Skip to main content

Articles

Page 288 of 327

  1. Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have bee...

    Authors: Maija Wolf, Miikka Korja, Ritva Karhu, Henrik Edgren, Sami Kilpinen, Kalle Ojala, Spyro Mousses, Anne Kallioniemi and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:181
  2. Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is eff...

    Authors: Gregory Riedlinger, Jonathan Adams, John R Stehle Jr, Michael J Blanks, Anne M Sanders, Amy M Hicks, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:179
  3. Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers...

    Authors: Walid Sasi, Wen G Jiang, Anup Sharma and Kefah Mokbel
    Citation: BMC Cancer 2010 10:178
  4. Metastasis formation is the leading cause of death among colon cancer patients. We established a new in-situ model of in vivo microscopy of the lung to analyse initiating events of metastatic tumor cell adhesi...

    Authors: Peter Gassmann, Mi-Li Kang, Soeren T Mees and Joerg Haier
    Citation: BMC Cancer 2010 10:177
  5. Metastasis is a major cancer-related cause of death. Recent studies have described metastasis pathways. However, the exact contribution of each pathway remains unclear. Another key feature of a tumor is the pr...

    Authors: Michael Pierre, Benoît DeHertogh, Anthoula Gaigneaux, Bertrand DeMeulder, Fabrice Berger, Eric Bareke, Carine Michiels and Eric Depiereux
    Citation: BMC Cancer 2010 10:176
  6. Advanced cancer is a multifactorial disease that demands treatments targeting multiple cellular pathways. Chinese herbal cocktail which contains various phytochemicals may target multiple dys-regulated pathway...

    Authors: Jean-San Chia, Jia-Ling Du, Wei-Bin Hsu, Andy Sun, Chun-Pin Chiang and Won-Bo Wang
    Citation: BMC Cancer 2010 10:175
  7. Current frequent follow-up after treatment for breast cancer does not meet its intended aims, but does depend on expensive and scarce specialized knowledge for routine history taking and physical examinations....

    Authors: Merel L Kimman, Monique MF Bloebaum, Carmen D Dirksen, Ruud MA Houben, Philippe Lambin and Liesbeth J Boersma
    Citation: BMC Cancer 2010 10:174
  8. Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription quant...

    Authors: Kah Hoong Chang, Pieter Mestdagh, Jo Vandesompele, Michael J Kerin and Nicola Miller
    Citation: BMC Cancer 2010 10:173
  9. We have previously demonstrated that tumour islet infiltration by macrophages is associated with extended survival (ES) in NSCLC. We therefore hypothesised that patients with improved survival would have high ...

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding
    Citation: BMC Cancer 2010 10:172
  10. The management of early breast cancer (BC) with skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) is not based on level-1 evidence. In this study, the oncological outcome, post-operative ...

    Authors: Sara Reefy, Neill Patani, Anne Anderson, Gwyne Burgoyne, Hisham Osman and Kefah Mokbel
    Citation: BMC Cancer 2010 10:171
  11. The elevated expression of vascular endothelial growth factor C (VEGF-C) is correlated with clinical cervical cancer metastasis and patient survival, which is interpreted by VEGF-C functions to stimulate angio...

    Authors: Mian He, Yang Cheng, Wen Li, Qiongshan Liu, Junxiu Liu, Jinghe Huang and Xiaodong Fu
    Citation: BMC Cancer 2010 10:170
  12. We reported increased levels of Phosphatidyl Inositol synthase (PI synthase), (enzyme that catalyses phosphatidyl inositol (PI) synthesis-implicated in intracellular signaling and regulation of cell growth) in...

    Authors: Jatinder Kaur, Meenakshi Sawhney, Siddartha DattaGupta, Nootan K Shukla, Anurag Srivastava and Ranju Ralhan
    Citation: BMC Cancer 2010 10:168
  13. We performed multicenter study to define clinical characteristics of noncutaneous melanomas and to establish prognostic factors patients who received curative resection.

    Authors: Hyo Song Kim, Eun Kyoung Kim, Hyun Jung Jun, Sung Yong Oh, Keon Woo Park, Do Hyoung Lim, Soon Il Lee, Jung Han Kim, Kyoung Mee Kim, Dae Ho Lee and Jeeyun Lee
    Citation: BMC Cancer 2010 10:167
  14. Subsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their resistance to apoptosis-inducing stimuli has been related to carcinoma recurrence and treatment ...

    Authors: Lisa J Harper, Daniela Elena Costea, Luke Gammon, Bilal Fazil, Adrian Biddle and Ian C Mackenzie
    Citation: BMC Cancer 2010 10:166
  15. The prostate gland represents a multifaceted system in which prostate epithelia and stroma have distinct physiological roles. To understand the interaction between stroma and glandular epithelia, it is essenti...

    Authors: Jennifer L Gregg, Kathleen E Brown, Eric M Mintz, Helen Piontkivska and Gail C Fraizer
    Citation: BMC Cancer 2010 10:165
  16. Lymphovascular invasion (LVI) and lymph node metastasis are conventional pathological factors associated with an unfavorable prognosis of urothelial carcinoma of the upper urinary tract (UC-UUT), but little is...

    Authors: Takao Kamai, Hiromichi Shirataki, Kimihiro Nakanishi, Nobutaka Furuya, Tsunehito Kambara, Hideyuki Abe, Tetsunari Oyama and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2010 10:164
  17. Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed.

    Authors: Li Tang, Gary R Zirpoli, Vijayvel Jayaprakash, Mary E Reid, Susan E McCann, Chukwumere E Nwogu, Yuesheng Zhang, Christine B Ambrosone and Kirsten B Moysich
    Citation: BMC Cancer 2010 10:162
  18. Human cervical cancer oncoprotein 1 (HCCR-1), reported as a negative regulator of p53, is over-expressed in a variety of human cancers. However, it is yet unknown whether HCCR-1 plays any role in pancreatic ca...

    Authors: Zekuan Xu, Yi Zhang, Jiakai Jiang, Yang Yang, Ruihua Shi, Bo Hao, Zhihong Zhang, Zuhu Huang, Jin W Kim and Guoxin Zhang
    Citation: BMC Cancer 2010 10:161
  19. Nasopharyngeal carcinoma associated gene 6 (NGX6) is down-regulated in most colon cancer cell lines and tumor tissues when compared with their normal tissue samples. As a novel suppress tumor gene, it could in...

    Authors: Minji Liu, Ya Peng, Xiaoyan Wang, Qin Guo, Shourong Shen and Guiyuan Li
    Citation: BMC Cancer 2010 10:160
  20. Recently, extremely low frequency electromagnetic fields (ELF-EMF) have been studied with great interest due to their possible effects on human health. In this study, we evaluated the effect of 4.5 mT - 120 Hz...

    Authors: Mónica Noemí Jiménez-García, Jaime Arellanes-Robledo, Diana Ivette Aparicio-Bautista, Miguel Ángel Rodríguez-Segura, Saúl Villa-Treviño and Juan José Godina-Nava
    Citation: BMC Cancer 2010 10:159
  21. Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) activity is a marker of osteoclast number and is elevated in breast cancer (BC) patients with extensive bone metastasis, which might in turn reflect the ...

    Authors: Yi-Ying Wu, Anthony J Janckila, Chih-Hung Ku, Cheng-Ping Yu, Jyh-Cherng Yu, Su-Hui Lee, Hsin-Yi Liu, Lung T Yam and Tsu-Yi Chao
    Citation: BMC Cancer 2010 10:158
  22. Hypoxic microenvironments in tumors contribute to transformation, which may alter metabolism, growth, and therapeutic responsiveness. The α-enolase gene encodes both a glycolytic enzyme (α-enolase) and a DNA-b...

    Authors: Kara C Sedoris, Shelia D Thomas and Donald M Miller
    Citation: BMC Cancer 2010 10:157
  23. Breast cancer is the most frequently diagnosed cancer in women. Intraepithelial lesions (IELs), such as usual ductal hyperplasia (UH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) are...

    Authors: Giovanni P Burrai, Sulma I Mohammed, Margaret A Miller, Vincenzo Marras, Salvatore Pirino, Maria F Addis, Sergio Uzzau and Elisabetta Antuofermo
    Citation: BMC Cancer 2010 10:156
  24. The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and...

    Authors: Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson and Pamela S Douglas
    Citation: BMC Cancer 2010 10:155
  25. Racial and ethnic disparities in breast cancer incidence, stage at diagnosis, survival and mortality are well documented; but few studies have reported on disparities in breast cancer treatment. This paper com...

    Authors: Parvin Yavari, Maria Cristina Barroetavena, T Greg Hislop and Chris D Bajdik
    Citation: BMC Cancer 2010 10:154
  26. Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this ...

    Authors: F Jeroen Vogelaar, Wilma E Mesker, Arjen M Rijken, Gaby W van Pelt, Antonia M van Leeuwen, Hans J Tanke, Rob A Tollenaar and Gerrit J Liefers
    Citation: BMC Cancer 2010 10:153
  27. Despite the large number of men diagnosed with localized prostate cancer, there is as yet no consensus concerning appropriate treatment. The purpose of this study was to describe the initial treatment patterns...

    Authors: Maria J Schymura, Amy R Kahn, Robert R German, Mei-Chin Hsieh, Rosemary D Cress, Jack L Finch, John P Fulton, Tiefu Shen and Erik Stuckart
    Citation: BMC Cancer 2010 10:152
  28. The urokinase plasminogen activating system (uPAS) is implicated in neoplastic progression and high tissue levels of uPAS components correlate with a poor prognosis in different human cancers. Despite that, re...

    Authors: Salvatore Ulisse, Enke Baldini, Marcella Mottolese, Steno Sentinelli, Patrizia Gargiulo, Brancato Valentina, Salvatore Sorrenti, Anna Di Benedetto, Enrico De Antoni and Massimino D'Armiento
    Citation: BMC Cancer 2010 10:151
  29. Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a Eu...

    Authors: Antoine Lurkin, Francoise Ducimetière, Dominique Ranchère Vince, Anne-Valérie Decouvelaere, Dominic Cellier, François N Gilly, Dimitri Salameire, Pierre Biron, Guy de Laroche, Jean Yves Blay and Isabelle Ray-Coquard
    Citation: BMC Cancer 2010 10:150
  30. Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neu...

    Authors: Rene' G Feichtinger, Franz Zimmermann, Johannes A Mayr, Daniel Neureiter, Cornelia Hauser-Kronberger, Freimut H Schilling, Neil Jones, Wolfgang Sperl and Barbara Kofler
    Citation: BMC Cancer 2010 10:149
  31. Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumours (PNETs) are the most common highly aggressive paediatric brain tumours. In spite of extensive research on these tumours, there are on...

    Authors: Kristiina Nordfors, Joonas Haapasalo, Miikka Korja, Anssi Niemelä, Jukka Laine, Anna-Kaisa Parkkila, Silvia Pastorekova, Jaromir Pastorek, Abdul Waheed, William S Sly, Seppo Parkkila and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:148
  32. The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed TP53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of c...

    Authors: Mang Xiao, Lei Zhang, Xinhua Zhu, Jun Huang, Huifen Jiang, Sunhong Hu and Yuehui Liu
    Citation: BMC Cancer 2010 10:147
  33. Bacterial targeting of tumours is an important anti-cancer strategy. We previously showed that strain SL7838 of Salmonella typhimurium targets and kills cancer cells. Whether NO generation by the bacteria has a r...

    Authors: Yoram Barak, Frank Schreiber, Steve H Thorne, Christopher H Contag, Dirk deBeer and A Matin
    Citation: BMC Cancer 2010 10:146
  34. Germline mutations in the BRCA1 gene predispose to the development of breast cancer, exhibiting a specific histological phenotype. Identification of possible hallmarks of these tumors is important for selectin...

    Authors: Marise R Heerma van Voss, Petra van der Groep, Jos Bart, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2010 10:145
  35. Despite evidence that breast cancer screening reduces morbidity and mortality, until recently most women have not undergone regular mammogram examinations in Korea. We aimed to identify factors associated with...

    Authors: Kiheon Lee, Hyung Taek Lim and Sang Min Park
    Citation: BMC Cancer 2010 10:144
  36. Emerging reports suggest resistance, increased tumor invasiveness and metastasis arising from treatment with drugs targeting vascular endothelial growth factor (VEGF). It is believed that increased tumoral hyp...

    Authors: Mohammad H Pourgholami, Zhao Y Cai, Samina Badar, Kiran Wangoo, Marianne S Poruchynsky and David L Morris
    Citation: BMC Cancer 2010 10:143
  37. Endogenously produced interferons can regulate the growth of melanoma cells and are administered exogenously as therapeutic agents to patients with advanced cancer. We investigated the role of negative regulat...

    Authors: Gregory B Lesinski, Jason M Zimmerer, Melanie Kreiner, John Trefry, Matthew A Bill, Gregory S Young, Brian Becknell and William E Carson III
    Citation: BMC Cancer 2010 10:142
  38. Previous studies showed a differential distribution of the four regulatory subunits of cAMP-dependent protein kinases inside the brain, that changed in rodent gliomas: therefore, the distribution of these prot...

    Authors: Carla Mucignat-Caretta, Luca Denaro, Marco Redaelli, Domenico D'Avella and Antonio Caretta
    Citation: BMC Cancer 2010 10:141
  39. Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers ...

    Authors: Rita G Ladstein, Ingeborg M Bachmann, Oddbjørn Straume and Lars A Akslen
    Citation: BMC Cancer 2010 10:140
  40. Angiogenesis appears to play an important role in ovarian cancer. Vascular endothelial growth factor (VEGF) has recently been implicated as a therapeutic target in ovarian cancer. The tissue inhibitor of metal...

    Authors: Sven Mahner, Linn Woelber, Christine Eulenburg, Joerg Schwarz, Walter Carney, Fritz Jaenicke, Karin Milde-Langosch and Volkmar Mueller
    Citation: BMC Cancer 2010 10:139
  41. Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the ab...

    Authors: Noushin Taghavi, Firouzeh Biramijamal, Masoud Sotoudeh, Hooman Khademi, Reza Malekzadeh, Omeed Moaven, Bahram Memar, Azadeh A'rabi and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2010 10:138
  42. The aim of our study was to analyze the effect of taxane-based chemotherapy on tumor angiogenesis in patients with advanced epithelial ovarian cancer.

    Authors: Martin Pölcher, Christian Rudlowski, Nicolaus Friedrichs, Marieke Mielich, Tobias Höller, Mathias Wolfgarten, Kirsten Kübler, Reinhard Büttner, Walther Kuhn and Michael Braun
    Citation: BMC Cancer 2010 10:137
  43. Mutational analysis of the KRAS gene has recently been established as a complementary in vitro diagnostic tool for the identification of patients with colorectal cancer who will not benefit from anti-epidermal gr...

    Authors: Alfonso Sánchez-Muñoz, Elena Gallego, Vanessa de Luque, Luís G Pérez-Rivas, Luís Vicioso, Nuria Ribelles, José Lozano and Emilio Alba
    Citation: BMC Cancer 2010 10:136
  44. Microtubules are considered major therapeutic targets in patients with breast cancer. In spite of their essential role in biological functions including cell motility, cell division and intracellular transport...

    Authors: Rouba Hage-Sleiman, Stéphanie Herveau, Eva-Laure Matera, Jean-Fabien Laurier and Charles Dumontet
    Citation: BMC Cancer 2010 10:135
  45. Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model. In this work we defined the expr...

    Authors: Jaclyn H Neo, Eleanor I Ager, Peter W Angus, Jin Zhu, Chandana B Herath and Christopher Christophi
    Citation: BMC Cancer 2010 10:134
  46. It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression i...

    Authors: Guo-Fen Yang, Wei-Peng He, Mu-Yan Cai, Li-Ru He, Jun-Hang Luo, Hai-Xia Deng, Xin-Yuan Guan, Mu-Sheng Zeng, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2010 10:133
  47. Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet.

    Authors: Matthias Bache, Matthias Kappler, Henri Wichmann, Swetlana Rot, Antje Hahnel, Thomas Greither, Harun M Said, Matthias Kotzsch, Peter Würl, Helge Taubert and Dirk Vordermark
    Citation: BMC Cancer 2010 10:132
  48. The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for...

    Authors: Ying Gao, Zi Liu, Fei Gao and Xiao-yu Meng
    Citation: BMC Cancer 2010 10:131

Featured videos

View featured videos from across the BMC-series journals