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  1. The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play an important role in carcinogenesis and cancer metastasis, yet its role in the developmen...

    Authors: Ke Liu, Gefang Wang, Houzhong Ding, Ying Chen, Guanzhen Yu and Jiejun Wang
    Citation: BMC Cancer 2010 10:428
    Content type: Research article Published on:

  2. Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state. HSPGs bind to numerous growth factor ligands including fibrobl...

    Authors: Sarah M Peterson, Andrea Iskenderian, Lynette Cook, Alla Romashko, Kristen Tobin, Michael Jones, Angela Norton, Alicia Gómez-Yafal, Michael W Heartlein, Michael F Concino, Lucy Liaw and Paolo GV Martini
    Citation: BMC Cancer 2010 10:427
    Content type: Research article Published on:

  3. We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes betwee...

    Authors: Xinglai Ji, Jie Tang, Richard Halberg, Dana Busam, Steve Ferriera, Maria Marjorette O Peña, Chinnambally Venkataramu, Timothy J Yeatman and Shaying Zhao
    Citation: BMC Cancer 2010 10:426
    Content type: Research article Published on:

  4. As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membr...

    Authors: Jung-Young Shin, Jeong-Oh Kim, Suk Kyeong Lee, Hiun-Suk Chae and Jin-Hyoung Kang
    Citation: BMC Cancer 2010 10:425
    Content type: Research article Published on:

  5. Gliomatosis cerebri (GC) is characterized by a diffuse infiltration of tumor cells throughout CNS, however, few details are available about the chemotherapeutic effect on GC. The aim of this study was to inves...

    Authors: Doo-Sik Kong, Sung Tae Kim, Jung-Il Lee, Yeon-Lim Suh, Do Hoon Lim, Won Seog Kim, Ki-Hoon Kwon, Kwan Park, Jong Hyun Kim and Do-Hyun Nam
    Citation: BMC Cancer 2010 10:424
    Content type: Research article Published on:

  6. Skeletal metastases are often accompanied by bone pain. To investigate the clinical meaning of bone pain associated with skeletal metastasis in breast cancer patients after surgery, we explored whether the pre...

    Authors: Mitsuru Koizumi, Masataka Yoshimoto, Fujio Kasumi, Takuji Iwase and Etsuro Ogata
    Citation: BMC Cancer 2010 10:423
    Content type: Research article Published on:

  7. Cigarette smoking is the most established risk factor, and genetic variants and/or gene promoter methylations are also considered to play an essential role in development of lung cancer, but the pathogenesis o...

    Authors: Yongtang Jin, Heyun Xu, Chunye zhang, Yunming Kong, Yong Hou, Yingchun Xu and Shaoli Xue
    Citation: BMC Cancer 2010 10:422
    Content type: Research article Published on:

  8. Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic disea...

    Authors: Hezhi Fang, Lijun Shen, Tao Chen, Jing He, Zhinan Ding, Jia Wei, Jianchun Qu, Guorong Chen, Jianxin Lu and Yidong Bai
    Citation: BMC Cancer 2010 10:421
    Content type: Research article Published on:

  9. CYP1B1 is a P450 enzyme which is involved in the activation of pro-carcinogens to carcinogens as well as sex hormone metabolism. Because differences in the activity of the enzyme have been correlated with vari...

    Authors: Joanna Trubicka, Ewa Grabowska-KÅ‚ujszo, Janina Suchy, BartÅ‚omiej Masojć, Pablo Serrano-Fernandez, Grzegorz Kurzawski, Cezary Cybulski, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Elżbieta ZÅ‚owocka, Józef KÅ‚adny, Zbigniew Banaszkiewicz, RafaÅ‚ WiÅ›niowski, Elżbieta Kowalska…
    Citation: BMC Cancer 2010 10:420
    Content type: Research article Published on:

  10. H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there i...

    Authors: Chenghai Zhao, Xiaomei Lu, Xianmin Bu, Ning Zhang and Wei Wang
    Citation: BMC Cancer 2010 10:419
    Content type: Research article Published on:

  11. Prostate cancer is a leading cause of cancer-related death in men worldwide. Survivin is a member of the inhibitor of apoptosis (IAP) protein family that is expressed in the majority of human tumors including ...

    Authors: Xichun Liu, Ruijuan Gao, Yan Dong, Lifang Gao, Yanying Zhao, Lijuan Zhao, Xuejian Zhao and Haitao Zhang
    Citation: BMC Cancer 2010 10:418
    Content type: Research article Published on:

  12. Radiotherapy for head and neck cancer results in severe and chronic salivary gland dysfunction in most individuals. This results in significant side effects including xerostomia, dysphagia, and malnutrition wh...

    Authors: Oliver Grundmann, Jamia L Fillinger, Kerton R Victory, Randy Burd and Kirsten H Limesand
    Citation: BMC Cancer 2010 10:417
    Content type: Research article Published on:

  13. Lymphatic vessel spread is considered a major route for head and neck squamous cell carcinoma metastasis. Formation of new lymphatic vessels could facilitate the process, raising the malignant potential of the...

    Authors: Darío Garcia-Carracedo, Juan Pablo Rodrigo, Aurora Astudillo, Carlos Suarez Nieto and Maria Victoria Gonzalez
    Citation: BMC Cancer 2010 10:416
    Content type: Research article Published on:

  14. Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the dir...

    Authors: Chao Wang, Shouqiang Cao, Ying Yan, Qiao Ying, Tao Jiang, Ke Xu and Anhua Wu
    Citation: BMC Cancer 2010 10:415
    Content type: Research article Published on:

  15. In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44+/CD24- stem cell phenotype. However, the MCF-7 cell line, which has a luminal ep...

    Authors: Masahiro Uchino, Hiroko Kojima, Kenta Wada, Mika Imada, Fumitoshi Onoda, Hiroyuki Satofuka, Takahiko Utsugi and Yasufumi Murakami
    Citation: BMC Cancer 2010 10:414
    Content type: Research article Published on:

  16. Genetically, colorectal cancers (CRCs) can be subdivided into tumors with chromosomal instability (CIN) or microsatellite instability (MSI). In both types of CRCs genes that are involved in the degradation of ...

    Authors: Silvio K Scheel, Marc Porzner, Sabine Pfeiffer, Steffen Ormanns, Thomas Kirchner and Andreas Jung
    Citation: BMC Cancer 2010 10:413
    Content type: Research article Published on:

  17. Breast cancer treatment is based on a combination of adjuvant chemotherapy followed by radiotherapy effecting intracellular signal transduction. With the tyrosine kinase inhibitors new targeted drugs are avail...

    Authors: Marion T Weigel, Linda Dahmke, Christian Schem, Dirk O Bauerschlag, Katrin Weber, Peter Niehoff, Maret Bauer, Alexander Strauss, Walter Jonat, Nicolai Maass and Christoph Mundhenke
    Citation: BMC Cancer 2010 10:412
    Content type: Research article Published on:

  18. Breast cancer cells with CD44+/CD24- cell surface marker expression profile are proposed as cancer stem cells (CSCs). Normal breast epithelial cells that are CD44+/CD24- express higher levels of stem/progenito...

    Authors: Poornima Bhat-Nakshatri, Hitesh Appaiah, Christopher Ballas, Patricia Pick-Franke, Robert Goulet Jr, Sunil Badve, Edward F Srour and Harikrishna Nakshatri
    Citation: BMC Cancer 2010 10:411
    Content type: Research article Published on:

  19. Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from no...

    Authors: Christopher CL Liao, Nicholas Ward, Simon Marsh, Tan Arulampalam and John D Norton
    Citation: BMC Cancer 2010 10:410
    Content type: Research article Published on:

  20. Elevated Hsp90 expression has been documented in breast ductal carcinomas, whereas decreased Hsp90 expression has been reported in precursor lobular lesions. This study aims to assess Hsp90 expression in infil...

    Authors: Flora Zagouri, Theodoros Sergentanis, Afrodite Nonni, Christos Papadimitriou, Anastasia Pazaiti, Nikolaos V Michalopoulos, Panagiotis Safioleas, Andreas Lazaris, George Theodoropoulos, Effstratios Patsouris and George Zografos
    Citation: BMC Cancer 2010 10:409
    Content type: Research article Published on:

  21. MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas. In order to identify mutations in MUTYH gene we applied High Resolution...

    Authors: Isabel López-Villar, Rosa Ayala, Jan Wesselink, Juan Diego Morillas, Elena López, José Carlos Marín, José Díaz-Tasende, Sara González, Luis Robles and Joaquín Martínez-López
    Citation: BMC Cancer 2010 10:408
    Content type: Research article Published on:

  22. Neurofibromatosis type 1 is a common autosomal dominant disorder with full penetrance and variable expression. The condition predisposes individuals to the development of malignant nervous system tumours, most...

    Authors: German Melean, Alba Marina Hernández, María Carmen Valero, Elisabete Hernández-Imaz, Yolanda Martín and Concepción Hernández-Chico
    Citation: BMC Cancer 2010 10:407
    Content type: Case report Published on:

  23. Cancer patients may benefit from physical exercise programs. It is unclear, however, how sustained levels of physical activity are best achieved in this population. A systematic review was performed to summari...

    Authors: Ruud H Knols, Eling D de Bruin, Kei Shirato, Daniel Uebelhart and Neil K Aaronson
    Citation: BMC Cancer 2010 10:406
    Content type: Research article Published on:

  25. The response to treatment varies among patients with multiple myeloma and markers for prediction of treatment outcome are highly needed. Bioactivation of cyclophosphamide and thalidomide, and biodegradation of...

    Authors: Annette J Vangsted, Karen Søeby, Tobias W Klausen, Niels Abildgaard, Niels F Andersen, Peter Gimsing, Henrik Gregersen, Ulla Vogel, Thomas Werge and Henrik B Rasmussen
    Citation: BMC Cancer 2010 10:404
    Content type: Research article Published on:

  26. Siah proteins play an important role in cancer progression. We evaluated the effect of Siah1, its splice variants Siah1L and the Siah1 mutant with the RING finger deleted (Siah1ΔR) on radiosensitization of hum...

    Authors: Hai-Tao He, Emmanouil Fokas, An You, Rita Engenhart-Cabillic and Han-Xiang An
    Citation: BMC Cancer 2010 10:403
    Content type: Research article Published on:

  27. Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that ...

    Authors: Yongsheng Wang, Changyang Gong, Li Yang, Qinjie Wu, Shuai Shi, Huashan Shi, Zhiyong Qian and Yuquan Wei
    Citation: BMC Cancer 2010 10:402
    Content type: Research article Published on:

  28. Gene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation.

    Authors: Julien Rocquain, Nadine Carbuccia, Virginie Trouplin, Stéphane Raynaud, Anne Murati, Meyer Nezri, Zoulika Tadrist, Sylviane Olschwang, Norbert Vey, Daniel Birnbaum, Véronique Gelsi-Boyer and Marie-Joelle Mozziconacci
    Citation: BMC Cancer 2010 10:401
    Content type: Research article Published on:

  29. Emerging trends and new policies suggest that more cancer patients might die at home in the future. However, not all have equal chances of achieving this. Furthermore, there is lack of evidence to support that...

    Authors: Barbara Gomes, Paul McCrone, Sue Hall, Jonathan Koffman and Irene J Higginson
    Citation: BMC Cancer 2010 10:400
    Content type: Study protocol Published on:

  30. CpG island methylator phenotype (CIMP), in which multiple genes concordantly methylated, has been demonstrated to be associated with progression, recurrence, as well as overall survival in some types of cancer.

    Authors: Li-Ming Wu, Feng Zhang, Lin Zhou, Zhe Yang, Hai-Yang Xie and Shu-Sen Zheng
    Citation: BMC Cancer 2010 10:399
    Content type: Research article Published on:

  32. Vascular endothelial growth factor (VEGF) is a primary stimulant of angiogenesis under physiological and pathological conditions. Anti-VEGF therapy is a clinically proven strategy for the treatment of a variet...

    Authors: Kristi D Lynn, D Gomika Udugamasooriya, Christina L Roland, Diego H Castrillon, Thomas J Kodadek and Rolf A Brekken
    Citation: BMC Cancer 2010 10:397
    Content type: Research article Published on:

  33. HER2 gene copy status, and concomitant administration of trastuzumab (Herceptin), remains one of the best examples of targeted cancer therapy based on understanding the genomic etiology of disease. However, newl...

    Authors: Shelly Gunn, I-Tien Yeh, Irina Lytvak, Budi Tirtorahardjo, Natasha Dzidic, Soheila Zadeh, Jaeweon Kim, Chris McCaskill, Lony Lim, Mercedes Gorre and Mansoor Mohammed
    Citation: BMC Cancer 2010 10:396
    Content type: Technical advance Published on:

  34. Mutations of the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome. Our group and others have shown that Men1 disruption in mice recapitulates MEN1 pathology. Intriguingly, rare lesions ...

    Authors: Christelle Seigne, Sandra Fontanière, Christine Carreira, Jieli Lu, Wei-Ming Tong, Bernard Fontanière, Zhao-Qi Wang, Chang Xian Zhang and Lucien Frappart
    Citation: BMC Cancer 2010 10:395
    Content type: Research article Published on:

  35. NF-κB is a survival signaling transcription factor complex involved in the malignant phenotype of many cancers, including squamous cell carcinomas (SCC). The citrus coumarin, auraptene (AUR), and the ethno-med...

    Authors: Heather E Kleiner-Hancock, Runhua Shi, Angela Remeika, Delira Robbins, Misty Prince, Jennifer N Gill, Zanobia Syed, Patrick Adegboyega, J Michael Mathis and John L Clifford
    Citation: BMC Cancer 2010 10:394
    Content type: Research article Published on:

  36. The hTERT (human telomerase reverse transcriptase) gene contains five variable number tandem repeats (VNTR) and previous studies have described polymorphisms for hTERT-VNTR2-2nd. We investigated how allelic varia...

    Authors: Se-Lyun Yoon, Se-Il Jung, Eun-Ju Do, Se-Ra Lee, Sang-Yeop Lee, In-Sun Chu, Wun-Jae Kim, Jaeil Jung, Choung Soo Kim, Sang-Hyeon Cheon and Sun-Hee Leem
    Citation: BMC Cancer 2010 10:393
    Content type: Research article Published on:

  37. Cinnamomum cassia bark is the outer skin of an evergreen tall tree belonging to the family Lauraceae containing several active components such as essential oils (cinnamic aldehyde and cinnamyl aldehyde), tannin,...

    Authors: Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Chang-Rok Im, Sung Haeng Lee, Zee Yong Park and Sin-Hyeog Im
    Citation: BMC Cancer 2010 10:392
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1113

  39. Breast cancer is one the highest causes of female cancer death worldwide. Many standard chemotherapeutic agents currently used to treat breast cancer are relatively non-specific and act on all rapidly dividing...

    Authors: Fariborz Rashid-Kolvear, Michael AS Taboski, Johnny Nguyen, Dong-Yu Wang, Lea A Harrington and Susan J Done
    Citation: BMC Cancer 2010 10:390
    Content type: Research article Published on:

  40. Familial adenomatous polyposis, an autosomal dominant inherited disease caused by germline mutations within the APC gene, is characterized by early onset colorectal cancer as a consequence of the intrinsic phenot...

    Authors: Florentia Fostira, Georgia Thodi, Raphael Sandaltzopoulos, George Fountzilas and Drakoulis Yannoukakos
    Citation: BMC Cancer 2010 10:389
    Content type: Research article Published on:

  41. Cancer cells recurrently develop into acquired resistance to the administered drugs. The iatrogenic mechanisms of induced chemotherapy-resistance remain elusive and the degree of drug resistance did not exclus...

    Authors: Ji Yeon Yang, Seon-Ah Ha, Yun-Sik Yang and Jin Woo Kim
    Citation: BMC Cancer 2010 10:388
    Content type: Research article Published on:

  42. Histone deacetylase (HDAC) inhibitors are a novel anti-tumor therapy. To determine whether HDAC inhibitors may be useful in the treatment of adult acute lymphoblastic leukemia (ALL), we examined the acetylatio...

    Authors: Anjali S Advani, Sarah E Gibson, Elizabeth Douglas, Tao Jin, Xiaoxian Zhao, Matt Kalaycio, Ed Copelan, Ronald Sobecks, Mikkael Sekeres, Shawnda Sungren and Eric D Hsi
    Citation: BMC Cancer 2010 10:387
    Content type: Research article Published on:

  43. Melanoma is an aggressive tumor with increasing incidence. To develop accurate prognostic markers and targeted therapies, changes leading to malignant transformation of melanocytes need to be understood. In the X...

    Authors: Janka Teutschbein, Johannes M Haydn, Birgit Samans, Michael Krause, Martin Eilers, Manfred Schartl and Svenja Meierjohann
    Citation: BMC Cancer 2010 10:386
    Content type: Research article Published on:

  44. Neuroendocrine (NE) differentiation in prostate cancer has been correlated with a poor prognosis and hormone refractory disease. In a previous report, we demonstrated the presence of immunoreactive cytoplasmic...

    Authors: Nastaran Monsef, Maria Soller, Ioannis Panagopoulos and Per Anders Abrahamsson
    Citation: BMC Cancer 2010 10:385
    Content type: Research article Published on:

  45. Glioblastoma is the most common brain tumor in adults. The mechanisms leading to glioblastoma are not well understood but animal studies support that inactivation of tumor suppressor genes in neural stem cells...

    Authors: Patrick Evers, Percy P Lee, John DeMarco, Nzhde Agazaryan, James W Sayre, Michael Selch and Frank Pajonk
    Citation: BMC Cancer 2010 10:384
    Content type: Research article Published on:

  47. Endometrial cancer is the most common gynaecological malignancy in women of developed countries. Many risk factors implicated in endometrial cancer trigger inflammatory events; therefore, alterations in immune...

    Authors: Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds, Mark McEvoy, John Attia and Rodney J Scott
    Citation: BMC Cancer 2010 10:382
    Content type: Research article Published on:

  49. Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation...

    Authors: Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley and Dean A Fennell
    Citation: BMC Cancer 2010 10:380
    Content type: Research article Published on:

  50. Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains the effectiveness of new therapeutic strategies. Ap...

    Authors: Felix Rückert, Nicole Samm, Anne-Kathrin Lehner, Hans-Detlev Saeger, Robert Grützmann and Christian Pilarsky
    Citation: BMC Cancer 2010 10:379
    Content type: Research article Published on:

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