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  1. The use of cancer related therapy in cancer patients at the end-of-life has increased over time in many countries. Given a lack of published Swiss data, the objective of this study was to describe delivery of ...

    Authors: Klazien W Matter-Walstra, Rita Achermann, Roland Rapold, Dirk Klingbiel, Andrea Bordoni, Silvia Dehler, Gernot Jundt, Isabelle Konzelmann, Kerri M Clough-Gorr, Thomas D Szucs, Matthias Schwenkglenks and Bernhard C Pestalozzi
    Citation: BMC Cancer 2014 14:306
    Content type: Research article Published on:

  3. Conventional chemotherapy in malignant pleural mesothelioma (MPM) has minimal impact on patient survival due to the supposed chemoresistance of cancer stem cells (CSCs). We sought to identify a sub-population ...

    Authors: Lourdes Cortes-Dericks, Laurene Froment, Ruben Boesch, Ralph Alexander Schmid and Golnaz Karoubi
    Citation: BMC Cancer 2014 14:304
    Content type: Research article Published on:

  4. Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeuti...

    Authors: Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti and Diego Russo
    Citation: BMC Cancer 2014 14:303
    Content type: Review Published on:

  5. The androgen receptor (AR) plays a central role in the oncogenesis of different tumors, as is the case in prostate cancer. In triple negative breast cancer (TNBC) a gene expression classification has described...

    Authors: María D Cuenca-López, Juan C Montero, Jorge C Morales, Aleix Prat, Atanasio Pandiella and Alberto Ocana
    Citation: BMC Cancer 2014 14:302
    Content type: Research article Published on:

  6. In Japan, transarterial infusion chemotherapy using cisplatin (CDDP-TAI) is frequently used for advanced hepatocellular carcinoma (HCC). Moreover, oral chemotherapy with S-1, an oral fluoropyrimidine derivativ...

    Authors: Tetsuji Terazawa, Shunsuke Kondo, Hiroko Hosoi, Chigusa Morizane, Satoshi Shimizu, Shuichi Mitsunaga, Masafumi Ikeda, Hideki Ueno and Takuji Okusaka
    Citation: BMC Cancer 2014 14:301
    Content type: Research article Published on:

  7. Gastric cancer remains a major health issue and a leading cause of death worldwide. This study presented a long-term survival data of gastric cancer registered in Shanghai of China from 1972–2003, with aims to...

    Authors: Leizhen Zheng, Chunxiao Wu, Pan Xi, Meiling Zhu, Li Zhang, Siyu Chen, Xiaoping Li, Jianchun Gu and Ying Zheng
    Citation: BMC Cancer 2014 14:300
    Content type: Research article Published on:

  8. Mercaptopurine (6-MP) plays a pivotal role in treatment of childhood acute lymphoblastic leukemia (ALL); however, interindividual variability in toxicity of this drug due to genetic polymorphism in 6-MP metabo...

    Authors: Mauricio J Farfan, Carolina Salas, Cristina Canales, Felipe Silva, Milena Villarroel, Katherine Kopp, Juan P Torres, María E Santolaya and Jorge Morales
    Citation: BMC Cancer 2014 14:299
    Content type: Research article Published on:

  9. Metformin may exhibit inhibitory effects on cancer cells by inhibiting mTOR signaling pathway. The aim of our retrospective study was to examine if patients with breast carcinoma (BC) and diabetes mellitus (DM...

    Authors: Nikola Besic, Nika Satej, Ivica Ratosa, Andreja Gojkovic Horvat, Tanja Marinko, Barbara Gazic and Rok Petric
    Citation: BMC Cancer 2014 14:298
    Content type: Research article Published on:

  10. Sirtuin 3 (Sirt3), one of the seven Sirtuins family members, plays critical roles in the progression of multiple cancer types. However, its role in the prognosis of hepatocellular carcinoma (HCC) has not yet b...

    Authors: Jia-Xing Wang, Yong Yi, Yi-Wei Li, Xiao-Yan Cai, Hong-Wei He, Xiao-Chun Ni, Jian Zhou, Yun-Feng Cheng, Jian-Jun Jin, Jia Fan and Shuang-Jian Qiu
    Citation: BMC Cancer 2014 14:297
    Content type: Research article Published on:

  11. Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is assoc...

    Authors: Hassan Brim, Marwah Zahaf, Adeyinka O Laiyemo, Mehdi Nouraie, Guillermo I Pérez-Pérez, Duane T Smoot, Edward Lee, Hadie Razjouyan and Hassan Ashktorab
    Citation: BMC Cancer 2014 14:296
    Content type: Research article Published on:

  12. Ganglioside GD2 is expressed on plasma membranes of various types of malignant cells. One of the most promising approaches for cancer immunotherapy is the treatment with monoclonal antibodies recognizing tumor...

    Authors: Igor I Doronin, Polina A Vishnyakova, Irina V Kholodenko, Eugene D Ponomarev, Dmitry Y Ryazantsev, Irina M Molotkovskaya and Roman V Kholodenko
    Citation: BMC Cancer 2014 14:295
    Content type: Research article Published on:

  13. Lung cancer patients with mutations in the epidermal growth factor receptor (EGFR) are primary candidates for EGFR-targeted therapy. Reliable analyses of such mutations have previously been possible only in tu...

    Authors: Britta Weber, Peter Meldgaard, Henrik Hager, Lin Wu, Wen Wei, Julie Tsai, Azza Khalil, Ebba Nexo and Boe S Sorensen
    Citation: BMC Cancer 2014 14:294
    Content type: Research article Published on:

  14. Surgical therapies are the first-line treatments for hepatocellular carcinoma (HCC) patients. However, the high incidence of tumor metastasis after liver surgery remains a severe problem. We aim to investigate...

    Authors: Chang Xian Li, Bing L Wong, Chang Chun Ling, Yuen Yuen Ma, Yan Shao, Wei Geng, Xiang Qi, Sze Hang Lau, Sui Yi Kwok, Na Wei, Fei Chuen Tzang, Kevin TP Ng, Xiao Bing Liu, Chung Mau Lo and Kwan Man
    Citation: BMC Cancer 2014 14:293
    Content type: Research article Published on:

  15. PAX8 is a member of the paired box (Pax) multigene family of transcription factors, which are involved in the developmental and tissue-specific control of the expression of several genes in both vertebrates an...

    Authors: Tina Di Palma, Valeria Lucci, Tiziana de Cristofaro, Maria Grazia Filippone and Mariastella Zannini
    Citation: BMC Cancer 2014 14:292
    Content type: Research article Published on:

  16. CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and function...

    Authors: Tomoyuki Irino, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori and Yuko Kitagawa
    Citation: BMC Cancer 2014 14:291
    Content type: Research article Published on:

  17. The efficacy and safety of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 in combination with pemetrexed and cisplatin was evaluated in...

    Authors: Chandra P Belani, Nobuyuki Yamamoto, Igor M Bondarenko, Artem Poltoratskiy, Silvia Novello, Jie Tang, Paul Bycott, Andreas G Niethammer, Antonella Ingrosso, Sinil Kim and Giorgio V Scagliotti
    Citation: BMC Cancer 2014 14:290
    Content type: Research article Published on:

  18. The objective of this study was to identify breast cancer patients with a high risk of developing brain metastases who may benefit from pre-emptive medical intervention.

    Authors: Volker Rudat, Hamdan El-Sweilmeen, Iris Brune-Erber, Alaa Ahmad Nour, Nidal Almasri, Saleh Altuwaijri and Elias Fadel
    Citation: BMC Cancer 2014 14:289
    Content type: Research article Published on:

  19. Malignant ascites is often present at diagnostic in women with advanced ovarian cancer (OC) and its presence is associated with a worse outcome. Human peritoneal mesothelial cells (HPMCs) are key components of...

    Authors: Isabelle Matte, Denis Lane, Dimcho Bachvarov, Claudine Rancourt and Alain Piché
    Citation: BMC Cancer 2014 14:288
    Content type: Research article Published on:

  20. The DNA damage checkpoint signalling cascade sense damaged DNA and coordinates cell cycle arrest, DNA repair, and/or apoptosis. However, it is still not well understood how the signalling system differentiates...

    Authors: Satish Bodakuntla, Libi Anandi V, Surojit Sural, Prasad Trivedi and Mayurika Lahiri
    Citation: BMC Cancer 2014 14:287
    Content type: Research article Published on:

  21. Mammary microcalcifications have a crucial role in breast cancer detection, but the processes that induce their formation are unknown. Moreover, recent studies have described the occurrence of the epithelial–m...

    Authors: Manuel Scimeca, Elena Giannini, Chiara Antonacci, Chiara Adriana Pistolese, Luigi Giusto Spagnoli and Elena Bonanno
    Citation: BMC Cancer 2014 14:286
    Content type: Research article Published on:

  24. Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER) α -positive breast cancer patients. Although the mechanisms behind tamoxifen resistance are still not completely understood, c...

    Authors: Marja Moerkens, Yinghui Zhang, Lynn Wester, Bob van de Water and John HN Meerman
    Citation: BMC Cancer 2014 14:283
    Content type: Research article Published on:

  25. The risk of hepatocellular carcinoma (HCC) increases in chronic hepatitis B surface antigen (HBsAg) carriers who often have concomitant increase in the levels of benzo[alpha]pyrene-7,8-diol-9,10-epoxide(±) (BP...

    Authors: Jin-Yan Chen, Wan-Nan Chen, Bo-Yan Jiao, Wan-Song Lin, Yun-Li Wu, Ling-Ling Liu and Xu Lin
    Citation: BMC Cancer 2014 14:282
    Content type: Research article Published on:

  26. Zalypsis® is a marine compound in phase II clinical trials for multiple myeloma, cervical and endometrial cancer, and Ewing’s sarcoma. However, the determinants of the response to Zalypsis are not well known. ...

    Authors: Victoria Moneo, Beatriz G Serelde, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Pablo Avilés, Gemma Santamaría, Juan C Tercero, Carmen Cuevas and Amancio Carnero
    Citation: BMC Cancer 2014 14:281
    Content type: Research article Published on:

  27. Malignant pleural effusion (MPE) is a common complication of advanced lung cancer. Research has shown that secreted phosphoprotein-1 (SPP1) is essential in MPE associated with lung cancer. This retrospective s...

    Authors: He Zhang, Hong-bing Liu, Dong-mei Yuan, Zhao-feng Wang, Yun-fen Wang and Yong Song
    Citation: BMC Cancer 2014 14:280
    Content type: Research article Published on:

  28. Breast carcinoma can be classified as either Estrogen Receptor (ER) positive or negative by immunohistochemical phenotyping, although ER expression may vary from 1 to 100% of malignant cells within an ER + tum...

    Authors: Mark C Lloyd, Khalid O Alfarouk, Daniel Verduzco, Marilyn M Bui, Robert J Gillies, Muntaser E Ibrahim, Joel S Brown and Robert A Gatenby
    Citation: BMC Cancer 2014 14:279
    Content type: Research article Published on:

  29. The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory progra...

    Authors: Aleksandra B Adomas, Sara A Grimm, Christine Malone, Motoki Takaku, Jennifer K Sims and Paul A Wade
    Citation: BMC Cancer 2014 14:278
    Content type: Research article Published on:

  30. Colorectal cancer (CRC) is a disease of the elderly. However, geriatric patients are often excluded from clinical trials. The combination of capecitabine, oxaliplatin and bevacizumab (XELOX/BEV) has not been a...

    Authors: Lambros Vamvakas, Alexios Matikas, Athanasios Karampeazis, Dora Hatzidaki, Stelios Kakolyris, Charalampos Christophylakis, Ioannis Boukovinas, Aris Polyzos, Vassilis Georgoulias and John Souglakos
    Citation: BMC Cancer 2014 14:277
    Content type: Research article Published on:

  31. E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis. E2F1 overexpression has been demonstrated in small...

    Authors: Zunling Li, Yanxia Guo, Hanming Jiang, Tingguo Zhang, Changzhu Jin, Charles YF Young and Huiqing Yuan
    Citation: BMC Cancer 2014 14:276
    Content type: Research article Published on:

  32. While glucocorticoids and the liganded glucocorticoid receptor (GR) have a well-established role in the maintenance of differentiation and suppression of apoptosis in breast tissue, the involvement of unligand...

    Authors: Heather D Ritter and Christopher R Mueller
    Citation: BMC Cancer 2014 14:275
    Content type: Research article Published on:

  33. CDK4 is a protein kinase in the CDK family important for G1/S phase cell cycle progression. However, the roles and molecular mechanisms of CDK4 triggering nasopharynx carcinogenesis are still unclear.

    Authors: Zhen Liu, Xiaobin Long, Cheng Chao, Chen Yan, Qiangyun Wu, Shengni Hua, Yajie Zhang, Aibing Wu and Weiyi Fang
    Citation: BMC Cancer 2014 14:274
    Content type: Research article Published on:

  35. There is evidence that cancer survivors are at increased risk of second primary cancers. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks.

    Authors: Aishah Coyte, David S Morrison and Philip McLoone
    Citation: BMC Cancer 2014 14:272
    Content type: Research article Published on:

  36. Cholangiocarcinoma (CCA), a devastating neoplasm, is highly resistant to current chemotherapies. CCA cells frequently overexpress the antiapoptotic protein myeloid cell leukemia-1(Mcl-1), which is responsible ...

    Authors: Xiwei Ding, Bin Zhang, Qingshan Pei, Jianmei Pan, Shuling Huang, Yan Yang, Zhu Zhu, Ying Lv and Xiaoping Zou
    Citation: BMC Cancer 2014 14:271
    Content type: Research article Published on:

  37. Cetuximab is a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR). Skin reactions are the most common side effects of cetuximab. Rhagades of the tips of the fingers and toes, the ...

    Authors: Karin Potthoff, Gregor Habl, Thomas Bruckner, Christian Suppan, Jessica Hassel, Dirk Jäger, Martin Indorf and Juergen Debus
    Citation: BMC Cancer 2014 14:270
    Content type: Study protocol Published on:

  38. The receptor for urokinase-type plasminogen activator (uPAR) is associated with cancer development and progression. Within the tumor microenvironment uPAR is expressed by malignant cells as well as tumor-assoc...

    Authors: Martin C Boonstra, Floris PR Verbeek, Andrew P Mazar, Hendrica AJM Prevoo, Peter JK Kuppen, Cornelis JH van de Velde, Alexander L Vahrmeijer and Cornelis FM Sier
    Citation: BMC Cancer 2014 14:269
    Content type: Research article Published on:

  39. Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target f...

    Authors: Kristina Buder, Constantin Lapa, Michael C Kreissl, Andreas Schirbel, Ken Herrmann, Alexander Schnack, Eva-Bettina Bröcker, Matthias Goebeler, Andreas K Buck and Jürgen C Becker
    Citation: BMC Cancer 2014 14:268
    Content type: Research article Published on:

  40. Despite the improvement in the care management, women cancer patients who are still in employment find themselves for the most part obliged to stop working while they are having treatment. Their return-to-work...

    Authors: Clémence Vidor, Ariane Leroyer, Véronique Christophe, Mélanie Seillier, Jérome Foncel, Justine Van de Maële, Jacques Bonneterre and Sophie Fantoni
    Citation: BMC Cancer 2014 14:267
    Content type: Study protocol Published on:

  41. Data from in vivo and in vitro studies suggest that activation of Akt regulates cell survival signaling and plays a key role in tumorigenesis. Hence, transgenic mice were created to explore the oncogenic role of ...

    Authors: Yanyuan Wu, Juri Kim, Yayha Elshimali, Marianna Sarkissyan and Jaydutt V Vadgama
    Citation: BMC Cancer 2014 14:266
    Content type: Research article Published on:

  42. In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.

    Authors: Nam P Nguyen, Siyoung Jang, Jacqueline Vock, Vincent Vinh-Hung, Alexander Chi, Paul Vos, Judith Pugh, Richard A Vo, Misty Ceizyk, Anand Desai and Lexie Smith-Raymond
    Citation: BMC Cancer 2014 14:265
    Content type: Research article Published on:

  43. Loss of lean body mass (LBM) is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes [Clin Oncol, 22(4):281–288, 2010; Appl Physiol Nutr Metab, 34(5):950–9...

    Authors: Cameron McDonald, Judy Bauer, Sandra Capra and Joseph Coll
    Citation: BMC Cancer 2014 14:264
    Content type: Study protocol Published on:

  44. Evaluation of the effectiveness of a patient decision aid (nurse-managed telephone support line and/or colorectal cancer screening website), distributed to patients by their family physician, in improving feca...

    Authors: Kathleen Clouston, Alan Katz, Patricia J Martens, Jeff Sisler, Donna Turner, Michelle Lobchuk, Susan McClement and Gary Crow
    Citation: BMC Cancer 2014 14:263
    Content type: Research article Published on:

  45. Extraneural metastases (ENM) rarely occur in medulloblastoma (MBL) patients and only few cases of subcutaneous localizations have been described. ENM indicate an aggressive disease associated with a worse prog...

    Authors: Angela Mastronuzzi, Evelina Miele, Agnese Po, Manila Antonelli, Francesca Romana Buttarelli, Giovanna Stefania Colafati, Francesca del Bufalo, Roberta Faedda, Gian Paolo Spinelli, Andrea Carai, Felice Giangaspero, Alberto Gulino, Franco Locatelli and Elisabetta Ferretti
    Citation: BMC Cancer 2014 14:262
    Content type: Case report Published on:

  46. With 14.234 diagnoses and over 4047 deaths reported in 2007, colorectal cancer (CRC) is the second most common cancer and second most common cause of cancer-related mortality in Australia. The direct treatment...

    Authors: Driss A Ouakrim, Alex Boussioutas, Trevor Lockett, John L Hopper and Mark A Jenkins
    Citation: BMC Cancer 2014 14:261
    Content type: Research article Published on:

  48. Cathepsin X is a cysteine protease involved in mechanisms of malignant progression. It is secreted from tumour cells as a proenzyme and may serve to predict the disease status and risk of death for cancer pati...

    Authors: Tjaša Vižin, Ib Jarle Christensen, Michael Wilhelmsen, Hans Jørgen Nielsen and Janko Kos
    Citation: BMC Cancer 2014 14:259
    Content type: Research article Published on:

  50. STAT1 has been attributed a function as tumor suppressor. However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes bel...

    Authors: Piotr Tymoszuk, Pornpimol Charoentong, Hubert Hackl, Rita Spilka, Elisabeth Müller-Holzner, Zlatko Trajanoski, Peter Obrist, Françoise Revillion, Jean-Philippe Peyrat, Heidi Fiegl and Wolfgang Doppler
    Citation: BMC Cancer 2014 14:257
    Content type: Research article Published on:

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