Skip to main content

Articles

Page 266 of 329

  1. During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome impro...

    Authors: Robin H Kennedy, Anne Francis, Susan Dutton, Sharon Love, Sarah Pearson, Jane M Blazeby, Philip Quirke, Peter J Franks and David J Kerr
    Citation: BMC Cancer 2012 12:181
    Content type: Study protocol Published on:

  2. Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect r...

    Authors: Anping Gui, Akira Kobayashi, Hiroaki Motoyama, Masato Kitazawa, Michiko Takeoka and Shinichi Miyagawa
    Citation: BMC Cancer 2012 12:179
    Content type: Research article Published on:

  3. MicroRNAs expression has been extensively studied in hepatocellular carcinoma but little is known regarding the relationship, if any, with inflammation, production of reactive oxygen species (ROS), host’s repa...

    Authors: Cardin Romilda, Piciocchi Marika, Sinigaglia Alessandro, Lavezzo Enrico, Bortolami Marina, Kotsafti Andromachi, Cillo Umberto, Zanus Giacomo, Mescoli Claudia, Rugge Massimo and Farinati Fabio
    Citation: BMC Cancer 2012 12:177
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2014 14:284

  4. Overcoming platinum resistance is a major obstacle in the treatment of Epithelial Ovarian Cancer (EOC). In our previous work Decoy Receptor 3 (DcR3) was found to be related to platinum resistance. The major ob...

    Authors: Joseph P Connor, Mildred Felder, Arvinder Kapur and Nonyem Onujiogu
    Citation: BMC Cancer 2012 12:176
    Content type: Research article Published on:

  5. To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases.

    Authors: Nam P Nguyen, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Benjamin Slane, Alexander Chi, Anand Desai, Shane P Krafft, Siyoung Jang, Russ Hamilton, Ulf Karlsson and Dave Abraham
    Citation: BMC Cancer 2012 12:175
    Content type: Research article Published on:

  7. Psychological distress is common in cancer survivors. Although there is some evidence on effectiveness of psychosocial care in distressed cancer patients, referral rate is low. Lack of adequate screening instr...

    Authors: Anne-Marie H Krebber, C René Leemans, Remco de Bree, Annemieke van Straten, Filip Smit, Egbert F Smit, Annemarie Becker, Guus M Eeckhout, Aartjan TF Beekman, Pim Cuijpers and Irma M Verdonck-de Leeuw
    Citation: BMC Cancer 2012 12:173
    Content type: Study protocol Published on:

  8. Due to early detection and advances in treatment, the number of women surviving breast cancer is increasing. Whilst there are many positive aspects of improved survival, breast cancer survival is associated wi...

    Authors: Camille E Short, Erica L James, Afaf Girgis, Patrick Mcelduff and Ronald C Plotnikoff
    Citation: BMC Cancer 2012 12:172
    Content type: Study protocol Published on:

  9. Patients ≥ 70 years with small, low-risk breast cancer who are operated but not irradiated how local relapse rates around 4% after 4 years. With adjuvant whole breast radiotherapy (WBRT) the local relapse rate...

    Authors: Christian Neumaier, Sperk Elena, Welzel Grit, Abo-Madyan Yasser, Kraus-Tiefenbacher Uta, Keller Anke, Gerhardt Axel, Sütterlin Marc and Wenz Frederik
    Citation: BMC Cancer 2012 12:171
    Content type: Study protocol Published on:

  10. In the US, Hispanic women have a higher incidence of, and mortality from, cervical cancer than non-Hispanic white women. The reason for this disparity may be attributable to both low rates of screening and poo...

    Authors: Catherine Duggan, Gloria Coronado, Javiera Martinez, Theresa L Byrd, Elizabeth Carosso, Cathy Lopez, Maria Benavides and Beti Thompson
    Citation: BMC Cancer 2012 12:170
    Content type: Study protocol Published on:

  11. Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogen...

    Authors: Monica Mannelqvist, Ingunn M Stefansson, Elisabeth Wik, Kanthida Kusonmano, Maria B Raeder, Anne M Øyan, Karl-Henning Kalland, Marsha A Moses, Helga B Salvesen and Lars A Akslen
    Citation: BMC Cancer 2012 12:169
    Content type: Research article Published on:

  13. A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the res...

    Authors: Karin Nordin, Ritva Rissanen, Johan Ahlgren, Gunilla Burell, Marie-Louise Fjällskog, Susanne Börjesson and Cecilia Arving
    Citation: BMC Cancer 2012 12:167
    Content type: Study protocol Published on:

  14. Despite recent advances in the treatment of hepatocellular carcinoma (HCC), the chemotherapy efficacy against HCC is still unsatisfactory. The mammalian target of rapamycin (mTOR) has been emerged as an import...

    Authors: Cun Wang, Dongmei Gao, Kun Guo, Xiaonan Kang, Kai Jiang, Chun Sun, Yan Li, Lu Sun, Hong Shu, Guangzhi Jin, Haiyan Sun, Weizhong Wu and Yinkun Liu
    Citation: BMC Cancer 2012 12:166
    Content type: Research article Published on:

  15. The 3-weekly combination of trastuzumab and paclitaxel has been approved for the treatment of advanced breast cancer based on a large pivotal study. However, mono and combination chemotherapy trials suggest th...

    Authors: Matthias John, Axel Hinke, Martina Stauch, Heiner Wolf, Benno Mohr, Hans-Joachim Hindenburg, Jens Papke and Joachim Schlosser
    Citation: BMC Cancer 2012 12:165
    Content type: Research article Published on:

  16. It has previously been shown that indirubin derivative E804 (IDR-E804) blocks signal transducer and activator of transcription-3 signaling in human breast and prostate cancer cells and inhibits Src kinase acti...

    Authors: Eun-Kyung Shin and Jin-Kyung Kim
    Citation: BMC Cancer 2012 12:164
    Content type: Research article Published on:

  17. The COSMIC trial is designed to evaluate toxicity in dose-escalated treatment with intensity-modulated radiotherapy (IMRT) and carbon ion boost for malignant salivary gland tumors (MSGT) of the head and neck i...

    Authors: Alexandra D Jensen, Anna V Nikoghosyan, Karen Lossner, Klaus K Herfarth, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2012 12:163
    Content type: Research article Published on:

  18. We reported previously that 18F-2-fluoro-2-deoxyglucose positron emission tomography/ computed tomography (FDG PET/CT) had potential for evaluating early response to treatment by tyrosine kinase inhibitors (TKIs)...

    Authors: Daiki Ueno, Masahiro Yao, Ukihide Tateishi, Ryogo Minamimoto, Kazuhide Makiyama, Narihiko Hayashi, Futoshi Sano, Takayuki Murakami, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Ichiro Ikeda, Yoshiharu Ohgo, Tomio Inoue, Yoshinobu Kubota…
    Citation: BMC Cancer 2012 12:162
    Content type: Research article Published on:

  19. In premenopausal women, endocrine adjuvant therapy for breast cancer primarily consists of tamoxifen alone or with ovarian suppressive strategies. Toremifene is a chlorinated derivative of tamoxifen, but with ...

    Authors: Ran Gu, Weijuan Jia, Yunjie Zeng, Nanyan Rao, Yue Hu, Shunrong Li, Jiannan Wu, Liang Jin, Lijuan Chen, Meijun Long, Kai Chen, Lili Chen, Qiaozhen Xiao, Mei Wu, Erwei Song and Fengxi Su
    Citation: BMC Cancer 2012 12:161
    Content type: Research article Published on:

  20. Studies have shown that type-specific persistence of high-risk human papillomavirus (HPV) infection contributed significantly to cervical carcinogenesis.

    Authors: Shizhuo Wang, Heng Wei, Ning Wang, Shulan Zhang, Yao Zhang, Qiang Ruan, Weiguo Jiang, Qian Xiao, Xiaomei Luan, Xiuyan Qian, Lili Zhang, Xiang Gao and Xiaowei Sun
    Citation: BMC Cancer 2012 12:160
    Content type: Research article Published on:

  21. The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing ...

    Authors: Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei and Guojun Li
    Citation: BMC Cancer 2012 12:159
    Content type: Research article Published on:

  22. The prognosis of pT1a-pT1b breast cancer (BC) used to be considered very good, with a 10-y RFS of 90%. However, some retrospective studies reported a 10-y RFS of 81%–86% and suggested benefit from adjuvant sys...

    Authors: Stefania Gori, Matteo Clavarezza, Salvatore Siena, Jennifer Foglietta, Emiliana Tarenzi, Monica Giordano, Annamaria Molino, Claudio Graiff, Vittorio Fusco, Oscar Alabiso, Editta Baldini, Teresa Gamucci, Giuseppe Altavilla, Davide Dondi and Marco Venturini
    Citation: BMC Cancer 2012 12:158
    Content type: Research article Published on:

  23. According to a fundamental law of radiobiology (“Law of Bergonié and Tribondeau”, 1906), the brain is a paradigm of a highly differentiated organ with low mitotic activity, and is thus radio-resistant. This as...

    Authors: Eugenio Picano, Eliseo Vano, Luciano Domenici, Matteo Bottai and Isabelle Thierry-Chef
    Citation: BMC Cancer 2012 12:157
    Content type: Review Published on:

  24. Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased ov...

    Authors: Cristina Trejo-Solís, Dolores Jimenez-Farfan, Sara Rodriguez-Enriquez, Francisca Fernandez-Valverde, Arturo Cruz-Salgado, Lena Ruiz-Azuara and Julio Sotelo
    Citation: BMC Cancer 2012 12:156
    Content type: Research article Published on:

  25. To construct the Bifidobacterium infantis-mediated soluble kinase insert domain receptor (sKDR) prokaryotic expression system and to observe its inhibitory effect on growth of human umbilicus vessel endothelial c...

    Authors: Zhao-Jun Li, Hong Zhu, Bu-Yun Ma, Fen Zhao, Shu-Hua Mao, Tai-Guo Liu, Jian-Ping He, Li-Cong Deng, Cheng Yi and Ying Huang
    Citation: BMC Cancer 2012 12:155
    Content type: Research article Published on:

  26. Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading to its aggressiveness and a poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor a PAX3-FKHR ...

    Authors: Lingling Liu, Yong-Dong Wang, Jing Wu, Jimmy Cui and Taosheng Chen
    Citation: BMC Cancer 2012 12:154
    Content type: Research article Published on:

  27. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the po...

    Authors: Liu Zheng, Zhang Weilun, Jiang Minghong, Zhang Yaxi, Liu Shilian, Liu Yanxin and Zheng Dexian
    Citation: BMC Cancer 2012 12:153
    Content type: Research article Published on:

  28. The financial burden of medical expenses has been increasing for cancer patients. We investigated the relationship between household income and financial burden among patients with chronic myelogenous leukaemi...

    Authors: Yuko Kodama, Ryoko Morozumi, Tomoko Matsumura, Yukiko Kishi, Naoko Murashige, Yuji Tanaka, Morihito Takita, Nobuyo Hatanaka, Eiji Kusumi, Masahiro Kami and Akihiko Matsui
    Citation: BMC Cancer 2012 12:152
    Content type: Research article Published on:

  29. Increasing incidence and lack of survival improvement in adolescents and young adults (AYAs) with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was...

    Authors: Fatima A Haggar, David B Preen, Gavin Pereira, Cashel DJ Holman and Kristjana Einarsdottir
    Citation: BMC Cancer 2012 12:151
    Content type: Research article Published on:

  30. An understanding of the nature and magnitude of the impact of cancer is critical to planning how best to deliver supportive care to the growing population of cancer survivors whose need for care may span many ...

    Authors: Allison W Boyes, Afaf Girgis, Catherine D’Este and Alison C Zucca
    Citation: BMC Cancer 2012 12:150
    Content type: Research article Published on:

  31. Body mass index (BMI) may be an important factor affecting breast cancer outcome. Studies conducted mainly in Western countries have reported a relationship between higher BMI and a higher risk of all-cause de...

    Authors: Masaaki Kawai, Yuko Minami, Yoshikazu Nishino, Kayoko Fukamachi, Noriaki Ohuchi and Yoichiro Kakugawa
    Citation: BMC Cancer 2012 12:149
    Content type: Research article Published on:

  32. The prolonged survival of individuals diagnosed with cancer has led to an increase in the number of secondary primary malignancies. We undertook to perform a definitive study to characterize and predict progno...

    Authors: Qing-An Zeng, Jiliang Qiu, Ruhai Zou, Yijie Li, Shengping Li, Binkui Li, Pinzhu Huang, Jian Hong, Yun Zheng, Xiangming Lao and Yunfei Yuan
    Citation: BMC Cancer 2012 12:148
    Content type: Research article Published on:

  33. Our recent study showed that tetrathiomolybdate (TM), a drug to treat copper overload disorders, can sensitize drug-resistant endometrial cancer cells to reactive oxygen species (ROS)-generating anticancer dru...

    Authors: Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard and Richard G Moore
    Citation: BMC Cancer 2012 12:147
    Content type: Research article Published on:

  34. HOX genes encode homeodomain-containing transcription factors involved in the regulation of cellular proliferation and differentiation during embryogenesis. However, members of this family demonstrated oncogen...

    Authors: Carolina Cavalcante Bitu, Maria Fernanda de Souza Setúbal Destro, Manoela Carrera, Sabrina Daniela da Silva, Edgard Graner, Luiz Paulo Kowalski, Fernando Augusto Soares and Ricardo D Coletta
    Citation: BMC Cancer 2012 12:146
    Content type: Research article Published on:

  35. Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway in...

    Authors: Cornel J Phillip, Christopher K Giardina, Birdal Bilir, David J Cutler, Yu-Heng Lai, Omer Kucuk and Carlos S Moreno
    Citation: BMC Cancer 2012 12:145
    Content type: Research article Published on:

  36. 15-20% of all patients initially diagnosed with colorectal cancer develop metastatic disease and surgical resection remains the only potentially curative treatment available. Current 5-year survival following ...

    Authors: Carl Christoph Schimanski, Markus Möhler, Michael Schön, Eric van Cutsem, Richard Greil, Wolf Otto Bechstein, Susanna Hegewisch-Becker, Götz von Wichert, Matthias Vöhringer, Michael Heike, Volker Heinemann, Marc Peeters, Stephan Kanzler, Stefan Kasper, Friedrich Overkamp, Jan Schröder…
    Citation: BMC Cancer 2012 12:144
    Content type: Study protocol Published on:

  37. Glioblastoma multiforme (GBM) is the most common primary central nervous system malignancy and its unique invasiveness renders it difficult to treat. This invasive phenotype, like other cellular processes, may...

    Authors: Sunwoo Koo, Gail S Martin, Kevin J Schulz, Matthew Ronck and L Gerard Toussaint
    Citation: BMC Cancer 2012 12:143
    Content type: Research article Published on:

  38. Currently, it remains unclear, if patients with colon cancer and synchronous unresectable metastases who present without severe symptoms should undergo resection of the primary tumour prior to systemic chemoth...

    Authors: Nuh N Rahbari, Florian Lordick, Christine Fink, Ulrich Bork, Annika Stange, Dirk Jäger, Steffen P Luntz, Stefan Englert, Inga Rossion, Moritz Koch, Markus W Büchler, Meinhard Kieser and Jürgen Weitz
    Citation: BMC Cancer 2012 12:142
    Content type: Study protocol Published on:

  39. The phosphatidylinositol-3-kinase (PI3K-PKB), mitogen activated protein kinase (MEK-ERK) and the mammalian target of rapamycin (mTOR- p70S6K), are thought to regulate many aspects of tumour cell proliferation ...

    Authors: Ji Eun Kim, Clare Stones, Wayne R Joseph, Euphemia Leung, Graeme J Finlay, Andrew N Shelling, Wayne A Phillips, Peter R Shepherd and Bruce C Baguley
    Citation: BMC Cancer 2012 12:141
    Content type: Research article Published on:

  40. An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for ...

    Authors: Maike Ihnen, Kerstin Kress, Jan Felix Kersten, Ergin Kilic, Matthias Choschzick, Hilke Zander, Volkmar Müller, Sven Mahner, Fritz Jänicke, Linn Woelber and Karin Milde-Langosch
    Citation: BMC Cancer 2012 12:140
    Content type: Research article Published on:

  41. Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs) have been identified in se...

    Authors: Sara R Martins-Neves, Áurio O Lopes, Anália do Carmo, Artur A Paiva, Paulo C Simões, Antero J Abrunhosa and Célia MF Gomes
    Citation: BMC Cancer 2012 12:139
    Content type: Research article Published on:

  42. Sound and rigorous well-established, and newly extended, methods for genetic epidemiological analysis were used to analyze population evidence for genetic contributions to risk for numerous common cancer sites...

    Authors: Frederick Albright, Craig Teerlink, Theresa L Werner and Lisa A Cannon-Albright
    Citation: BMC Cancer 2012 12:138
    Content type: Research article Published on:

  43. Treatment standard for patients with rectal cancer depends on the initial staging and includes surgical resection, radiotherapy as well as chemotherapy. For stage II and III tumors, radiochemotherapy should be...

    Authors: Stephanie E Combs, Meinhard Kieser, Daniel Habermehl, Jürgen Weitz, Dirk Jäger, Piero Fossati, Roberto Orrechia, Rita Engenhart-Cabillic, Richard Pötter, Manjit Dosanjh, Oliver Jäkel, Markus W Büchler and Jürgen Debus
    Citation: BMC Cancer 2012 12:137
    Content type: Study protocol Published on:

  44. Common measures of surgical quality are 30-day morbidity and mortality, which poorly describe breast cancer surgical quality with extremely low morbidity and mortality rates. Several national quality programs ...

    Authors: Erin J Aiello Bowles, Heather Spencer Feigelson, Tom Barney, Katherine Broecker, Andrew Sterrett, Kimberly Bischoff, Jessica Engel, Gabrielle Gundersen, Johanna Sheehey-Jones, Richard Single, Adedayo Onitilo, Ted A James and Laurence E McCahill
    Citation: BMC Cancer 2012 12:136
    Content type: Correspondence Published on:

  46. Clinical relevance of tumor infiltrating lymphocytes (TILs) in breast cancer is controversial. Here, we used a tumor microarray including a large series of ductal and lobular breast cancers with long term foll...

    Authors: Raoul Droeser, Inti Zlobec, Ergin Kilic, Uwe Güth, Michael Heberer, Giulio Spagnoli, Daniel Oertli and Coya Tapia
    Citation: BMC Cancer 2012 12:134
    Content type: Research article Published on:

  47. The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon i...

    Authors: Stephanie E Combs, Julia Bauer, Daniel Unholtz, Christopher Kurz, Thomas Welzel, Daniel Habermehl, Thomas Haberer, Jürgen Debus and Katia Parodi
    Citation: BMC Cancer 2012 12:133
    Content type: Study protocol Published on:

  48. Breast cancer outcome, including response to therapy, risk of metastasis and survival, is difficult to predict using currently available methods, highlighting the urgent need for more informative biomarkers. A...

    Authors: Kate M Peters, Stacey L Edwards, Shalima S Nair, Juliet D French, Peter J Bailey, Kathryn Salkield, Sandra Stein, Sarah Wagner, Glenn D Francis, Susan J Clark and Melissa A Brown
    Citation: BMC Cancer 2012 12:132
    Content type: Research article Published on:

  49. It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, l...

    Authors: Antje Hahnel, Henri Wichmann, Thomas Greither, Matthias Kappler, Peter Würl, Matthias Kotzsch, Helge Taubert, Dirk Vordermark and Matthias Bache
    Citation: BMC Cancer 2012 12:131
    Content type: Research article Published on:

  50. Activation of MEK5 in many cancers is associated with carcinogenesis through aberrant cell proliferation. In this study, we determined the level of phosphorylated MEK5 (pMEK5) expression in human colorectal ca...

    Authors: Bang Hu, Donglin Ren, Dan Su, Hongcheng Lin, Zhenyu Xian, Xingyang Wan, Junxiao Zhang, Xinhui Fu, Li Jiang, Dechan Diao, Xinjuan Fan, Lei Wang and Jianping Wang
    Citation: BMC Cancer 2012 12:127
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow