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  1. Infection with high-risk human papillomavirus is an important factor associated with cervical cancer, and the distribution of HPV types varies greatly worldwide. Determination of type-specific HPV prevalence c...

    Authors: En-qi Wu, Guo-nan Zhang, Xiang-hui Yu, Yuan Ren, Ying Fan, Yong-ge Wu, Wei Kong and Xiao Zha

    Citation: BMC Cancer 2008 8:202

    Content type: Research article

    Published on:

  2. The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies. Despite knowing the at risk populations ...

    Authors: Gary Beale, Dipankar Chattopadhyay, Joe Gray, Stephen Stewart, Mark Hudson, Christopher Day, Paolo Trerotoli, Gianluigi Giannelli, Derek Manas and Helen Reeves

    Citation: BMC Cancer 2008 8:200

    Content type: Research article

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  3. Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, ma...

    Authors: Yoonseok Kam, Cherise Guess, Lourdes Estrada, Brandy Weidow and Vito Quaranta

    Citation: BMC Cancer 2008 8:198

    Content type: Technical advance

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  4. HO-1 participates in the degradation of heme. Its products can exert unique cytoprotective effects. Numerous tumors express high levels of HO-1 indicating that this enzyme might be a potential therapeutic targ...

    Authors: Dominika Nowis, Marek Bugajski, Magdalena Winiarska, Jacek Bil, Angelika Szokalska, Pawel Salwa, Tadeusz Issat, Halina Was, Alicja Jozkowicz, Jozef Dulak, Tomasz Stoklosa and Jakub Golab

    Citation: BMC Cancer 2008 8:197

    Content type: Research article

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  5. hRad9 is a cell cycle checkpoint gene that is up-regulated in breast cancer. We have previously shown that the mRNA up-regulation correlated with tumor size and local recurrence. Immunohistochemical studies were...

    Authors: Vivian Chan, US Khoo, MS Wong, Ken Lau, Dacita Suen, George Li, Ava Kwong and TK Chan

    Citation: BMC Cancer 2008 8:196

    Content type: Research article

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  6. Patients with acute myeloid leukemia (AML) are often neutropenic as a result of their disease. Furthermore, these patients typically experience profound neutropenia following induction and/or consolidation che...

    Authors: Jorge Sierra, Jeffrey Szer, Jeannine Kassis, Richard Herrmann, Mario Lazzarino, Xavier Thomas, Stephen J Noga, Nigel Baker, Roger Dansey and Alberto Bosi

    Citation: BMC Cancer 2008 8:195

    Content type: Research article

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  7. Cathepsin B and L (CATB, CATL), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 play an important role in colorectal cancer invasion. The tumor marker utility and prognostic relevance of the...

    Authors: László Herszényi, Fabio Farinati, Romilda Cardin, Gábor István, László D Molnár, István Hritz, Massimo De Paoli, Mario Plebani and Zsolt Tulassay

    Citation: BMC Cancer 2008 8:194

    Content type: Research article

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  8. Variant translocations t(9;22) occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60–80% of patients in blast crisis (BC). Here, we report on a CML patient in blast crisis ...

    Authors: An De Weer, Bruce Poppe, Barbara Cauwelier, Andre Carlier, Jan Dierick, Bruno Verhasselt, Jan Philippé, Nadine Van Roy and Frank Speleman

    Citation: BMC Cancer 2008 8:193

    Content type: Research article

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  9. Recent meta-analyses have found a survival advantage with gemcitabine based combinations over single agent gemcitabine in patients with advanced pancreatic cancer. There is paucity of evidence in the form of d...

    Authors: Asma Sultana, Paula Ghaneh, David Cunningham, Naureen Starling, John P Neoptolemos and Catrin Tudur Smith

    Citation: BMC Cancer 2008 8:192

    Content type: Research article

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  10. TGFβ has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT). Some evidence suggests that these effects may be int...

    Authors: Sharon Sheahan, Christopher O Bellamy, Stephen N Hartland, David J Harrison and Sandrine Prost

    Citation: BMC Cancer 2008 8:191

    Content type: Research article

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  11. Kaposi sarcoma (KS) is a multifocal, vascular lesion of low-grade malignant potential that presents most frequently in mucocutaneous sites. KS also commonly involves lymph nodes and visceral organs. This artic...

    Authors: Liron Pantanowitz and Bruce J Dezube

    Citation: BMC Cancer 2008 8:190

    Content type: Review

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  12. Signaling downstream of Ras is mediated by three major pathways, Raf/ERK, phosphatidylinositol 3 kinase (PI3K), and Ral guanine nucleotide exchange factor (RalGEF). Ras signal transduction pathways play an imp...

    Authors: Michael D Oberst, Stacey J Beberman, Liu Zhao, Juan Juan Yin, Yvona Ward and Kathleen Kelly

    Citation: BMC Cancer 2008 8:189

    Content type: Research article

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  13. A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports...

    Authors: Masashi Ishikawa, Takayuki Miyauchi and Yutaka Kashiwagi

    Citation: BMC Cancer 2008 8:188

    Content type: Research article

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  14. Mortality from colorectal cancer is mainly due to metastatic liver disease. Improved understanding of the molecular events underlying metastasis is crucial for the development of new methods for early detectio...

    Authors: Donia P Macartney-Coxson, Kylie A Hood, Hong-jun Shi, Teresa Ward, Anna Wiles, Rosemary O'Connor, David A Hall, Rod A Lea, Janice A Royds, Richard S Stubbs and Serena Rooker

    Citation: BMC Cancer 2008 8:187

    Content type: Research article

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  15. The aim of this study is to investigate the relationship between16-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF (vascular endothelial growth factor) expression in patients with benign and ...

    Authors: Shu-Hua Ma, Hong-Bo Le, Bao-hui Jia, Zhao-Xin Wang, Zhuang-Wei Xiao, Xiao-Ling Cheng, Wei Mei, Min Wu, Zhi-Guo Hu and Yu-Guang Li

    Citation: BMC Cancer 2008 8:186

    Content type: Research article

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  16. Syndecan-1 is a transmembrane proteoglycan with important roles in cell-cell and cell-extracellular matrix adhesion and as a growth factor co-receptor. Syndecan-1 is highly expressed by normal epithelial cells...

    Authors: Yosuke Hashimoto, Marek Skacel and Josephine C Adams

    Citation: BMC Cancer 2008 8:185

    Content type: Research article

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  17. Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recu...

    Authors: David Lindgren, Sigurdur Gudjonsson, Kowan Ja Jee, Fredrik Liedberg, Sonja Aits, Anna Andersson, Gunilla Chebil, Åke Borg, Sakari Knuutila, Thoas Fioretos, Wiking Månsson and Mattias Höglund

    Citation: BMC Cancer 2008 8:183

    Content type: Research article

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  18. Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas.

    Authors: Anxun Wang, Bin Zhang, Hongzhang Huang, Leitao Zhang, Donglin Zeng, Qian Tao, Jianguang Wang and Chaobin Pan

    Citation: BMC Cancer 2008 8:182

    Content type: Research article

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  19. Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to amphibole forms of asbestos, chrysotile asbestos fail to a...

    Authors: Beatriz A Cortez and Glaucia M Machado-Santelli

    Citation: BMC Cancer 2008 8:181

    Content type: Research article

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  20. Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of ...

    Authors: Diana J Leeming, Inger Byrjalsen, Per Qvist, Mitsuru Koizumi, Niels Lynnerup, Michael Fregerslev, Mette G Sørensen, Claus Christiansen and Morten A Karsdal

    Citation: BMC Cancer 2008 8:180

    Content type: Research article

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  21. A Disintegrin And Metalloprotease (ADAM) 9 has been implicated in tumour progression of various solid tumours, however, little is known about its role in renal cell carcinoma. We evaluated the expression of ADAM...

    Authors: Florian R Fritzsche, Kirsten Wassermann, Monika Jung, Angelika Tölle, Ilka Kristiansen, Michael Lein, Manfred Johannsen, Manfred Dietel, Klaus Jung and Glen Kristiansen

    Citation: BMC Cancer 2008 8:179

    Content type: Research article

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  22. CXCR2 chemokine ligands CXCL1, CXCL5 and CXCL6 were shown to be involved in chemoattraction, inflammatory responses, tumor growth and angiogenesis. Here, we comparatively analyzed their expression profile in r...

    Authors: Claudia Rubie, Vilma Oliveira Frick, Mathias Wagner, Jochen Schuld, Stefan Gräber, Brigitte Brittner, Rainer M Bohle and Martin K Schilling

    Citation: BMC Cancer 2008 8:178

    Content type: Research article

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  23. Pain is said to be one of the most feared and distressing symptoms of cancer and one that disrupts all aspects of life. The purposes of this study were: 1) to compare depression and quality of life among Irani...

    Authors: Azadeh Tavoli, Ali Montazeri, Rasool Roshan, Zahra Tavoli and Mahdiyeh Melyani

    Citation: BMC Cancer 2008 8:177

    Content type: Research article

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  24. Rapamycin, an inhibitor of mammalian target of Rapamycin (mTOR), is an immunosuppressive agent that has anti-proliferative effects on some tumors. However, the role of Rapamycin-induced immune suppression on t...

    Authors: Elena V Svirshchevskaya, Jacopo Mariotti, Mollie H Wright, Natalia Y Viskova, William Telford, Daniel H Fowler and Lyuba Varticovski

    Citation: BMC Cancer 2008 8:176

    Content type: Research article

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  25. Copper homeostasis proteins ATP7A and ATP7B are assumed to be involved in the intracellular transport of cisplatin. The aim of the present study was to assess the relevance of sub cellular localisation of thes...

    Authors: Ganna V Kalayda, Christina H Wagner, Irina Buß, Jan Reedijk and Ulrich Jaehde

    Citation: BMC Cancer 2008 8:175

    Content type: Research article

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  26. The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the par...

    Authors: Isabel Conde, María VT Lobo, Javier Zamora, Julio Pérez, Francisco J González, Emilio Alba, Benito Fraile, Ricardo Paniagua and María I Arenas

    Citation: BMC Cancer 2008 8:174

    Content type: Research article

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  27. Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor...

    Authors: Evi Michels, Jasmien Hoebeeck, Katleen De Preter, Alexander Schramm, Bénédicte Brichard, Anne De Paepe, Angelika Eggert, Geneviève Laureys, Jo Vandesompele and Frank Speleman

    Citation: BMC Cancer 2008 8:173

    Content type: Research article

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  28. S100A4 is a metastasis-associated protein which has been linked to multiple cellular events, and has been identified extracellularly, in the cytoplasm and in the nucleus of tumor cells; however, the biological...

    Authors: Mads H Haugen, Kjersti Flatmark, Svein-Ole Mikalsen and Gunhild M Malandsmo

    Citation: BMC Cancer 2008 8:172

    Content type: Research article

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  29. Colorectal cancer (CRC) is the second most commonly diagnosed cancer for both sexes in developed countries. This study assessed the knowledge, attitudes, and preventive practices regarding CRC of adults in Italy.

    Authors: Alessandra Sessa, Rossella Abbate, Gabriella Di Giuseppe, Paolo Marinelli and Italo F Angelillo

    Citation: BMC Cancer 2008 8:171

    Content type: Research article

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  30. Resectable adenocarcinomas in the pancreatic head, by definition "periampullary", originate from ampullary, duodenal, biliary, or ductal pancreatic epithelium. Typically, periampullary adenocarcinomas have eit...

    Authors: Arne Westgaard, Svetlana Tafjord, Inger N Farstad, Milada Cvancarova, Tor J Eide, Oystein Mathisen, Ole Petter F Clausen and Ivar P Gladhaug

    Citation: BMC Cancer 2008 8:170

    Content type: Research article

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  31. Cetuximab, a monoclonal antibody targeting Epidermal Growth Factor Receptor (EGFR), is currently used in metastatic colorectal cancer (mCRC), but predictive factors for therapeutic response are lacking. Mutati...

    Authors: Anthony Gonçalves, Séverine Esteyries, Brynn Taylor-Smedra, Arnaud Lagarde, Mounay Ayadi, Geneviève Monges, François Bertucci, Benjamin Esterni, Jean-Robert Delpero, Olivier Turrini, Bernard Lelong, Patrice Viens, Jean-Paul Borg, Daniel Birnbaum, Sylviane Olschwang and Frédéric Viret

    Citation: BMC Cancer 2008 8:169

    Content type: Research article

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  32. Regional lymph node metastasis is an important prognostic factor in head and neck squamous cell carcinoma (HNSCC) and plays a decisive role in the choice of treatment. Here, we present an independent gene expr...

    Authors: Erik F Hensen, Maria J De Herdt, Jelle J Goeman, Jan Oosting, Vincent THBM Smit, Cees J Cornelisse and Robert J Baatenburg de Jong

    Citation: BMC Cancer 2008 8:168

    Content type: Research article

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  33. Limited information is available on the effects of progestins on breast cancer progression and metastasis. Cell migration and invasion are central for these processes, and require dynamic cytoskeletal and cell...

    Authors: Xiao-Dong Fu, Maria Silvia Giretti, Lorenzo Goglia, Marina Ines Flamini, Angel Matias Sanchez, Chiara Baldacci, Silvia Garibaldi, Regine Sitruk-Ware, Andrea Riccardo Genazzani and Tommaso Simoncini

    Citation: BMC Cancer 2008 8:166

    Content type: Research article

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  34. Accurate evaluation of axillary lymph node (ALN) involvement is mandatory before treatment of primary breast cancer. The aim of this study is to compare preoperative diagnostic accuracy between positron emissi...

    Authors: Shigeto Ueda, Hitoshi Tsuda, Hideki Asakawa, Jiro Omata, Kazuhiko Fukatsu, Nobuo Kondo, Tadaharu Kondo, Yukihiro Hama, Katsumi Tamura, Jiro Ishida, Yoshiyuki Abe and Hidetaka Mochizuki

    Citation: BMC Cancer 2008 8:165

    Content type: Research article

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  35. The Satisfaction with Cancer Information Profile (SCIP) has previously been shown to be a valid and reliable measure responsive to changes in patient satisfaction over time. It has been suggested that the SCIP...

    Authors: Matthew C Hankins and Carrie D Llewellyn

    Citation: BMC Cancer 2008 8:164

    Content type: Research article

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  36. Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment of OSCC requires the identification of molecular targets and signal...

    Authors: Sanjukta Chakraborty, SM Azeem Mohiyuddin, KS Gopinath and Arun Kumar

    Citation: BMC Cancer 2008 8:163

    Content type: Research article

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  37. p53 is an important tumour suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent...

    Authors: Karen R Reed, Valerie S Meniel, Victoria Marsh, Alicia Cole, Owen J Sansom and Alan R Clarke

    Citation: BMC Cancer 2008 8:162

    Content type: Research article

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  38. Viscum album (VA) preparations have been used as a complimentary therapy in cancer. In addition to their cytotoxic properties, they have also been shown to have immunostimulatory properties. In the present study...

    Authors: Sri Ramulu Elluru, Jean-Paul Duong van Huyen, Sandrine Delignat, Michel D Kazatchkine, Alain Friboulet, Srini V Kaveri and Jagadeesh Bayry

    Citation: BMC Cancer 2008 8:161

    Content type: Research article

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  39. Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. ANT has been known to be a major component of the permeabi...

    Authors: Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon, Khin Chaw aYu Aung and Chul-Woo Kim

    Citation: BMC Cancer 2008 8:160

    Content type: Research article

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  40. Antisense oligonucleotides against hTR (As-ODN-hTR) have shown promising results as treatment strategies for various human malignancies. All-trans retinoic acid (ATRA) is a signalling molecule with important r...

    Authors: Qin Xu, Zhiyuan Zhang, Ping Zhang and Wantao Chen

    Citation: BMC Cancer 2008 8:159

    Content type: Research article

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  41. Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor, and stimulates growth in prostate cancer cells. The current study is to determine a potent...

    Authors: Kiwon Lee, Yin Liu, Jun Qin Mo, Jinsong Zhang, Zhongyun Dong and Shan Lu

    Citation: BMC Cancer 2008 8:158

    Content type: Research article

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  42. Progress in lung cancer is hampered by the lack of clinically useful diagnostic markers. The goal of this study was to provide a detailed evaluation of lung cancer tumor markers indicative of molecular abnorma...

    Authors: Min Cheng, Yongyan Chen, Xiaoqing Yu, Zhigang Tian and Haiming Wei

    Citation: BMC Cancer 2008 8:156

    Content type: Research article

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  43. The identification of a BRCA1 or BRCA2 mutation in familial breast cancer kindreds allows genetic testing of at risk relatives. However, considerable controversy exists regarding the cancer risks in women who tes...

    Authors: D Gareth Evans, Andrew Shenton, Emma Woodward, Fiona Lalloo, Anthony Howell and Eamonn R Maher

    Citation: BMC Cancer 2008 8:155

    Content type: Research article

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  44. Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and...

    Authors: Erik Noetzel, Jürgen Veeck, Dieter Niederacher, Oliver Galm, Felicitas Horn, Arndt Hartmann, Ruth Knüchel and Edgar Dahl

    Citation: BMC Cancer 2008 8:154

    Content type: Research article

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