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  1. Carfilzomib is a next-generation proteasome inhibitor with single-agent activity in patients with relapsed and refractory multiple myeloma (R/R MM). In PX-171-003-A1, a single-arm phase 2 study of carfilzomib ...

    Authors: Roman Hájek, Richard Bryce, Sunhee Ro, Barbara Klencke and Heinz Ludwig
    Citation: BMC Cancer 2012 12:415
    Content type: Study protocol Published on:

  2. Causes of the rapidly increasing incidence of breast cancer in Middle East and Asian countries are incompletely understood. We evaluated risk factors for postmenopausal breast cancer and estimated their attrib...

    Authors: Reza Ghiasvand, Shahram Bahmanyar, Kazem Zendehdel, Sedigheh Tahmasebi, Abdolrasoul Talei, Hans-Olov Adami and Sven Cnattingius
    Citation: BMC Cancer 2012 12:414
    Content type: Research article Published on:

  3. Colorectal cancer (CRC) is one of the most commonly occurring neoplasms and a leading cause of cancer death worldwide, and new preventive strategies are needed to lower the burden of this disease. Eicosapentae...

    Authors: Takuma Higurashi, Kunihiro Hosono, Hiroki Endo, Hirokazu Takahashi, Hiroshi Iida, Takashi Uchiyama, Akiko Ezuka, Shiori Uchiyama, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Shin Maeda, Satoshi Morita, Yutaka Natsumeda, Hajime Nagase and Atsushi Nakajima
    Citation: BMC Cancer 2012 12:413
    Content type: Study protocol Published on:

  5. Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase act...

    Authors: Afsar Ali Mian, Anna Metodieva, Susanne Badura, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Oliver Gerhard Ottmann, Jamal Mahajna and Martin Ruthardt
    Citation: BMC Cancer 2012 12:411
    Content type: Research article Published on:

  7. Recent studies suggest the potential benefits of statins as anti-cancer agents. Mechanisms by which statins induce apoptosis in cancer cells are not clear. We previously showed that simvastatin inhibit prostat...

    Authors: Anna Goc, Samith T Kochuparambil, Belal Al-Husein, Ahmad Al-Azayzih, Shuaib Mohammad and Payaningal R Somanath
    Citation: BMC Cancer 2012 12:409
    Content type: Research article Published on:

  8. A subset of KIT/PDGFRA wild-type gastrointestinal stromal tumors (WT GIST) have been associated with alteration of the succinate dehydrogenase (SDH) complex II function. A recent report identified four non-syn...

    Authors: Antoine Italiano, Chun-Liang Chen, Yun-Shao Sung, Samuel Singer, Ronald P DeMatteo, Michael P LaQuaglia, Peter Besmer, Nicholas Socci and Cristina R Antonescu
    Citation: BMC Cancer 2012 12:408
    Content type: Research article Published on:

  9. Ovarian cancer is a heterogeneous disease and prognosis for apparently similar cases of ovarian cancer varies. Recurrence of the disease in early stage (FIGO-stages I-II) serous ovarian cancer results in survi...

    Authors: Ingiridur Skirnisdottir, Markus Mayrhofer, Maria Rydåker, Helena Åkerud and Anders Isaksson
    Citation: BMC Cancer 2012 12:407
    Content type: Research article Published on:

  10. The prognosis of human glioma is poor, and the highly invasive nature of the disease represents a major impediment to current therapeutic modalities. The oncoprotein B-cell-specific Moloney murine leukemia vir...

    Authors: Lili Jiang, Jueheng Wu, Yi Yang, Liping Liu, Libing Song, Jun Li and Mengfeng Li
    Citation: BMC Cancer 2012 12:406
    Content type: Research article Published on:

  11. Numerous efficacious chemotherapy regimens may cause thrombocytopenia. Thrombopoietin receptor (TPO-R) agonists, such as eltrombopag, represent a novel approach for the treatment of chemotherapy-induced thromb...

    Authors: Connie L Erickson-Miller, Kodandaram Pillarisetti, Jennifer Kirchner, David J Figueroa, Lone Ottesen, Anne-Marie Martin, Yuan Liu, Yasser Mostafa Kamel and Conrad Messam
    Citation: BMC Cancer 2012 12:405
    Content type: Research article Published on:

  12. In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes...

    Authors: W Jeffrey Petty, Mebea Aklilu, Victor A Varela, James Lovato, Paul D Savage and Antonius A Miller
    Citation: BMC Cancer 2012 12:404
    Content type: Research article Published on:

  13. Disseminated tumour cells (DTCs) in the bone marrow of patients with breast cancer have been identified as an independent predictor of poor prognosis in patients with non-metastatic disease. This prospective s...

    Authors: Anna-Karin Falck, Pär-Ola Bendahl, Christian Ingvar, Jorma Isola, Per-Ebbe Jönsson, Pia Lindblom, Kristina Lövgren, Karin Rennstam, Mårten Fernö and Lisa Rydén
    Citation: BMC Cancer 2012 12:403
    Content type: Research article Published on:

  14. Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellula...

    Authors: Fatima Rangwala, Kevin P Williams, Ginger R Smith, Zainab Thomas, Jennifer L Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A Morse and Gayathri R Devi
    Citation: BMC Cancer 2012 12:402
    Content type: Research article Published on:

  15. Hematopoietic stem cell transplantation is an intensive therapy used to improve survivorship and cure various oncologic diseases. However, this therapy is associated with high mortality rates and numerous nega...

    Authors: Carolina Chamorro-Viña, Gregory MT Guilcher, Faisal M Khan, Karen Mazil, Fiona Schulte, Amanda Wurz, Tanya Williamson, Raylene A Reimer and S Nicole Culos-Reed
    Citation: BMC Cancer 2012 12:401
    Content type: Study protocol Published on:

  16. The prognosis for an abnormal medical finding is affected by both early detection and adherence to the presecribed schedule for follow-up examinations. In this study, we examined the time to follow up after an...

    Authors: Hoo-Yeon Lee, Kui Son Choi, Jae Kwan Jun, Myung-Il Hahm and Eun-Cheol Park
    Citation: BMC Cancer 2012 12:400
    Content type: Research article Published on:

  17. To evaluate the prognostic significance of the pre-operative C-reactive protein (CRP) serum level in patients with renal cell cancer (RCC).

    Authors: Sandra Steffens, Astrid Köhler, Raphael Rudolph, Hendrik Eggers, Christoph Seidel, Martin Janssen, Gerd Wegener, Mark Schrader, Markus A Kuczyk and Andres J Schrader
    Citation: BMC Cancer 2012 12:399
    Content type: Research article Published on:

  19. We have recently identified HOP hoemobox (HOPX) as a tumor suppressor gene candidate, characterized by tumor-specific promoter DNA hypermethylation in human cancers, and it can remarkably inhibit tumors’ aggre...

    Authors: Mina Waraya, Keishi Yamashita, Hiroshi Katoh, Akira Ooki, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura, Akira Ema and Masahiko Watanabe
    Citation: BMC Cancer 2012 12:397
    Content type: Research article Published on:

  20. Thyroid nodules with indeterminate cytological features on fine needle aspiration (FNA) cytology have a 20% risk of thyroid cancer. The aim of the current study was to determine the diagnostic utility of an 8-...

    Authors: Sara Tomei, Ivo Marchetti, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio, Generoso Bevilacqua and Chiara Mazzanti
    Citation: BMC Cancer 2012 12:396
    Content type: Research article Published on:

  21. The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models...

    Authors: Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean M Grimmond, Robert L Sutherland, Andrew V Biankin and Roger J Daly
    Citation: BMC Cancer 2012 12:395
    Content type: Research article Published on:

  22. After completion of curative breast cancer treatment, patients go through a transition from patient to survivor. During this re-entry phase, patients are faced with a broad range of re-entry topics, concerning...

    Authors: Sanne W van den Berg, Marieke F M Gielissen, Petronella B Ottevanger and Judith B Prins
    Citation: BMC Cancer 2012 12:394
    Content type: Study protocol Published on:

  23. More than 1.2 million new cases of colorectal cancer are reported each year worldwide. Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor progno...

    Authors: Stefanie Bünger, Ulrike Haug, Maria Kelly, Nicole Posorski, Katja Klempt-Giessing, Andrew Cartwright, Stephen P Fitzgerald, Vicki Toner, Damien McAleer, Timo Gemoll, Tilman Laubert, Jürgen Büning, Klaus Fellermann, Hans-Peter Bruch, Uwe J Roblick, Hermann Brenner…
    Citation: BMC Cancer 2012 12:393
    Content type: Research article Published on:

  24. Cytological fluid from a needle aspiration biopsy (NAB) is obtained directly from tumor tissue, therefore many biomarker candidates will be present in high concentrations. The aim of this study was to prospect...

    Authors: Jin Hur, Hye-Jeong Lee, Ji Eun Nam, Young Jin Kim, Yoo Jin Hong, Hee Yeong Kim, Se Kyu Kim, Joon Chang, Joo-Hang Kim, Kyung Young Chung, Hye Sun Lee and Byoung Wook Choi
    Citation: BMC Cancer 2012 12:392
    Content type: Research article Published on:

  25. Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify n...

    Authors: Lionel Flamant, Edith Roegiers, Michael Pierre, Aurélie Hayez, Christiane Sterpin, Olivier De Backer, Thierry Arnould, Yves Poumay and Carine Michiels
    Citation: BMC Cancer 2012 12:391
    Content type: Research article Published on:

  26. In patients with cancers of the pancreatic and biliary tract quality of life (QOL) improvement is the main treatment goal, since survival can be prolonged only marginally. Up to date, knowledge on QOL impairme...

    Authors: August Zabernigg, Johannes M Giesinger, Georg Pall, Eva-Maria Gamper, Klaus Gattringer, Lisa M Wintner, Monika J Sztankay and Bernhard Holzner
    Citation: BMC Cancer 2012 12:390
    Content type: Research article Published on:

  27. Lower concentrations of the insulin–like growth factor binding protein-1 (IGFBP-1) and elevated concentrations of insulin or C-peptide have been associated with an increase in colorectal cancer risk (CRC). How...

    Authors: Adriana C Vidal, Pauline Kay Lund, Cathrine Hoyo, Joseph Galanko, Lauren Burcal, Rachel Holston, Berri Massa, Oluwaseun Omofoye, Robert S Sandler and Temitope O Keku
    Citation: BMC Cancer 2012 12:389
    Content type: Research article Published on:

  28. Antiangiogenic agents that disrupt the vascular endothelial growth factor pathway have been demonstrated to normalize tumor vasculature and improve tumor oxygenation in some studies and to induce hypoxia in ot...

    Authors: Jon-Vidar Gaustad, Trude G Simonsen, Marit N Leinaas and Einar K Rofstad
    Citation: BMC Cancer 2012 12:388
    Content type: Research article Published on:

  29. Peto's paradox stipulates that there is no association between body mass (a surrogate of number of cells and longevity) and cancer prevalence in wildlife species. Resolving this paradox is a very promising res...

    Authors: Benjamin Roche, Michael E Hochberg, Aleah F Caulin, Carlo C Maley, Robert A Gatenby, Dorothée Misse and Frédéric Thomas
    Citation: BMC Cancer 2012 12:387
    Content type: Debate Published on:

  30. Hepatocellular carcinoma (HCC) still represents an unmet medical need. Epigenetic inactivation of tumor suppressor genes like RASSF1A or APC by overexpression of DNA methyltransferases (DNMTs) has been shown t...

    Authors: Steffen Zopf, Matthias Ocker, Daniel Neureiter, Beate Alinger, Susanne Gahr, Markus F Neurath and Pietro Di Fazio
    Citation: BMC Cancer 2012 12:386
    Content type: Research article Published on:

  32. Colorectal cancer is a major public health problem in Malaysia. However, it is also one of the most treatable cancers, resulting in significant numbers of survivors. Therefore, the impact of surviving treatmen...

    Authors: Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani, Ismail Sagap, Jasiah Zakaria, Jane M Blazeby and Chee Wei Law
    Citation: BMC Cancer 2012 12:384
    Content type: Study protocol Published on:

  33. ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter that localizes to plasma membranes. Recently, a number of studies have investigated the relationship between the C421A polymorphism i...

    Authors: Pin Chen, Lin Zhao, Peng Zou, Haitao Xu, Ailin Lu and Peng Zhao
    Citation: BMC Cancer 2012 12:383
    Content type: Research article Published on:

  34. The full extent of chromosomal alterations and their biological implications in early breast carcinogenesis has not been well examined. In this study, we aimed to identify chromosomal alterations associated wi...

    Authors: Seung-Hyun Jung, Ahwon Lee, Seon-Hee Yim, Hae-Jin Hu, Chungyoul Choe and Yeun-Jun Chung
    Citation: BMC Cancer 2012 12:382
    Content type: Research article Published on:

  35. Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to che...

    Authors: Allan D Heibein, Baoqing Guo, Jason A Sprowl, David A MacLean and Amadeo M Parissenti
    Citation: BMC Cancer 2012 12:381
    Content type: Research article Published on:

  36. Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior. This complex interaction between genomic organization and gene, as well as pr...

    Authors: Christoph Standfuß, Heike Pospisil and Andreas Klein
    Citation: BMC Cancer 2012 12:380
    Content type: Research article Published on:

  37. Cell line models have proven to be effective tools to investigate a variety of ovarian cancer features. Due to the limited number of cell lines, particularly of the serous subtype, the heterogeneity of the dis...

    Authors: Isabelle J Létourneau, Michael CJ Quinn, Lu-Lin Wang, Lise Portelance, Katia Y Caceres, Louis Cyr, Nathalie Delvoye, Liliane Meunier, Manon de Ladurantaye, Zhen Shen, Suzanna L Arcand, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2012 12:379
    Content type: Research article Published on:

  38. MicroRNAs (miRNAs) and their role during tumor development have been studied in great detail during the last decade, albeit their expression pattern and regulation during normal development are however not so ...

    Authors: Jelena Põlajeva, Fredrik J Swartling, Yiwen Jiang, Umashankar Singh, Kristian Pietras, Lene Uhrbom, Bengt Westermark and Pernilla Roswall
    Citation: BMC Cancer 2012 12:378
    Content type: Research article Published on:

  39. The high frequencies of recurrence and distant metastasis of adenoid cystic carcinoma (AdCC) emphasize the need to better understand the biological factors associated with these outcomes. To analyze the mechan...

    Authors: Miyuki Shimoda, Tsuyoshi Sugiura, Ikumi Imajyo, Kotaro Ishii, Satomi Chigita, Katsuhiro Seki, Yousuke Kobayashi and Kanemitsu Shirasuna
    Citation: BMC Cancer 2012 12:377
    Content type: Research article Published on:

  40. Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene. This study aimed to investigate the impact of BRMS1 on metastasis in nasopharyngeal carcinoma (NPC) and to evaluate the prognostic...

    Authors: Rui-Xue Cui, Na Liu, Qing-Mei He, Wen-Fei Li, Bi-Jun Huang, Ying Sun, Ling-Long Tang, Mo Chen, Ning Jiang, Lei Chen, Jing-Ping Yun, Jing Zeng, Ying Guo, Hui-Yun Wang and Jun Ma
    Citation: BMC Cancer 2012 12:376
    Content type: Research article Published on:

  41. Chondrosarcoma is the second most common primary sarcoma of bone. High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome. In pre-clinical research aiming at the identifi...

    Authors: Jolieke G van Oosterwijk, Danielle de Jong, Maayke AJH van Ruler, Pancras CW Hogendoorn, PD Sander Dijkstra, Carla SP van Rijswijk, Isidro Machado, Antonio Llombart-Bosch, Karoly Szuhai and Judith VMG Bovée
    Citation: BMC Cancer 2012 12:375
    Content type: Research article Published on:

  43. The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in...

    Authors: Nasir Kamat, Mohammed A Khidhir, Mohammed Jaloudi, Sabir Hussain, Mouied M Alashari, Khaled H Al Qawasmeh and Ulf Rannug
    Citation: BMC Cancer 2012 12:373
    Content type: Research article Published on:

  44. Thrombospondin (TSP) is a multi-functional protein that appears to have dual roles in cancer, that is, either as a promoter or a suppressor. 4N1K is a TSP-derived peptide that has been reported to be associate...

    Authors: Yasuyoshi Miyata, Shin-ichi Watanabe, Hiroshi Kanetake and Hideki Sakai
    Citation: BMC Cancer 2012 12:372
    Content type: Research article Published on:

  45. Despite a lack of consensus regarding effectiveness, androgen deprivation therapy (ADT) is a common treatment for non-metastatic, low-risk prostate cancer. To examine a particular clinical concern regarding th...

    Authors: Herta H Chao, Edward Uchio, Sheng Zhang, Sien Hu, Sarah R Bednarski, Xi Luo, Michal Rose, John Concato and Chiang-shan R Li
    Citation: BMC Cancer 2012 12:371
    Content type: Research article Published on:

  46. NDRG2, a member of N-Myc downstream regulated gene family, plays some roles in cellular stress, cell differentiation and tumor suppression. We have found that NDRG2 expression in cervical cancer Hela cells inc...

    Authors: Junye Liu, Le Yang, Jian Zhang, Jing Zhang, Yongbin Chen, Kangchu Li, Yurong Li, Yan Li, Libo Yao and Guozhen Guo
    Citation: BMC Cancer 2012 12:370
    Content type: Research article Published on:

  47. Alterations of mTOR gene expression have been implicated in the pathogenesis of endometrioid endometrial cancer however only few studies explored the cause of increased mTOR activation in this malignancy. miRN...

    Authors: Anna Torres, Kamil Torres, Anna Pesci, Marcello Ceccaroni, Tomasz Paszkowski, Paola Cassandrini, Giuseppe Zamboni and Ryszard Maciejewski
    Citation: BMC Cancer 2012 12:369
    Content type: Research article Published on:

  48. Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitiv...

    Authors: Katie Twigger, Victoria Roulstone, Joan Kyula, Eleni M Karapanagiotou, Konstantinos N Syrigos, Richard Morgan, Christine White, Shreerang Bhide, Gerard Nuovo, Matt Coffey, Brad Thompson, Adel Jebar, Fiona Errington, Alan A Melcher, Richard G Vile, Hardev S Pandha…
    Citation: BMC Cancer 2012 12:368
    Content type: Research article Published on:

  49. Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical and structural aberrations, breakpoints and disrupted genes have yet to be identified in esophageal squa...

    Authors: Jia-Jie Hao, Zhi-Zhou Shi, Zhi-Xin Zhao, Yu Zhang, Ting Gong, Chun-Xiang Li, Ting Zhan, Yan Cai, Jin-Tang Dong, Song-Bin Fu, Qi-Min Zhan and Ming-Rong Wang
    Citation: BMC Cancer 2012 12:367
    Content type: Research article Published on:

  50. Increase of Serum amyloid A (SAA) level has been observed in patients with a variety of cancers. The objective of this study was to determined whether SAA level could be used as a prognostic parameter in patie...

    Authors: Jun-Ye Wang, Yu-Zhen Zheng, Juan Yang, Yue-Hao Lin, Shu-Qin Dai, Ge Zhang and Wan-Li Liu
    Citation: BMC Cancer 2012 12:365
    Content type: Research article Published on:

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