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  1. The oncoprotein HER-2 is over-expressed and/or has undergone gene amplification in between 20 to 30% of breast and ovarian cancers. HER-2 amplified breast cancer is associated with a poor prognosis and increas...

    Authors: Aisha Siddiqa, Linda M Long, Liuxia Li, Robert A Marciniak and Irene Kazhdan
    Citation: BMC Cancer 2008 8:129
  2. The inactivation of tumor suppressor genes (TSGs) by aberrant DNA methylation plays an important role in the development of malignancy. Since this epigenetic change is reversible, it is a potential target for ...

    Authors: Maryse Lemaire, Guy G Chabot, Noël JM Raynal, Louise F Momparler, Annie Hurtubise, Mark L Bernstein and Richard L Momparler
    Citation: BMC Cancer 2008 8:128
  3. Breast cancer (BC) mortality is declining such that the number of survivors of BC in the community is increasing. BC survivors report a range of sequelae from their cancer and its management beyond the period ...

    Authors: Marijana Lijovic, Susan R Davis, Pam Fradkin, Maria La China, Helen Farrugia, Rory Wolfe and Robin J Bell
    Citation: BMC Cancer 2008 8:126
  4. TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of...

    Authors: Arnaud Guilbert, Isabelle Dhennin-Duthille, Yassine EL Hiani, Nathalie Haren, Hafida Khorsi, Henri Sevestre, Ahmed Ahidouch and Halima Ouadid-Ahidouch
    Citation: BMC Cancer 2008 8:125
  5. Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy ...

    Authors: Rui Yang, Wei-Wei Li, Bang H Hoang, Hansoo Kim, Debabrata Banerjee, Albert Kheradpour, John H Healey, Paul A Meyers, Joseph R Bertino and Richard Gorlick
    Citation: BMC Cancer 2008 8:124
  6. Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mecha...

    Authors: Sung Yong Oh, Hyuk-Chan Kwon, Sung-Hyun Kim, Jin Seok Jang, Min Chan Kim, Kyeong Hee Kim, Jin-Yeong Han, Chung Ock Kim, Su-Jin Kim, Jin-sook Jeong and Hyo-Jin Kim
    Citation: BMC Cancer 2008 8:123
  7. Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen....

    Authors: Christoph Otto, Ulrike Kaemmerer, Bertram Illert, Bettina Muehling, Nadja Pfetzer, Rainer Wittig, Hans Ullrich Voelker, Arnulf Thiede and Johannes F Coy
    Citation: BMC Cancer 2008 8:122
  8. Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in huma...

    Authors: Chen Liu, Yaohui Chen, Xianjun Yu, Chen Jin, Jin Xu, Jiang Long, Quanxing Ni, Deliang Fu, Hong Jin and Chen Bai
    Citation: BMC Cancer 2008 8:121
  9. Surgical resection of liver metastases arising from colorectal cancer is considered the only curative treatment option. However, many patients subsequently experience disease recurrence. We prospectively inves...

    Authors: Birgit Gruenberger, Werner Scheithauer, Robert Punzengruber, Christoph Zielinski, Dietmar Tamandl and Thomas Gruenberger
    Citation: BMC Cancer 2008 8:120
  10. To gain a better understanding of the effects of therapeutic agents on the tumor microenvironment in invasive cancers, we developed a co-culture model from an invasive lobular carcinoma. Tumor cells expressing...

    Authors: Marie P Piechocki
    Citation: BMC Cancer 2008 8:119
  11. The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact of CD24 cross-linking on human breast cancer cell line MCF-7.

    Authors: Jong Bin Kim, Eunyoung Ko, Wonshik Han, Jeong Eon Lee, Kyung-Min Lee, Incheol Shin, Sangmin Kim, Jong Won Lee, Jihyoung Cho, Ji-Yeon Bae, Hyeon-Gun Jee and Dong-Young Noh
    Citation: BMC Cancer 2008 8:118
  12. The ATM gene has been frequently involved in hereditary breast cancer as a low-penetrance susceptibility gene but evidence regarding the role of ATM as a breast cancer susceptibility gene has been contradictory.

    Authors: Patricio González-Hormazábal, Teresa Bravo, Rafael Blanco, Carlos Y Valenzuela, Fernando Gómez, Enrique Waugh, Octavio Peralta, Waldo Ortuzar, Jose M Reyes and Lilian Jara
    Citation: BMC Cancer 2008 8:117
  13. SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a p53 protein with a greatly reduced capacity to indu...

    Authors: Joerg Bittenbring, Frédérique Parisot, Alain Wabo, Monika Mueller, Lynn Kerschenmeyer, Markus Kreuz, Lorenz Truemper, Olfert Landt, Alain Menzel, Michael Pfreundschuh and Klaus Roemer
    Citation: BMC Cancer 2008 8:116
  14. Hepatitis B virus (HBV) infection in diffuse large B-cell lymphoma (DLBCL) patients is a common complication in China. However, the clinical relevance of HBV infection with respect to DLBCL disease stages and ...

    Authors: Feng Wang, Rui-hua Xu, Hui-yan Luo, Dong-shen Zhang, Wen-qi Jiang, Hui-qiang Huang, Xiao-fei Sun, Zhong-jun Xia and Zhong-zhen Guan
    Citation: BMC Cancer 2008 8:115
  15. Combined chemo- and radiotherapy are established in breast cancer treatment. Chemotherapy is recommended prior to radiotherapy but decisive data on the optimal sequence are rare. This retrospective analysis ai...

    Authors: Marc D Piroth, Michael Pinkawa, Bernd Gagel, Sven Stanzel, Branka Asadpour and Michael J Eble
    Citation: BMC Cancer 2008 8:114
  16. The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor...

    Authors: Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg…
    Citation: BMC Cancer 2008 8:113
  17. Patients with chronic inflammatory bowel disease (IBD) are at an increased risk of colorectal cancer (CRC) and it is estimated that one in six persons diagnosed with IBD will develop CRC. This fact suggests th...

    Authors: Janina Suchy, Ewa Kłujszo-Grabowska, Józef Kładny, Cezary Cybulski, Dominika Wokołorczyk, Jolanta Szymańska-Pasternak, Grzegorz Kurzawski, Rodney J Scott and Jan Lubiński
    Citation: BMC Cancer 2008 8:112
  18. Breast cancer is the first cause of cancer death among women and its incidence doubled in the last two decades. Several approaches for the treatment of these cancers have been developed. The axillary lymph nod...

    Authors: Anne Robe, Emilie Pic, Henri-Pierre Lassalle, Lina Bezdetnaya, François Guillemin and Frédéric Marchal
    Citation: BMC Cancer 2008 8:111
  19. On its physiological cellular context, PTTG1 controls sister chromatid segregation during mitosis. Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity for which gained the o...

    Authors: Manuel Hidalgo, Jose Jorge Galan, Carmen Sáez, Eduardo Ferrero, Carolina Castilla, Reposo Ramirez-Lorca, Pablo Pelaez, Agustin Ruiz, Miguel A Japón and Jose Luis Royo
    Citation: BMC Cancer 2008 8:110
  20. Xenobiotic Metabolizing Enzymes (XMEs) contribute to the detoxification of numerous cancer therapy-induced products. This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C1...

    Authors: Achraf Khedhaier, Elham Hassen, Noureddine Bouaouina, Sallouha Gabbouj, Slim Ben Ahmed and Lotfi Chouchane
    Citation: BMC Cancer 2008 8:109
  21. Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulat...

    Authors: Feng Ye, Caiyun Zhou, Qi Cheng, Jiajie Shen and Huaizeng Chen
    Citation: BMC Cancer 2008 8:108
  22. Breast carcinomas represent a heterogeneous group of tumors diverse in behavior, outcome, and response to therapy. Identification of proteins resembling the tumor biology can improve the diagnosis, prediction,...

    Authors: Jan Vydra, Irena Selicharová, Kateřina Smutná, Miloslav Šanda, Eva Matoušková, Eva Buršíková, Markéta Prchalová, Zuzana Velenská, David Coufal and Jiří Jiráček
    Citation: BMC Cancer 2008 8:107
  23. Mantle cell lymphoma (MCL) is an incurable B cell lymphoma and accounts for 6% of all non-Hodgkin's lymphomas. On the genetic level, MCL is characterized by the hallmark translocation t(11;14) that is present ...

    Authors: Steffen Blenk, Julia C Engelmann, Stefan Pinkert, Markus Weniger, Jörg Schultz, Andreas Rosenwald, Hans K Müller-Hermelink, Tobias Müller and Thomas Dandekar
    Citation: BMC Cancer 2008 8:106
  24. Loss of heterozygosity (LOH) at chromosome arm 16q is frequently observed in human breast cancer, suggesting that one or more target tumor suppressor genes (TSGs) are located there. However, detailed mapping o...

    Authors: Anne-Marie Cleton-Jansen, Ronald van Eijk, Marcel Lombaerts, Marjanka K Schmidt, Laura J Van't Veer, Katja Philippo, Rhyenne ME Zimmerman, Johannes L Peterse, Vincent TBHM Smit, Tom van Wezel and Cees J Cornelisse
    Citation: BMC Cancer 2008 8:105
  25. Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practition...

    Authors: François Eisinger, Laurent Cals, Anne Calazel-Benque, Jean-Yves Blay, Yvan Coscas, Sylvie Dolbeault, Moïse Namer, Xavier Pivot, Olivier Rixe, Daniel Serin, Claire Roussel and Jean-François Morère
    Citation: BMC Cancer 2008 8:104
  26. Cancer-related self-tests are currently available to buy in pharmacies or over the internet, including tests for faecal occult blood, PSA and haematuria. Self-tests have potential benefits (e.g. convenience) b...

    Authors: Sue Wilson, Angela V Ryan, Sheila M Greenfield, Sue C Clifford, Roger L Holder, Helen M Pattison, David A Fitzmaurice and Richard J McManus
    Citation: BMC Cancer 2008 8:102
  27. Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorecto...

    Authors: Larissa I Batista, Karen H Lu, Elisabeth K Beahm, Banu K Arun, Diane C Bodurka and Funda Meric-Bernstam
    Citation: BMC Cancer 2008 8:101
  28. Breast cancers (BC) in women carrying mutations in BRCA1 gene are more frequently estrogen receptor negative than the nonhereditary BC. Nevertheless, tamoxifen has been found to have a protective effect in pre...

    Authors: Maria M Litwiniuk, Krzysztof Rożnowski, Violetta Filas, Dariusz D Godlewski, Małgorzata Stawicka, Remigiusz Kaleta and Jan Bręborowicz
    Citation: BMC Cancer 2008 8:100
  29. Currently, there is clear evidence that apoptosis plays an important role in the development and progression of tumors. One of the best characterized apoptosis triggering systems is the CD95/Fas/APO-1 pathway;...

    Authors: Adriana Aguilar-Lemarroy, Jose E Romero-Ramos, Vicente Olimon-Andalon, Georgina Hernandez-Flores, Jose M Lerma-Diaz, Pablo C Ortiz-Lazareno, Gilberto Morgan-Villela, Susana del Toro-Arreola, Alejandro Bravo-Cuellar and Luis F Jave-Suarez
    Citation: BMC Cancer 2008 8:99
  30. Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and progn...

    Authors: Ana Carneiro, Anna Isinger, Anna Karlsson, Jan Johansson, Göran Jönsson, Pär-Ola Bendahl, Dan Falkenback, Britta Halvarsson and Mef Nilbert
    Citation: BMC Cancer 2008 8:98
  31. One of the major challenges in currently chemotherapeutic theme is lacking effective biomarkers for drug response and sensitivity. Our current study focus on two promising biomarkers, ERCC1 (excision repair cr...

    Authors: Lifeng Wang, Jia Wei, Xiaoping Qian, Haitao Yin, Yang Zhao, Lixia Yu, Tingting Wang and Baorui Liu
    Citation: BMC Cancer 2008 8:97
  32. The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymo...

    Authors: Luca Cavallone, Suzanna L Arcand, Christine Maugard, Parviz Ghadirian, Anne-Marie Mes-Masson, Diane Provencher and Patricia N Tonin
    Citation: BMC Cancer 2008 8:96
  33. Mutations in the mitochondrial genome (mtgenome) have been associated with many disorders, including breast cancer. Nipple aspirate fluid (NAF) from symptomatic women could potentially serve as a minimally inv...

    Authors: John P Jakupciak, Andrea Maggrah, Samantha Maragh, Jennifer Maki, Brian Reguly, Katrina Maki, Roy Wittock, Kerry Robinson, Paul D Wagner, Robert E Thayer, Ken Gehman, Teresa Gehman, Sudhir Srivastava, Alioune Ngom, Gabriel D Dakubo and Ryan L Parr
    Citation: BMC Cancer 2008 8:95
  34. Listeria monocytogenes is a highly versatile bacterial carrier system for introducing protein, DNA and RNA into mammalian cells. The delivery of tumor antigens with the help of this carrier into tumor-bearing an...

    Authors: Jochen Stritzker, Sabine Pilgrim, Aladar A Szalay and Werner Goebel
    Citation: BMC Cancer 2008 8:94
  35. The process of diagnosis and management of solitary pulmonary nodules (SPNs) between 1 and 3 cm is not standardized. This multicentre study investigated how diagnosis of newly discovered SPNs is managed in rou...

    Authors: Kazem Alzahouri, Michel Velten, Patrick Arveux, Marie-Christine Woronoff-Lemsi, Damien Jolly and Francis Guillemin
    Citation: BMC Cancer 2008 8:93
  36. Prospero-related homeobox 1 (Prox1) transcription factor was described as a tumor-suppressor gene in liver tumors. In contrast, Prox1 knock out in murine embryos drastically reduces proliferation of hepatoblasts.

    Authors: Jozsef Dudas, Tümen Mansuroglu, Federico Moriconi, Florian Haller, Joerg Wilting, Thomas Lorf, Laszlo Füzesi and Giuliano Ramadori
    Citation: BMC Cancer 2008 8:92
  37. Recent advances in genomics, proteomics, and the increasing demands for biomarker validation studies have catalyzed changes in the landscape of cancer research, fueling the development of tissue banks for tran...

    Authors: Sambit K Mohanty, Amita T Mistry, Waqas Amin, Anil V Parwani, Andrew K Pople, Linda Schmandt, Sharon B Winters, Erin Milliken, Paula Kim, Nancy B Whelan, Ghada Farhat, Jonathan Melamed, Emanuela Taioli, Rajiv Dhir, Harvey I Pass and Michael J Becich
    Citation: BMC Cancer 2008 8:91
  38. The variable penetrance of ovarian cancer in BRCA1 mutation carriers suggests that other genetic or environmental factors modify disease risk. The C to T transition in the 3' untranslated region of the prohibitin...

    Authors: Anna Jakubowska, Jacek Gronwald, Janusz Menkiszak, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Axel Benner, Jan Lubiński, Rodney J Scott and Ute Hamann
    Citation: BMC Cancer 2008 8:90
  39. This study examined sex-specific patterns and temporal trends in the incidence of solid tumours in the Northern Region of England from 1968 to 2005. This updates earlier analyses from the region where sex was ...

    Authors: Brooke L Magnanti, M Tevfik Dorak, Louise Parker, Alan W Craft, Peter W James and Richard JQ McNally
    Citation: BMC Cancer 2008 8:89
  40. To investigate the changes of the neoplastic microenvironment during the different morphological alterations of hyperplastic and pre-invasive breast lesions.

    Authors: Kitty Pavlakis, Irene Messini, Thomas Vrekoussis, Petros Yiannou, Dimitrios Keramopoullos, Niki Louvrou, Theodoros Liakakos and Efstathios N Stathopoulos
    Citation: BMC Cancer 2008 8:88
  41. Colorectal cancer is one of the most common causes of cancer-related mortality. The disease is clinically and genetically heterogeneous though a strong hereditary component has been identified. However, only a...

    Authors: Simone Picelli, Jana Vandrovcova, Siân Jones, Tatjana Djureinovic, Johanna Skoglund, Xiao-Lei Zhou, Victor E Velculescu, Bert Vogelstein and Annika Lindblom
    Citation: BMC Cancer 2008 8:87
  42. To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL).

    Authors: Wendy Jeanneret-Sozzi, Alphonse Taghian, Ron Epelbaum, Philip Poortmans, Daniel Zwahlen, Beat Amsler, Sylviane Villette, Yazid Belkacémi, Tan Nguyen, Pierre Scalliet, Philippe Maingon, Cristina Gutiérrez, Pauline Gastelblum, Marco Krengli, Rita Abi Raad, Mahmut Ozsahin…
    Citation: BMC Cancer 2008 8:86
  43. At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, M...

    Authors: Susanne Knoll, Sabiene Zimmer, Anke Hinney, André Scherag, Andreas Neubauer and Johannes Hebebrand
    Citation: BMC Cancer 2008 8:85
  44. Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established. Furthermore, it is not clear whether MMP...

    Authors: Bin Zhang, Xuchen Cao, Yanxue Liu, Wenfeng Cao, Fei Zhang, Shiwu Zhang, Hongtao Li, Liansheng Ning, Li Fu, Yun Niu, Ruifang Niu, Baocun Sun and Xishan Hao
    Citation: BMC Cancer 2008 8:83
  45. Single-agent gemcitabine (GEM) is a standard treatment for advanced and metastatic pancreatic cancer. This study examines the question whether GEM-based combination chemotherapy can further improve treatment e...

    Authors: Volker Heinemann, Stefan Boeck, Axel Hinke, Roberto Labianca and Christophe Louvet
    Citation: BMC Cancer 2008 8:82
  46. Metastatic prostate cancer is associated with a high morbidity and mortality but the spreading mechanisms are still poorly understood. The aminobisphosphonate alendronate, used to reduce bone loss, has also be...

    Authors: Johanna M Tuomela, Maija P Valta, Kalervo Väänänen and Pirkko L Härkönen
    Citation: BMC Cancer 2008 8:81
  47. Aim of this longitudinal study was to investigate the sensitivity to change of the Swedish Self Evaluation of Communication Experiences after Laryngeal Cancer questionnaire (the S-SECEL), addressing communicat...

    Authors: Mia Johansson, Anna Rydén and Caterina Finizia
    Citation: BMC Cancer 2008 8:80

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