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  1. FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been repo...

    Authors: Nuran Bektas, Anette ten Haaf, Jürgen Veeck, Peter Johannes Wild, Juliane Lüscher-Firzlaff, Arndt Hartmann, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:42
  2. IBC (Inflammatory Breast cancer) is a rare form of breast cancer with a particular phenotype. New molecular targets are needed to improve the treatment of this rapidly fatal disease. Given the role of NF-κB-re...

    Authors: Florence Lerebours, Sophie Vacher, Catherine Andrieu, Marc Espie, Michel Marty, Rosette Lidereau and Ivan Bieche
    Citation: BMC Cancer 2008 8:41
  3. Over expression of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs, abbreviated as OAcSGP) has been demonstrated as a disease-associated antigen on the lymphoblasts of childhood acute lymphoblastic leukaemia (AL...

    Authors: Suchandra Chowdhury, Suman Bandyopadhyay, Chandan Mandal, Sarmila Chandra and Chitra Mandal
    Citation: BMC Cancer 2008 8:40
  4. Gelsolin-like actin-capping protein (CapG) is a ubiquitous gelsolin-family actin-modulating protein involved in cell signalling, receptor-mediated membrane ruffling, phagocytosis, and motility. CapG has genera...

    Authors: Hitomi Nomura, Katsuhiro Uzawa, Takashi Ishigami, Yukinao Kouzu, Hirofumi Koike, Katsunori Ogawara, Masashi Siiba, Hiroki Bukawa, Hidetaka Yokoe, Hitoshi Kubosawa and Hideki Tanzawa
    Citation: BMC Cancer 2008 8:39
  5. Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the ...

    Authors: Malene Herbsleb, Ole F Christensen, Thomas Thykjaer, Carsten Wiuf, Michael Borre, Torben F Ørntoft and Lars Dyrskjøt
    Citation: BMC Cancer 2008 8:37
  6. In women with duct carcinoma in-situ (DCIS) receiving breast conservation therapy (BCT), in-breast recurrences are seen in approximately 10%, but cannot be accurately predicted using clinical and histological ...

    Authors: Swati Kulkarni, Deepa B Patil, Leslie K Diaz, Elizabeth L Wiley, Monica Morrow and Seema A Khan
    Citation: BMC Cancer 2008 8:36
  7. The Comunitat Valenciana (CV) is a tourist region on the Mediterranean coast of Spain with a high rate of retirement migration. Lung cancer in women is the cancer mortality cause that has increased most in the...

    Authors: Oscar Zurriaga, Hermelinda Vanaclocha, Miguel A Martinez-Beneito and Paloma Botella-Rocamora
    Citation: BMC Cancer 2008 8:35
  8. This study was performed in order to determine whether monocyte in vitro function is associated with presence, stage and prognosis of head and neck squamous cell carcinoma (HNSCC) disease.

    Authors: John-Helge Heimdal, Kenneth Kross, Beate Klementsen, Jan Olofsson and Hans Jørgen Aarstad
    Citation: BMC Cancer 2008 8:34
  9. Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island met...

    Authors: Takako Kawasaki, Katsuhiko Nosho, Mutsuko Ohnishi, Yuko Suemoto, Jonathan N Glickman, Andrew T Chan, Gregory J Kirkner, Mari Mino-Kenudson, Charles S Fuchs and Shuji Ogino
    Citation: BMC Cancer 2008 8:33
  10. TP53 is one of major tumour suppressor genes being essential in preservation of genome integrity. Two very common polymorphisms have been demonstrated to contribute to cancer susceptibility and tumour behaviour....

    Authors: Sandra Costa, Daniela Pinto, Deolinda Pereira, Helena Rodrigues, Jorge Cameselle-Teijeiro, Rui Medeiros and Fernando Schmitt
    Citation: BMC Cancer 2008 8:32
  11. The incidence of ovarian cancer increases sharply with age, and many elderly patients have coexisting diseases. If patients with comorbidities are diagnosed with advanced stages, this would explain the poor su...

    Authors: Mette S Tetsche, Claus Dethlefsen, Lars Pedersen, Henrik T Sorensen and Mette Norgaard
    Citation: BMC Cancer 2008 8:31
  12. Neuroblastoma is a severe pediatric tumor, histologically characterised by a variety of cellular phenotypes. One of the pharmacological approaches to neuroblastoma is the treatment with retinoic acid. The mech...

    Authors: Elio Messi, Maria C Florian, Claudio Caccia, Mariarosa Zanisi and Roberto Maggi
    Citation: BMC Cancer 2008 8:30
  13. Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extrem...

    Authors: Hua Chen, Qiang Huang, Jun Dong, De-Zhong Zhai, Ai-Dong Wang and Qing Lan
    Citation: BMC Cancer 2008 8:29
  14. Inflammatory breast cancer (IBC) is a distinct and aggressive form of locally-advanced breast cancer with high metastatic potential. In Tunisia, IBC is associated with a high death rate. Among the major molecu...

    Authors: Azza Ben Hamida, Intidhar S Labidi, Karima Mrad, Emmanuelle Charafe-Jauffret, Saïda Ben Arab, Benjamin Esterni, Luc Xerri, Patrice Viens, François Bertucci, Daniel Birnbaum and Jocelyne Jacquemier
    Citation: BMC Cancer 2008 8:28
  15. Taxane-platinum therapy (TP) has replaced platinum-based therapy (PC or PAC, DNA damaging chemotherapy) in the postoperative treatment of ovarian cancer patients; however, it is not always effective. TP53 prot...

    Authors: Jolanta Kupryjanczyk, Ewa Kraszewska, Izabela Ziolkowska-Seta, Radoslaw Madry, Agnieszka Timorek, Janina Markowska, Jerzy Stelmachow and Mariusz Bidzinski
    Citation: BMC Cancer 2008 8:27
  16. To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT.

    Authors: Laurent Quero, Pierre Mongiat-Artus, Vincent Ravery, Claude Maylin, François Desgrandchamps and Christophe Hennequin
    Citation: BMC Cancer 2008 8:26
  17. The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain – bikunin, encoded by AMBP – and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITI...

    Authors: Alexander Hamm, Juergen Veeck, Nuran Bektas, Peter J Wild, Arndt Hartmann, Uwe Heindrichs, Glen Kristiansen, Tamra Werbowetski-Ogilvie, Rolando Del Maestro, Ruth Knuechel and Edgar Dahl
    Citation: BMC Cancer 2008 8:25
  18. Patients with advanced cancer suffer from cachexia, which is characterised by a marked weight loss, and is invariably associated with the presence of tumoral and humoral factors which are mainly responsible fo...

    Authors: Claudia L Yano, Gislaine Ventrucci, William N Field, Michael J Tisdale and Maria Cristina C Gomes-Marcondes
    Citation: BMC Cancer 2008 8:24
  19. Osteosarcoma is the most frequent bone tumor in childhood and adolescence. Patients with primary metastatic disease have a poor prognosis. It is therefore important to better characterize the biology of this t...

    Authors: Irene von Luettichau, Stephan Segerer, Alexandra Wechselberger, Mike Notohamiprodjo, Michaela Nathrath, Markus Kremer, Anna Henger, Roghieh Djafarzadeh, Stefan Burdach, Ralf Huss and Peter J Nelson
    Citation: BMC Cancer 2008 8:23
  20. Bone tumours are comparatively rare tumours and delays in diagnosis and treatment are common. The purpose of this study was to analyse sociodemographic risk factors for bone tumour patients in order to identif...

    Authors: Christoph Schnurr, Mathias Pippan, Hartmut Stuetzer, Karl S Delank, Joern WP Michael and Peer Eysel
    Citation: BMC Cancer 2008 8:22
  21. Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histo...

    Authors: Maddalena T Tilli, Angela R Parrish, Ion Cotarla, Laundette P Jones, Michael D Johnson and Priscilla A Furth
    Citation: BMC Cancer 2008 8:21
  22. Quantitative real-time RT-PCR (RT-qPCR) has become a valuable molecular technique in basic and translational biomedical research, and is emerging as an equally valuable clinical tool. Correlation of inter-samp...

    Authors: Maria B Lyng, Anne-Vibeke Lænkholm, Niels Pallisgaard and Henrik J Ditzel
    Citation: BMC Cancer 2008 8:20
  23. Melanoma progression occurs through three major stages: radial growth phase (RGP), confined to the epidermis; vertical growth phase (VGP), when the tumor has invaded into the dermis; and metastasis. In this wo...

    Authors: Josane F Sousa and Enilza M Espreafico
    Citation: BMC Cancer 2008 8:19
  24. In a previously published pilot study we explored the performance of microarrays in predicting clinical behaviour of ovarian tumours. For this purpose we performed microarray analysis on 20 patients and estima...

    Authors: Olivier Gevaert, Frank De Smet, Toon Van Gorp, Nathalie Pochet, Kristof Engelen, Frederic Amant, Bart De Moor, Dirk Timmerman and Ignace Vergote
    Citation: BMC Cancer 2008 8:18
  25. Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethyla...

    Authors: Joshua Z Press, Alessandro De Luca, Niki Boyd, Sean Young, Armelle Troussard, Yolanda Ridge, Pardeep Kaurah, Steve E Kalloger, Katherine A Blood, Margaret Smith, Paul T Spellman, Yuker Wang, Dianne M Miller, Doug Horsman, Malek Faham, C Blake Gilks…
    Citation: BMC Cancer 2008 8:17
  26. Cervical cancer is the second most common cancer in women worldwide. NK and cytotoxic T cells play an important role in the elimination of virus-infected and tumor cells through NKG2D activating receptors, whi...

    Authors: Naela A Arreygue-Garcia, Adrian Daneri-Navarro, Alicia del Toro-Arreola, Angel Cid-Arregui, Oscar Gonzalez-Ramella, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy, Rogelio Troyo-Sanroman, Alejandro Bravo-Cuellar, Vidal Delgado-Rizo, Trinidad Garcia-Iglesias, Georgina Hernandez-Flores and Susana del Toro-Arreola
    Citation: BMC Cancer 2008 8:16
  27. To investigate the neuropsychological outcome of children treated with surgery and posterior fossa irradiation for localized infratentorial ependymoma.

    Authors: Katja von Hoff, Virginie Kieffer, Jean-Louis Habrand, Chantal Kalifa, Georges Dellatolas and Jacques Grill
    Citation: BMC Cancer 2008 8:15
  28. Endocan was originally described as a dermatan sulfate proteoglycan found freely circulating in the blood. Endocan expression confers tumorigenic properties to epithelial cell lines or accelerate the growth of...

    Authors: Florence Depontieu, Bogdan-Dragos Grigoriu, Arnaud Scherpereel, Estelle Adam, Maryse Delehedde, Philippe Gosset and Philippe Lassalle
    Citation: BMC Cancer 2008 8:14
  29. Many cancer cells produce interleukin-6 (IL-6), a cytokine that plays a role in growth stimulation, metastasis, and angiogenesis of secondary tumours in a variety of malignancies, including colorectal cancer. ...

    Authors: Wolfgang Brozek, Giovanna Bises, Gerhild Fabjani, Heide S Cross and Meinrad Peterlik
    Citation: BMC Cancer 2008 8:13
  30. Despite intensive multimodal treatment, outcome of patients with malignant glioma remains poor, and a standard dose of radiotherapy for anaplastic astrocytoma has not been defined. In the past RTOG study (83-0...

    Authors: Takuma Nomiya, Kenji Nemoto, Toshihiro Kumabe, Yoshihiro Takai and Shogo Yamada
    Citation: BMC Cancer 2008 8:11
  31. EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of the protein, as well as gene amplification were asso...

    Authors: Cátia Moutinho, Ana R Mateus, Fernanda Milanezi, Fátima Carneiro, Raquel Seruca and Gianpaolo Suriano
    Citation: BMC Cancer 2008 8:10
  32. A number of recent studies have suggested that cancer incidence rates may be lower in patients receiving statin treatment for hypercholesterolemia. We examined the effects of statin drugs on in vitro proliferatio...

    Authors: Sharon A Glynn, Dermot O'Sullivan, Alex J Eustace, Martin Clynes and Norma O'Donovan
    Citation: BMC Cancer 2008 8:9
  33. The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with ...

    Authors: Byoung Chul Cho, Joong Bae Ahn, Jinsil Seong, Jae Kyung Roh, Joo Hang Kim, Hyun Cheol Chung, Joo Hyuk Sohn and Nam Kyu Kim
    Citation: BMC Cancer 2008 8:8
  34. Medical research has not been able to establish whether a father's occupational exposures are associated with the development of acute leukemia (AL) in their offspring. The studies conducted have weaknesses th...

    Authors: Maria Luisa Perez-Saldivar, Manuel Carlos Ortega-Alvarez, Arturo Fajardo-Gutierrez, Roberto Bernaldez-Rios, Maria de los Angeles del Campo-Martinez, Aurora Medina-Sanson, Miguel Angel Palomo-Colli, Rogelio Paredes-Aguilera, Armando Martínez-Avalos, Victor Hugo Borja-Aburto, Maria de Jesus Rodriguez-Rivera, Victor Manuel Vargas-Garcia, Jesus Zarco-Contreras, Janet Flores-Lujano and Juan Manuel Mejia-Arangure
    Citation: BMC Cancer 2008 8:7
  35. Estrogens are crucial tumorigenic hormones, which impact the cell growth and proliferation during breast cancer development. Estrogens are metabolized by a series of enzymes including COMT, which converts cate...

    Authors: Ummiye V Onay, Kirsimari Aaltonen, Laurent Briollais, Julia A Knight, Noel Pabalan, Outi Kilpivaara, Irene L Andrulis, Carl Blomqvist, Heli Nevanlinna and Hilmi Ozcelik
    Citation: BMC Cancer 2008 8:6
  36. The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of ...

    Authors: Arne Westgaard, Svetlana Tafjord, Inger N Farstad, Milada Cvancarova, Tor J Eide, Oystein Mathisen, Ole Petter F Clausen and Ivar P Gladhaug
    Citation: BMC Cancer 2008 8:5
  37. Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2...

    Authors: Xiao-Hua Zhang, Du-Ping Huang, Gui-Long Guo, Guo-Rong Chen, Hu-Xiang Zhang, Li Wan and Sheng-Ying Chen
    Citation: BMC Cancer 2008 8:4
  38. The status of the EGFR and HER2-neu genes has not been fully defined in ovarian cancer. An integrated analysis of both genes could help define the proportion of patients that would potentially benefit from tar...

    Authors: Joanna Vermeij, Erik Teugels, Claire Bourgain, Ji Xiangming, Peter in 't Veld, Vanessa Ghislain, Bart Neyns and Jacques De Grève
    Citation: BMC Cancer 2008 8:3
  39. High tumour interstitial fluid pressure (IFP) has been adversely linked to poor drug uptake in patients, and to treatment response following radiotherapy in cervix cancer patients. In this study we measured IF...

    Authors: Sarah Jane Lunt, Tuula MK Kalliomaki, Allison Brown, Victor X Yang, Michael Milosevic and Richard P Hill
    Citation: BMC Cancer 2008 8:2
  40. Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion.

    Authors: Sally Järvelä, Seppo Parkkila, Helena Bragge, Marketta Kähkönen, Anna-Kaisa Parkkila, Ylermi Soini, Silvia Pastorekova, Jaromir Pastorek and Hannu Haapasalo
    Citation: BMC Cancer 2008 8:1
  41. Medicinal plant is a main source of cancer drug development. Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines. It is of g...

    Authors: Ze Tian, Jianyong Si, Qi Chang, Liang Zhou, Shilin Chen, Peigen Xiao and Erxi Wu
    Citation: BMC Cancer 2007 7:237
  42. Currently, there are no satisfactory biomarkers available to screen for diffuse large B cell lymphoma (DLBCL) or to identify patients who do not benefit from standard anti-cancer therapies. In this study, we u...

    Authors: Xing Zhang, Bo Wang, Xiao-shi Zhang, Zhi-ming Li, Zhong-zhen Guan and Wen-qi Jiang
    Citation: BMC Cancer 2007 7:235
  43. The aim of our study was to investigate and evaluate the prognostic value of and correlations between preclinical and clinical factors such as the stage of the disease, blood Hb level before treatment, size of...

    Authors: Rūta Grigienė, Konstantinas P Valuckas, Eduardas Aleknavičius, Juozas Kurtinaitis and Simona R Letautienė
    Citation: BMC Cancer 2007 7:234
  44. Small heat shock proteins are molecular chaperones that protect proteins against stress-induced aggregation. They have also been found to have anti-apoptotic activity and to play a part in the development of t...

    Authors: Eva Pozsgai, Eva Gomori, Andras Szigeti, Arpad Boronkai, Ferenc Gallyas Jr, Balazs Sumegi and Szabolcs Bellyei
    Citation: BMC Cancer 2007 7:233
  45. The heat shock proteins (HSPs) 27-kDa (HSP27) and 72-kDa (HSP72), are ubiquitous chaperone molecules inducible in cells exposed to different stress conditions. Increased level of HSPs are reported in several h...

    Authors: Antonello A Romani, Pellegrino Crafa, Silvia Desenzani, Gallia Graiani, Costanza Lagrasta, Mario Sianesi, Paolo Soliani and Angelo F Borghetti
    Citation: BMC Cancer 2007 7:232
  46. A platinum doublet is the current standard treatment for good performance status patients with advanced non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC) with good performanc...

    Authors: Matthew A Beldner, Carol A Sherman, Mark R Green, Elizabeth Garrett-Mayer, Uzair Chaudhary, Mario L Meyer, Andrew S Kraft and Alberto J Montero
    Citation: BMC Cancer 2007 7:231
  47. Although the diagnostic criteria and pathogenesis of gastrointestinal stromal tumors (GIST) have recently been elucidated, knowledge of the epidemiology of this malignancy is still limited. This study examined...

    Authors: Claudia Mucciarini, Giulio Rossi, Federica Bertolini, Riccardo Valli, Claudia Cirilli, Ivan Rashid, Luigi Marcheselli, Gabriele Luppi and Massimo Federico
    Citation: BMC Cancer 2007 7:230

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