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  1. Stem cell protein Piwil1 functions as an oncogene in various tumor types. However, the exact function and mechanism of Piwil1 in endometrial cancer remains unclear.

    Authors: Zheng Chen, Qi Che, Xiaoying He, Fangyuan Wang, Huihui Wang, Minjiao Zhu, Jing Sun and Xiaoping Wan
    Citation: BMC Cancer 2015 15:811
  2. The anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (moAbs) cetuximab or panitumumab are administered to colorectal cancer (CRC) patients who harbor wild-type RAS proto-oncogenes. However, a pe...

    Authors: Laura Lupini, Cristian Bassi, Jitka Mlcochova, Gentian Musa, Marta Russo, Petra Vychytilova-Faltejskova, Marek Svoboda, Silvia Sabbioni, Radim Nemecek, Ondrej Slaby and Massimo Negrini
    Citation: BMC Cancer 2015 15:808
  3. Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substituti...

    Authors: C. F. Farias, M. H. Massaoka, N. Girola, R. A. Azevedo, A. K. Ferreira, S. D. Jorge, L. C. Tavares, C. R. Figueiredo and L. R. Travassos
    Citation: BMC Cancer 2015 15:807
  4. Since the landmark study conducted by Huggins and Hodges in 1941, a failure to distinguish between the role of testosterone in prostate cancer development and progression has led to the prevailing opinion that...

    Authors: Xiaohui Xu, Xinguang Chen, Hui Hu, Amy B. Dailey and Brandie D. Taylor
    Citation: BMC Cancer 2015 15:806
  5. There is significant evidence that severe tumor hypoxia may cause resistance to chemoradiotherapy and promote metastatic spread in locally advanced carcinoma of the uterine cervix. Some clinical investigations...

    Authors: Christine Ellingsen, Lise Mari K. Andersen, Kanthi Galappathi and Einar K. Rofstad
    Citation: BMC Cancer 2015 15:805
  6. Undifferentiated pleomorphic sarcoma (UPS) is a heterogeneous tumor group, and little is known about molecular target therapy for UPS. Heat shock protein 90 (HSP90) is an expressed chaperone that refolds certa...

    Authors: Hirofumi Bekki, Kenichi Kohashi, Akira Maekawa, Yuichi Yamada, Hidetaka Yamamoto, Katsumi Harimaya, Michiyuki Hakozaki, Kazuki Nabeshima, Yukihide Iwamoto and Yoshinao Oda
    Citation: BMC Cancer 2015 15:804
  7. Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with unresectable and metastatic MEC have poor long-term cl...

    Authors: Jie Chen, Jian-Liang Li, Zirong Chen, James D. Griffin and Lizi Wu
    Citation: BMC Cancer 2015 15:803
  8. This prospective, open-label phase II study assessed the impact of liver-directed therapy with selective internal radiation therapy (SIRT) and systemic chemotherapy on progression-free survival (PFS) in liver-...

    Authors: Peter Gibbs, Cuong Do, Lara Lipton, David N. Cade, Michael J. Tapner, David Price, Geoff D. Bower, Richard Dowling, Meir Lichtenstein and Guy A. van Hazel
    Citation: BMC Cancer 2015 15:802
  9. Hepatocellular carcinoma (HCC) is the most common type of tumor and is associated with high morbidity and mortality rates. Patients with HCC routinely undergo surgery followed by adjuvant radiation therapy and...

    Authors: Xuening Ji, Shi Jin, Xiaotong Qu, Kejun Li, Hongjiang Wang, Hui He, Fuchao Guo and Lei Dong
    Citation: BMC Cancer 2015 15:801
  10. Missense mutation of VHL gene is frequently detected in type 2 VHL diseases and linked to a wide range of pVHL functions and stability. Certain mutant pVHLs retain ability to regulate HIFs but lose their function...

    Authors: Kyeong-Su Park, Ju Hee Kim, Hee Won Shin, Kyung-Sook Chung, Dong-Soo Im, Jung Hwa Lim and Cho-Rok Jung
    Citation: BMC Cancer 2015 15:800
  11. Enhanced recovery after surgery (ERAS) protocols may reduce postoperative complications and the length of hospital stay. Studies of the effectiveness of ERAS should include not only doctor-reported outcomes, b...

    Authors: Dai Shida, Kotaro Wakamatsu, Yuu Tanaka, Atsushi Yoshimura, Masahiko Kawaguchi, Sachio Miyamoto and Kyoko Tagawa
    Citation: BMC Cancer 2015 15:799
  12. Chronic diseases and multimorbidity are common in western countries and associated with increased breast cancer mortality. This study aims to investigate non-participation in breast cancer screening among wome...

    Authors: L. F. Jensen, A. F. Pedersen, B. Andersen, M. Vestergaard and P. Vedsted
    Citation: BMC Cancer 2015 15:798
  13. Pancreatic cancer remains one of the most difficult cancers to treat with the poorest prognosis. The key to improving survival rates in this disease is early detection and monitoring of disseminated and residu...

    Authors: Julie Earl, Sandra Garcia-Nieto, Jose Carlos Martinez-Avila, José Montans, Alfonso Sanjuanbenito, Mercedes Rodríguez-Garrote, Eduardo Lisa, Elena Mendía, Eduardo Lobo, Núria Malats, Alfredo Carrato and Carmen Guillen-Ponce
    Citation: BMC Cancer 2015 15:797
  14. The anticancer TS-1® combination capsules of tegafur, gimeracil, and oteracil potassium (Taiho Pharmaceutical Co. Ltd, Japan) causes side effects, i. e., corneal epithelial disorder and dacryostenosis. However, i...

    Authors: Shin Mizoguchi, Yuka Okada, Masahide Kokado and Shizuya Saika
    Citation: BMC Cancer 2015 15:796
  15. Although some molecularly targeted drugs for colorectal cancer are used clinically and contribute to a better prognosis, the current median survival of advanced colorectal cancer patients is not sufficient. Au...

    Authors: Kosuke Sakitani, Yoshihiro Hirata, Yohko Hikiba, Yoku Hayakawa, Sozaburo Ihara, Hirobumi Suzuki, Nobumi Suzuki, Takako Serizawa, Hiroto Kinoshita, Kei Sakamoto, Hayato Nakagawa, Keisuke Tateishi, Shin Maeda, Tsuneo Ikenoue, Shoji Kawazu and Kazuhiko Koike
    Citation: BMC Cancer 2015 15:795
  16. The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal...

    Authors: Hidenori Takahashi, Toshiaki Ishikawa, Megumi Ishiguro, Satoshi Okazaki, Kaoru Mogushi, Hirotoshi Kobayashi, Satoru Iida, Hiroshi Mizushima, Hiroshi Tanaka, Hiroyuki Uetake and Kenichi Sugihara
    Citation: BMC Cancer 2015 15:794
  17. Emerging evidence indicates that inappropriate cell-cell fusion might contribute to cancer progression. Similarly, mesenchymal stem cells (MSCs) can also fuse with other cells spontaneously and capable of adop...

    Authors: Jianguo Xue, Yuan Zhu, Zixuan Sun, Runbi Ji, Xu Zhang, Wenrong Xu, Xiao Yuan, Bin Zhang, Yongmin Yan, Lei Yin, Huijuan Xu, Leilei Zhang, Wei Zhu and Hui Qian
    Citation: BMC Cancer 2015 15:793
  18. Carcinogenesis affects not only humans but almost all metazoan species. Understanding the rules driving the occurrence of cancers in the wild is currently expected to provide crucial insights into identifying ...

    Authors: Hugo Ducasse, Beata Ujvari, Eric Solary, Marion Vittecoq, Audrey Arnal, Florence Bernex, Nelly Pirot, Dorothée Misse, François Bonhomme, François Renaud, Frédéric Thomas and Benjamin Roche
    Citation: BMC Cancer 2015 15:792
  19. In breast cancer, progesterone receptor (PR) positivity or abundance is positively associated with survival and treatment response. It was initially believed that PR was a useful diagnostic marker of estrogen ...

    Authors: Eleanor F. Need, Luke A. Selth, Andrew P. Trotta, Damien A. Leach, Lauren Giorgio, Melissa A. O’Loughlin, Eric Smith, Peter G. Gill, Wendy V. Ingman, J. Dinny Graham and Grant Buchanan
    Citation: BMC Cancer 2015 15:791
  20. Tumor-associated macrophages (TAMs) promote tumor progression and have an effect on survival in human cancer. However, little is known regarding their influence on tumor progression and prognosis in human hila...

    Authors: Georgi Atanasov, Hans-Michael Hau, Corinna Dietel, Christian Benzing, Felix Krenzien, Andreas Brandl, Georg Wiltberger, Ivan Matia, Isabel Prager, Katrin Schierle, Simon C. Robson, Anja Reutzel-Selke, Johann Pratschke, Moritz Schmelzle and Sven Jonas
    Citation: BMC Cancer 2015 15:790
  21. Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to eval...

    Authors: Chih-Ming Ho, Chi-Jung Huang, Shih-Hung Huang, Shwu-Fen Chang and Wen-Fang Cheng
    Citation: BMC Cancer 2015 15:789
  22. Hypercalcemia is the most common oncologic metabolic emergency but very rarely observed in patients with gastrointestinal stromal tumour, which is a rare mesenchymal malignancy of the gastrointestinal tract. W...

    Authors: Katrine Hygum, Christian Nielsen Wulff, Torben Harsløf, Anders Kindberg Boysen, Philip Blach Rossen, Bente Lomholt Langdahl and Akmal Ahmed Safwat
    Citation: BMC Cancer 2015 15:788
  23. Healthcare resource utilization in breast cancer varies by disease characteristics and treatment choices. However, lack of clarity in guidelines can result in varied interpretation and heterogeneous treatment ...

    Authors: Guy Jerusalem, Patrick Neven, Nina Marinsek, Jie Zhang, Ravi Degun, Giancarlo Benelli, Stephen Saletan, Jean-François Ricci and Fabrice Andre
    Citation: BMC Cancer 2015 15:787
  24. Although number of elderly patients with metastatic colorectal cancer (mCRC) is rapidly increasing, this population is often underrepresented in clinical trials. Recently, a phase II trial demonstrated that ca...

    Authors: Yoshinori Munemoto, Mitsuro Kanda, Keiichiro Ishibashi, Taishi Hata, Michiya Kobayashi, Junichi Hasegawa, Mutsumi Fukunaga, Akinori Takagane, Toshio Otsuji, Yasuhiro Miyake, Michitaka Nagase, Junichi Sakamoto, Masaki Matsuoka, Koji Oba and Hideyuki Mishima
    Citation: BMC Cancer 2015 15:786
  25. The aim of this study was to elucidate the value of putative cancer stem cell markers Musashi-1, ALDH1, Sox2, and CD49f in predicting the prognosis in cervical squamous cell carcinoma (CSCC).

    Authors: Teng Hou, Weijing Zhang, Chongjie Tong, Gallina Kazobinka, Xin Huang, Yongwen Huang and Yanna Zhang
    Citation: BMC Cancer 2015 15:785
  26. Cyclin A1 is essential for male gametopoiesis. In acute myeloid leukemia, it acts as a leukemia-associated antigen. Cyclin A1 expression has been reported in several epithelial malignancies, including testicul...

    Authors: Ruza Arsenic, Elena Ilona Braicu, Anne Letsch, Manfred Dietel, Jalid Sehouli, Ulrich Keilholz and Sebastian Ochsenreither
    Citation: BMC Cancer 2015 15:784
  27. The tumor microenvironment impacts pancreatic cancer (PC) development, progression and metastasis. How intratumoral inflammatory mediators modulate this biology remains poorly understood. We hypothesized that ...

    Authors: Daniel Delitto, Brian S. Black, Heather L. Sorenson, Andrea E. Knowlton, Ryan M. Thomas, George A. Sarosi, Lyle L. Moldawer, Kevin E. Behrns, Chen Liu, Thomas J. George, Jose G. Trevino, Shannon M. Wallet and Steven J. Hughes
    Citation: BMC Cancer 2015 15:783
  28. The prognostic significance of Epstein-Barr virus (EBV) infection in gastric cancer (GC) remains unclear. Recently, a number of studies have investigated the association between EBV infection and the prognosis...

    Authors: Xuechao Liu, Jianjun Liu, Haibo Qiu, Pengfei Kong, Shangxiang Chen, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Dazhi Xu and Xiaowei Sun
    Citation: BMC Cancer 2015 15:782
  29. Cancer survivorship has emerged as an important aspect of oncology due to the possibility of physical and psychosocial complications. The purpose of this study was to assess the feasibility of the Ambulatory M...

    Authors: Gisèle Compaci, Manuela Rueter, Sébastien Lamy, Lucie Oberic, Christian Recher, Maryse Lapeyre-Mestre, Guy Laurent and Fabien Despas
    Citation: BMC Cancer 2015 15:781
  30. Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear.

    Authors: Mehdi Brahmi, Laurent Alberti, Armelle Dufresne, Isabelle Ray-Coquard, Philippe Cassier, Pierre Meeus, Anne-Valérie Decouvelaere, Dominique Ranchère-Vince and Jean-Yves Blay
    Citation: BMC Cancer 2015 15:780
  31. Selective BRAF inhibitors, vemurafenib and dabrafenib, and the MEK inhibitor, trametinib, have been approved for treatment of metastatic melanomas with a BRAF p.V600E mutation. The clinical significance of non-co...

    Authors: Gang Zheng, Li-Hui Tseng, Guoli Chen, Lisa Haley, Peter Illei, Christopher D. Gocke, James R. Eshleman and Ming-Tseh Lin
    Citation: BMC Cancer 2015 15:779
  32. Pilocytic astrocytoma is the most common type of brain tumor in the pediatric population, with a generally favorable prognosis, although recurrences or leptomeningeal dissemination are sometimes also observed....

    Authors: Krzysztof Zakrzewski, Michał Jarząb, Aleksandra Pfeifer, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Paweł P. Liberski and Magdalena Zakrzewska
    Citation: BMC Cancer 2015 15:778
  33. The nerve growth factor (NGF) receptor tyrosine-kinase TrkA is a well-known determinant of the melanocytic lineage, through modulation of the MAPK and AKT cascades. While TrkA gene is frequently rearranged in ...

    Authors: Luigi Pasini, Angela Re, Toma Tebaldi, Gianluca Ricci, Sebastiana Boi, Valentina Adami, Mattia Barbareschi and Alessandro Quattrone
    Citation: BMC Cancer 2015 15:777
  34. Infection by the liver fluke, Opisthorchis viverrini, remains an important public health problem in Thailand and has resulted in the highest prevalence of infection and incidence of subsequent cholangiocarcinoma ...

    Authors: Supot Kamsa-ard, Vor Luvira, Ake Pugkhem, Varisara Luvira, Bandit Thinkhamrop, Krittika Suwanrungruang and Vajarabhongsa Bhudhisawasdi
    Citation: BMC Cancer 2015 15:776
  35. Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non-Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specifi...

    Authors: Jan Peveling-Oberhag, Franziska Wolters, Claudia Döring, Dirk Walter, Ludger Sellmann, René Scholtysik, Marco Lucioni, Max Schubach, Marco Paulli, Saskia Biskup, Stefan Zeuzem, Ralf Küppers and Martin-Leo Hansmann
    Citation: BMC Cancer 2015 15:773
  36. Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique that has shown promise for the ablation of lesions in proximity to vital structures such as blood vessels and bile ducts. The...

    Authors: Hester J. Scheffer, Laurien G P H Vroomen, Karin Nielsen, Aukje A J M van Tilborg, Emile F I Comans, Cornelis van Kuijk, Bram B. van der Meijs, Janneke van den Bergh, Petrousjka M P van den Tol and Martijn R. Meijerink
    Citation: BMC Cancer 2015 15:772
  37. The prognosis for adult patients with Ph(-) B-precursor acute lymphoblastic leukaemia (ALL) who are refractory to treatment or experience relapse (R/R), is poor; over 90 % of these patients die from the diseas...

    Authors: Deborah Saltman, Arie Barlev, Divyagiri Seshagiri, Ioannis Katsoulis, Vincent Lin and Beth Barber
    Citation: BMC Cancer 2015 15:771
  38. Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, howeve...

    Authors: Priscilla S. Simon, Sarah K. Sharman, Chunwan Lu, Dafeng Yang, Amy V. Paschall, Sidhartha S. Tulachan and Kebin Liu
    Citation: BMC Cancer 2015 15:770
  39. Alterations in methylation patterns, miRNA expression, and stem cell protein expression occur in germ cell tumors (GCTs). Our goal is to integrate molecular data across platforms to identify molecular signatur...

    Authors: Jenny N. Poynter, Jessica R. B. M. Bestrashniy, Kevin A. T. Silverstein, Anthony J. Hooten, Christopher Lees, Julie A. Ross and Jakub Tolar
    Citation: BMC Cancer 2015 15:769
  40. Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, wa...

    Authors: Mathangi Ravi, Shilpa Tentu, Ganga Baskar, Surabhi Rohan Prasad, Swetha Raghavan, Prajisha Jayaprakash, Jeyaraman Jeyakanthan, Suresh K Rayala and Ganesh Venkatraman
    Citation: BMC Cancer 2015 15:768
  41. Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodalit...

    Authors: J. Joshua Smith, Oliver S. Chow, Marc J. Gollub, Garrett M. Nash, Larissa K. Temple, Martin R. Weiser, José G. Guillem, Philip B. Paty, Karin Avila and Julio Garcia-Aguilar
    Citation: BMC Cancer 2015 15:767
  42. CXC chemokine receptor 2 (CXCR2) has been reported to play an important role in the proliferation and invasion of gastric cancer cells. The present study aims to investigate the impact of CXCR2 expression on t...

    Authors: Zhenglin Wang, Hao Liu, Zhenbin Shen, Xuefei Wang, Heng Zhang, Jing Qin, Jiejie Xu, Yihong Sun and Xinyu Qin
    Citation: BMC Cancer 2015 15:766
  43. About one third of breast cancer survivors suffer from persistent severe fatigue after completion of curative cancer treatment. Face-to-face cognitive behavioral therapy (F2F CBT), especially designed for fati...

    Authors: H. J. G. Abrahams, M. F. M. Gielissen, M. M. Goedendorp, T. Berends, M. E. W. J. Peters, H. Poort, C. A. H. H. V. M. Verhagen and H. Knoop
    Citation: BMC Cancer 2015 15:765
  44. In locally advanced rectal cancer (LARC) preoperative chemoradiation (CRT) is the standard of care, but the risk of local recurrence is low with good quality total mesorectal excision (TME), although many stil...

    Authors: R. Glynne-Jones, N. Hava, V. Goh, S. Bosompem, J. Bridgewater, I. Chau, A. Gaya, H. Wasan, B. Moran, L. Melcher, A. MacDonald, M. Osborne, S. Beare, M. Jitlal, A. Lopes, M. Hall…
    Citation: BMC Cancer 2015 15:764
  45. Considering cell cycle dependent cytotoxicity, intercalation of chemotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) may be a treatment option in non-small cell lung cancer ...

    Authors: Yoon Ji Choi, Dae Ho Lee, Chang Min Choi, Jung Shin Lee, Seung Jin Lee, Jin-Hee Ahn and Sang-We Kim
    Citation: BMC Cancer 2015 15:763
  46. Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no predictive biomarkers in clinical practice for cytotoxic drugs. We used...

    Authors: Kasia Matula, Elaina Collie-Duguid, Graeme Murray, Khyati Parikh, Heike Grabsch, Patrick Tan, Salina Lalwani, Roberta Garau, Yuhan Ong, Gillian Bain, Asa-Dahle Smith, Gordon Urquhart, Jacek Bielawski, Michael Finnegan and Russell Petty
    Citation: BMC Cancer 2015 15:762
  47. Microcalcifications can be the early and only presenting sign of breast cancer. One shared characteristic of breast cancer is the appearance of mammographic mammary microcalcifications that can routinely be us...

    Authors: Andrés M. Castellaro, Alfredo Tonda, Hugo H. Cejas, Héctor Ferreyra, Beatriz L. Caputto, Oscar A. Pucci and German A. Gil
    Citation: BMC Cancer 2015 15:761

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