Skip to main content

Articles

Page 224 of 329

  1. The optimal form of exercise for individuals with cancer has yet to be identified, but there is evidence that exercise improves their quality of life. The aim of this study is to assess the efficacy and effici...

    Authors: Aintzane Sancho, Sergio Carrera, Marisol Arietaleanizbeascoa, Veronica Arce, Nere Mendizabal Gallastegui, Anna Giné March, Aitor Sanz-Guinea, Araceli Eskisabel, Ana Lopez Rodriguez, Rosa A Martín, Guillermo Lopez-Vivanco and Gonzalo Grandes
    Citation: BMC Cancer 2015 15:40
    Content type: Study protocol Published on:

  2. Trogocytosis is defined as the transfer of cell-surface membrane proteins and membrane patches from one cell to another through contact. It is reported that human epidermal growth factor receptor 2 (HER2) coul...

    Authors: Eiji Suzuki, Tatsuki R Kataoka, Masahiro Hirata, Kosuke Kawaguchi, Mariko Nishie, Hironori Haga and Masakazu Toi
    Citation: BMC Cancer 2015 15:39
    Content type: Research article Published on:

  3. Epidemiologic data indicates that Asian diets, which are high in soy protein, reduce a women’s risk of developing breast cancer. However, it has been difficult to dissociate the benefits of soy from other vari...

    Authors: Katrina L Watson, Leanne Stalker, Robert A Jones and Roger A Moorehead
    Citation: BMC Cancer 2015 15:37
    Content type: Research article Published on:

  4. Human epidermal growth factor receptor-2 (HER2) overexpression and gene amplification are currently established by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively. This stud...

    Authors: Thomas v O Hansen, Jonas Vikesaa, Sine S Buhl, Henrik H Rossing, Vera Timmermans-Wielenga and Finn C Nielsen
    Citation: BMC Cancer 2015 15:35
    Content type: Research article Published on:

  5. Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. Melatonin (mel) act...

    Authors: Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos and Francisco Eduardo Martinez
    Citation: BMC Cancer 2015 15:34
    Content type: Research article Published on:

  6. Adenocarcinomas of both the gastroesophageal junction and stomach are molecularly complex, but differ with respect to epidemiology, etiology and survival. There are few data directly comparing the frequencies ...

    Authors: Hector H Li-Chang, Katayoon Kasaian, Ying Ng, Amy Lum, Esther Kong, Howard Lim, Steven JM Jones, David G Huntsman, David F Schaeffer and Stephen Yip
    Citation: BMC Cancer 2015 15:32
    Content type: Research article Published on:

  7. Lung adenocarcinoma patients with EGFR gene mutations have shown a dramatic response to gefitinib. However, drug resistance eventually emerges which limits the mean duration of response. With that in view, we exa...

    Authors: Rintaro Noro, Masahiro Seike, Fenfei Zou, Chie Soeno, Kuniko Matsuda, Teppei Sugano, Nobuhiko Nishijima, Masaru Matsumoto, Kazuhiro Kitamura, Seiji Kosaihira, Yuji Minegishi, Akinobu Yoshimura, Kaoru Kubota and Akihiko Gemma
    Citation: BMC Cancer 2015 15:31
    Content type: Research article Published on:

  8. Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer (BC) in several populations. Nevertheless its contribution in the South-American population is unknown. The goal of t...

    Authors: Yessica Leyton, Patricio Gonzalez-Hormazabal, Rafael Blanco, Teresa Bravo, Ricardo Fernandez-Ramires, Sebastian Morales, Natalia Landeros, Jose M Reyes, Octavio Peralta, Julio C Tapia, Fernando Gomez, Enrique Waugh, Gladys Ibañez, Janara Pakomio, Gilberto Grau and Lilian Jara
    Citation: BMC Cancer 2015 15:30
    Content type: Research article Published on:

  9. Esophageal carcinoma is one of the most common malignancies with high cancer-related morbidity and mortality worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate a wide variety of c...

    Authors: Tingting Yu, Risheng Cao, Shuo Li, Mingen Fu, Lihua Ren, Weixu Chen, Hong Zhu, Qiang Zhan and Ruihua Shi
    Citation: BMC Cancer 2015 15:29
    Content type: Research article Published on:

  10. While weight gain following breast cancer is considered common, results supporting these findings are dated. This work describes changes in body weight following breast cancer over 72 months, compares weight w...

    Authors: Dimitrios Vagenas, Tracey DiSipio, Diana Battistutta, Wendy Demark-Wahnefried, Sheree Rye, John Bashford, Chris Pyke, Christobel Saunders and Sandra C Hayes
    Citation: BMC Cancer 2015 15:28
    Content type: Research article Published on:

  11. The ability of medical practitioners to communicate risk estimates effectively to patients diagnosed with melanoma relies on accurate information about prognostic factors and their impact on survival. This stu...

    Authors: Peter D Baade, Patrick Royston, Philipa H Youl, Martin A Weinstock, Alan Geller and Joanne F Aitken
    Citation: BMC Cancer 2015 15:27
    Content type: Research article Published on:

  12. The number of predictive biomarkers that will be necessary to assess in clinical practice will increase with the availability of drugs that target specific molecular alterations. Therefore, diagnostic laborato...

    Authors: Bastiaan BJ Tops, Nicola Normanno, Henriette Kurth, Eliana Amato, Andrea Mafficini, Nora Rieber, Delphine Le Corre, Anna Maria Rachiglio, Anne Reiman, Orla Sheils, Christoph Noppen, Ludovic Lacroix, Ian A Cree, Aldo Scarpa, Marjolijn JL Ligtenberg and Pierre Laurent-Puig
    Citation: BMC Cancer 2015 15:26
    Content type: Research article Published on:

  13. Caveolin-1 (CAV1) may be upregulated by hypoxia and acts in a tumor-dependent manner. We investigated CAV1 in tongue squamous cell carcinoma (TSCC) and its association with clinical outcomes, and studied in vitro

    Authors: Marilena Vered, Meri Lehtonen, Lari Hotakainen, Emma Pirilä, Susanna Teppo, Pia Nyberg, Raija Sormunen, Ayelet Zlotogorski-Hurvitz, Tuula Salo and Dan Dayan
    Citation: BMC Cancer 2015 15:25
    Content type: Research article Published on:

  14. The discovery of cancer stem cells and tumor heterogeneity prompted the exploration of additional mechanisms aside from genetic mutations for carcinogenesis and cancer progression. The aim of the present study...

    Authors: Xianghui He, Baosong Li, Yang Shao, Na Zhao, Yiling Hsu, Zhixiang Zhang and Liwei Zhu
    Citation: BMC Cancer 2015 15:24
    Content type: Research article Published on:

  15. Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a paraneoplastic ocular syndrome occurring in patients with systemic, often occult but advanced carcinoma and is the hallmark of poor prognosis. Ocu...

    Authors: Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio and Mandeep S Sagoo
    Citation: BMC Cancer 2015 15:23
    Content type: Case report Published on:

  16. A breast cancer susceptibility locus has been mapped to the gene encoding TOX3. Little is known regarding the expression pattern or biological role of TOX3 in breast cancer or in the mammary gland. Here we ana...

    Authors: Akop Seksenyan, Asha Kadavallore, Ann E Walts, Brian de la Torre, Dror Berel, Samuel P Strom, Parinaz Aliahmad, Vincent A Funari and Jonathan Kaye
    Citation: BMC Cancer 2015 15:22
    Content type: Research article Published on:

  17. Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. How...

    Authors: Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia and Patricia Garcia-Lopez
    Citation: BMC Cancer 2015 15:21
    Content type: Research article Published on:

  18. PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss resul...

    Authors: Catherine E Bond, Mark L Bettington, Sally-Ann Pearson, Diane M McKeone, Barbara A Leggett and Vicki LJ Whitehall
    Citation: BMC Cancer 2015 15:20
    Content type: Research article Published on:

  19. Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of ce...

    Authors: Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong and Kyung Seok Han
    Citation: BMC Cancer 2015 15:19
    Content type: Research article Published on:

  20. EphA5 is a member of the Eph/ephrin family and plays a critical role in the regulation of carcinogenesis. A significant reduction of EphA5 transcripts in high-grade prostate cancer tissue was shown using a tra...

    Authors: Shibao Li, Yingfeng Zhu, Chunguang Ma, Zhenhua Qiu, Xinju Zhang, Zhihua Kang, Zhiyuan Wu, Hua Wang, Xiao Xu, Hu Zhang, Guoqiang Ren, Jianmin Tang, Xiangyu Li and Ming Guan
    Citation: BMC Cancer 2015 15:18
    Content type: Research article Published on:

  21. DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer r...

    Authors: Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli
    Citation: BMC Cancer 2015 15:17
    Content type: Research article Published on:

  22. Ewing sarcoma is a rare tumor that occurs commonly in the long bones of children or adolescents that can also arise in soft tissues including the extremities, retroperitoneum, chest wall, and rarely in the liv...

    Authors: Yukinori Ozaki, Yuji Miura, Shigehiro Koganemaru, Koichi Suyama, Naoko Inoshita, Takeshi Fujii, Masaji Hashimoto, Tetsuo Tamura, Kazuo Takeuchi and Toshimi Takano
    Citation: BMC Cancer 2015 15:16
    Content type: Case report Published on:

  23. SBA is a rare tumour which carries a poor prognosis. Very few data on prognostic factors and treatment outcomes are available. We conducted a retrospective analysis of patients treated for SBA at our institution.

    Authors: Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham and Ian Chau
    Citation: BMC Cancer 2015 15:15
    Content type: Research article Published on:

  24. Metastatic dissemination can exist before a pathologically and clinically detectable manifestation. The structural heterogeneity of colon cancer (CC) in histological sections with respect to the morphology of ...

    Authors: Caren Jayasinghe, Nektaria Simiantonaki and Charles James Kirkpatrick
    Citation: BMC Cancer 2015 15:14
    Content type: Research article Published on:

  25. The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) an...

    Authors: Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang and Jianfeng Li
    Citation: BMC Cancer 2015 15:13
    Content type: Research article Published on:

  28. Anthracycline adjuvant therapy has taken a particular role in the treatment of early stage breast cancer with an associated decrease in rates of both relapse and death. Their success however has been limited b...

    Authors: Alain Mina, Hind Rafei, Maya Khalil, Yasmine Hassoun, Zeina Nasser and Arafat Tfayli
    Citation: BMC Cancer 2015 15:10
    Content type: Research article Published on:

  29. Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor (AR) signalling. The principal treatment for PCa is androgen deprivation therapy, although the majority of patients even...

    Authors: Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan and David J Elliott
    Citation: BMC Cancer 2015 15:9
    Content type: Research article Published on:

  32. c-Met, one of current potential hot targets, has been suggested as a potential tumor marker in the development of esophageal squamous cell carcinoma (ESCC). Our aim was to investigate the expression of c-Met i...

    Authors: Yingying Xu, Zhi Peng, Zhongwu Li, Ming Lu, Jing Gao, Yilin Li, Yanyan Li and Lin Shen
    Citation: BMC Cancer 2015 15:6
    Content type: Research article Published on:

  33. The transcription factor nuclear factor (erythroid-2)–related factor 2 (Nrf2) was originally identified as a critical regulator of intracellular anti-oxidants and of phase II detoxification enzymes through its...

    Authors: Yota Kawasaki, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Akihiro Nakajo, Yuko Kijima, Kosei Maemura and Shoji Natsugoe
    Citation: BMC Cancer 2015 15:5
    Content type: Research article Published on:

  34. Tumour stromal macrophages differentiate to tumour-associated macrophages (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a central role in promoting tumour vascularisation, cancer...

    Authors: Sofia Sousa, Seppo Auriola, Jukka Mönkkönen and Jorma Määttä
    Citation: BMC Cancer 2015 15:4
    Content type: Research article Published on:

  35. Adult T-cell Leukemia (ATL) is a disease with no known cure. The disease manifests itself as an aggressive proliferation of CD4+ cells with the human T-cell Lymphotropic virus type 1 (HTLV-1). The leukemogenesis ...

    Authors: Steve Harakeh, Rania Azar, Esam Azhar, Ghazi A Damanhouri, Mourad Assidi, Muhammad Abu-Elmagd, Mohammed H Alqahtani, Taha Kumosani, Aleksandra Niedzwiecki, Mathias Rath, Ahmed Al-Hejin, Elie Barbour and Mona Diab-Assaf
    Citation: BMC Cancer 2015 15(Suppl 1):S2
    Content type: Research Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  36. The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within a tumour is responsible for the initiation and progression of neoplasia. The original and best evidence for the existenc...

    Authors: Sara Santos Franco, Hadas Raveh-Amit, Julianna Kobolák, Mohammed H Alqahtani, Ali Mobasheri and András Dinnyes
    Citation: BMC Cancer 2015 15(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  37. Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, ...

    Authors: Sarah M Judge, Chia-Ling Wu, Adam W Beharry, Brandon M Roberts, Leonardo F Ferreira, Susan C Kandarian and Andrew R Judge
    Citation: BMC Cancer 2014 14:997
    Content type: Research article Published on:

  38. Aberrantly expressed and constitutively active STAT3 signaling plays a pivotal role in initiation and progression of human papillomavirus-induced cervical carcinogenesis. However, the underlying mechanism(s) r...

    Authors: Gauri Shishodia, Gaurav Verma, Yogesh Srivastava, Ravi Mehrotra, Bhudev Chandra Das and Alok Chandra Bharti
    Citation: BMC Cancer 2014 14:996
    Content type: Research article Published on:

  39. The calpains are intracellular cysteine proteases that function in a variety of important cellular functions, including signalling, motility, apoptosis and survival. In breast cancer high calpain-1 and calpain...

    Authors: Jillian Davis, Stewart G Martin, Poulam M Patel, Andrew R Green, Emad A Rakha, Ian O Ellis and Sarah J Storr
    Citation: BMC Cancer 2014 14:995
    Content type: Research article Published on:

  40. It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate...

    Authors: Marjolaine Ngollo, Andre Lebert, Aslihan Dagdemir, Gaelle Judes, Seher Karsli-Ceppioglu, Marine Daures, Jean-Louis Kemeny, Frederique Penault-Llorca, Jean-Paul Boiteux, Yves-Jean Bignon, Laurent Guy and Dominique Bernard-Gallon
    Citation: BMC Cancer 2014 14:994
    Content type: Research article Published on:

  41. Paclitaxel treatment produces dose-limiting peripheral neurotoxicity, which adversely affects treatment and long-term outcomes. In the present study, the contribution of genetic polymorphisms to paclitaxel-ind...

    Authors: Susanna B Park, John B Kwok, Clement T Loy, Michael L Friedlander, Cindy S-Y Lin, Arun V Krishnan, Craig R Lewis and Matthew C Kiernan
    Citation: BMC Cancer 2014 14:993
    Content type: Research article Published on:

  42. Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor in adults. Despite multimodal therapies, almost all GBM recur within a narrow margin around the initial resected lesion. Thus, n...

    Authors: Frank A Giordano, Stefanie Brehmer, Yasser Abo-Madyan, Grit Welzel, Elena Sperk, Anke Keller, Frank Schneider, Sven Clausen, Carsten Herskind, Peter Schmiedek and Frederik Wenz
    Citation: BMC Cancer 2014 14:992
    Content type: Study protocol Published on:

  43. In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of hypercoagulability biomarkers could increase the sensitivity of ri...

    Authors: Mourad Chaari, Ines Ayadi, Aurelie Rousseau, Eleftheria Lefkou, Patrick Van Dreden, Fatoumata Sidibe, Hela Ketatni, Vassiliki Galea, Amir Khaterchi, Racem Bouzguenda, Mounir Frikha, Lilia Ghorbal, Jamel Daoud, Choumous Kallel, Martin Quinn, Joseph Gligorov…
    Citation: BMC Cancer 2014 14:991
    Content type: Research article Published on:

  44. There are many molecular differences between estrogen receptor α (ERα)-positive and ER-negative breast cancers. Recent analyses have shown that the former can be divided into two subtypes, luminal A and lumina...

    Authors: Yumi Endo, Hiroko Yamashita, Satoru Takahashi, Shinya Sato, Nobuyasu Yoshimoto, Tomoko Asano, Yukari Hato, Yu Dong, Yoshitaka Fujii and Tatsuya Toyama
    Citation: BMC Cancer 2014 14:990
    Content type: Research article Published on:

  45. Response Evaluation Criteria in Solid Tumors (RECIST) are widely used to assess the effect of chemotherapy in patients with cancer. We hypothesised that the change in unidimensional tumour size handled as a co...

    Authors: Anne-Claire Toffart, Denis Moro-Sibilot, Sébastien Couraud, Patrick Merle, Maurice Perol, Nicolas Girard, Pierre-Jean Souquet, Bénédicte Mastroianni, Gilbert R Ferretti, Philippe Romand, Patrick Chatellain, Aurélien Vesin, Elisabeth Brambilla, Christian Brambilla and Jean-François Timsit
    Citation: BMC Cancer 2014 14:989
    Content type: Research article Published on:

  47. Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen...

    Authors: Peng Zhao, Li Chen, Lin-Hu Li, Zhi-Feng Wei, Bei Tong, Yu-Gai Jia, Ling-Yi Kong, Yu-Feng Xia and Yue Dai
    Citation: BMC Cancer 2014 14:987
    Content type: Research article Published on:

  48. The purpose of this phase II study was to evaluate the safety and efficacy of weekly irinotecan and capecitabine (wXELIRI) treatment in patients with metastatic colorectal cancer, specifically the rate of seve...

    Authors: Wenhua Li, Jianming Xu, Lin Shen, Tianshu Liu, Weijian Guo, Wen Zhang, Zhiyu Chen, Xiaodong Zhu and Jin Li
    Citation: BMC Cancer 2014 14:986
    Content type: Research article Published on:

  49. Raised serum glucose has been linked to increased risk of many solid cancers. We performed a meta-analysis to quantify and summarise the evidence for this link.

    Authors: Danielle J Crawley, Lars Holmberg, Jennifer C Melvin, Massimo Loda, Simon Chowdhury, Sarah M Rudman and Mieke Van Hemelrijck
    Citation: BMC Cancer 2014 14:985
    Content type: Research article Published on:

  50. BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased s...

    Authors: Shibani Nicum, Corran Roberts, Lucy Boyle, Sylwia Kopijasz, Charlie Gourley, Marcia Hall, Ana Montes, Christopher Poole, Linda Collins, Anna Schuh and Susan J Dutton
    Citation: BMC Cancer 2014 14:983
    Content type: Study protocol Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us