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  1. Patients with cancer must make frequent visits to the clinic not only for chemotherapy but also for the management of treatment-related adverse effects. Neutropenia, the most common dose-limiting toxicity of m...

    Authors: Barry V Fortner, Kurt Tauer, Ling Zhu, Theodore A Okon, Kelley Moore, Davis Templeton and Lee Schwartzberg

    Citation: BMC Cancer 2004 4:22

    Content type: Research article

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  2. DNA microarray profiling performed on clinical tissue specimens can potentially provide significant information regarding human cancer biology. Biopsy cores, the typical source of human tumor tissue, however, ...

    Authors: Elizabeth M Goley, Soni J Anderson, Cynthia Ménard, Eric Chuang, Xing Lü, Philip J Tofilon and Kevin Camphausen

    Citation: BMC Cancer 2004 4:20

    Content type: Research article

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  3. Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adh...

    Authors: David L Crowe and Arthur Ohannessian

    Citation: BMC Cancer 2004 4:18

    Content type: Research article

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  4. Surveillance colonoscopy is commonly recommended following potentially curative surgery for colorectal cancer. We determined factors associated with patients undergoing a least one colonoscopy within five year...

    Authors: Robert J Hilsden, Heather E Bryant, Lloyd R Sutherland, Penny MA Brasher and Anthony LA Fields

    Citation: BMC Cancer 2004 4:14

    Content type: Research article

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  5. Most of the steps involved in the initiation and progression of Hürthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown.

    Authors: Valdemar Máximo, Ana Preto, Ana Crespo, Ana Sofia Rocha, José Carlos Machado, Paula Soares and Manuel Sobrinho-Simões

    Citation: BMC Cancer 2004 4:12

    Content type: Research article

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  6. Fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluoro-2'deoxyuridine (FUDR) are among the most effective chemotherapeutic agents for treatment of metastatic colorectal cancer (CRC). Increased expression...

    Authors: Massimo Libra, Patrick M Navolanic, Renato Talamini, Erica Cecchin, Franca Sartor, Salvatore Tumolo, Sara Masier, Salvatore Travali, Mauro Boiocchi and Giuseppe Toffoli

    Citation: BMC Cancer 2004 4:11

    Content type: Research article

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  7. Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer. Polymorphisms in DNA repa...

    Authors: Alice J Sigurdson, Michael Hauptmann, Nilanjan Chatterjee, Bruce H Alexander, Michele Morin Doody, Joni L Rutter and Jeffery P Struewing

    Citation: BMC Cancer 2004 4:9

    Content type: Research article

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  8. Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy is the choice of treatment for advanced stages of the disease. The prognosis is poor, wi...

    Authors: Pulivarthi H Rao, Hugo Arias-Pulido, Xin-Yan Lu, Charles P Harris, Hernan Vargas, Fang F Zhang, Gopeshwar Narayan, Achim Schneider, Mary Beth Terry and Vundavalli VVS Murty

    Citation: BMC Cancer 2004 4:5

    Content type: Research article

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  9. Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death. Publicly accessible databases conta...

    Authors: Ping Qiu, Luquan Wang, Mitch Kostich, Wei Ding, Jason S Simon and Jonathan R Greene

    Citation: BMC Cancer 2004 4:4

    Content type: Research article

    Published on:

  10. A case of Primitive Neuroectodermal Tumor (PNET) of the kidney in a 27-year-old woman is presented. Few cases are reported in the literature with a variable, nonspecific presentation and an aggressive behaviou...

    Authors: Giorgio Pomara, Francesco Cappello, Maria G Cuttano, Francesca Rappa, Girolamo Morelli, Pierantonio Mancini and Cesare Selli

    Citation: BMC Cancer 2004 4:3

    Content type: Case report

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  11. Although sentinel node biopsy (SNB) is becoming the standard approach for axillary staging in patients with small breast cancer, criteria for patient selection and some technical aspects of the procedure have ...

    Authors: Giorgio Zavagno, Gian Luca De Salvo, Dario Casara, Paola Del Bianco, Domenico Rubello, Fabrizio Meggiolaro, Carlo Riccardo Rossi, Mariaelena Pierobon and Mario Lise

    Citation: BMC Cancer 2004 4:2

    Content type: Research article

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  12. Kaposi's sarcoma (KS) is a mesenchymal tumour associated with human herpesvirus-8 infection. However, the incidence of human herpesvirus-8 infection is far higher than the prevalence of KS, suggesting that vir...

    Authors: Thierry Simonart

    Citation: BMC Cancer 2004 4:1

    Content type: Debate

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  13. Dysregulation of apoptosis, specifically overexpression of soluble Fas (sFas), has been proposed to play a role in the development of ovarian cancer. The main objective of the present study was to evaluate ser...

    Authors: Arslan Akhmedkhanov, Eva Lundin, Seth Guller, Annekatrin Lukanova, Andrea Micheli, Yuehong Ma, Yelena Afanasyeva, Anne Zeleniuch-Jacquotte, Vittorio Krogh, Per Lenner, Paola Muti, Sabina Rinaldi, Rudolf Kaaks, Franco Berrino, Göran Hallmans and Paolo Toniolo

    Citation: BMC Cancer 2003 3:33

    Content type: Research article

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  14. Patients with advanced (incurable) tumours usually experience a diverse burden of symptoms. Although many symptom assessment instruments are available, we examined whether these addressed tumour-related symptoms.

    Authors: Margherita J Barresi, Bruce Shadbolt, Don Byrne and Robin Stuart-Harris

    Citation: BMC Cancer 2003 3:32

    Content type: Research article

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  15. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number o...

    Authors: Marc E Lenburg, Louis S Liou, Norman P Gerry, Garrett M Frampton, Herbert T Cohen and Michael F Christman

    Citation: BMC Cancer 2003 3:31

    Content type: Research article

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  16. The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factor...

    Authors: Mary Beth Terry, Alfred I Neugut, Mahesh Mansukhani, Jerome Waye, Noam Harpaz and Hanina Hibshoosh

    Citation: BMC Cancer 2003 3:29

    Content type: Research article

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  17. Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effect...

    Authors: Antonio González-Pérez, Luis A García Rodríguez and Ruy López-Ridaura

    Citation: BMC Cancer 2003 3:28

    Content type: Research article

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  18. Morphologic criteria which might help to support the need for a preventive strategy for early detection of rectal cancer were analysed. Population-based data on rectal adenomas with high-grade dysplastic chang...

    Authors: René Scheiden, Julien Sand, Joseph Weber, Philippe Turk, Yolande Wagener and Catherine Capesius

    Citation: BMC Cancer 2003 3:27

    Content type: Technical advance

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  19. A systematic review was conducted to evaluate the literature regarding the impact of follow-up on colorectal cancer patient survival and, in a second phase, recommendations were developed.

    Authors: Alvaro Figueredo, R Bryan Rumble, Jean Maroun, Craig C Earle, Bernard Cummings, Robin McLeod, Lisa Zuraw and Caroline Zwaal

    Citation: BMC Cancer 2003 3:26

    Content type: Research article

    Published on:

  20. Tocopherols are lipid soluble antioxidants that exist as eight structurally different isoforms. The intake of γ-tocopherol is higher than α-tocopherol in the average US diet. The clinical results of the effect...

    Authors: Sharon E Campbell, William L Stone, Sarah G Whaley, Min Qui and Koyamangalath Krishnan

    Citation: BMC Cancer 2003 3:25

    Content type: Research article

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  21. Estrogen signaling plays a critical role in a number of normal physiological processes and has important implications in the treatment of breast cancer. The p160 nuclear receptor coactivator, AIB1 (amplified in b...

    Authors: Sarah L Anzick, David O Azorsa, S Stoney Simons Jr and Paul S Meltzer

    Citation: BMC Cancer 2003 3:22

    Content type: Research article

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  22. We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared ...

    Authors: Sanjay Sharma, Michael H Neale, Federica Di Nicolantonio, Louise A Knight, Pauline A Whitehouse, Stuart J Mercer, Bernard R Higgins, Alan Lamont, Richard Osborne, Andrew C Hindley, Christian M Kurbacher and Ian A Cree

    Citation: BMC Cancer 2003 3:19

    Content type: Research article

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  23. Breast and cervical cancer continue to represent major health challenges for African American women. among Caucasian women. The underlying reasons for this disparity are multifactorial and include lack of educ...

    Authors: Thelma C Hurd, Paola Muti, Deborah O Erwin and Sharita Womack

    Citation: BMC Cancer 2003 3:18

    Content type: Research article

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  24. To determine whether the dose-volume histograms (DVH's) for the rectum and bladder constructed using biological-effective dose (BED-DVH's) better correlate with late gastrointestinal (GI) and genitourinary (GU...

    Authors: Ashesh B Jani, Christopher M Hand, Charles A Pelizzari, John C Roeske, Lani Krauz and Srinivasan Vijayakumar

    Citation: BMC Cancer 2003 3:16

    Content type: Research article

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  25. MART-1, Melan-A, and Tyrosinase have shown encouraging results for evaluation of melanoma micrometastases in sentinel lymph nodes, as compared to conventionally used S-100 protein and HMB-45. To achieve higher...

    Authors: Vinod B Shidham, Dan Qi, R Nagarjun Rao, Scott M Acker, Chung-Che Chang, Bal Kampalath, Glen Dawson, Jinobya K Machhi and Richard A Komorowski

    Citation: BMC Cancer 2003 3:15

    Content type: Research article

    Published on:

  26. This study assesses whether comparatively high prostate cancer incidence rates among white men in Utah represent higher rates among members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormons), ...

    Authors: Ray M Merrill, Sterling C Hilton, Charles L Wiggins and Jared D Sturgeon

    Citation: BMC Cancer 2003 3:14

    Content type: Research article

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  27. Both phenotypic and cytogenetic variability have been reported for clones of breast carcinoma cell lines but have not been comprehensively studied. Despite this, cell lines such as MCF-7 cells are extensively ...

    Authors: Mélanie Nugoli, Paul Chuchana, Julie Vendrell, Béatrice Orsetti, Lisa Ursule, Catherine Nguyen, Daniel Birnbaum, Emmanuel JP Douzery, Pascale Cohen and Charles Theillet

    Citation: BMC Cancer 2003 3:13

    Content type: Research article

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  28. The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were ...

    Authors: Marcello Tamburini, Laura Gangeri, Cinzia Brunelli, Paolo Boeri, Claudia Borreani, Marco Bosisio, Claude Fusco Karmann, Margherita Greco, Guido Miccinesi, Luciana Murru and Patrizia Trimigno

    Citation: BMC Cancer 2003 3:12

    Content type: Research article

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  29. Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell p...

    Authors: John P Wiebe and Michael J Lewis

    Citation: BMC Cancer 2003 3:9

    Content type: Research article

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  30. Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human...

    Authors: Alfredo Hidalgo, Alberto Monroy, Rosa Ma Arana, Lucía Taja, Guelaguetza Vázquez and Mauricio Salcedo

    Citation: BMC Cancer 2003 3:8

    Content type: Research article

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  31. Kaposi's Sarcoma (KS) is a proliferation of aberrant vascular structures lined by spindle cells, and is caused by a gammaherpes virus (HHV8/KSHV). Its course is aggravated by co-infection with HIV-1, where the...

    Authors: Marion Cornelissen, Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, Carel JM van Noesel and Jaap Goudsmit

    Citation: BMC Cancer 2003 3:7

    Content type: Research article

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  32. RAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search f...

    Authors: Paola E Leone, Marta Mendiola, Javier Alonso, César Paz-y-Miño and Angel Pestaña

    Citation: BMC Cancer 2003 3:6

    Content type: Research article

    Published on:

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