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  1. PN is a secreted cell adhesion protein critical for carcinogenesis. In breast cancer, it is overexpressed compared to normal breast, and a few reports suggest that it has a potential role as a prognostic marker.

    Authors: P. V. Nuzzo, A. Rubagotti, L. Zinoli, S. Salvi, S. Boccardo and F. Boccardo
    Citation: BMC Cancer 2016 16:95
    Content type: Research article Published on:

  2. The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial c...

    Authors: Lu Zheng, Da Li, Yi-Ming Zhou, Hui Yang, Di Cheng and Xiao-Xin Ma
    Citation: BMC Cancer 2016 16:93
    Content type: Research article Published on:

  3. Early gastric cancer is defined as a lesion confined to the mucosa or submucosa, regardless of the size or lymph node metastasis. Treatment methods include endoscopic mucosal resection or endoscopic submucosal...

    Authors: Zhixue Zheng, Yinan Zhang, Lianhai Zhang, Ziyu Li, Xiaojiang Wu, Yiqiang Liu, Zhaode Bu and Jiafu Ji
    Citation: BMC Cancer 2016 16:92
    Content type: Research article Published on:

  4. The overall purpose of this study is to provide proof of concept for introducing the anthracycline epirubicin as an effective, biomarker-guided treatment for metastatic colorectal cancer (mCRC) patients who ar...

    Authors: Line S. Tarpgaard, Camilla Qvortrup, Sune B. Nygård, Signe L. Nielsen, Diana R. Andersen, Niels Frank Jensen, Jan Stenvang, Sönke Detlefsen, Nils Brünner and Per Pfeiffer
    Citation: BMC Cancer 2016 16:91
    Content type: Study protocol Published on:

  5. Intrahepatic cholangiocarcinoma (ICC) is an aggressive, highly lethal tumors and lacks of effective chemo and targeted therapies. Cell lines and animal models, even partially reflecting tumor characteristics, ...

    Authors: Giuliana Cavalloni, Caterina Peraldo-Neia, Francesco Sassi, Giovanna Chiorino, Ivana Sarotto, Massimo Aglietta and Francesco Leone
    Citation: BMC Cancer 2016 16:90
    Content type: Research article Published on:

  6. E.coli type II L-asparaginase is widely used for treatment of acute lymphoblastic leukemia. However, serious side effects such as allergic or hypersensitivity reactions are common for L-asparaginase treatment....

    Authors: Vadim S. Pokrovsky, Marat D. Kazanov, Ilya N. Dyakov, Marina V. Pokrovskaya and Svetlana S. Aleksandrova
    Citation: BMC Cancer 2016 16:89
    Content type: Research article Published on:

  8. Gastrointestinal stromal tumors (GISTs) are characterized by mutations of KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) or PDGFRA (platelet-derived growth factor receptor α) that may be effi...

    Authors: Francesca Maria Rizzo, Raffaele Palmirotta, Andrea Marzullo, Nicoletta Resta, Mauro Cives, Marco Tucci and Franco Silvestris
    Citation: BMC Cancer 2016 16:87
    Content type: Research article Published on:

  9. The rates of oropharyngeal cancers such as tonsil cancers are increasing. The tumour suppressor protein Programmed Cell Death Protein 4 (PDCD4) has been implicated in the development of various human cancers a...

    Authors: Xiaoying Zhang, Harriet Gee, Barbara Rose, C. Soon Lee, Jonathan Clark, Michael Elliott, Jennifer R. Gamble, Murray J. Cairns, Adrian Harris, Samantha Khoury and Nham Tran
    Citation: BMC Cancer 2016 16:86
    Content type: Research article Published on:

  10. The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are dys-regulated in some cancers. In this study we examined the expression...

    Authors: Richard Morgan, Guy Simpson, Sophie Gray, Cheryl Gillett, Zsuzsanna Tabi, James Spicer, Kevin J. Harrington and Hardev S. Pandha
    Citation: BMC Cancer 2016 16:85
    Content type: Research article Published on:

  11. Little is known about the safety of the anti-VEGF antibody bevacizumab in patients undergoing resection for colorectal liver metastases (CLM). This meta-analysis evaluates the impact of bevacizumab on parenchy...

    Authors: Andreas M. Volk, Johannes Fritzmann, Christoph Reissfelder, Georg F. Weber, Jürgen Weitz and Nuh N. Rahbari
    Citation: BMC Cancer 2016 16:84
    Content type: Research article Published on:

  12. Polymorphisms in the CYP1A2 genes have the potential to affect the individual capacity to convert pre-carcinogens into carcinogens. With these comprehensive meta-analyses, we aimed to provide a quantitative asses...

    Authors: Vladimir Vukovic, Carolina Ianuale, Emanuele Leoncini, Roberta Pastorino, Maria Rosaria Gualano, Rosarita Amore and Stefania Boccia
    Citation: BMC Cancer 2016 16:83
    Content type: Research article Published on:

  13. The purpose of this observational study was to evaluate feasibility, efficacy results and toxicity observations of capecitabine in routine first line treatment of patients with metastatic colorectal cancer, wi...

    Authors: Alexander Stein, Julia Quidde, Jan Klaus Schröder, Thomas Göhler, Barbara Tschechne, Annette-Rosel Valdix, Heinz-Gert Höffkes, Silke Schirrmacher-Memmel, Tim Wohlfarth, Axel Hinke, Andreas Engelen and Dirk Arnold
    Citation: BMC Cancer 2016 16:82
    Content type: Research article Published on:

  14. To date, standardized strategies for the treatment of recurrent glioma are lacking. Chemotherapy with the alkylating agent BCNU (1,3-bis (2-chloroethyl)-1-nitroso-urea) is a therapeutic option even though its ...

    Authors: Christine Jungk, Despina Chatziaslanidou, Rezvan Ahmadi, David Capper, Justo Lorenzo Bermejo, Janina Exner, Andreas von Deimling, Christel Herold-Mende and Andreas Unterberg
    Citation: BMC Cancer 2016 16:81
    Content type: Research article Published on:

  15. Inflammation is associated with cancer but there are conflicting reports on associations of biomarkers of inflammation with cancer risk and mortality. We investigated the associations of C-reactive protein (CR...

    Authors: Leavitt Morrison, Jari A. Laukkanen, Kimmo Ronkainen, Sudhir Kurl, Jussi Kauhanen and Adetunji T. Toriola
    Citation: BMC Cancer 2016 16:80
    Content type: Research article Published on:

  16. Intravoxel incoherent motion (IVIM) MR imaging has been applied in researches of various diseases, however its potential in cervical cancer patients has not been fully explored. The purpose of this study was t...

    Authors: Li Zhu, Lijing Zhu, Hua Shi, Huanhuan Wang, Jing Yan, Baorui Liu, Weibo Chen, Jian He, Zhengyang Zhou, Xiaofeng Yang and Tian Liu
    Citation: BMC Cancer 2016 16:79
    Content type: Research article Published on:

  17. The high incidence of breast cancer has sparked the development of novel targeted and personalized therapies. Personalization of cancer treatment requires reliable prediction of chemotherapy responses in indiv...

    Authors: Kishan A. T. Naipal, Nicole S. Verkaik, Humberto Sánchez, Carolien H. M. van Deurzen, Michael A. den Bakker, Jan H.J. Hoeijmakers, Roland Kanaar, Maaike P.G. Vreeswijk, Agnes Jager and Dik C. van Gent
    Citation: BMC Cancer 2016 16:78
    Content type: Research article Published on:

  18. In past, numerous quantitative structure-activity relationship (QSAR) based models have been developed for predicting anticancer activity for a specific class of molecules against different cancer drug targets...

    Authors: Harinder Singh, Rahul Kumar, Sandeep Singh, Kumardeep Chaudhary, Ankur Gautam and Gajendra P. S. Raghava
    Citation: BMC Cancer 2016 16:77
    Content type: Research article Published on:

  19. Additional accurate non-invasive biomarkers are needed in the clinical setting to improve prostate cancer (PCa) diagnosis. Here we have developed a new and improved multiplex mRNA urine test to detect prostate...

    Authors: Lourdes Mengual, Juan José Lozano, Mercedes Ingelmo-Torres, Laura Izquierdo, Mireia Musquera, María José Ribal and Antonio Alcaraz
    Citation: BMC Cancer 2016 16:76
    Content type: Research article Published on:

  20. Cachexia is a multi-factorial, systemic syndrome that especially affects patients with cancer of the gastrointestinal tract, and leads to reduced treatment response, survival and quality of life. The most impo...

    Authors: Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess and Marc E. Martignoni
    Citation: BMC Cancer 2016 16:75
    Content type: Review Published on:

  21. The genetic variation underlying atorvastatin (ATV) pharmacokinetics was evaluated in a Mexican population. Aims of this study were: 1) to reveal the frequency of 87 polymorphisms in 36 genes related to drug m...

    Authors: Rafael B. R. León-Cachón, Jorge A. Ascacio-Martínez, María E. Gamino-Peña, Ricardo M. Cerda-Flores, Irene Meester, Hugo L. Gallardo-Blanco, Magdalena Gómez-Silva, Everardo Piñeyro-Garza and Hugo A. Barrera-Saldaña
    Citation: BMC Cancer 2016 16:74
    Content type: Research article Published on:

  22. Intravenous leiomyomatosis (IVL) extending to inferior vena cava and heart is one of the most challenging conditions for surgical treatment. We explored the use of computerized tomography angiography (CTA) in ...

    Authors: Ting Gui, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ping Peng and Keng Shen
    Citation: BMC Cancer 2016 16:73
    Content type: Research article Published on:

  23. Glioblastoma multiforme is the most aggressive brain tumor. Microglia are prominent cells within glioma tissue and play important roles in tumor biology. This work presents an animal model designed for the stu...

    Authors: Fernando F. B. Resende, Xianshu Bai, Elaine Aparecida Del Bel, Frank Kirchhoff, Anja Scheller and Ricardo Titze-de-Almeida
    Citation: BMC Cancer 2016 16:72
    Content type: Research article Published on:

  24. Extensive research has increased our understanding of the molecular alterations needed for non-small cell lung cancer (NSCLC) development. Deregulation of a pathway including MYCN, HMGA2 and CDKN2A, with the p...

    Authors: Hanne A. Eide, Ann Rita Halvorsen, Maria Moksnes Bjaanæs, Hossein Piri, Ruth Holm, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Cecilie Essholt Kiserud and Åslaug Helland
    Citation: BMC Cancer 2016 16:71
    Content type: Research article Published on:

  25. FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whe...

    Authors: Yan Sun, Wenbin Yu, Erich M. Sturgis, Wei Peng, Dapeng Lei, Qingyi Wei, Xicheng Song and Guojun Li
    Citation: BMC Cancer 2016 16:70
    Content type: Research article Published on:

  26. Despite the improvements in diagnosis and treatment, colorectal cancer (CRC) is the second cause of cancer deaths in both sexes. Therefore, research in this field remains of great interest. The approval of bev...

    Authors: Antonio Avallone, Maria Carmela Piccirillo, Luigi Aloj, Guglielmo Nasti, Paolo Delrio, Francesco Izzo, Elena Di Gennaro, Fabiana Tatangelo, Vincenza Granata, Ernesta Cavalcanti, Piera Maiolino, Francesco Bianco, Pasquale Aprea, Mario De Bellis, Biagio Pecori, Gerardo Rosati…
    Citation: BMC Cancer 2016 16:69
    Content type: Study protocol Published on:

  27. The ToGA study showed that trastuzumab plus chemotherapy prolonged median survival in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer. Among chemotherapy options,...

    Authors: Jifang Gong, Tianshu Liu, Qingxia Fan, Li Bai, Feng Bi, Shukui Qin, Jinwan Wang, Nong Xu, Ying Cheng, Yuxian Bai, Wei Liu, Liwei Wang and Lin Shen
    Citation: BMC Cancer 2016 16:68
    Content type: Research article Published on:

  28. Various molecular-targeting therapies have become available for the treatment of advanced renal cell carcinoma (RCC). Accurate prognostication is desirable for choosing the appropriate treatment for individual...

    Authors: Noboru Nakaigawa, Keiichi Kondo, Ukihide Tateishi, Ryogo Minamimoto, Tomohiro Kaneta, Kazuhiro Namura, Daiki Ueno, Kazuki Kobayashi, Takeshi Kishida, Ichiro Ikeda, Hisashi Hasumi, Kazuhide Makiyama, Yoshinobu Kubota, Tomio Inoue and Masahiro Yao
    Citation: BMC Cancer 2016 16:67
    Content type: Research article Published on:

  29. Next Generation Sequencing (NGS) is expected to lift molecular diagnostics in clinical oncology to the next level. It enables simultaneous identification of mutations in a patient tumor, after which targeted t...

    Authors: S.E.P. Joosten, V.P. Retèl, V.M.H. Coupé, M.M. van den Heuvel and W.H. van Harten
    Citation: BMC Cancer 2016 16:66
    Content type: Research article Published on:

  30. Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world popu...

    Authors: Esther Freeman, Aggrey Semeere, Megan Wenger, Mwebesa Bwana, F. Chite Asirwa, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Antoine Jaquet, Francois Dabis, Habakkuk Azinyui Yumo, Jean Claude Dusingize, David Bangsberg, Kathryn Anastos…
    Citation: BMC Cancer 2016 16:65
    Content type: Research article Published on:

  31. Germline mutations in the BRCA1 and BRCA2 genes greatly increase a woman’s risk of developing breast and/or ovarian cancer. The prevalence and distribution of such mutations differ across races/ethnicities. Sever...

    Authors: Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao Xie, Xiao-Wen Ding, Zhi-Wen Pan, Wei-Wu Ye and Xiao-Jia Wang
    Citation: BMC Cancer 2016 16:64
    Content type: Research article Published on:

  32. Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recogn...

    Authors: Yuichiro Sato, Takanori Kubo, Kinjiro Morimoto, Kazuyoshi Yanagihara and Toshio Seyama
    Citation: BMC Cancer 2016 16:63
    Content type: Research article Published on:

  33. Rebiopsy is highly recommended to identify the mechanism of acquired resistance to EGFR-TKIs in advanced lung cancer. Recent advances in multiplex genotyping based on circulating tumor DNA (ctDNA) provide a st...

    Authors: Wenhua Liang, Qihua He, Ying Chen, Shaokun Chuai, Weiqiang Yin, Wei Wang, Guilin Peng, Caicun Zhou and Jianxing He
    Citation: BMC Cancer 2016 16:62
    Content type: Case report Published on:

  34. Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restri...

    Authors: Wendy Demark-Wahnefried, Jeffery W. Nix, Gary R. Hunter, Soroush Rais-Bahrami, Renee A. Desmond, Balu Chacko, Casey D. Morrow, Maria Azrad, Andrew D. Frugé, Yuko Tsuruta, Travis Ptacek, Scott A. Tully, Roanne Segal and William E. Grizzle
    Citation: BMC Cancer 2016 16:61
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:71

  35. Aberrant TGF-β1 signaling is suggested to be involved in gastric carcinogenesis. However, the role of TGF-β1 in intestinal-type [i-GC] and diffuse-type [d-GC] gastric cancer remains largely unknown. In this st...

    Authors: Kyung Ho Pak, Dong Hoon Kim, Hyunki Kim, Do Hyung Lee and Jae-Ho Cheong
    Citation: BMC Cancer 2016 16:60
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:99

  36. To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (...

    Authors: Antonio Cicione, Cosimo De Nunzio, Andrea Tubaro, Francesco Cantiello, Stefano Manno, Carlos Oliveira, Estevao Lima and Rocco Damiano
    Citation: BMC Cancer 2016 16:59
    Content type: Research article Published on:

  37. The occurrence of cancer during pregnancy merges two complex, poorly understood metabolic and hormonal conditions. This association can exacerbate the conditions of both the mother and the foetus. The branched...

    Authors: Bread Leandro Gomes Cruz, Priscila Cristina da Silva, Rebeka Tomasin, Andre Gustavo Oliveira, Lais Rosa Viana, Emilianne Miguel Salomao and Maria Cristina Cintra Gomes-Marcondes
    Citation: BMC Cancer 2016 16:58
    Content type: Research article Published on:

  38. This study investigated whether patients with acquired haemolytic anaemia (AHA) would have elevated cancer risk including that for non-haematological solid tumours. We further examined whether the cancer risk ...

    Authors: Victor C. Kok, Fung-Chang Sung, Chia-Hung Kao, Che-Chen Lin and Chun-Hung Tseng
    Citation: BMC Cancer 2016 16:57
    Content type: Research article Published on:

  39. Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fus...

    Authors: Ran Wang, Shuxun Chen, Changxian Li, Kevin Tak Pan Ng, Chi-wing Kong, Jinping Cheng, Shuk Han Cheng, Ronald A. Li, Chung Mau Lo, Kwan Man and Dong Sun
    Citation: BMC Cancer 2016 16:56
    Content type: Research article Published on:

  40. Transgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin in cancer is controversial, a number of studies have shown that elevated levels correlate with agg...

    Authors: Hui-min Zhou, Yuan-yuan Fang, Paul M. Weinberger, Ling-ling Ding, John K. Cowell, Farlyn Z. Hudson, Mingqiang Ren, Jeffrey R. Lee, Qi-kui Chen, Hong Su, William S. Dynan and Ying Lin
    Citation: BMC Cancer 2016 16:55
    Content type: Research article Published on:

  41. A mouse model of metastasis of human gastric cancer is one of the most important tools for studying the biological mechanisms underlying human gastric cancer metastasis. In this paper, we established a mouse m...

    Authors: Kesheng Li, Huifen Du, Xiaowen Lian, Dandan Chai, Xinwen Li, Rong Yang and Chunya Wang
    Citation: BMC Cancer 2016 16:54
    Content type: Research article Published on:

  42. Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transd...

    Authors: Hisako Inoue, Hiroyuki Takahashi, Miki Hashimura, Koji Eshima, Masashi Akiya, Toshihide Matsumoto and Makoto Saegusa
    Citation: BMC Cancer 2016 16:53
    Content type: Research article Published on:

  43. Toll-like receptors (TLRs) recognize known molecules from microbes and have an established role in tumorigenesis. Using a rat model of esophageal adenocarcinoma, and human clinical samples, we investigated gen...

    Authors: Ali H. Zaidi, Lori A. Kelly, Rachael E. Kreft, Mark Barlek, Ashten N. Omstead, Daisuke Matsui, Natalie H. Boyd, Kathryn E. Gazarik, Megan I. Heit, Laura Nistico, Pashtoon M. Kasi, Tracy L. Spirk, Barbara Byers, Emily J. Lloyd, Rodney J. Landreneau and Blair A. Jobe
    Citation: BMC Cancer 2016 16:52
    Content type: Research article Published on:

  44. Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system. As dependence on iron is a key feature of tumor...

    Authors: Claire Legendre, Sylvie Avril, Catherine Guillet and Emmanuel Garcion
    Citation: BMC Cancer 2016 16:51
    Content type: Research article Published on:

  45. To correlate parameters of Ultrasonography-guided Diffuse optical tomography (US-DOT) with pharmacokinetic features of Dynamic contrast-enhanced (DCE)-MRI and pathologic markers of breast cancer.

    Authors: Min Jung Kim, Min-Ying Su, Hon J Yu, Jeon-Hor Chen, Eun-Kyung Kim, Hee Jung Moon and Ji Soo Choi
    Citation: BMC Cancer 2016 16:50
    Content type: Research article Published on:

  46. Dual specificity phosphatases are a class of tumor-associated proteins involved in the negative regulation of the MAP kinase pathway. Downregulation of the dual specificity phosphatase 2 (DUSP2) has been reported...

    Authors: Tanja Haag, Antje M. Richter, Martin B. Schneider, Adriana P. Jiménez and Reinhard H. Dammann
    Citation: BMC Cancer 2016 16:49
    Content type: Research article Published on:

  48. Centrosome amplification (CA) has been reported in nearly all types of human cancer and is associated with deleterious clinical factors such as higher grade and stage. However, previous reports have not shown ...

    Authors: Ryan A. Denu, Lauren M. Zasadil, Craig Kanugh, Jennifer Laffin, Beth A. Weaver and Mark E. Burkard
    Citation: BMC Cancer 2016 16:47
    Content type: Research article Published on:

  49. The efficacy and safety of lenalidomide plus low-dose dexamethasone (Rd) in Chinese patients with relapsed/refractory multiple myeloma (RRMM) was demonstrated in a phase 2, multicenter trial (MM-021). MM-024 w...

    Authors: Xin Du, Jie Jin, Zhen Cai, Fangping Chen, Dao-bin Zhou, Li Yu, Xiaoyan Ke, Xiao Li, Depei Wu, Fanyi Meng, Dena DeMarco, Jingshan Zhang, Jay Mei and Jian Hou
    Citation: BMC Cancer 2016 16:46
    Content type: Research article Published on:

  50. Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion and ...

    Authors: Kun-peng Fang, Wei Dai, Yan-Hong Ren, Ye-Chuan Xu, She-min Zhang and Ye-Ben Qian
    Citation: BMC Cancer 2016 16:45
    Content type: Research article Published on:

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