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  1. Musashi1 (Msi1) is an RNA binding protein with a central role during nervous system development and stem cell maintenance. High levels of Msi1 have been reported in several malignancies including brain tumors ...

    Authors: Patricia C Sanchez-Diaz, Tarea L Burton, Suzanne C Burns, Jaclyn Y Hung and Luiz OF Penalva
    Citation: BMC Cancer 2008 8:280
  2. DNA microarray analysis has great potential to become an important clinical tool to individualize prognostication and treatment for breast cancer patients. However, with any emerging technology, there are many...

    Authors: Vietty Wong, Dong-Yu Wang, Keisha Warren, Supriya Kulkarni, Scott Boerner, Susan Jane Done and Wey Liang Leong
    Citation: BMC Cancer 2008 8:277
  3. The molecular mechanisms underlying melanoma tumor development and progression are still not completely understood. One of the new candidates that emerged from a recent gene expression profiling study is fatty ac...

    Authors: Ana Slipicevic, Kjersti Jørgensen, Martina Skrede, Anne Katrine Ree Rosnes, Gunhild Trøen, Ben Davidson and Vivi Ann Flørenes
    Citation: BMC Cancer 2008 8:276
  4. There is no biological or epidemiological data on the association between NOS3 promoter polymorphisms and prostate cancer. The polymorphisms in the promoter region of NOS3 gene may be responsible for variations i...

    Authors: Karina Marangoni, Thaíse G Araújo, Adriana F Neves and Luiz R Goulart
    Citation: BMC Cancer 2008 8:273
  5. Cyclin D1 is integral for the G1 to S phase of the cell cycle as it regulates cellular proliferation. A polymorphism in cyclin D1, 870 G>A, causes overexpression and supports uncontrollable cellular growth. Th...

    Authors: Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds, Mark McEvoy, John Attia, Michael Gilbert, Ute Hamann and Rodney J Scott
    Citation: BMC Cancer 2008 8:272
  6. Cancer incidence varies by socioeconomic group and these variations have been linked with environmental and lifestyle factors, differences in access to health care and health seeking behaviour. Socioeconomic v...

    Authors: Lorraine Shack, Catrina Jordan, Catherine S Thomson, Vivian Mak and Henrik Møller
    Citation: BMC Cancer 2008 8:271
  7. Deregulation of Stat5 in the mammary gland of transgenic mice causes tumorigenesis. Poorly differentiated carcinoma and highly differentiated papillary adenocarcinoma tumors evolve. To distinguish the genes an...

    Authors: Tali Eilon and Itamar Barash
    Citation: BMC Cancer 2008 8:270
  8. The human MutY homolog (hMYH), a DNA glycolsylase involved in the excision repair of oxidative DNA damage, is currently studied in colorectal cancer (CRC). We previously demonstrated a haplotype variant c.53C>T/c...

    Authors: Huimei Chen, Lizhi Xu, Qiufeng Qi, Yanweng Yao, Ming Zhu and Yaping Wang
    Citation: BMC Cancer 2008 8:269
  9. Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5) promoter has previously been shown to induce epidermal hy...

    Authors: Aijin Wang, Stacey Arantes, Leqin Yan, Kaoru Kiguchi, Mark J McArthur, Aysegul Sahin, Howard D Thames, C Marcelo Aldaz and Michael C MacLeod
    Citation: BMC Cancer 2008 8:268
  10. The intermediate filament forming protein keratin 8 (K8) is a tumour-associated antigen, which was shown to be over-expressed in a variety of malignancies. Here, we present a study of K8 expression in squamous...

    Authors: Christoph Matthias, Brigitte Mack, Alexander Berghaus and Olivier Gires
    Citation: BMC Cancer 2008 8:267
  11. MicroRNAs (miRNAs), some of which function as oncogenes or tumor suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell death. MicroRNA miR-34 was recently found to be a...

    Authors: Qing Ji, Xinbao Hao, Yang Meng, Min Zhang, Jeffrey DeSano, Daiming Fan and Liang Xu
    Citation: BMC Cancer 2008 8:266
  12. Production of interferon (IFN)-γ is key to efficient anti-tumor immunity. The present study was set out to investigate effects of IFNγ on the release of the potent pro-angiogenic mediator IL-8 by human A549 lu...

    Authors: Kim A Boost, Christian D Sadik, Malte Bachmann, Bernhard Zwissler, Josef Pfeilschifter and Heiko Mühl
    Citation: BMC Cancer 2008 8:265
  13. The cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells....

    Authors: Matteo Pellegrini, Jerry C Cheng, Jon Voutila, Dejah Judelson, Julie Taylor, Stanley F Nelson and Kathleen M Sakamoto
    Citation: BMC Cancer 2008 8:264
  14. MYH11 (also known as SMMHC) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the MYH11 locus is one of the most frequent chromosomal aberrations found...

    Authors: Pia Alhopuro, Auli Karhu, Robert Winqvist, Kati Waltering, Tapio Visakorpi and Lauri A Aaltonen
    Citation: BMC Cancer 2008 8:263
  15. Loss of heterozygosity (LOH) on the long arm of chromosome 16 is one of the most frequent genetic events in solid tumors. Recently, the AT-motif binding factor 1 (ATBF1)-A gene, which has been assigned to chromos...

    Authors: Kazuharu Kai, Zhenhuan Zhang, Hiroko Yamashita, Yutaka Yamamoto, Yutaka Miura and Hirotaka Iwase
    Citation: BMC Cancer 2008 8:262
  16. The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle pr...

    Authors: Ji Liu, Xue Li, Guang-Long Dong, Hong-Wei Zhang, Dong-Li Chen, Jian-Jun Du, Jian-Yong Zheng, Ji-Peng Li and Wei-Zhong Wang
    Citation: BMC Cancer 2008 8:261
  17. Dysregulated expression and splicing of cell adhesion marker CD44 is found in many types of cancer. In prostate cancer (PC) specifically, the standard isoform (CD44s) has been found to be downregulated compare...

    Authors: Eric W Robbins, Emily A Travanty, Kui Yang and Kenneth A Iczkowski
    Citation: BMC Cancer 2008 8:260
  18. Many cancers preferentially meet their energy requirements through the glycolytic pathway rather than via the more efficient oxidative phosphorylation pathway. It is thought that this is an important adaptatio...

    Authors: Danielle J Smith, Luke R Cossins, Irene Hatzinisiriou, Michelle Haber and Phillip Nagley
    Citation: BMC Cancer 2008 8:259
  19. Spain was the country that registered the greatest increases in ovarian cancer mortality in Europe. This study describes the municipal distribution of ovarian cancer mortality in Spain using spatial models for...

    Authors: Virginia Lope, Marina Pollán, Beatriz Pérez-Gómez, Nuria Aragonés, Enrique Vidal, Diana Gómez-Barroso, Rebeca Ramis, Javier García-Pérez, Anna Cabanes and Gonzalo López-Abente
    Citation: BMC Cancer 2008 8:258
  20. Fanconi anemia (FA) is an autosomal recessive DNA repair disorder with affected individuals having a high risk of developing acute myeloid leukaemia and certain solid tumours. Thirteen complementation groups h...

    Authors: Marc Tischkowitz, Douglas F Easton, Jan Ball, Shirley V Hodgson and Christopher G Mathew
    Citation: BMC Cancer 2008 8:257
  21. Gastrointestinal cancer, such as gastric, colon and rectal cancer, is a major medical and economic burden worldwide. However, the exact mechanism of gastrointestinal cancer development still remains unclear. RAS ...

    Authors: Yongjing Zhang, Mingjuan Jin, Bing Liu, Xinyuan Ma, Kaiyan Yao, Qilong Li and Kun Chen
    Citation: BMC Cancer 2008 8:256
  22. BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation ph...

    Authors: Sérgia Velho, Cátia Moutinho, Luís Cirnes, Cristina Albuquerque, Richard Hamelin, Fernando Schmitt, Fátima Carneiro, Carla Oliveira and Raquel Seruca
    Citation: BMC Cancer 2008 8:255
  23. It is of great significance to find better markers to correctly distinguish between high-risk and low-risk breast cancer patients since the majority of breast cancer cases are at present being overtreated.

    Authors: Elin Karlsson, Ulla Delle, Anna Danielsson, Björn Olsson, Frida Abel, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2008 8:254
  24. Nasopharyngeal carcinoma (NPC) is a head and neck malignancy with high occurrence in South-East Asia and Southern China. Recent findings suggest that epigenetic inactivation of multiple tumor suppressor genes ...

    Authors: Huaying Liu, Liming Zhang, Zhaoxia Niu, Ming Zhou, Cong Peng, Xiayu Li, Tan Deng, Lei Shi, Yixin Tan and Guiyuan Li
    Citation: BMC Cancer 2008 8:253
  25. Mucinous ovarian carcinoma have a poorer prognosis compared with other histological subtypes. The aim of this study was to evaluate, retrospectively, the activity of chemotherapy in patients with platinum sens...

    Authors: Sandro Pignata, Gabriella Ferrandina, Giovanna Scarfone, Paolo Scollo, Franco Odicino, Gennaro Cormio, Dionyssios Katsaros, Antonella Villa, Liliana Mereu, Fabio Ghezzi, Luigi Manzione, Rossella Lauria, Enrico Breda, Desiderio Gueli Alletti, Michela Ballardini, Alessandra Vernaglia Lombardi…
    Citation: BMC Cancer 2008 8:252
  26. The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological subtype – more so than th...

    Authors: Peter Schirmacher and Markus W Büchler
    Citation: BMC Cancer 2008 8:251
  27. In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. Th...

    Authors: Ali H Zarzour, Mohie Selim, Alaa A Abd-Elsayed, Diaa A Hameed and Mohammad A AbdelAziz
    Citation: BMC Cancer 2008 8:250
  28. Bioelectrical impedance analysis (BIA) is an easy-to-use, non-invasive, and reproducible technique to evaluate changes in body composition and nutritional status. Phase angle, determined by bioelectrical imped...

    Authors: Digant Gupta, Carolyn A Lammersfeld, Pankaj G Vashi, Jessica King, Sadie L Dahlk, James F Grutsch and Christopher G Lis
    Citation: BMC Cancer 2008 8:249
  29. We have been studying the native autoimmune response to cancer through the isolation of human monoclonal antibodies that are cancer specific from cancer patients. To facilitate this work we previously develope...

    Authors: Sergei Rudchenko, Matthew Scanlan, Gavreel Kalantarov, Victoria Yavelsky, Chen Levy, Alison Estabrook, Lloyd Old, Gerald L Chan, Leslie Lobel and Ilya Trakht
    Citation: BMC Cancer 2008 8:248
  30. We have been studying the native humoral immune response to cancer and have isolated a library of fully human autoantibodies to a variety of malignancies. We previously described the isolation and characteriza...

    Authors: Victoria Yavelsky, Sarit Rohkin, Ruthy Shaco-Levy, Alina Tzikinovsky, Tamar Amir, Hila Kohn, Berta Delgado, Alex Rabinovich, Benjamin Piura, Gerald Chan, Gavreel Kalantarov, Ilya Trakht and Leslie Lobel
    Citation: BMC Cancer 2008 8:247
  31. Persistent infection with oncogenic types of human papillomavirus (HPV) is the major risk factor for invasive cervical cancer (ICC), and non-European variants of HPV-16 are associated with an increased risk of...

    Authors: Patricia S de Araujo Souza, Paulo C Maciag, Karina B Ribeiro, Maria Luiza Petzl-Erler, Eduardo L Franco and Luisa L Villa
    Citation: BMC Cancer 2008 8:246
  32. Glioblastoma is the most lethal primary malignant brain tumor. Although considerable progress has been made in the treatment of this aggressive tumor, the clinical outcome for patients remains poor. Histone de...

    Authors: Agda KB Lucio-Eterovic, Maria AA Cortez, Elvis T Valera, Fabio JN Motta, Rosane GP Queiroz, Helio R Machado, Carlos G Carlotti Jr, Luciano Neder, Carlos A Scrideli and Luiz G Tone
    Citation: BMC Cancer 2008 8:243
  33. Honokiol is a major bioactive compound extracted from Magnolia. The present study was designed to determine whether liposomal honokiol has the antitumor activity against human lung cancer as well as potentiate...

    Authors: Qi-qi Jiang, Lin-yu Fan, Guang-li Yang, Wen-Hao Guo, Wen-li Hou, Li-juan Chen and Yu-quan Wei
    Citation: BMC Cancer 2008 8:242
  34. There is an urgent need to discover more sensitive and specific biomarkers to improve early diagnosis and screen high-risk patients for pancreatic ductal adenocarcinoma (PDAC). Pancreatic juice is an ideal spe...

    Authors: Mei Tian, Ya-Zhou Cui, Guan-Hua Song, Mei-Juan Zong, Xiao-Yan Zhou, Yu Chen and Jin-Xiang Han
    Citation: BMC Cancer 2008 8:241
  35. Prostate cancer is a frequent finding in man. In dogs, malignant disease of the prostate is also of clinical relevance, although it is a less common diagnosis. Even though there are numerous differences in ori...

    Authors: Melani AM Fork, Hugo Murua Escobar, Jan T Soller, Katharina A Sterenczak, Saskia Willenbrock, Susanne Winkler, Martina Dorsch, Nicola Reimann-Berg, Hans J Hedrich, Jörn Bullerdiek and Ingo Nolte
    Citation: BMC Cancer 2008 8:240
  36. BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 (CHEK2) is an imp...

    Authors: David J Novak, Long Qi Chen, Parviz Ghadirian, Nancy Hamel, Phil Zhang, Vanessa Rossiny, Guy Cardinal, André Robidoux, Patricia N Tonin, Francois Rousseau, Steven A Narod and William D Foulkes
    Citation: BMC Cancer 2008 8:239
  37. Epigenetic alterations are a hallmark of human cancer. In this study, we aimed to investigate whether aberrant DNA methylation of cancer-associated genes is related to urinary bladder cancer recurrence.

    Authors: Priscilla D Negraes, Francine P Favaro, João Lauro V Camargo, Maria Luiza CS Oliveira, José Goldberg, Cláudia A Rainho and Daisy MF Salvadori
    Citation: BMC Cancer 2008 8:238
  38. Epidemiologic and laboratory investigations suggest that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon cancer perhaps due at least in part to their ...

    Authors: Randall E Harris, Joanne Beebe-Donk and Galal A Alshafie
    Citation: BMC Cancer 2008 8:237
  39. Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to h...

    Authors: Waqas Amin, Anil V Parwani, Linda Schmandt, Sambit K Mohanty, Ghada Farhat, Andrew K Pople, Sharon B Winters, Nancy B Whelan, Althea M Schneider, John T Milnes, Federico A Valdivieso, Michael Feldman, Harvey I Pass, Rajiv Dhir, Jonathan Melamed and Michael J Becich
    Citation: BMC Cancer 2008 8:236
  40. The epidermal growth factor receptor (EGFR) is over-expressed in 70–75% of colorectal adenocarcinomas (CRC). The anti-EGFR monoclonal antibody cetuximab has been approved for the treatment of metastatic CRC, h...

    Authors: Evangelia Razis, Evangelos Briasoulis, Eleni Vrettou, Dimosthenis V Skarlos, Dimitrios Papamichael, Ioannis Kostopoulos, Epaminontas Samantas, Ioannis Xanthakis, Mattheos Bobos, Eleni Galanidi, Maria Bai, Ioanna Gikonti, Alona Koukouma, Georgia Kafiri, Pavlos Papakostas, Konstantine T Kalogeras…
    Citation: BMC Cancer 2008 8:234
  41. Many kinetochore proteins have been shown to be associated with human cancers. The aim of the present study was to clarify the expression of Centromere protein H (CENP-H), one of the fundamental components of ...

    Authors: Xian-Zhi Guo, Ge Zhang, Jun-Ye Wang, Wan-Li Liu, Fang Wang, Ju-Qin Dong, Li-Hua Xu, Jing-Yan Cao, Li-Bing Song and Mu-Sheng Zeng
    Citation: BMC Cancer 2008 8:233
  42. Proteins overexpressed on the surface of tumor cells can be selectively targeted. Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are among the most often targeted p...

    Authors: Li Shen, Yongjie Shui, Xiaojia Wang, Liming Sheng, Zhengyan Yang, Danfeng Xue and Qichun Wei
    Citation: BMC Cancer 2008 8:232
  43. The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and death from prostate cancer. These associations suggest the hy...

    Authors: Liesel M FitzGerald, Ilir Agalliu, Karynn Johnson, Melinda A Miller, Erika M Kwon, Antonio Hurtado-Coll, Ladan Fazli, Ashish B Rajput, Martin E Gleave, Michael E Cox, Elaine A Ostrander, Janet L Stanford and David G Huntsman
    Citation: BMC Cancer 2008 8:230
  44. Although lung cancer is among the few malignancies for which we know the primary etiological agent (i.e., cigarette smoke), a precise understanding of the temporal sequence of events that drive tumor progressi...

    Authors: Ellen Jorgensen, Andy Stinson, Lin Shan, Jin Yang, Diana Gietl and Anthony P Albino
    Citation: BMC Cancer 2008 8:229
  45. The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modifi...

    Authors: Kai Tao, Min Fang, Joseph Alroy and G Gary Sahagian
    Citation: BMC Cancer 2008 8:228
  46. EGFR is frequently overexpressed in colon cancer. We characterized HT-29 and Caco-2, human colon cancer cell lines, untreated and treated with cetuximab or gefitinib alone and in combination with EGF.

    Authors: Rossella Solmi, Mattia Lauriola, Mirko Francesconi, Désirée Martini, Manuela Voltattorni, Claudio Ceccarelli, Giampaolo Ugolini, Giancarlo Rosati, Simone Zanotti, Isacco Montroni, Gabriella Mattei, Mario Taffurelli, Donatella Santini, Furio Pezzetti, Alessandro Ruggeri, Gastone Castellani…
    Citation: BMC Cancer 2008 8:227

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