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  1. Dendritic cells (DCs) isolated from tumor bearing animals or from individuals with solid tumors display functional abnormalities and the DC impairment has emerged as one mechanism for tumor evasion from the co...

    Authors: Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch and Marie Larsson
    Citation: BMC Cancer 2010 10:87
    Content type: Research article Published on:

  2. To improve the efficacy of first-line therapy for advanced non-small cell lung cancer (NSCLC), additional maintenance chemotherapy may be given after initial induction chemotherapy in patients who did not prog...

    Authors: Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, Jesús Corral Jaime, Francesca Russo and Carla Visseren-Grul
    Citation: BMC Cancer 2010 10:85
    Content type: Study protocol Published on:

  3. Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated wit...

    Authors: Sunitha V Bachawal, Vikram B Wali and Paul W Sylvester
    Citation: BMC Cancer 2010 10:84
    Content type: Research article Published on:

  4. The hepaCAM gene encodes a new immunoglobulin-like cell adhesion molecule, and its expression is suppressed in a variety of human cancers. Additionally, hepaCAM possesses properties often observed in tumor sup...

    Authors: Yunfeng He, Xiaohou Wu, Chunli Luo, Lie Wang and Jie Lin
    Citation: BMC Cancer 2010 10:83
    Content type: Research article Published on:

  5. The local and systemic activation and regulation of the immune system by malignant cells during carcinogenesis is highly complex with involvement of the innate and acquired immune system. Despite the fact that...

    Authors: Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser and Andreas Thalheimer
    Citation: BMC Cancer 2010 10:82
    Content type: Research article Published on:

  7. Mitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs ...

    Authors: Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Mohammad Ilyas, Dumitru Constantin-Teodosiu, Brian J Rowlands and Dileep N Lobo
    Citation: BMC Cancer 2010 10:80
    Content type: Research article Published on:

  8. Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular mark...

    Authors: Jun Aruga, Yayoi Nozaki, Minoru Hatayama, Yuri S Odaka and Naoki Yokota
    Citation: BMC Cancer 2010 10:79
    Content type: Research article Published on:

  9. Increased transcription of oncogenes like the epidermal growth factor receptor (EGFR) is frequently caused by amplification of the whole gene or at least of regulatory sequences. Aim of this study was to pinpo...

    Authors: Konstantin Agelopoulos, Burkhard Greve, Hartmut Schmidt, Heike Pospisil, Stefan Kurtz, Kai Bartkowiak, Antje Andreas, Marek Wieczorek, Eberhard Korsching, Horst Buerger and Burkhard Brandt
    Citation: BMC Cancer 2010 10:78
    Content type: Research article Published on:

  10. Several different gene expression signatures have been proposed to predict response to therapy and clinical outcome in lung adenocarcinoma. Herein, we investigate if elements of published gene sets can be repr...

    Authors: Jens Neumann, Friedrich Feuerhake, Gian Kayser, Thorsten Wiech, Konrad Aumann, Bernward Passlick, Paul Fisch, Martin Werner and Axel zur Hausen
    Citation: BMC Cancer 2010 10:77
    Content type: Research article Published on:

  11. HAX-1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexp...

    Authors: Alicja Trebinska, Alina Rembiszewska, Karolina Ciosek, Konrad Ptaszynski, Sebastian Rowinski, Jolanta Kupryjanczyk, Janusz A Siedlecki and Ewa A Grzybowska
    Citation: BMC Cancer 2010 10:76
    Content type: Research article Published on:

  12. The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA regi...

    Authors: Vera N Senchenko, Ekaterina A Anedchenko, Tatiana T Kondratieva, George S Krasnov, Alexei A Dmitriev, Veronika I Zabarovska, Tatiana V Pavlova, Vladimir I Kashuba, Michael I Lerman and Eugene R Zabarovsky
    Citation: BMC Cancer 2010 10:75
    Content type: Research article Published on:

  13. Multiple myeloma is an uncommon cancer with a poor prognosis. Its incidence is expected to increase due to ageing populations and better diagnosis, and new treatments have been developed to improve survival. O...

    Authors: Christine Renshaw, Nicolas Ketley, Henrik Møller and Elizabeth A Davies
    Citation: BMC Cancer 2010 10:74
    Content type: Research article Published on:

  14. Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related death. Gene copy number alterations play an important role in the development of gastric cance...

    Authors: Siina Junnila, Arto Kokkola, Marja-Liisa Karjalainen-Lindsberg, Pauli Puolakkainen and Outi Monni
    Citation: BMC Cancer 2010 10:73
    Content type: Research article Published on:

  16. The aim of the study was to obtain stable radioresistant sub-lines from the human cervical cancer cell line HeLa by prolonged exposure to 252Cf neutron and X-rays. Radioresistance mechanisms were investigated in ...

    Authors: Yi Qing, Xue-Qin Yang, Zhao-Yang Zhong, Xin Lei, Jia-Yin Xie, Meng-Xia Li, De-Bing Xiang, Zeng-Peng Li, Zhen-Zhou Yang, Ge Wang and Dong Wang
    Citation: BMC Cancer 2010 10:71
    Content type: Research article Published on:

  17. The release of proteins from tumors can trigger an immune response in cancer patients involving T lymphocytes and B lymphocytes, which results in the generation of antibodies to tumor-derived proteins. Many st...

    Authors: Susanne Klein-Scory, Salwa Kübler, Hanna Diehl, Christina Eilert-Micus, Anke Reinacher-Schick, Kai Stühler, Bettina Warscheid, Helmut E Meyer, Wolff Schmiegel and Irmgard Schwarte-Waldhoff
    Citation: BMC Cancer 2010 10:70
    Content type: Research article Published on:

  18. Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region...

    Authors: Elizabeth A Tindall, Hoa N Hoang, Melissa C Southey, Dallas R English, John L Hopper, Graham G Giles, Gianluca Severi and Vanessa M Hayes
    Citation: BMC Cancer 2010 10:69
    Content type: Research article Published on:

  19. There is increasing evidence that cancers contain their own stem-like cells, and particular attention has been paid to one subset of cancer-stem cells termed side population (SP). Stem cells under normal physi...

    Authors: Jun-Xia Cao, Yu-Xin Cui, Zi-Jie Long, Zhong-Min Dai, Ji-Yan Lin, Yi Liang, Fei-Meng Zheng, Yi-Xin Zeng and Quentin Liu
    Citation: BMC Cancer 2010 10:68
    Content type: Research article Published on:

  20. Pancreatic cancer is one of the most aggressive human malignancies, with a very poor prognosis. To evaluate the effect of angiotensin II (Ang II) type 2 receptor (AT2) expression in the host's body on the growth ...

    Authors: Chiyo Doi, Noboru Egashira, Atsushi Kawabata, Dharmendra Kumar Maurya, Naomi Ohta, Deepthi Uppalapati, Rie Ayuzawa, Lara Pickel, Yuka Isayama, Deryl Troyer, Susumu Takekoshi and Masaaki Tamura
    Citation: BMC Cancer 2010 10:67
    Content type: Research article Published on:

  21. Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies.

    Authors: Cristina Patru, Luciana Romao, Pascale Varlet, Laure Coulombel, Eric Raponi, Josette Cadusseau, François Renault-Mihara, Cécile Thirant, Nadine Leonard, Alain Berhneim, Maria Mihalescu-Maingot, Jacques Haiech, Ivan Bièche, Vivaldo Moura-Neto, Catherine Daumas-Duport, Marie-Pierre Junier…
    Citation: BMC Cancer 2010 10:66
    Content type: Research article Published on:

  22. Survivin, a member of the inhibitor of apoptosis-protein family suppresses apoptosis and regulates cell division. It is strongly overexpressed in the vast majority of cancers. We were interested if survivin de...

    Authors: Helge Taubert, Chris Heidenreich, Hans-Jürgen Holzhausen, Antje Schulz, Matthias Bache, Matthias Kappler, Alexander W Eckert, Peter Würl, Ingo Melcher, Kathrin Hauptmann, Steffen Hauptmann and Klaus-Dieter Schaser
    Citation: BMC Cancer 2010 10:65
    Content type: Research article Published on:

  23. Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer ...

    Authors: Narasimhan Kothandaraman, Vladimir B Bajic, Pang NK Brendan, Chan Y Huak, Peh B Keow, Khalil Razvi, Manuel Salto-Tellez and Mahesh Choolani
    Citation: BMC Cancer 2010 10:64
    Content type: Research article Published on:

  24. Cutaneous melanoma (CM) is the most lethal form of skin malignancy, which registers a constant increase in incidence worldwide. The identification of molecular alteration(s) involved in its biological aggressi...

    Authors: Massimo Mascolo, Maria Luisa Vecchione, Gennaro Ilardi, Massimiliano Scalvenzi, Guido Molea, Maria Di Benedetto, Loredana Nugnes, Maria Siano, Gaetano De Rosa and Stefania Staibano
    Citation: BMC Cancer 2010 10:63
    Content type: Research article Published on:

  25. Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.

    Authors: Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo A Zucali and Pierpaolo Graziotti
    Citation: BMC Cancer 2010 10:62
    Content type: Case report Published on:

  26. It has been suggested that columnar cell lesions indicate an alteration of the human mammary gland involved in the development of breast cancer. They have not previously been described in canine mammary gland....

    Authors: Enio Ferreira, Helenice Gobbi, Bruna S Saraiva and Geovanni D Cassali
    Citation: BMC Cancer 2010 10:61
    Content type: Research article Published on:

  28. Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival rate of 4% and typically presents in an advanced stage. In this setting, prognostic markers identifying the more agrressive tumors co...

    Authors: David F Schaeffer, Daniel R Owen, Howard J Lim, Andrew K Buczkowski, Stephen W Chung, Charles H Scudamore, David G Huntsman, Sylvia SW Ng and David A Owen
    Citation: BMC Cancer 2010 10:59
    Content type: Research article Published on:

  29. PMS2 expression loss was reported in a variety of human. However, its importance has not been fully understood in cervical carcinoma. The aim of this study was to determine the expression of PMS2 in cervical c...

    Authors: Yuan Zhang, Yi Min Shu, Shu Fang Wang, Bang Hong Da, Ze Hua Wang and Hua Bin Li
    Citation: BMC Cancer 2010 10:58
    Content type: Research article Published on:

  31. We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival ...

    Authors: Masakazu Toi, Jeff Sperinde, Weidong Huang, Shigehira Saji, John Winslow, Xueguang Jin, Yuping Tan, Shinji Ohno, Seigo Nakamura, Hiroji Iwata, Norikazu Masuda, Kenjiro Aogi, Satoshi Morita, Christos Petropoulos and Michael Bates
    Citation: BMC Cancer 2010 10:56
    Content type: Research article Published on:

  32. Non-Hodgkin lymphoma (NHL) is a hematologic malignancy for which good diagnostic markers are lacking. Despite continued improvement in our understanding of NHL, efforts to identify diagnostic markers have yiel...

    Authors: Byong Chul Yoo, Sun-Young Kong, Sang-Geun Jang, Kyung-Hee Kim, Sun-A Ahn, Weon-Seo Park, Sohee Park, Tak Yun and Hyeon-Seok Eom
    Citation: BMC Cancer 2010 10:55
    Content type: Research article Published on:

  33. Malignant pleural mesothelioma is a rare disease known to be resistant to conventional therapies. A better understanding of mesothelioma biology may provide the rationale for new therapeutic strategies. In thi...

    Authors: Alice Melotti, Antonio Daga, Daniela Marubbi, Annalisa Zunino, Luciano Mutti and Giorgio Corte
    Citation: BMC Cancer 2010 10:54
    Content type: Research article Published on:

  34. We evaluated two molecular methods of HPV detection and their correlation with cytological and histological diagnosis in a large sample of Greek women.

    Authors: Sotirios Tsiodras, John Georgoulakis, Aikaterini Chranioti, Zanis Voulgaris, Amanda Psyrri, Angeliki Tsivilika, John Panayiotides and Petros Karakitsos
    Citation: BMC Cancer 2010 10:53
    Content type: Research article Published on:

  35. For years the Robert Koch Institute (RKI) has been annually pooling and reviewing the data from the German population-based cancer registries and evaluating them together with the cause-of-death statistics pro...

    Authors: Jörg Haberland, Joachim Bertz, Ute Wolf, Thomas Ziese and Bärbel-Maria Kurth
    Citation: BMC Cancer 2010 10:52
    Content type: Research article Published on:

  36. Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome. Therefore, the prevention of pulmonary metastases is critical for the improvement of the prognosis of patien...

    Authors: Junichi Aizawa, Kenshi Sakayama, Setsuya Kamei, Teruki Kidani, Haruyasu Yamamoto, Yoshiaki Norimatsu and Hiroshi Masuno
    Citation: BMC Cancer 2010 10:51
    Content type: Research article Published on:

  37. A frequent manifestation of advanced NSCLC is malnutrition, even though there are many studies which relate it with a poor survival, its relation with toxicity has not yet been consistently reported. The aim o...

    Authors: Oscar Arrieta, Rosa M Michel Ortega, Geraldine Villanueva-Rodríguez, Maria G Serna-Thomé, Diana Flores-Estrada, Consuelo Diaz-Romero, Cindy M Rodríguez, Luis Martínez and Karla Sánchez-Lara
    Citation: BMC Cancer 2010 10:50
    Content type: Research article Published on:

  38. Gefitinib is one of the small molecule inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR TKIs). Clinical trials have demonstrated it is effective for treatment of a subset of patients with a...

    Authors: Dan-Fang Yan, Sen-Xiang Yan, Jing-Song Yang, Yi-Xiang J Wang, Xiao-Li Sun, Xin-Biao Liao and Jun-Qing Liu
    Citation: BMC Cancer 2010 10:49
    Content type: Case report Published on:

  39. Epigenetic silencing of the MGMT gene by promoter methylation is associated with loss of MGMT expression, diminished DNA-repair activity and longer overall survival in patients with glioblastoma who, in addition ...

    Authors: Luca Morandi, Enrico Franceschi, Dario de Biase, Gianluca Marucci, Alicia Tosoni, Mario Ermani, Annalisa Pession, Giovanni Tallini and Alba Brandes
    Citation: BMC Cancer 2010 10:48
    Content type: Technical advance Published on:

  40. Half of the familial aggregation of ovarian cancer can't be explained by any known risk genes, suggesting the existence of other genetic risk factors. Some of these unknown factors may not be traditional prote...

    Authors: Jie Shen, Richard DiCioccio, Kunle Odunsi, Shashikant B Lele and Hua Zhao
    Citation: BMC Cancer 2010 10:47
    Content type: Research article Published on:

  41. The crude extract of the fruit bearing plant, Physalis peruviana (golden berry), demonstrated anti-hepatoma and anti-inflammatory activities. However, the cellular mechanism involved in this process is still unkn...

    Authors: Ching-Yu Yen, Chien-Chih Chiu, Fang-Rong Chang, Jeff Yi-Fu Chen, Chi-Ching Hwang, You-Cheng Hseu, Hsin-Ling Yang, Alan Yueh-Luen Lee, Ming-Tz Tsai, Zong-Lun Guo, Yu-Shan Cheng, Yin-Chang Liu, Yu-Hsuan Lan, Yu-Ching Chang, Ying-Chin Ko, Hsueh-Wei Chang…
    Citation: BMC Cancer 2010 10:46
    Content type: Research article Published on:

  42. The treatment paradigm in advanced renal cell carcinoma (RCC) has changed in the recent years. Sunitinib has been established as a new standard for first-line therapy. We studied the prognostic significance of...

    Authors: Aristotelis Bamias, Alexandra Karadimou, Sofia Lampaki, George Lainakis, Lia Malettou, Eleni Timotheadou, Kostas Papazisis, Charalambos Andreadis, Loukas Kontovinis, Ioannis Anastasiou, Kostas Stravodimos, Ioannis Xanthakis, Andreas Skolarikos, Christos Christodoulou, Kostas Syrigos, Christos Papandreou…
    Citation: BMC Cancer 2010 10:45
    Content type: Research article Published on:

  43. Alu methylation is correlated with the overall level of DNA methylation and recombination activity of the genome. However, the maintenance and methylation status of each CpG site within Alu elements (Alu) and it...

    Authors: Shengyan Xiang, Zhaojun Liu, Baozhen Zhang, Jing Zhou, Bu-Dong Zhu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2010 10:44
    Content type: Research article Published on:

  44. Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis. Pyk2 i...

    Authors: Siyang Zhang, Dawei Guo, Wenting Luo, Qingfu Zhang, Ying Zhang, Chunyan Li, Yao Lu, Zeshi Cui and Xueshan Qiu
    Citation: BMC Cancer 2010 10:43
    Content type: Research article Published on:

  45. Many cancer survivors suffer a range of physical and psychological symptoms which may persist for months or years after cessation of treatment. Despite the known benefits of exercise and its potential to addre...

    Authors: Julie M Walsh, Juliette Hussey, Emer Guinan and Dearbhaile O' Donnell
    Citation: BMC Cancer 2010 10:42
    Content type: Study protocol Published on:

  46. Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. In this study, we took advantage of several strains of the Rous sarcoma virus (RSV) to characterize the ...

    Authors: Bart M Maślikowski, Benjamin D Néel, Ying Wu, Lizhen Wang, Natalie A Rodrigues, Germain Gillet and Pierre-André Bédard
    Citation: BMC Cancer 2010 10:41
    Content type: Research article Published on:

  47. GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have imp...

    Authors: Amy M Lum, Bruce B Wang, Gabriele B Beck-Engeser, Lauri Li, Namitha Channa and Matthias Wabl
    Citation: BMC Cancer 2010 10:40
    Content type: Research article Published on:

  48. To investigate the outcome of locoregionally advanced nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT) after induction chemotherapy, with or without concomitant chemothe...

    Authors: Shaojun Lin, Jiade Jay Lu, Lu Han, Qisong Chen and Jianji Pan
    Citation: BMC Cancer 2010 10:39
    Content type: Research article Published on:

  49. Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions in human dis...

    Authors: Lan Li, Chaohui Yu, Hengjun Gao and Youming Li
    Citation: BMC Cancer 2010 10:38
    Content type: Research article Published on:

  50. Socioeconomic status (SES) is known to be positively associated with breast cancer risk but its relationship with mammographic density, a marker of susceptibility to breast cancer, is unclear. This study aims ...

    Authors: Zoe Aitken, Kate Walker, Bernardine H Stegeman, Petra A Wark, Sue M Moss, Valerie A McCormack and Isabel dos Santos Silva
    Citation: BMC Cancer 2010 10:35
    Content type: Research article Published on:

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