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  1. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the po...

    Authors: Liu Zheng, Zhang Weilun, Jiang Minghong, Zhang Yaxi, Liu Shilian, Liu Yanxin and Zheng Dexian
    Citation: BMC Cancer 2012 12:153
  2. The financial burden of medical expenses has been increasing for cancer patients. We investigated the relationship between household income and financial burden among patients with chronic myelogenous leukaemi...

    Authors: Yuko Kodama, Ryoko Morozumi, Tomoko Matsumura, Yukiko Kishi, Naoko Murashige, Yuji Tanaka, Morihito Takita, Nobuyo Hatanaka, Eiji Kusumi, Masahiro Kami and Akihiko Matsui
    Citation: BMC Cancer 2012 12:152
  3. Increasing incidence and lack of survival improvement in adolescents and young adults (AYAs) with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was...

    Authors: Fatima A Haggar, David B Preen, Gavin Pereira, Cashel DJ Holman and Kristjana Einarsdottir
    Citation: BMC Cancer 2012 12:151
  4. An understanding of the nature and magnitude of the impact of cancer is critical to planning how best to deliver supportive care to the growing population of cancer survivors whose need for care may span many ...

    Authors: Allison W Boyes, Afaf Girgis, Catherine D’Este and Alison C Zucca
    Citation: BMC Cancer 2012 12:150
  5. Body mass index (BMI) may be an important factor affecting breast cancer outcome. Studies conducted mainly in Western countries have reported a relationship between higher BMI and a higher risk of all-cause de...

    Authors: Masaaki Kawai, Yuko Minami, Yoshikazu Nishino, Kayoko Fukamachi, Noriaki Ohuchi and Yoichiro Kakugawa
    Citation: BMC Cancer 2012 12:149
  6. The prolonged survival of individuals diagnosed with cancer has led to an increase in the number of secondary primary malignancies. We undertook to perform a definitive study to characterize and predict progno...

    Authors: Qing-An Zeng, Jiliang Qiu, Ruhai Zou, Yijie Li, Shengping Li, Binkui Li, Pinzhu Huang, Jian Hong, Yun Zheng, Xiangming Lao and Yunfei Yuan
    Citation: BMC Cancer 2012 12:148
  7. Our recent study showed that tetrathiomolybdate (TM), a drug to treat copper overload disorders, can sensitize drug-resistant endometrial cancer cells to reactive oxygen species (ROS)-generating anticancer dru...

    Authors: Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard and Richard G Moore
    Citation: BMC Cancer 2012 12:147
  8. HOX genes encode homeodomain-containing transcription factors involved in the regulation of cellular proliferation and differentiation during embryogenesis. However, members of this family demonstrated oncogen...

    Authors: Carolina Cavalcante Bitu, Maria Fernanda de Souza Setúbal Destro, Manoela Carrera, Sabrina Daniela da Silva, Edgard Graner, Luiz Paulo Kowalski, Fernando Augusto Soares and Ricardo D Coletta
    Citation: BMC Cancer 2012 12:146
  9. Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway in...

    Authors: Cornel J Phillip, Christopher K Giardina, Birdal Bilir, David J Cutler, Yu-Heng Lai, Omer Kucuk and Carlos S Moreno
    Citation: BMC Cancer 2012 12:145
  10. 15-20% of all patients initially diagnosed with colorectal cancer develop metastatic disease and surgical resection remains the only potentially curative treatment available. Current 5-year survival following ...

    Authors: Carl Christoph Schimanski, Markus Möhler, Michael Schön, Eric van Cutsem, Richard Greil, Wolf Otto Bechstein, Susanna Hegewisch-Becker, Götz von Wichert, Matthias Vöhringer, Michael Heike, Volker Heinemann, Marc Peeters, Stephan Kanzler, Stefan Kasper, Friedrich Overkamp, Jan Schröder…
    Citation: BMC Cancer 2012 12:144
  11. Glioblastoma multiforme (GBM) is the most common primary central nervous system malignancy and its unique invasiveness renders it difficult to treat. This invasive phenotype, like other cellular processes, may...

    Authors: Sunwoo Koo, Gail S Martin, Kevin J Schulz, Matthew Ronck and L Gerard Toussaint
    Citation: BMC Cancer 2012 12:143
  12. Currently, it remains unclear, if patients with colon cancer and synchronous unresectable metastases who present without severe symptoms should undergo resection of the primary tumour prior to systemic chemoth...

    Authors: Nuh N Rahbari, Florian Lordick, Christine Fink, Ulrich Bork, Annika Stange, Dirk Jäger, Steffen P Luntz, Stefan Englert, Inga Rossion, Moritz Koch, Markus W Büchler, Meinhard Kieser and Jürgen Weitz
    Citation: BMC Cancer 2012 12:142
  13. The phosphatidylinositol-3-kinase (PI3K-PKB), mitogen activated protein kinase (MEK-ERK) and the mammalian target of rapamycin (mTOR- p70S6K), are thought to regulate many aspects of tumour cell proliferation ...

    Authors: Ji Eun Kim, Clare Stones, Wayne R Joseph, Euphemia Leung, Graeme J Finlay, Andrew N Shelling, Wayne A Phillips, Peter R Shepherd and Bruce C Baguley
    Citation: BMC Cancer 2012 12:141
  14. An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for ...

    Authors: Maike Ihnen, Kerstin Kress, Jan Felix Kersten, Ergin Kilic, Matthias Choschzick, Hilke Zander, Volkmar Müller, Sven Mahner, Fritz Jänicke, Linn Woelber and Karin Milde-Langosch
    Citation: BMC Cancer 2012 12:140
  15. Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs) have been identified in se...

    Authors: Sara R Martins-Neves, Áurio O Lopes, Anália do Carmo, Artur A Paiva, Paulo C Simões, Antero J Abrunhosa and Célia MF Gomes
    Citation: BMC Cancer 2012 12:139
  16. Sound and rigorous well-established, and newly extended, methods for genetic epidemiological analysis were used to analyze population evidence for genetic contributions to risk for numerous common cancer sites...

    Authors: Frederick Albright, Craig Teerlink, Theresa L Werner and Lisa A Cannon-Albright
    Citation: BMC Cancer 2012 12:138
  17. Treatment standard for patients with rectal cancer depends on the initial staging and includes surgical resection, radiotherapy as well as chemotherapy. For stage II and III tumors, radiochemotherapy should be...

    Authors: Stephanie E Combs, Meinhard Kieser, Daniel Habermehl, Jürgen Weitz, Dirk Jäger, Piero Fossati, Roberto Orrechia, Rita Engenhart-Cabillic, Richard Pötter, Manjit Dosanjh, Oliver Jäkel, Markus W Büchler and Jürgen Debus
    Citation: BMC Cancer 2012 12:137
  18. Common measures of surgical quality are 30-day morbidity and mortality, which poorly describe breast cancer surgical quality with extremely low morbidity and mortality rates. Several national quality programs ...

    Authors: Erin J Aiello Bowles, Heather Spencer Feigelson, Tom Barney, Katherine Broecker, Andrew Sterrett, Kimberly Bischoff, Jessica Engel, Gabrielle Gundersen, Johanna Sheehey-Jones, Richard Single, Adedayo Onitilo, Ted A James and Laurence E McCahill
    Citation: BMC Cancer 2012 12:136
  19. Clinical relevance of tumor infiltrating lymphocytes (TILs) in breast cancer is controversial. Here, we used a tumor microarray including a large series of ductal and lobular breast cancers with long term foll...

    Authors: Raoul Droeser, Inti Zlobec, Ergin Kilic, Uwe Güth, Michael Heberer, Giulio Spagnoli, Daniel Oertli and Coya Tapia
    Citation: BMC Cancer 2012 12:134
  20. The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon i...

    Authors: Stephanie E Combs, Julia Bauer, Daniel Unholtz, Christopher Kurz, Thomas Welzel, Daniel Habermehl, Thomas Haberer, Jürgen Debus and Katia Parodi
    Citation: BMC Cancer 2012 12:133
  21. Breast cancer outcome, including response to therapy, risk of metastasis and survival, is difficult to predict using currently available methods, highlighting the urgent need for more informative biomarkers. A...

    Authors: Kate M Peters, Stacey L Edwards, Shalima S Nair, Juliet D French, Peter J Bailey, Kathryn Salkield, Sandra Stein, Sarah Wagner, Glenn D Francis, Susan J Clark and Melissa A Brown
    Citation: BMC Cancer 2012 12:132
  22. It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, l...

    Authors: Antje Hahnel, Henri Wichmann, Thomas Greither, Matthias Kappler, Peter Würl, Matthias Kotzsch, Helge Taubert, Dirk Vordermark and Matthias Bache
    Citation: BMC Cancer 2012 12:131
  23. Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-...

    Authors: Martin Laschak, Klaus-Dieter Spindler, Andres J Schrader, Andrea Hessenauer, Wolfgang Streicher, Mark Schrader and Marcus V Cronauer
    Citation: BMC Cancer 2012 12:130
  24. Angiogenesis plays an important role in tumor growth and metastasis, therefore antiangiogenic therapy was widely investigated as a promising approach for cancer therapy. Recently, pigment epithelium-derived fa...

    Authors: Qin Jie Wu, Chang Yang Gong, Shun Tao Luo, Dong Mei Zhang, Shuang Zhang, Hua Shan Shi, Lian Lu, Heng Xiu Yan, Sha Sha He, Dan Dan Li, Li Yang, Xia Zhao and Yu Quan Wei
    Citation: BMC Cancer 2012 12:129
  25. Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial can...

    Authors: Tianhui Chen, Lina Jansen, Adam Gondos, Meike Ressing, Bernd Holleczek, Alexander Katalinic and Hermann Brenner
    Citation: BMC Cancer 2012 12:128
  26. Activation of MEK5 in many cancers is associated with carcinogenesis through aberrant cell proliferation. In this study, we determined the level of phosphorylated MEK5 (pMEK5) expression in human colorectal ca...

    Authors: Bang Hu, Donglin Ren, Dan Su, Hongcheng Lin, Zhenyu Xian, Xingyang Wan, Junxiao Zhang, Xinhui Fu, Li Jiang, Dechan Diao, Xinjuan Fan, Lei Wang and Jianping Wang
    Citation: BMC Cancer 2012 12:127
  27. Cutaneous squamous cell carcinoma (SCC) is associated with underlying immunosuppression, so it may be a prognostic marker in patients with subsequent cancer. We therefore conducted a nationwide population-base...

    Authors: Sigrun Alba Johannesdottir, Timothy L Lash, Annette Østergaard Jensen, Dóra Körmendiné Farkas and Anne Braae Olesen
    Citation: BMC Cancer 2012 12:126
  28. Epstein-Barr virus (EBV) establishes its latency in EBV-associated malignancies, accompanied by occasionally reactivated lytic cycle. Promoter CpG methylation of EBV genome plays an essential role in maintaini...

    Authors: Lili Li, Xianwei Su, Gigi Ching Gee Choi, Ya Cao, Richard F Ambinder and Qian Tao
    Citation: BMC Cancer 2012 12:125
  29. With over 20 million formalin-fixed, paraffin-embedded (FFPE) tissue samples archived each year in the United States alone, archival tissues remain a vast and under-utilized resource in the genomic study of ca...

    Authors: Levi Waldron, Peter Simpson, Giovanni Parmigiani and Curtis Huttenhower
    Citation: BMC Cancer 2012 12:124
  30. Studies indicate that strength training has beneficial effects on clinical health outcomes in prostate cancer patients during androgen deprivation therapy. However, randomized controlled trials are needed to s...

    Authors: Lene Thorsen, Tormod S Nilsen, Truls Raastad, Kerry S Courneya, Eva Skovlund and Sophie D Fosså
    Citation: BMC Cancer 2012 12:123
  31. Although socioeconomic status (SES) has been focused on as a key determinant of cancer stage at diagosis in western countries, there has been no systemic study on the relationship of SES and breast cancer stag...

    Authors: Qiong Wang, Jing Li, Shan Zheng, Jia-Yuan Li, Yi Pang, Rong Huang, Bao-Ning Zhang, Bin Zhang, Hong-Jian Yang, Xiao-Ming Xie, Zhong-Hua Tang, Hui Li, Jian-Jun He, Jin-Hu Fan and You-Lin Qiao
    Citation: BMC Cancer 2012 12:122
  32. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence t...

    Authors: Patricia González-Arriaga, Teresa Pascual, Arturo García-Alvarez, Ana Fernández-Somoano, M Felicitas López-Cima and Adonina Tardón
    Citation: BMC Cancer 2012 12:121
  33. Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of br...

    Authors: Punit Kaur, Ganachari M Nagaraja, Hongying Zheng, Dawit Gizachew, Moses Galukande, Sunil Krishnan and Alexzander Asea
    Citation: BMC Cancer 2012 12:120
  34. P53 mutations are an adverse prognostic factor in esophageal cancer. P53 and KRas mutations are involved in chemo-radioresistance. Circulating anti-p53 or anti-KRas antibodies are associated with gene mutation...

    Authors: Pierre Blanchard, Laurent Quero, Vincent Pacault, Marie-Helene Schlageter, Valerie Baruch-Hennequin and Christophe Hennequin
    Citation: BMC Cancer 2012 12:119
  35. Colorectal cancer is one of the major neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease. Metformin, a biguanide, which is wid...

    Authors: Takuma Higurashi, Hirokazu Takahashi, Hiroki Endo, Kunihiro Hosono, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takashi Uchiyama, Yasuo Hata, Nobutaka Fujisawa, Shiori Uchiyama, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Nobuyuki Matsuhashi, Shoji Yamanaka…
    Citation: BMC Cancer 2012 12:118
  36. Esthesioneuroblastoma (ENB) is a rare, aggressive tumor with no established treatment in children. We analyzed a series of pediatric ENB patients with the aim of improving our knowledge of this disease.

    Authors: Gianni Bisogno, Pietro Soloni, Massimo Conte, Marta Podda, Andrea Ferrari, Alberto Garaventa, Roberto Luksch and Giovanni Cecchetto
    Citation: BMC Cancer 2012 12:117
  37. Abnormal expression of Rho-GTPases has been reported in several human cancers. However, the expression of these proteins in cervical cancer has been poorly investigated. In this study we analyzed the expressio...

    Authors: Miguel A Mendoza-Catalán, Gema R Cristóbal-Mondragón, Jesús Adame-Gómez, Heidi N del Valle-Flores, José Fco Coppe, Laura Sierra-López, Mirna A Romero-Hernández, Luz del Carmen Alarcón-Romero, Berenice Illades-Aguiar and Eduardo Castañeda-Saucedo
    Citation: BMC Cancer 2012 12:116
  38. An elevated level of EMMPRIN in cancer tissues have been correlated with tumor invasion in numerous cancers including oral cavity and larynx. Although EMMPRIN's effect has been generally attributed to its MMP ...

    Authors: Géraldine Lescaille, Suzanne Menashi, Bénédicte Cavelier-Balloy, Farah Khayati, Cathy Quemener, Marie Pierre Podgorniak, Benyoussef Naïmi, Fabien Calvo, Céleste Lebbe and Samia Mourah
    Citation: BMC Cancer 2012 12:115
  39. Epithelial mesenchymal transition (EMT) is a crucial event likely involved in dissemination of epithelial cancer cells. This process enables them to acquire migratory/invasive properties, contributing to tumor...

    Authors: Guislaine Barrière, Alain Riouallon, Joël Renaudie, Michel Tartary and Michel Rigaud
    Citation: BMC Cancer 2012 12:114
  40. Diet has long been suspected to impact on breast cancer risk. In this study we evaluated whether the degree of adherence to a Mediterranean diet pattern modifies breast cancer risk amongst Greek-Cypriot women.

    Authors: Christiana A Demetriou, Andreas Hadjisavvas, Maria A Loizidou, Giorgos Loucaides, Ioanna Neophytou, Sabina Sieri, Eleni Kakouri, Nicos Middleton, Paolo Vineis and Kyriacos Kyriacou
    Citation: BMC Cancer 2012 12:113
  41. The current standard treatment, at least in Europe, for patients with primarily resectable tumors, consists of surgery followed by adjuvant chemotherapy. But even in this prognostic favourable group, long term...

    Authors: Falk Roeder, Carmen Timke, Ladan Saleh-Ebrahimi, Lutz Schneider, Thilo Hackert, Werner Hartwig, Annette Kopp-Schneider, Frank W Hensley, Markus W Buechler, Juergen Debus, Peter E Huber and Jens Werner
    Citation: BMC Cancer 2012 12:112
  42. miRNAs are a group of small RNA molecules regulating target genes by inducing mRNA degradation or translational repression. Aberrant expression of miRNAs correlates with various cancers. Although miR-135a has ...

    Authors: Yating Chen, Jin Zhang, Huijun Wang, Jiayi Zhao, Cheng Xu, Yingying Du, Xin Luo, Fengyun Zheng, Rui Liu, Hongwei Zhang and Duan Ma
    Citation: BMC Cancer 2012 12:111
  43. Patients with high Gleason score, elevated prostate specific antigen (PSA) level, and advanced clinical stage are at increased risk for both local and systemic relapse. Recent data suggests higher radiation do...

    Authors: Hiroyuki Konaka, Shin Egawa, Shiro Saito, Atsunori Yorozu, Hiroyuki Takahashi, Keiko Miyakoda, Masanori Fukushima, Takushi Dokiya, Hidetoshi Yamanaka, Nelson N Stone and Mikio Namiki
    Citation: BMC Cancer 2012 12:110
  44. Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transpo...

    Authors: Michael Heise, Anja Lautem, Johanna Knapstein, Jörn M Schattenberg, Maria Hoppe-Lotichius, Daniel Foltys, Nina Weiler, Anca Zimmermann, Arno Schad, Dirk Gründemann, Gerd Otto, Peter R Galle, Marcus Schuchmann and Tim Zimmermann
    Citation: BMC Cancer 2012 12:109
  45. The epidermal growth factor receptor monoclonal antibody cetuximab has proven activity in metastatic colorectal cancer. To date, the mechanisms of action are not completely understood. Especially the impact on...

    Authors: Anne Katrin Berger, Carl von Gall, Ulrich Abel, Stefan Delorme, Matthias Kloor, Jennifer Ose, Tim Frederik Weber, Annika Stange, Georg Martin Haag, Uwe Haberkorn, Florian Lordick and Dirk Jäger
    Citation: BMC Cancer 2012 12:108
  46. Gastrointestinal stromal tumors (GIST) mutational status is recognized factor related to the results of tyrosine kinase inhibitors therapy such as imatinib (IM) or sunitinib (SU). Arterial hypertension (AH) is...

    Authors: Piotr Rutkowski, Elżbieta Bylina, Anna Klimczak, Tomasz Świtaj, Sławomir Falkowski, Jacek Kroc, Iwona Ługowska, Magdalena Brzeskwiniewicz, Wojciech Melerowicz, Czesław Osuch, Ewa Mierzejewska, Kacper Wasielewski, Agnieszka Woźniak, Urszula Grzesiakowska, Zbigniew I Nowecki, Janusz A Siedlecki…
    Citation: BMC Cancer 2012 12:107
  47. Traditional determinants proven to be of prognostic importance in breast cancer include the TNM staging, histological grade, proliferative activity, hormone receptor status and HER2 overexpression. One of the ...

    Authors: Andrea Malfettone, Concetta Saponaro, Angelo Paradiso, Giovanni Simone and Annita Mangia
    Citation: BMC Cancer 2012 12:106
  48. A single nucleotide polymorphism located in the 3'-untranslated region of the KRAS oncogene (KRAS variant; rs61764370) disrupts a let-7 miRNA binding and was recently reported to act as a genetic marker for incre...

    Authors: Jasmina-Ziva Cerne, Vida Stegel, Ksenija Gersak and Srdjan Novakovic
    Citation: BMC Cancer 2012 12:105
  49. RRM1 and ERCC1 overexpression has been extensively investigated as potential predictive markers of tumor sensitivity to conventional chemotherapy agents, most thoroughly in lung cancer. However, data in pancre...

    Authors: Matias E Valsecchi, Thomas Holdbrook, Benjamin E Leiby, Edward Pequignot, Susan J Littman, Charles J Yeo, Jonathan R Brody and Agnieszka K Witkiewicz
    Citation: BMC Cancer 2012 12:104

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