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  1. The fusion protein VEGF121/rGel composed of the growth factor VEGF121 and the plant toxin gelonin targets the tumor neovasculature and exerts impressive anti-vascular effects. We have previously shown that VEGF12...

    Authors: Khalid A Mohamedali, Sophia Ran, Candelaria Gomez-Manzano, Latha Ramdas, Jing Xu, Sehoon Kim, Lawrence H Cheung, Walter N Hittelman, Wei Zhang, Johannes Waltenberger, Philip E Thorpe and Michael G Rosenblum
    Citation: BMC Cancer 2011 11:358
    Content type: Research article Published on:

  2. Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a rol...

    Authors: Benedicte Stavik, Grethe Skretting, Hans-Christian Aasheim, Mari Tinholt, Lillian Zernichow, Marit Sletten, Per Morten Sandset and Nina Iversen
    Citation: BMC Cancer 2011 11:357
    Content type: Research article Published on:

  3. Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this st...

    Authors: María Luisa Pérez-Saldivar, Arturo Fajardo-Gutiérrez, Roberto Bernáldez-Ríos, Armando Martínez-Avalos, Aurora Medina-Sanson, Laura Espinosa-Hernández, José de Diego Flores-Chapa, Raquel Amador-Sánchez, José Gabriel Peñaloza-González, Francisco Javier Álvarez-Rodríguez, Victoria Bolea-Murga, Janet Flores-Lujano, María del Carmen Rodríguez-Zepeda, Roberto Rivera-Luna, Elisa María Dorantes-Acosta, Elva Jiménez-Hernández…
    Citation: BMC Cancer 2011 11:355
    Content type: Research article Published on:

  4. We describe early dissemination patterns for first-line bevacizumab given for metastatic colorectal cancer treatment.

    Authors: S Yousuf Zafar, Jennifer L Malin, Steven C Grambow, David H Abbott, Deborah Schrag, Jane T Kolimaga, Leah L Zullig, Jane C Weeks, Mona N Fouad, John Z Ayanian, Robert Wallace, Katherine L Kahn, Patricia A Ganz, Paul Catalano, Dee W West and Dawn Provenzale
    Citation: BMC Cancer 2011 11:354
    Content type: Research article Published on:

  7. RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C

    Authors: Giorgio Malpeli, Eliana Amato, Mario Dandrea, Caterina Fumagalli, Valentina Debattisti, Letizia Boninsegna, Giuseppe Pelosi, Massimo Falconi and Aldo Scarpa
    Citation: BMC Cancer 2011 11:351
    Content type: Research article Published on:

  8. Epithelial-mesenchymal transition (EMT) is a crucial process in tumorigenesis since tumor cells attain fibroblast-like features enabling them to invade to surrounding tissue. Two transcription factors, TWIST and

    Authors: Anna Jouppila-Mättö, Mervi Närkiö-Mäkelä, Ylermi Soini, Matti Pukkila, Reijo Sironen, Hanna Tuhkanen, Arto Mannermaa and Veli-Matti Kosma
    Citation: BMC Cancer 2011 11:350
    Content type: Research article Published on:

  9. The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is prima...

    Authors: Marcia S Brose, Christopher M Nutting, Steven I Sherman, Young Kee Shong, Johannes WA Smit, Gerhard Reike, John Chung, Joachim Kalmus, Christian Kappeler and Martin Schlumberger
    Citation: BMC Cancer 2011 11:349
    Content type: Study protocol Published on:

  10. Breast cancer consists of a variety of tumours, which differ by their morphological features, molecular characteristics and outcome. Well-known prognostic factors, e.g. tumour grade and size, Ki-67, hormone re...

    Authors: Pia Boström, Mirva Söderström, Tero Vahlberg, Karl-Ove Söderström, Peter J Roberts, Olli Carpén and Pirkko Hirsimäki
    Citation: BMC Cancer 2011 11:348
    Content type: Research article Published on:

  12. Despite major improvements in the perioperative outcome of pancreas surgery, the prognosis of pancreatic cancer after curative resection remains poor. Adjuvant chemotherapy increases disease-free and overall s...

    Authors: Stefan Heinrich, Bernhard Pestalozzi, Mickael Lesurtel, Frederik Berrevoet, Stéphanie Laurent, Jean-Robert Delpero, Jean-Luc Raoul, Phillippe Bachellier, Patrick Dufour, Markus Moehler, Achim Weber, Hauke Lang, Xavier Rogiers and Pierre-Alain Clavien
    Citation: BMC Cancer 2011 11:346
    Content type: Study protocol Published on:

  13. Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression of Dicer mRNA in normal mucosa (n = 162), primary colorectal cancer (CRC) (n = 162) and liver metas...

    Authors: Johannes Stratmann, Chao-Jie Wang, Sebastian Gnosa, Åsa Wallin, David Hinselwood, Xiao-Feng Sun and Hong Zhang
    Citation: BMC Cancer 2011 11:345
    Content type: Research article Published on:

  14. Colorectal carcinoma (CRC) with CpG island methylator phenotype (CIMP) is recognized as a distinct subgroup of CRC, and CIMP status affects prognosis and response to chemotherapy. Identification of CIMP status...

    Authors: Byung-Hoon Min, Jeong Mo Bae, Eui Jin Lee, Hong Suk Yu, Young-Ho Kim, Dong Kyung Chang, Hee Cheol Kim, Cheol Keun Park, Suk-Hee Lee, Kyoung-Mee Kim and Gyeong Hoon Kang
    Citation: BMC Cancer 2011 11:344
    Content type: Research article Published on:

  15. Melanoma of the anal region is a very uncommon disease, accounting for only 0.2-0.3% of all melanoma cases. Mutations of the BRAF gene are usually absent in melanomas occurring in this region as well as in other ...

    Authors: Conrado Martinez-Cadenas, Nuria Bosch, Lucas Peñas, Esther Flores-Couce, Enrique Ochoa, Javier Munárriz, Juan P Aracil, Marcos Tajahuerce, Ramón Royo, Rafael Lozoya and Enrique Boldó
    Citation: BMC Cancer 2011 11:343
    Content type: Case report Published on:

  17. An increasing number of neo-adjuvant breast cancer studies are being conducted and a novel model for tumor biological studies, the "window-of-opportunity" model, has revealed several advantages. Change in tumo...

    Authors: Quinci Romero, Pär-Ola Bendahl, Marie Klintman, Niklas Loman, Christian Ingvar, Lisa Rydén, Carsten Rose, Dorthe Grabau and Signe Borgquist
    Citation: BMC Cancer 2011 11:341
    Content type: Research article Published on:

  18. CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration. CD44s plays an important role in invasion and metastasis of various ca...

    Authors: Yoon Ho Ko, Hye Sung Won, Eun Kyoung Jeon, Sook Hee Hong, Sang Young Roh, Young Seon Hong, Jae Ho Byun, Chan-Kwon Jung and Jin Hyoung Kang
    Citation: BMC Cancer 2011 11:340
    Content type: Research article Published on:

  19. Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with sever...

    Authors: Anna Abulí, Ceres Fernández-Rozadilla, Virginia Alonso-Espinaco, Jenifer Muñoz, Victoria Gonzalo, Xavier Bessa, Dolors González, Joan Clofent, Joaquin Cubiella, Juan D Morillas, Joaquim Rigau, Mercedes Latorre, Fernando Fernández-Bañares, Elena Peña, Sabino Riestra, Artemio Payá…
    Citation: BMC Cancer 2011 11:339
    Content type: Research article Published on:

  20. Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to hypoxia. It is essential for angiogenesis and is associated with tumor progression and overexpression of HIF-1α has b...

    Authors: Sonal M Manohar, Amol A Padgaonkar, Archana Jalota-Badhwar, Vinay Sonawane, Maggie J Rathos, Sanjay Kumar and Kalpana S Joshi
    Citation: BMC Cancer 2011 11:338
    Content type: Research article Published on:

  21. The therapeutic success of chemotherapeutic agents is often limited by severe adverse effects. To reduce toxicity of these drugs, nanoscale particle-based drug delivery systems (DDS) are used. DDS accumulate t...

    Authors: Jürgen Eckes, Oliver Schmah, Jan W Siebers, Ursula Groh, Stefan Zschiedrich, Beate Rautenberg, Annette Hasenburg, Martin Jansen, Martin J Hug, Karl Winkler and Gerhard Pütz
    Citation: BMC Cancer 2011 11:337
    Content type: Research article Published on:

  22. The diagnostic value and prognostic significance of circulating tumor cell (CTC) detection in patients with bladder cancer is controversial. We performed a meta-analysis to consolidate current evidence regardi...

    Authors: Pavlos Msaouel and Michael Koutsilieris
    Citation: BMC Cancer 2011 11:336
    Content type: Research article Published on:

  23. Male breast cancer (MBC) is a rare disease accounting for approximately 1% of all breast carcinomas. Presently treatment recommendations are derived from the standards for female breast cancer. However, those ...

    Authors: Robert Foerster, Frank G Foerster, Volkhard Wulff, Birgit Schubotz, Dieter Baaske, Matthias Wolfgarten, Walther C Kuhn and Christian Rudlowski
    Citation: BMC Cancer 2011 11:335
    Content type: Research article Published on:

  24. A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and meta...

    Authors: Ju-Hee Kang, Ki-Hoon Song, Kyung-Chae Jeong, Sunshin Kim, Changsun Choi, Chang Hoon Lee and Seung Hyun Oh
    Citation: BMC Cancer 2011 11:334
    Content type: Research article Published on:

  25. Nucleolin expressed at the cell surface is a binding protein for a variety of ligands implicated in tumorigenesis and angiogenesis. By using a specific antagonist that binds the C-terminal RGG domain of nucleo...

    Authors: Bernard Krust, Diala El Khoury, Isabelle Nondier, Calaiselvy Soundaramourty and Ara G Hovanessian
    Citation: BMC Cancer 2011 11:333
    Content type: Research article Published on:

  26. High serum levels of estradiol are associated with increased risk of postmenopausal breast cancer. Little is known about the gene expression in normal breast tissue in relation to levels of circulating serum e...

    Authors: Vilde D Haakensen, Trine Bjøro, Torben Lüders, Margit Riis, Ida K Bukholm, Vessela N Kristensen, Melissa A Troester, Marit M Homen, Giske Ursin, Anne-Lise Børresen-Dale and Åslaug Helland
    Citation: BMC Cancer 2011 11:332
    Content type: Research article Published on:

  29. Radical surgery is the cornerstone in the treatment of resectable gastric cancer. The Intergroup 0116 and MAGIC trials have shown benefit of postoperative chemoradiation and perioperative chemotherapy, respect...

    Authors: Johan L Dikken, Johanna W van Sandick, HA Maurits Swellengrebel, Pehr A Lind, Hein Putter, Edwin PM Jansen, Henk Boot, Nicole CT van Grieken, Cornelis JH van de Velde, Marcel Verheij and Annemieke Cats
    Citation: BMC Cancer 2011 11:329
    Content type: Study protocol Published on:

  31. Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identifi...

    Authors: Henna Mattila, Martin Schindler, Jarkko Isotalo, Tarja Ikonen, Mauno Vihinen, Hannu Oja, Teuvo LJ Tammela, Tiina Wahlfors and Johanna Schleutker
    Citation: BMC Cancer 2011 11:327
    Content type: Research article Published on:

  32. Standard treatment for patients with disseminated germ cell tumors is combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This treatment is highly effective, but the majority of patients ex...

    Authors: Jesper F Christensen, Jesper L Andersen, Lis Adamsen, Birgitte Lindegaard, Abigail L Mackey, Rie H Nielsen, Mikael Rørth and Gedske Daugaard
    Citation: BMC Cancer 2011 11:326
    Content type: Study protocol Published on:

  34. Oral cancer incidence is high on the Island of Puerto Rico (PR), particularly among males. As part of a larger study conducted in PR, we evaluated smoking and drinking as risk factors for oral potentially mali...

    Authors: Lin Li, Walter J Psoter, Carmen J Buxó, Augusto Elias, Lumarie Cuadrado and Douglas E Morse
    Citation: BMC Cancer 2011 11:324
    Content type: Research article Published on:

  36. 5-allyl-7-gen-difluoromethoxychrysin (AFMC) is a novel synthetic analogue of chrysin that has been reported to inhibit proliferation in various cancer cell lines. Tumor necrosis factor-related apoptosis-induci...

    Authors: Zhao-Hui Xie, Mei-Fang Quan, Fei Liu, Jian-Guo Cao and Jian-Song Zhang
    Citation: BMC Cancer 2011 11:322
    Content type: Research article Published on:

  37. Primary intestinal non-Hodgkin lymphoma (NHL) is a heterogeneous disease with regard to anatomic and histologic distribution. Thus, analyses focusing on primary intestinal NHL with large number of patients are...

    Authors: Seok Jin Kim, Chul Won Choi, Yeung-Chul Mun, Sung Yong Oh, Hye Jin Kang, Soon Il Lee, Jong Ho Won, Min Kyoung Kim, Jung Hye Kwon, Jin Seok Kim, Jae-Yong Kwak, Jung Mi Kwon, In Gyu Hwang, Hyo Jung Kim, Jae Hoon Lee, Sukjoong Oh…
    Citation: BMC Cancer 2011 11:321
    Content type: Research article Published on:

  38. CD133 is known to be a cancer stem cell (CSC) marker. However, recent studies have revealed that CD133 is not restricted to CSC but to be expressed not only in human normal tissues but also in some cancers and...

    Authors: Linni Fan, Furong He, Hongxiang Liu, Jin Zhu, Yixiong Liu, Zhiyong Yin, Lu Wang, Ying Guo, Zhe Wang, Qingguo Yan and Gaosheng Huang
    Citation: BMC Cancer 2011 11:320
    Content type: Research article Published on:

  39. Currently, there are no standard guidelines for recommending re-administration of a chemotherapeutic drug to a patient after a serious adverse drug reaction (ADR) incident. The decision on whether to rechallen...

    Authors: Pei Yi Loke, Lita Chew and Chun Wei Yap
    Citation: BMC Cancer 2011 11:319
    Content type: Research article Published on:

  40. MANTICORE 101 - Breast (Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research) is a randomized trial to determine if conventional heart failure pharmacotherapy (angiotensin converting e...

    Authors: Edith Pituskin, Mark Haykowsky, John R Mackey, Richard B Thompson, Justin Ezekowitz, Sheri Koshman, Gavin Oudit, Kelvin Chow, Joseph J Pagano and Ian Paterson
    Citation: BMC Cancer 2011 11:318
    Content type: Study protocol Published on:

  41. Prostate cancer is the most common male cancer in developed countries and diagnosis and treatment carries with it substantial morbidity and related unmet supportive care needs. These difficulties may be amplif...

    Authors: Suzanne K Chambers, Robert U Newton, Afaf Girgis, Lisa Nielsen, Stephen Lepore, Cathrine Mihalopoulos, RA Gardiner, Daniel A Galvão and Stefano Occhipinti
    Citation: BMC Cancer 2011 11:317
    Content type: Study protocol Published on:

  42. Patients with cancer have an increased risk of VTE. We compared VTE rates and bleeding complications in 1) cancer patients receiving LMWH or UFH and 2) patients with or without cancer.

    Authors: Sylvia Haas, Sebastian M Schellong, Ulrich Tebbe, Horst-Eberhard Gerlach, Rupert Bauersachs, Nima Melzer, Claudia Abletshauser, Christian Sieder, Peter Bramlage and Hanno Riess
    Citation: BMC Cancer 2011 11:316
    Content type: Research article Published on:

  43. Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy targeting this metabolic phenotype is glucose res...

    Authors: Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach and Johannes Rieger
    Citation: BMC Cancer 2011 11:315
    Content type: Research article Published on:

  44. Mammographic density (MD) and malignant-appearing microcalcifications (MAMCs) represent the earliest mammographic findings of non-palpable breast carcinomas. Matrix proteoglycans versican and decorin are frequ...

    Authors: Spyros S Skandalis, Vassiliki T Labropoulou, Panagiota Ravazoula, Eleni Likaki-Karatza, Katalin Dobra, Haralabos P Kalofonos, Nikos K Karamanos and Achilleas D Theocharis
    Citation: BMC Cancer 2011 11:314
    Content type: Research article Published on:

  45. This phase 1b study assessed the maximum tolerated dose (MTD), safety, and pharmacokinetics of motesanib (a small-molecule antagonist of VEGF receptors 1, 2, and 3; platelet-derived growth factor receptor; and...

    Authors: Dusan Kotasek, Niall Tebbutt, Jayesh Desai, Stephen Welch, Lillian L Siu, Sheryl McCoy, Yu-Nien Sun, Jessica Johnson, Adeboye H Adewoye and Timothy Price
    Citation: BMC Cancer 2011 11:313
    Content type: Research article Published on:

  46. Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the rol...

    Authors: Nelma Pértega-Gomes, José R Vizcaíno, Vera Miranda-Gonçalves, Céline Pinheiro, Joana Silva, Helena Pereira, Pedro Monteiro, Rui M Henrique, Rui M Reis, Carlos Lopes and Fátima Baltazar
    Citation: BMC Cancer 2011 11:312
    Content type: Research article Published on:

  47. Strategies for cancer reduction and management are targeted at both individual and area levels. Area-level strategies require careful understanding of geographic differences in cancer incidence, in particular ...

    Authors: Susanna M Cramb, Kerrie L Mengersen and Peter D Baade
    Citation: BMC Cancer 2011 11:311
    Content type: Research article Published on:

  48. Open transthoracic oesophagectomy is the standard treatment for infracarinal resectable oesophageal carcinomas, although it is associated with high mortality and morbidity rates of 2 to 10% and 30 to 50%, resp...

    Authors: Nicolas Briez, Guillaume Piessen, Franck Bonnetain, Cécile Brigand, Nicolas Carrere, Denis Collet, Christophe Doddoli, Renaud Flamein, Jean-Yves Mabrut, Bernard Meunier, Simon Msika, Thierry Perniceni, Frédérique Peschaud, Michel Prudhomme, Jean-Pierre Triboulet and Christophe Mariette
    Citation: BMC Cancer 2011 11:310
    Content type: Study protocol Published on:

  49. E7080 is an orally active multi-targeted kinase inhibitor whose targets include vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor...

    Authors: Hilary Glen, Susan Mason, Hitesh Patel, Kenneth Macleod and Valerie G Brunton
    Citation: BMC Cancer 2011 11:309
    Content type: Research article Published on:

  50. Ovarian cancer is the most deadly gynecological cancer with a very poor prognosis. Xenograft mouse models have proven to be one very useful tool in testing candidate therapeutic agents and gene function in vivo. ...

    Authors: Ashley Stuckey, Andrew Fischer, Daniel H Miller, Sara Hillenmeyer, Kyu K Kim, Anna Ritz, Rakesh K Singh, Benjamin J Raphael, Laurent Brard and Alexander S Brodsky
    Citation: BMC Cancer 2011 11:308
    Content type: Research article Published on:

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