosed and there is a h...

    Authors: Yukie Sato-Kuwabara, José I Neves, José HTG Fregnani, Rubens A Sallum and Fernando A Soares
    Citation: BMC Cancer 2009 9:6
    Content type: Research article Published on:

  14. We had earlier used the comparison of RAPD (Random Amplification of Polymorphic DNA) DNA fingerprinting profiles of tumor and corresponding normal DNA to identify genetic alterations in primary human glial tum...

    Authors: Kunzang Chosdol, Anjan Misra, Sachin Puri, Tapasya Srivastava, Parthaprasad Chattopadhyay, Chitra Sarkar, Ashok K Mahapatra and Subrata Sinha
    Citation: BMC Cancer 2009 9:5
    Content type: Research article Published on:

  15. Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 prote...

    Authors: Cathy B Moelans, Roel A de Weger, Chantal Ezendam and Paul J van Diest
    Citation: BMC Cancer 2009 9:4
    Content type: Research article Published on:

  17. Epithelial ovarian cancer survivors (EOCSs) frequently report multiple complaints after their treatment. The objective was to study somatic and mental morbidity in EOCSs associated with their Self- Rated Healt...

    Authors: Astrid Helene Liavaag, Anne Dørum, Sophie D Fosså, Claes Tropé and Alv A Dahl
    Citation: BMC Cancer 2009 9:2
    Content type: Research article Published on:

  18. The development of novel chemotherapeutic agents in colorectal cancer has improved survival. Following initial response to chemotherapeutic strategies many patients develop refractory disease. This poses a sig...

    Authors: Dara O Kavanagh, Gillian Chambers, Liam O' Grady, Kevin M Barry, Ronan P Waldron, Fadel Bennani, Paul W Eustace and Iqdam Tobbia
    Citation: BMC Cancer 2009 9:1
    Content type: Research article Published on:

  19. Accuracy in the diagnosis of breast cancer and classification of cancer subtypes has improved over the years with the development of well-established immunohistopathological criteria. More recently, diagnostic...

    Authors: Bala Gur-Dedeoglu, Ozlen Konu, Serkan Kir, Ahmet Rasit Ozturk, Betul Bozkurt, Gulusan Ergul and Isik G Yulug
    Citation: BMC Cancer 2008 8:396
    Content type: Research article Published on:

  20. The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dyspl...

    Authors: Jian-na Li, Chong-jin Feng, Yong-jun Lu, Hui-jun Li, Zheng Tu, Gui-qing Liao and Chun Liang
    Citation: BMC Cancer 2008 8:395
    Content type: Research article Published on:

  22. The treatment strategy usually depends on the disease state in the individual patient. However, it is difficult to estimate the disease state before treatment in many patients. The purpose of this study was to...

    Authors: Tomoko Furuya, Tetsuji Uchiyama, Atsushi Adachi, Takae Okada, Motonao Nakao, Atsunori Oga, Song-Ju Yang, Shigeto Kawauchi and Kohsuke Sasaki
    Citation: BMC Cancer 2008 8:393
    Content type: Research article Published on:

  23. SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet...

    Authors: Mehmet Ender Avci, Ozlen Konu and Tamer Yagci
    Citation: BMC Cancer 2008 8:392
    Content type: Research article Published on:

  24. Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical...

    Authors: Ilija Androic, Andrea Krämer, Ruilan Yan, Franz Rödel, Regine Gätje, Manfred Kaufmann, Klaus Strebhardt and Juping Yuan
    Citation: BMC Cancer 2008 8:391
    Content type: Research article Published on:

  25. Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are...

    Authors: Zohar A Dotan, Aviva Dotan, Jacob Ramon and Lydia Avivi
    Citation: BMC Cancer 2008 8:390
    Content type: Research article Published on:

  26. Better breast cancer prognostication may improve selection of patients for adjuvant therapy. We conducted a retrospective follow-up study in which we investigated sera of high-risk primary breast cancer patien...

    Authors: Marie-Christine W Gast, Harm van Tinteren, Marijke Bontenbal, René QGCM van Hoesel, Marianne A Nooij, Sjoerd Rodenhuis, Paul N Span, Vivianne CG Tjan-Heijnen, Elisabeth GE de Vries, Nathan Harris, Jos WR Twisk, Jan HM Schellens and Jos H Beijnen
    Citation: BMC Cancer 2008 8:389
    Content type: Research article Published on:

  27. Histone H1x is a ubiquitously expressed member of the H1 histone family. H1 histones, also called linker histones, stabilize compact, higher order structures of chromatin. In addition to their role as structur...

    Authors: Julia Warneboldt, Florian Haller, Olaf Horstmann, Bernhard C Danner, László Füzesi, Detlef Doenecke and Nicole Happel
    Citation: BMC Cancer 2008 8:388
    Content type: Research article Published on:

  28. Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, litt...

    Authors: Ryan P Theis, Suzanne M Dolwick Grieb, Deborah Burr, Tariq Siddiqui and Nabih R Asal
    Citation: BMC Cancer 2008 8:387
    Content type: Research article Published on:

  29. Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression of ERCC1 correlates with insens...

    Authors: Kazumi Uchida, Peter V Danenberg, Kathleen D Danenberg and Jean L Grem
    Citation: BMC Cancer 2008 8:386
    Content type: Research article Published on:

  30. Vitamin D serum levels have been found to be related to sun exposure and diet, together with cell differentiation, growth control and consequently, cancer risk. Vitamin D receptor (VDR) genotypes may influence ca...

    Authors: Eva Barroso, Lara P Fernandez, Roger L Milne, Guillermo Pita, Elena Sendagorta, Uxua Floristan, Marta Feito, Jose A Aviles, Manuel Martin-Gonzalez, Jose I Arias, Pilar Zamora, Monserrat Blanco, Pablo Lazaro, Javier Benitez and Gloria Ribas
    Citation: BMC Cancer 2008 8:385
    Content type: Research article Published on:

  31. Higher standardized uptake value (SUV) detected by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) correlates with proliferation of primary breast cancer. The purpose of th...

    Authors: Shigeto Ueda, Nobuo Kondoh, Hitoshi Tsuda, Souhei Yamamoto, Hideki Asakawa, Kazuhiko Fukatsu, Takayuki Kobayashi, Junji Yamamoto, Katsumi Tamura, Jiro Ishida, Yoshiyuki Abe, Mikio Yamamoto and Hidetaka Mochizuki
    Citation: BMC Cancer 2008 8:384
    Content type: Research article Published on:

  32. Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies.

    Authors: Jie Yang, Lu Wang, Zhaoli Chen, Zhi-Qiang Shen, Min Jin, Xin-Wei Wang, Yufei Zheng, Zhi-Gang Qiu, Jing-feng Wang and Jun-Wen Li
    Citation: BMC Cancer 2008 8:383
    Content type: Research article Published on:

  33. Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic ...

    Authors: Pablo Sáenz-López, Rafael Carretero, José Manuel Cózar, José Maria Romero, Julia Canton, José Ramón Vilchez, Miguel Tallada, Federico Garrido and Francisco Ruiz-Cabello
    Citation: BMC Cancer 2008 8:382
    Content type: Research article Published on:

  34. Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known funct...

    Authors: Florian R Fritzsche, Wilko Weichert, Annika Röske, Volker Gekeler, Thomas Beckers, Carsten Stephan, Klaus Jung, Katharina Scholman, Carsten Denkert, Manfred Dietel and Glen Kristiansen
    Citation: BMC Cancer 2008 8:381
    Content type: Research article Published on:

  37. Matrix metalloproteases (MMPs) constitute a family of enzymes capable of degrading different components of the extracellular matrix and are implicated in the invasion of tumor cells through the basement membra...

    Authors: Patricia González-Arriaga, M Felicitas López-Cima, Ana Fernández-Somoano, Teresa Pascual, Manuel G Marrón, Xose S Puente and Adonina Tardón
    Citation: BMC Cancer 2008 8:378
    Content type: Research article Published on:

  38. The effects of the olive oil-rich Mediterranean diet on breast cancer risk might be underestimated when HER2 (ERBB2) oncogene-positive and HER2-negative breast carcinomas are considered together. We here investig...

    Authors: Javier A Menendez, Alejandro Vazquez-Martin, Rocio Garcia-Villalba, Alegria Carrasco-Pancorbo, Cristina Oliveras-Ferraros, Alberto Fernandez-Gutierrez and Antonio Segura-Carretero
    Citation: BMC Cancer 2008 8:377
    Content type: Research article Published on:

  39. Cimetidine, a histamine type-2 receptor antagonist, has been reported to inhibit the growth of glandular tumors such as colorectal cancer, however the mechanism of action underlying this effect is unknown. Ade...

    Authors: Masakatsu Fukuda, Kaoru Kusama and Hideaki Sakashita
    Citation: BMC Cancer 2008 8:376
    Content type: Research article Published on:

  40. Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been suggested to explain the development ...

    Authors: Xianling Guo, Nannan Ma, Jin Wang, Jianrui Song, Xinxin Bu, Yue Cheng, Kai Sun, Haiyan Xiong, Guocheng Jiang, Baihe Zhang, Mengchao Wu and Lixin Wei
    Citation: BMC Cancer 2008 8:375
    Content type: Research article Published on:

  41. There is no standard palliative chemotherapy regimen in biliary tract cancers (BTC). Fluoropyrimidine or gemcitabine, with or without platinum, are most frequently used. We conducted this study to clarify the ...

    Authors: Mi-Jung Kim, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Seock-Ah Im, Tae-You Kim, Dae Seog Heo and Yung-Jue Bang
    Citation: BMC Cancer 2008 8:374
    Content type: Research article Published on:

  42. In a previous report we have demonstrated that the chymotryptic-like serine protease kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic cancer. In normal skin, hK7 is thought to participate in skin desquamati...

    Authors: Vishnu C Ramani, Leah Hennings and Randy S Haun
    Citation: BMC Cancer 2008 8:373
    Content type: Research article Published on:

  43. Chemotherapy resistance remains a major obstacle for the treatment of small cell lung cancer (SCLC). Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, plays a critical role in chemother...

    Authors: Yingyan Wang, Wei Wang, Siyan Wang, Jiarui Wang, Shujuan Shao and Qi Wang
    Citation: BMC Cancer 2008 8:372
    Content type: Research article Published on:

  44. Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinom...

    Authors: Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha and Manuel Rodrigues Teixeira
    Citation: BMC Cancer 2008 8:371
    Content type: Research article Published on:

  45. Rejection of transplanted tumors by the immune system is a rare event in syngeneic hosts, and is considered to be dependent on the local interaction of defensive immune reactions and tumor tolerance mechanisms...

    Authors: Alexander Y Wagner, Eric Holle, Lori Holle, Xianzhong Yu and Günter Schwamberger
    Citation: BMC Cancer 2008 8:370
    Content type: Research article Published on:

  46. The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncoge...

    Authors: Achim Weber, Ilka Kristiansen, Manfred Johannsen, Beibei Oelrich, Katharina Scholmann, Sven Gunia, Matthias May, Hellmuth-Alexander Meyer, Silvia Behnke, Holger Moch and Glen Kristiansen
    Citation: BMC Cancer 2008 8:369
    Content type: Research article Published on:

  47. From 1968 to 2002, Singapore experienced an almost four-fold increase in prostate cancer incidence. This paper examines the incidence, mortality and survival patterns for prostate cancer among all residents in...

    Authors: Sin Eng Chia, Chuen Seng Tan, Gek Hsiang Lim, Xueling Sim, Yudi Pawitan, Marie Reilly, Safiyya Mohamed Ali, Weber Lau and Kee Seng Chia
    Citation: BMC Cancer 2008 8:368
    Content type: Research article Published on:

  48. Several evidences suggested that ovarian cancer (OC) patients showing isolated lymph node recurrence (ILNR) have an indolent evolution. The aim of the study was to retrospectively review ILNR observed in our I...

    Authors: Francesco Legge, Marco Petrillo, Vincenzo Adamo, Salvatore Pisconti, Giovanni Scambia and Gabriella Ferrandina
    Citation: BMC Cancer 2008 8:367
    Content type: Research article Published on:

  50. Carcinoma-associated fibroblasts (CAFs) can promote carcinogenesis and tumor progression. Only limited data on the response of CAFs to chemotherapy and their potential impact on therapy outcome are available. ...

    Authors: Maike Sonnenberg, Heiko van der Kuip, Silke Haubeiß, Peter Fritz, Werner Schroth, Godehard Friedel, Wolfgang Simon, Thomas E Mürdter and Walter E Aulitzky
    Citation: BMC Cancer 2008 8:364
    Content type: Research article Published on:

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