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  1. Patients with dedifferentiated or anaplastic thyroid carcinomas currently lack appropriate treatment options. Kinase inhibitors are among the most promising new agents as alternative strategies. The BRAF- and ...

    Authors: Martina Broecker-Preuss, Stefan Müller, Martin Britten, Karl Worm, Kurt Werner Schmid, Klaus Mann and Dagmar Fuhrer
    Citation: BMC Cancer 2015 15:184
    Content type: Research article Published on:

  2. Germline mutations in breast cancer susceptibility gene 1 (BRCA1) increase the risk of breast and ovarian cancers. However, no association between BRCA1 germline mutation and glioblastoma malignancy has ever been...

    Authors: Meriem Boukerroucha, Claire Josse, Karin Segers, Sonia El-Guendi, Pierre Frères, Guy Jerusalem and Vincent Bours
    Citation: BMC Cancer 2015 15:181
    Content type: Case report Published on:

  3. Systematic analysis of cancer gene-expression patterns using high-throughput transcriptional profiling technologies has led to the discovery and publication of hundreds of gene-expression signatures. However, ...

    Authors: Brian David Lehmann, Yan Ding, Daniel Joseph Viox, Ming Jiang, Yi Zheng, Wang Liao, Xi Chen, Wei Xiang and Yajun Yi
    Citation: BMC Cancer 2015 15:179
    Content type: Research article Published on:

  4. Experimental analysis of the metastatic cascade requires suitable model systems which allow tracing of disseminated tumor cells and the identification of factors leading to metastatic outgrowth in distant orga...

    Authors: Claudia Maenz, Eva Lenfert, Klaus Pantel, Udo Schumacher, Wolfgang Deppert and Florian Wegwitz
    Citation: BMC Cancer 2015 15:178
    Content type: Research article Published on:

  5. To investigate the efficacy and safety of FOLFIRI plus bevacizumab regimen with irinotecan (180 mg/m2) in patients with advanced or recurrent colorectal cancer who were of the wild-type or heterozygous group for

    Authors: Mitsukuni Suenaga, Tomohiro Nishina, Nobuyuki Mizunuma, Hisateru Yasui, Takashi Ura, Tadamichi Denda, Junichi Ikeda, Taito Esaki, Hogara Nishisaki, Yoshinao Takano, Yasuyuki Sugiyama and Kei Muro
    Citation: BMC Cancer 2015 15:176
    Content type: Research article Published on:

  6. Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in p...

    Authors: Michael J Wagner, Leo Ismaila Amodu, Mei Sheng Duh, Caroline Korves, Franco Solleza, Stephanie C Manson, José Diaz, Maureen P Neary and George D Demetri
    Citation: BMC Cancer 2015 15:175
    Content type: Research article Published on:

  7. We have developed a new diagnostic method using the photosensitizer 5-aminolevulinic acid (5ALA) for diagnosing intrathoracic malignant lesions. When ingested exogenously, 5ALA is metabolized to a heme precurs...

    Authors: Masahiro Kitada, Yoshinobu Ohsaki, Yoshinari Matsuda, Satoshi Hayashi and Kei Ishibashi
    Citation: BMC Cancer 2015 15:174
    Content type: Research Published on:

  8. Authors: Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Marc Van den Eynde, Raphaël Maréchal, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried…
    Citation: BMC Cancer 2015 15:173
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2013 13:190

  9. Mutant Ras plays multiple functions in tumorigenesis including tumor formation and metastasis. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a metastasis inhibitor gene, suppresses matrix ...

    Authors: Hsuan-Heng Yeh, Yu-Fen Tseng, Yu-Chiao Hsu, Sheng-Hui Lan, Shan-Ying Wu, Giri Raghavaraju, Da-En Cheng, Ying-Ray Lee, Tsuey-Yu Chang, Nan-Haw Chow, Wen-Chun Hung and Hsiao-Sheng Liu
    Citation: BMC Cancer 2015 15:172
    Content type: Research article Published on:

  10. Relatively poor penetration and retention in tumor tissue has been documented for large molecule drugs including therapeutic antibodies and recombinant immunoglobulin constant region (Fc)-fusion proteins due t...

    Authors: Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu and Wenzhi Tian
    Citation: BMC Cancer 2015 15:170
    Content type: Research article Published on:

  11. Overexpression of HER2 is observed in 20 to 30% of breast carcinomas. The use of trastuzumab has improved the treatment of these patients, especially when it is associated with docetaxel. To optimize the use o...

    Authors: Esther Schmitt, Frédérique Végran, Sandy Chevrier, Laura Burillier, Muriel Cadouot, Sarab Lizard-Nacol, Bruno Coudert, Pierre Fumoleau, Laurent Arnould and Romain Boidot
    Citation: BMC Cancer 2015 15:169
    Content type: Research article Published on:

  12. Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome. They have important regulatory functions in chromatin remodeling and gene expression. Dysregulated lncRNAs have been studied in cancers...

    Authors: Yibin Hao, Wei Wu, Fachun Shi, Rodrigo JS Dalmolin, Ming Yan, Fu Tian, Xiaobing Chen, Guoyong Chen and Wei Cao
    Citation: BMC Cancer 2015 15:168
    Content type: Research article Published on:

  13. To determine the prevalence of RET rearrangement genes, RET copy number gains and expression in tumor samples from four Phase III non-small-cell lung cancer (NSCLC) trials of vandetanib, a selective inhibitor of ...

    Authors: Adam Platt, John Morten, Qunsheng Ji, Paul Elvin, Chris Womack, Xinying Su, Emma Donald, Neil Gray, Jessica Read, Graham Bigley, Laura Blockley, Carl Cresswell, Angela Dale, Amanda Davies, Tianwei Zhang, Shuqiong Fan…
    Citation: BMC Cancer 2015 15:171
    Content type: Research article Published on:

  14. Molecularly defined subgroups of tumors characterized by specific driver mutations have been identified in the majority of cancers. The availability of novel drugs capable of targeting signaling pathways activ...

    Authors: Nicola Normanno and Ian A Cree
    Citation: BMC Cancer 2015 15:141
    Content type: Commentary Published on:

  15. There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies ...

    Authors: Jung-Yun Lee, Jina Youm, Jae-Weon Kim, Jeong Yeon Cho, Min A Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim, Noh Hyun Park and Yong-Sang Song
    Citation: BMC Cancer 2015 15:167
    Content type: Research article Published on:

  16. 17β-hydroxysteroid dehydrogenase type 10 (HSD10) has been shown to play a protective role in cells undergoing stress. Upregulation of HSD10 under nutrient-limiting conditions leads to recovery of a homeostatic...

    Authors: Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu and Shirley ShiDu Yan
    Citation: BMC Cancer 2015 15:166
    Content type: Research article Published on:

  17. Electroporation is a novel treatment technique utilizing electric pulses, traveling between two or more electrodes, to ablate targeted tissue. The first in human studies have proven the safety of IRE for the a...

    Authors: Peter GK Wagstaff, Daniel M de Bruin, Patricia J Zondervan, C Dilara Savci Heijink, Marc RW Engelbrecht, Otto M van Delden, Ton G van Leeuwen, Hessel Wijkstra, Jean JMCH de la Rosette and M Pilar Laguna Pes
    Citation: BMC Cancer 2015 15:165
    Content type: Study protocol Published on:

  18. The EphB4 receptor tyrosine kinase is overexpressed in many cancers including prostate cancer. The molecular mechanisms by which this ephrin receptor influences cancer progression are complex as there are tumo...

    Authors: Inga Mertens-Walker, Bruno C Fernandini, Mohanan SN Maharaj, Anja Rockstroh, Colleen C Nelson, Adrian C Herington and Sally-Anne Stephenson
    Citation: BMC Cancer 2015 15:164
    Content type: Research article Published on:

  19. Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with ca...

    Authors: Kirsty Balachandran, Alicia Okines, Ranga Gunapala, Daniel Morganstein and Sanjay Popat
    Citation: BMC Cancer 2015 15:163
    Content type: Research article Published on:

  20. The potential benefits of colorectal cancer screening are limited by low uptake. This study tested whether providing narrative accounts of the colorectal cancer (CRC) screening experience positively affected b...

    Authors: Lesley M McGregor, Christian von Wagner, Gemma Vart, Wing Chee Yuen, Rosalind Raine, Jane Wardle and Kathryn A Robb
    Citation: BMC Cancer 2015 15:162
    Content type: Research article Published on:

  22. Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as m...

    Authors: Viktor H Koelzer, Pia Herrmann, Inti Zlobec, Eva Karamitopoulou, Alessandro Lugli and Ulrike Stein
    Citation: BMC Cancer 2015 15:160
    Content type: Research article Published on:

  23. High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key act...

    Authors: Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang and Qibing Zhou
    Citation: BMC Cancer 2015 15:159
    Content type: Research article Published on:

  24. Although microRNAs offer great potential as cancer biomarkers, effective clinical dignostics and tumor maker have not been verified to diagnose with colorectal cancer (CRC). The purpose of our study is to syst...

    Authors: Juan Peng, Zhengyong Xie, Liyang Cheng, Yuxin Zhang, Junyong Chen, Hongping Yu, Zehang Li and Huixing Kang
    Citation: BMC Cancer 2015 15:158
    Content type: Research article Published on:

  25. Thyroid neoplasias with oncocytic features represent a specific phenotype in non-medullary thyroid cancer, reflecting the unique biological phenomenon of mitochondrial hyperplasia in the cytoplasm. Oncocytic t...

    Authors: Cecilia Evangelisti, Dario de Biase, Ivana Kurelac, Claudio Ceccarelli, Holger Prokisch, Thomas Meitinger, Paola Caria, Roberta Vanni, Giovanni Romeo, Giovanni Tallini, Giuseppe Gasparre and Elena Bonora
    Citation: BMC Cancer 2015 15:157
    Content type: Research article Published on:

  26. We systematically reviewed the evidence for the interaction of microsatellite instability status (MSI) and treatment with 5FU in colorectal cancer to determine how well MSI status predicts health outcomes in p...

    Authors: Elizabeth M Webber, Tia L Kauffman, Elizabeth O’Connor and Katrina AB Goddard
    Citation: BMC Cancer 2015 15:156
    Content type: Research article Published on:

  27. The role of urine markers in the surveillance of patients with non-muscle invasive bladder cancer (NMIBC) is discussed extensively. In case of negative cystoscopy the additional prognostic value of these marke...

    Authors: Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl and Christian Schwentner
    Citation: BMC Cancer 2015 15:155
    Content type: Research article Published on:

  28. We retrospectively reviewed outcomes of treatment with pazopanib, an oral multi-tyrosine kinase angiogenesis inhibitor, in patients with advanced soft tissue sarcoma, a rare and heterogeneous tumor group with ...

    Authors: Kwai Han Yoo, Hyo Song Kim, Su Jin Lee, Se Hoon Park, Sung Joo Kim, Soo Hee Kim, Yoon La Choi, Kyoo-Ho Shin, Yong Jin Cho, Jeeyun Lee and Sun Young Rha
    Citation: BMC Cancer 2015 15:154
    Content type: Research article Published on:

  30. One of the major controversies of contemporary medicine is created by an increased consumption of nicotine and growing evidence of its connection to cancer, which urges elucidation of the molecular mechanisms ...

    Authors: Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy and Sergei A Grando
    Citation: BMC Cancer 2015 15:152
    Content type: Research article Published on:

  31. Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct m...

    Authors: Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard and Finn C Nielsen
    Citation: BMC Cancer 2015 15:151
    Content type: Research article Published on:

  32. Tobacco smoking and red meat consumption are some of the known risk factors associated with the development of oesophageal cancer. N-acetytransferases (NAT1 and NAT2) play a key role in metabolism of carcinogenic...

    Authors: Marco Matejcic, Matjaz Vogelsang, Yabing Wang and Iqbal M Parker
    Citation: BMC Cancer 2015 15:150
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:658

  33. To compare the prognosis of upper urinary tract (UUT)-urothelial carcinoma (UC) and UC of the bladder (UCB) by pathological staging in patients treated with radical surgeries.

    Authors: Myong Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim and Ja Hyeon Ku
    Citation: BMC Cancer 2015 15:149
    Content type: Research article Published on:

  34. Mutations in the TP53 (Tumour Protein 53) gene can lead to expression of mutant p53 proteins that accumulate in cancer cells and can induce circulating p53 antibodies in cancer patients. Our aim was to evaluate t...

    Authors: Manlio Mattioni, Silvia Soddu, Andrea Prodosmo, Paolo Visca, Salvatore Conti, Gabriele Alessandrini, Francesco Facciolo and Lidia Strigari
    Citation: BMC Cancer 2015 15:148
    Content type: Research article Published on:

  35. Studies evaluating the presence of viral sequences in breast cancer (BC), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. Most were based on RT-PCR and

    Authors: Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou and Vincent Detours
    Citation: BMC Cancer 2015 15:147
    Content type: Research article Published on:

  36. With advances in hepatocellular carcinoma (HCC) screening and treatment, the incidence of diagnosing a case of extrahepatic primary malignancy (EHPM) in patients with HCC has increased. This study aimed to elu...

    Authors: Sukho Hong, Sook-Hyang Jeong, Sang Soo Lee, Jung Wha Chung, Sung Wook Yang, Seong Min Chung, Eun Sun Jang, Jin-Wook Kim, Jee Hyun Kim, Haeryoung Kim, Jai Young Cho, Yoo-Seok Yoon and Ho-Seong Han
    Citation: BMC Cancer 2015 15:146
    Content type: Research article Published on:

  37. CBX7 is a Polycomb group protein that shows variable expression changes in various cancers that are often contradictive. A mouse knockout experiment has validated the tumor suppressor role in carcinogenesis. T...

    Authors: Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2015 15:145
    Content type: Research article Published on:

  38. HIV infection is a known risk factor for cancer but little is known about HIV testing patterns and the burden of HIV infection in cancer patients. We did a cross-sectional analysis to identify predictors of pr...

    Authors: Mazvita Sengayi, Chantal Babb, Matthias Egger and Margaret I Urban
    Citation: BMC Cancer 2015 15:144
    Content type: Research article Published on:

  39. Breast density and single-nucleotide polymorphisms (SNPs) have both been associated with breast cancer risk. To determine the extent to which these two breast cancer risk factors are associated, we investigate...

    Authors: Brad M Keller, Anne Marie McCarthy, Jinbo Chen, Katrina Armstrong, Emily F Conant, Susan M Domchek and Despina Kontos
    Citation: BMC Cancer 2015 15:143
    Content type: Research article Published on:

  40. Preoperative radiochemotherapy improves outcomes in patients with locally advanced rectal carcinoma, and has been used increasingly in patient management. However, there is a strong clinical need to assess tum...

    Authors: Lianhuang Li, Zhifen Chen, Xingfu Wang, Hongsheng Li, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan and Jianxin Chen
    Citation: BMC Cancer 2015 15:142
    Content type: Research article Published on:

  41. Lactate dehydrogenase A (LDHA) and Pyruvate Kinase M2 (PKM2) are important enzymes of glycolysis. Both of them can be phosphorylated and therefore regulated by Fibroblast growth factor receptor 1 (FGFR1). Whil...

    Authors: Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle and Cuong Hoang-Vu
    Citation: BMC Cancer 2015 15:140
    Content type: Research article Published on:

  42. Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and indu...

    Authors: Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao and Li-Shun Wang
    Citation: BMC Cancer 2015 15:139
    Content type: Research article Published on:

  43. Response to endocrine therapy in breast cancer correlates with estrogen receptor (ER) and progesterone receptor (PR) status. Generally, hormone receptor-positive (HR+) breast cancers have favorable prognosis. ...

    Authors: Soo Youn Bae, Sangmin Kim, Jun Ho Lee, Hyun-chul Lee, Se Kyung Lee, Won Ho Kil, Seok Won Kim, Jeong Eon Lee and Seok Jin Nam
    Citation: BMC Cancer 2015 15:138
    Content type: Research article Published on:

  44. The use of imaging to implement on-treatment adaptation of radiotherapy is a promising paradigm but current data on imaging changes during radiotherapy is limited. This is a hypothesis-generating pilot study t...

    Authors: Manil Subesinghe, Andrew F Scarsbrook, Steven Sourbron, Daniel J Wilson, Garry McDermott, Richard Speight, Neil Roberts, Brendan Carey, Roan Forrester, Sandeep Vijaya Gopal, Jonathan R Sykes and Robin JD Prestwich
    Citation: BMC Cancer 2015 15:137
    Content type: Research article Published on:

  45. Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. This study was to determine the feasibility of dynamic contrast-enhanced ultrasound (CEU...

    Authors: Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li and Jian-hua Zhou
    Citation: BMC Cancer 2015 15:136
    Content type: Research article Published on:

  46. Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated....

    Authors: Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson and Patricia N Tonin
    Citation: BMC Cancer 2015 15:135
    Content type: Research article Published on:

  47. Hepatocellular carcinoma (HCC) is a major cause of cancer deaths worldwide. However, current chemotherapeutic drugs for HCC are either poorly effective or expensive, and treatment with these drugs has not led ...

    Authors: Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen and Cheng-Da Hsu
    Citation: BMC Cancer 2015 15:134
    Content type: Research article Published on:

  48. The burden of cancer is likely to increase among the human immunodeficiency virus (HIV)-positive population as it ages due to successful antiretroviral therapy (ART). The purpose of this study was to determine...

    Authors: Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin and Hsiu-Chen Lin
    Citation: BMC Cancer 2015 15:133
    Content type: Research article Published on:

  49. ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in tripl...

    Authors: Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang and Wenjian Wang
    Citation: BMC Cancer 2015 15:132
    Content type: Research article Published on:

  50. Osteopontin (OPN) can recruit macrophages to the site of inflammation and promote tumorigenesis. M2 tumor-associated macrophages (M2-TAMs) also play an important role in cancer progression. This study aimed to...

    Authors: Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai and Yan-Shen Shan
    Citation: BMC Cancer 2015 15:128
    Content type: Research article Published on:

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