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  1. The occurrence of cancer during pregnancy merges two complex, poorly understood metabolic and hormonal conditions. This association can exacerbate the conditions of both the mother and the foetus. The branched...

    Authors: Bread Leandro Gomes Cruz, Priscila Cristina da Silva, Rebeka Tomasin, Andre Gustavo Oliveira, Lais Rosa Viana, Emilianne Miguel Salomao and Maria Cristina Cintra Gomes-Marcondes
    Citation: BMC Cancer 2016 16:58
    Content type: Research article Published on:

  2. Transgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin in cancer is controversial, a number of studies have shown that elevated levels correlate with agg...

    Authors: Hui-min Zhou, Yuan-yuan Fang, Paul M. Weinberger, Ling-ling Ding, John K. Cowell, Farlyn Z. Hudson, Mingqiang Ren, Jeffrey R. Lee, Qi-kui Chen, Hong Su, William S. Dynan and Ying Lin
    Citation: BMC Cancer 2016 16:55
    Content type: Research article Published on:

  3. A mouse model of metastasis of human gastric cancer is one of the most important tools for studying the biological mechanisms underlying human gastric cancer metastasis. In this paper, we established a mouse m...

    Authors: Kesheng Li, Huifen Du, Xiaowen Lian, Dandan Chai, Xinwen Li, Rong Yang and Chunya Wang
    Citation: BMC Cancer 2016 16:54
    Content type: Research article Published on:

  4. Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transd...

    Authors: Hisako Inoue, Hiroyuki Takahashi, Miki Hashimura, Koji Eshima, Masashi Akiya, Toshihide Matsumoto and Makoto Saegusa
    Citation: BMC Cancer 2016 16:53
    Content type: Research article Published on:

  5. Toll-like receptors (TLRs) recognize known molecules from microbes and have an established role in tumorigenesis. Using a rat model of esophageal adenocarcinoma, and human clinical samples, we investigated gen...

    Authors: Ali H. Zaidi, Lori A. Kelly, Rachael E. Kreft, Mark Barlek, Ashten N. Omstead, Daisuke Matsui, Natalie H. Boyd, Kathryn E. Gazarik, Megan I. Heit, Laura Nistico, Pashtoon M. Kasi, Tracy L. Spirk, Barbara Byers, Emily J. Lloyd, Rodney J. Landreneau and Blair A. Jobe
    Citation: BMC Cancer 2016 16:52
    Content type: Research article Published on:

  6. Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system. As dependence on iron is a key feature of tumor...

    Authors: Claire Legendre, Sylvie Avril, Catherine Guillet and Emmanuel Garcion
    Citation: BMC Cancer 2016 16:51
    Content type: Research article Published on:

  7. To correlate parameters of Ultrasonography-guided Diffuse optical tomography (US-DOT) with pharmacokinetic features of Dynamic contrast-enhanced (DCE)-MRI and pathologic markers of breast cancer.

    Authors: Min Jung Kim, Min-Ying Su, Hon J Yu, Jeon-Hor Chen, Eun-Kyung Kim, Hee Jung Moon and Ji Soo Choi
    Citation: BMC Cancer 2016 16:50
    Content type: Research article Published on:

  8. Dual specificity phosphatases are a class of tumor-associated proteins involved in the negative regulation of the MAP kinase pathway. Downregulation of the dual specificity phosphatase 2 (DUSP2) has been reported...

    Authors: Tanja Haag, Antje M. Richter, Martin B. Schneider, Adriana P. Jiménez and Reinhard H. Dammann
    Citation: BMC Cancer 2016 16:49
    Content type: Research article Published on:

  10. Centrosome amplification (CA) has been reported in nearly all types of human cancer and is associated with deleterious clinical factors such as higher grade and stage. However, previous reports have not shown ...

    Authors: Ryan A. Denu, Lauren M. Zasadil, Craig Kanugh, Jennifer Laffin, Beth A. Weaver and Mark E. Burkard
    Citation: BMC Cancer 2016 16:47
    Content type: Research article Published on:

  11. The efficacy and safety of lenalidomide plus low-dose dexamethasone (Rd) in Chinese patients with relapsed/refractory multiple myeloma (RRMM) was demonstrated in a phase 2, multicenter trial (MM-021). MM-024 w...

    Authors: Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei and Jian Hou
    Citation: BMC Cancer 2016 16:46
    Content type: Research article Published on:

  12. Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion and ...

    Authors: Kun-peng Fang, Wei Dai, Yan-Hong Ren, Ye-Chuan Xu, She-min Zhang and Ye-Ben Qian
    Citation: BMC Cancer 2016 16:45
    Content type: Research article Published on:

  13. Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on cli...

    Authors: Neli S. Slavova-Azmanova, Catalina Lizama, Claire E. Johnson, Herbert P. Ludewick, Leanne Lester, Shanka Karunarathne and Martin Phillips
    Citation: BMC Cancer 2016 16:44
    Content type: Research article Published on:

  14. Over 20 % of ovarian cancer patients have preoperative thrombocytosis or hyperfibrinogenemia. We aimed to demonstrate the clinical and prognostic significance of thrombocytosis and hyperfibrinogenemia in high-...

    Authors: Zheng Feng, Hao Wen, Rui Bi, Yachen Duan, Wentao Yang and Xiaohua Wu
    Citation: BMC Cancer 2016 16:43
    Content type: Research article Published on:

  15. With increasing numbers of patients with unresectable locoregionally advanced (LA) head and neck squamous cell carcinoma (HNSCC) receiving cetuximab/radiotherapy (RT), several guidelines on the early detection...

    Authors: Guopei Zhu, Jin-Ching Lin, Sung-Bae Kim, Jacques Bernier, Jai Prakash Agarwal, Jan B. Vermorken, Dang Huy Quoc Thinh, Hoi-Ching Cheng, Hwan Jung Yun, Imjai Chitapanarux, Prasert Lertsanguansinchai, Vijay Anand Reddy and Xia He
    Citation: BMC Cancer 2016 16:42
    Content type: Correspondence Published on:

  16. The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully expl...

    Authors: Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki and Hideki Nakayama
    Citation: BMC Cancer 2016 16:41
    Content type: Research article Published on:

  17. There is considerable information on the methylation of the promoter regions of different genes involved in gastric carcinogenesis. However, there is a lack of information on how this epigenetic process differ...

    Authors: Rita Kupcinskaite-Noreikiene, Rasa Ugenskiene, Alius Noreika, Viktoras Rudzianskas, Jurgita Gedminaite, Jurgita Skieceviciene and Elona Juozaityte
    Citation: BMC Cancer 2016 16:40
    Content type: Research article Published on:

  18. Cancer metastasis is one of the most common causes of treatment failure and death in cancer patients. It has been acknowledged that aberrant activation of epithelial-to-mesenchymal transition (EMT) program, en...

    Authors: Poulami Khan, Argha Manna, Shilpi Saha, Suchismita Mohanty, Shravanti Mukherjee, Minakshi Mazumdar, Deblina Guha and Tanya Das
    Citation: BMC Cancer 2016 16:39
    Content type: Research article Published on:

  19. Long Interspersed Nuclear Element-1 (L1) is an oncogenic mammalian retroelement silenced early in development via tightly controlled epigenetic mechanisms. We have previously shown that the regulatory region o...

    Authors: Diego E. Montoya-Durango, Kenneth A. Ramos, Pasano Bojang, Lorell Ruiz, Irma N. Ramos and Kenneth S. Ramos
    Citation: BMC Cancer 2016 16:38
    Content type: Research article Published on:

  20. Photoimmunotherapy (PIT) is a novel type of molecular optical imaging-guided cancer phototherapy based on a monoclonal antibody conjugated to a photosensitizer, IR700, in combination with near-infrared (NIR) l...

    Authors: Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisataka Kobayashi and Hisao Tajiri
    Citation: BMC Cancer 2016 16:37
    Content type: Research article Published on:

  21. A neuroendocrine tumor (NET) can develop anywhere in the body, but is mainly found in the pancreas, gastrointestinal tract, and lungs. This report is a retrospective study of the clinicopathological features o...

    Authors: Jiro Akimoto, Hirokazu Fukuhara, Tomohiro Suda, Kenta Nagai, Megumi Ichikawa, Shinjiro Fukami, Michihiro Kohno, Jun Matsubayashi and Toshitaka Nagao
    Citation: BMC Cancer 2016 16:36
    Content type: Research article Published on:

  22. c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good...

    Authors: Chi Hoon Park, Sung Yun Cho, Jae Du Ha, Heejung Jung, Hyung Rae Kim, Chong Ock Lee, In-Young Jang, Chong Hak Chae, Heung Kyoung Lee and Sang Un Choi
    Citation: BMC Cancer 2016 16:35
    Content type: Research article Published on:

  23. Studies in taxane and/or anthracycline refractory metastatic breast cancer (mBC) patients have shown approximately 30 % response rates to irinotecan. Hence, a significant number of patients will experience iri...

    Authors: Haatisha Jandu, Kristina Aluzaite, Louise Fogh, Sebastian Wingaard Thrane, Julie B. Noer, Joanna Proszek, Khoa Nguyen Do, Stine Ninel Hansen, Britt Damsgaard, Signe Lykke Nielsen, Magnus Stougaard, Birgitta R. Knudsen, José Moreira, Petra Hamerlik, Madhavsai Gajjar, Marcel Smid…
    Citation: BMC Cancer 2016 16:34
    Content type: Research article Published on:

  24. miRNAs can regulate cellular survival in various cancer cell types. Recent evidence implicates the formation of lipid droplets as a hallmark event during apoptotic cell death response. It is presently unknown ...

    Authors: Punashi Dutta, Edward Haller, Arielle Sharp and Meera Nanjundan
    Citation: BMC Cancer 2016 16:33
    Content type: Research article Published on:

  25. The three members of the human heterochromatin protein 1 (HP1) family of proteins, HP1α, HP1β, and HPγ, are involved in chromatin packing and epigenetic gene regulation. HP1α is encoded from the CBX5 gene and is ...

    Authors: Johan Vad-Nielsen, Kristine Raaby Jakobsen, Tina Fuglsang Daugaard, Rune Thomsen, Anja Brügmann, Boe Sandahl Sørensen and Anders Lade Nielsen
    Citation: BMC Cancer 2016 16:32
    Content type: Research article Published on:

  26. Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection...

    Authors: Tatiana C. Schneider, Ellen Kapiteijn, Tom van Wezel, Jan W. A. Smit, Jacobus J. M. van der Hoeven and Hans Morreau
    Citation: BMC Cancer 2016 16:31
    Content type: Case report Published on:

  27. Trabectedin is an antineoplastic agent used for patients with soft tissue sarcoma (STS) who fail standard-of-care treatment. Real-world data of its performance is scarce. This study evaluates the safety and ef...

    Authors: Fernando A. Angarita, Amanda J. Cannell, Albiruni R. Abdul Razak, Brendan C. Dickson and Martin E. Blackstein
    Citation: BMC Cancer 2016 16:30
    Content type: Research article Published on:

  28. Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unk...

    Authors: Shuang-Xi Li, Sang Hyuk Seo, Yoon Young Choi, Masatoshi Nakagawa, Ji Yeong An, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung and Sung Hoon Noh
    Citation: BMC Cancer 2016 16:29
    Content type: Research article Published on:

  29. Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype o...

    Authors: Johanna Samulin Erdem, Vidar Skaug, Per Bakke, Amund Gulsvik, Aage Haugen and Shanbeh Zienolddiny
    Citation: BMC Cancer 2016 16:28
    Content type: Research article Published on:

  30. Biopsy for lung cancer diagnosis is usually done at a single site. But it is unclear that genetic information at one biopsy site represents that of other lesions and is sufficient for therapeutic decision making.

    Authors: Eun Young Kim, Eun Na Cho, Heae Surng Park, Arum Kim, Ji Young Hong, Seri Lim, Jong Pil Youn, Seung Yong Hwang and Yoon Soo Chang
    Citation: BMC Cancer 2016 16:27
    Content type: Research article Published on:

  32. It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity – however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may...

    Authors: Kerstin Maria Kampa-Schittenhelm, Olaf Salitzky, Figen Akmut, Barbara Illing, Lothar Kanz, Helmut Rainer Salih and Marcus Matthias Schittenhelm
    Citation: BMC Cancer 2016 16:25
    Content type: Research article Published on:

  33. Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumours. Treatment options are limited and gemcitabine-based chemotherapy remains the standard of care. Although growing evidence sh...

    Authors: Dannel Yeo, Hong He, Oneel Patel, Andrew M. Lowy, Graham S. Baldwin and Mehrdad Nikfarjam
    Citation: BMC Cancer 2016 16:24
    Content type: Research article Published on:

  34. Betulinic acid (BA), a member of pentacyclic triterpenes has shown important biological activities like anti-bacterial, anti-malarial, anti-inflammatory and most interestingly anticancer property. To overcome ...

    Authors: Debasmita Dutta, Biswajit Chakraborty, Ankita Sarkar, Chinmay Chowdhury and Padma Das
    Citation: BMC Cancer 2016 16:23
    Content type: Research article Published on:

  35. Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal t...

    Authors: Peter Reichardt, George D. Demetri, Hans Gelderblom, Piotr Rutkowski, Seock-Ah Im, Sudeep Gupta, Yoon-Koo Kang, Patrick Schöffski, Jochen Schuette, Denis Soulières, Jean-Yves Blay, David Goldstein, Kolette Fly, Xin Huang, Massimo Corsaro, Maria Jose Lechuga…
    Citation: BMC Cancer 2016 16:22
    Content type: Research article Published on:

  36. The current study was conducted to examine the activity of a docetaxel/oxaliplatin (DocOx) combination as second line treatment for advanced pancreatic ductal adenocarcinoma (Trial registration: NCT00690300. R...

    Authors: Thomas J. Ettrich, Lukas Perkhofer, Goetz von Wichert, Thomas M. Gress, Patrick Michl, Holger F. Hebart, Petra Büchner-Steudel, Michael Geissler, Rainer Muche, Bettina Danner, Volker Kächele, Andreas W. Berger, Melanie Güthle and Thomas Seufferlein
    Citation: BMC Cancer 2016 16:21
    Content type: Research article Published on:

  37. Deregulated signal transducer and activator of transcription 3 (STAT3) signaling has been well documented in certain cancers. Alterations in specific negative regulators, such as protein inhibitor of activated...

    Authors: Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, Chee-Yin Chai and Yao-Tsung Yeh
    Citation: BMC Cancer 2016 16:20
    Content type: Research article Published on:

  38. Cetuximab, in combination with platinum chemotherapy plus 5-fluoruracil (5-FU), is approved for the first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). Cetuximab ...

    Authors: Denis Soulières, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin and Douglas Adkins
    Citation: BMC Cancer 2016 16:19
    Content type: Research article Published on:

  39. To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing sal...

    Authors: F. Blok, E. M. Roes, G. J. L. H. van Leenders and H. J. van Beekhuizen
    Citation: BMC Cancer 2016 16:18
    Content type: Research article Published on:

  40. Silvestrol is a cyclopenta[b]benzofuran that was isolated from the fruits and twigs of Aglaia foveolata, a plant indigenous to Borneo in Southeast Asia. The purpose of the current study was to determine if inhibi...

    Authors: Wei-Lun Chen, Li Pan, A. Douglas Kinghorn, Steven M. Swanson and Joanna E. Burdette
    Citation: BMC Cancer 2016 16:17
    Content type: Research article Published on:

  41. FoxC2 is an epithelial–mesenchymal transition (EMT) regulator which induces metastasis. The purpose of this study is to assess the prognostic value of FoxC2 expression in non-small cell lung cancer (NSCLC), al...

    Authors: Wei Jiang, Hong Fan, Cheng Qian, Jianyong Ding, Qun Wang and Xuguang Pang
    Citation: BMC Cancer 2016 16:16
    Content type: Research article Published on:

  42. Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide, and CD133 is a popular cancer stem cell (CSC) marker for HCC. CD133+ CSCs have been reported to resist conventional chemo- and radio...

    Authors: Jian Li, Jin-Na Chen, Ting-Ting Zeng, Fan He, Shu-Peng Chen, Stephanie Ma, Jiong Bi, Xiao-Feng Zhu and Xin-Yuan Guan
    Citation: BMC Cancer 2016 16:15
    Content type: Research article Published on:

  43. The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering che...

    Authors: Hannah Lui Park, Argyrios Ziogas, Jenny Chang, Bhumi Desai, Leona Bessonova, Chad Garner, Eunjung Lee, Susan L. Neuhausen, Sophia S. Wang, Huiyan Ma, Jessica Clague, Peggy Reynolds, James V. Lacey Jr, Leslie Bernstein and Hoda Anton-Culver
    Citation: BMC Cancer 2016 16:14
    Content type: Research article Published on:

  44. Less than 20 % of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify ne...

    Authors: Olga M. Sinilnikova, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Francesca Damiola, Laure Barjhoux, Morgane Marcou, Carole Verny-Pierre, Valérie Sornin, Lucie Toulemonde, Juana Beauvallet, Dorothée Le Gal, Noura Mebirouk, Muriel Belotti, Olivier Caron, Marion Gauthier-Villars, Isabelle Coupier…
    Citation: BMC Cancer 2016 16:13
    Content type: Research article Published on:

  46. The Ras Association Domain Family Member 1 (RASSF1) is one of the most frequently reported methylation-inactivated tumor suppressor genes in primary pancreatic ductal adenocarcinomas (PDAC). Limited information i...

    Authors: Eliana Amato, Stefano Barbi, Matteo Fassan, Claudio Luchini, Caterina Vicentini, Matteo Brunelli, Giuseppe Malleo, Aldo Scarpa and Giorgio Malpeli
    Citation: BMC Cancer 2016 16:11
    Content type: Research article Published on:

  47. For decades, planar bone scintigraphy has been the standard practice for detection of bone metastases in prostate cancer and has been endorsed by recent oncology/urology guidelines. It is a sensitive method wi...

    Authors: Randi F. Fonager, Helle D. Zacho, Niels C. Langkilde and Lars J. Petersen
    Citation: BMC Cancer 2016 16:10
    Content type: Study protocol Published on:

  48. Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisat...

    Authors: Yves-Paul Vandewynckel, Debby Laukens, Lindsey Devisscher, Eliene Bogaerts, Annelies Paridaens, Anja Van den Bussche, Sarah Raevens, Xavier Verhelst, Christophe Van Steenkiste, Bart Jonckx, Louis Libbrecht, Anja Geerts, Peter Carmeliet and Hans Van Vlierberghe
    Citation: BMC Cancer 2016 16:9
    Content type: Research article Published on:

  49. Authors: Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham and Claudio Festuccia
    Citation: BMC Cancer 2016 16:8
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2015 15:941

  50. GAGE cancer/testis antigens are frequently expressed in various types of malignancies and represent attractive targets for immunotherapy, however their role in cancer initiation and progression has remained el...

    Authors: Morten Frier Gjerstorff, Mikkel Green Terp, Malene Bredahl Hansen and Henrik Jørn Ditzel
    Citation: BMC Cancer 2016 16:7
    Content type: Research article Published on:

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