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  1. No novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen for extensive-stage small cell lung carcinoma (ES-SCLC) over the past decade...

    Authors: In-Jae Oh, Kyu-Sik Kim, Cheol-Kyu Park, Young-Chul Kim, Kwan-Ho Lee, Jin-Hong Jeong, Sun-Young Kim, Jeong-Eun Lee, Kye-Chul Shin, Tae-Won Jang, Hyun-Kyung Lee, Kye-Young Lee and Sung-Yong Lee
    Citation: BMC Cancer 2016 16:690
    Content type: Research article Published on:

  2. Cisplatin-based treatment has been considered the standard treatment regimen of HNSCC. Cetuximab is an emerging target therapy that has potential therapeutic benefits over cisplatin. Nevertheless, curative eff...

    Authors: Jingwen Huang, Jing Zhang, Changle Shi, Lei Liu and Yuquan Wei
    Citation: BMC Cancer 2016 16:689
    Content type: Research article Published on:

  3. The management of ovarian cancer remains a challenge. Because of the lack of early symptoms, it is often diagnosed at a late stage when it is likely to have metastasized beyond ovaries. Currently, platinum bas...

    Authors: Zaynab Al-Eisawi, Philip Beale, Charles Chan, Jun Qing Yu, Nicholas Proschogo, Mark Molloy and Fazlul Huq
    Citation: BMC Cancer 2016 16:688
    Content type: Research article Published on:

  4. Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the p...

    Authors: Jiafeng Shou, Zhigang Zhang, Yucheng Lai, Zhigang Chen and Jian Huang
    Citation: BMC Cancer 2016 16:687
    Content type: Research article Published on:

  5. The efficacy of the classical treatment modalities surgery and radiotherapy in the treatment of aggressive fibromatosis is presently disputed and there is a shift towards a more conservative approach. The aim ...

    Authors: Danique L.M. van Broekhoven, Dirk J. Grünhagenl, Thijs van Dalen, Frits van Coevorden, Han J. Bonenkamp, Lukas B. Been, Marc H.A. Bemelmans, Sander D.S. Dijkstra, Chiara Colombo, Alessandro Gronchi and Cornelis Verhoef
    Citation: BMC Cancer 2016 16:686
    Content type: Study protocol Published on:

  6. Oral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive forms of head and neck/oral cancer (HNOC), and is a complex disease with extensive genetic and epigenetic defects, including microRNA d...

    Authors: Qianting He, Zujian Chen, Qian Dong, Leitao Zhang, Dan Chen, Aditi Patel, Ajay Koya, Xianghong Luan, Robert J. Cabay, Yang Dai, Anxun Wang and Xiaofeng Zhou
    Citation: BMC Cancer 2016 16:685
    Content type: Research article Published on:

  7. Dermatomyositis is an autoimmune myopathy characterized by proximal muscle weakness, muscle inflammation, and typical skin findings. It is a rare disease with an incidence of ~1/100 000. About 15–30 % of adult...

    Authors: Ondřej Kubeček, Tomáš Soukup, Adam Paulík and Jindřich Kopecký
    Citation: BMC Cancer 2016 16:684
    Content type: Case report Published on:

  8. The progression of colorectal cancer (CRC) involves recurrent amplifications/mutations in the epidermal growth factor receptor (EGFR) and downstream signal transducers of the Ras pathway, KRAS and BRAF. Whethe...

    Authors: Narendra Padhan, Torbjörn E. M. Nordling, Magnus Sundström, Peter Åkerud, Helgi Birgisson, Peter Nygren, Sven Nelander and Lena Claesson-Welsh
    Citation: BMC Cancer 2016 16:683
    Content type: Research article Published on:

  9. Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-re...

    Authors: José Francisco Meneses-Echávez, Emilio González Jiménez, Jacqueline Schmidt Río-Valle, Jorge Enrique Correa-Bautista, Mikel Izquierdo and Robinson Ramírez-Vélez
    Citation: BMC Cancer 2016 16:682
    Content type: Research article Published on:

  10. T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) has been implicated in tumor occurrence and progression. Recent studies have shown that high expression levels of Tiam1 protein appear to be associ...

    Authors: Zhenling Li, Qixiang Liu, Junjie Piao, Fenjian Hua, Jing Wang, Guang Jin, Zhenhua Lin and Yan Zhang
    Citation: BMC Cancer 2016 16:681
    Content type: Research article Published on:

  11. Galectin-7 (Gal-7) is negatively regulated in cervical cancer, and appears to be a link between the apoptotic response triggered by cancer and the anti-tumoral activity of the immune system. Our understanding ...

    Authors: Juan Carlos Higareda-Almaraz, Juan S. Ruiz-Moreno, Jana Klimentova, Daniela Barbieri, Raquel Salvador-Gallego, Regina Ly, Ilse A. Valtierra-Gutierrez, Christiane Dinsart, Gabriel A. Rabinovich, Jiri Stulik, Frank Rösl and Bladimiro Rincon-Orozco
    Citation: BMC Cancer 2016 16:680
    Content type: Research article Published on:

  12. While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for thyroiditis. We describe a case with progressive rec...

    Authors: Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel and Sebastien Salas
    Citation: BMC Cancer 2016 16:679
    Content type: Case report Published on:

  13. shRNA-mediated lethality screening is a useful tool to identify essential targets in cancer biology. Ovarian cancer (OC) is extremely heterogeneous and most cases are advanced stages at diagnosis. OC has a hig...

    Authors: Marianne K. Kim, Natasha Caplen, Sirisha Chakka, Lidia Hernandez, Carrie House, Georgios Pongas, Elizabeth Jordan and Christina M. Annunziata
    Citation: BMC Cancer 2016 16:678
    Content type: Research article Published on:

  14. Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of neoplasm-related death in the United States. Several studies analyzed the efficacy of bevacizumab combined...

    Authors: Tobias Engel Ayer Botrel, Luciana Gontijo de Oliveira Clark, Luciano Paladini and Otávio Augusto C. Clark
    Citation: BMC Cancer 2016 16:677
    Content type: Research article Published on:

  15. Chromosome 3 amplification affecting the 3q26 region is a common genomic alteration in cervical cancer, typically marking the transition of precancerous intraepithelial lesions to an invasive phenotype. Though...

    Authors: Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer and Zoltan Ferenc Takacs
    Citation: BMC Cancer 2016 16:676
    Content type: Research article Published on:

  16. The aims of this study were to evaluate the impact of initial uterus-preserving surgery, such as myomectomy or subtotal hysterectomy, on the recurrence rates of patients with uterine sarcoma found incidentally...

    Authors: Jung-Yun Lee, Hyun Soo Kim, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim and Young Tae Kim
    Citation: BMC Cancer 2016 16:675
    Content type: Research article Published on:

  17. Vitamin D receptor (VDR) gene polymorphisms affect the risk of prostate cancer. However, studies investigating the relationship between VDR gene polymorphisms (Cdx2 and ApaI) and prostate cancer risk are equivoca...

    Authors: Kewei Wang, Guosheng Wu, Jinping Li and Wentao Song
    Citation: BMC Cancer 2016 16:674
    Content type: Research article Published on:

  18. Women harboring BRCA1/2 germline mutations have high lifetime risk of developing breast/ovarian cancer. The recommendation to pursue BRCA1/2 testing is based on patient’s family history of breast/ovarian cancer, ...

    Authors: Muhammad Usman Rashid, Noor Muhammad, Seerat Bajwa, Saima Faisal, Muhammad Tahseen, Justo Lorenzo Bermejo, Asim Amin, Asif Loya and Ute Hamann
    Citation: BMC Cancer 2016 16:673
    Content type: Research article Published on:

  19. The Response Evaluation Criteria in Solid Tumors (RECIST) are the current standard for evaluating disease progression or therapy response in patients with solid tumors. RECIST 1.1 calls for axial, longest-diam...

    Authors: Kathleen E. Fenerty, Les R. Folio, Nicholas J. Patronas, Jennifer L. Marté, James L. Gulley and Christopher R. Heery
    Citation: BMC Cancer 2016 16:672
    Content type: Research article Published on:

  20. TBX3 is a T-box transcription factor repressor that is elevated in metastatic breast cancer and is believed to promote malignancy of tumor cells, possibly by promoting cell survival and epithelial-mesenchymal ...

    Authors: Milica Krstic, Connor D. Macmillan, Hon S. Leong, Allen G. Clifford, Lesley H. Souter, David W. Dales, Carl O. Postenka, Ann F. Chambers and Alan B. Tuck
    Citation: BMC Cancer 2016 16:671
    Content type: Research article Published on:

  22. Nasopharyngeal carcinoma (NPC) is a type of head-neck cancer with a distinguishable geographic and racial distribution worldwide. Increasing evidence supports that the accumulation of additional genetic and ep...

    Authors: Pei-Yu Huang, Ting-Ting Zeng, Xiaojiao Ban, Meng-Qing Li, Bao-Zhu Zhang, Ying-Hui Zhu, Wen-Feng Hua, Hai-Qiang Mai, Li Zhang, Xin-Yuan Guan and Yan Li
    Citation: BMC Cancer 2016 16:669
    Content type: Research article Published on:

  23. Ampullary adenocarcinoma is a rare gastrointestinal cancer associated with diverse outcomes due to clinical and pathological heterogeneity. Standardized methods to better prognosticate and inform therapeutic s...

    Authors: Michael J. Overman, Harris S. Soifer, Aaron Joel Schueneman, Joe Ensor Jr, Volkan Adsay, Burcu Saka, Nastaran Neishaboori, Robert A. Wolff, Huamin Wang, Catherine A. Schnabel and Gauri Varadhachary
    Citation: BMC Cancer 2016 16:668
    Content type: Research article Published on:

  24. Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and a...

    Authors: María Díaz-Núñez, Alejandro Díez-Torre, Olivier De Wever, Ricardo Andrade, Jon Arluzea, Margarita Silió and Juan Aréchaga
    Citation: BMC Cancer 2016 16:667
    Content type: Research article Published on:

  25. Pulmonary tumor thrombotic microangiopathy (PTTM), a rare complication of advanced cancer, is histologically characterized by tumor embolisms and fibrocellular intimal proliferation of small pulmonary arteries...

    Authors: Yui Takahashi, Hironori Uruga, Takeshi Fujii, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Atsuko Kurosaki and Kazuma Kishi
    Citation: BMC Cancer 2016 16:666
    Content type: Case report Published on:

  26. Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the mos...

    Authors: Ting Yue, Xiaodong Zheng, Yaling Dou, Xiaohu Zheng, Rui Sun, Zhigang Tian and Haiming Wei
    Citation: BMC Cancer 2016 16:665
    Content type: Research article Published on:

  27. Disparate and contradictory results make studies necessary to investigate in more depth the relationship between diagnostic delay and survival in colorectal cancer (CRC) patients. The aim of this study is to a...

    Authors: Salvador Pita-Fernández, Luis González-Sáez, Beatriz López-Calviño, Teresa Seoane-Pillado, Elena Rodríguez-Camacho, Alejandro Pazos-Sierra, Paloma González-Santamaría and Sonia Pértega-Díaz
    Citation: BMC Cancer 2016 16:664
    Content type: Research article Published on:

  28. Treatment for localized soft tissue sarcoma includes surgery and radiation, while the role of chemotherapy is controversial. Biomarkers that could predict therapeutic response or prognosticate overall survival...

    Authors: Elizabeth J. Davis, Lili Zhao, David R. Lucas, Scott M. Schuetze, Laurence H. Baker, Mark M. Zalupski, Dafydd Thomas and Rashmi Chugh
    Citation: BMC Cancer 2016 16:663
    Content type: Research article Published on:

  29. Acute lymphocytic leukemia (ALL) is the most common pediatric cancer. The exact cause is not known in most cases, but past epidemiological research has suggested a number of potential risk factors. This study ...

    Authors: Sameera Ezzat, Wafaa M. Rashed, Sherin Salem, M. Tevfik Dorak, Mai El-Daly, Mohamed Abdel-Hamid, Iman Sidhom, Alaa El-Hadad and Christopher Loffredo
    Citation: BMC Cancer 2016 16:662
    Content type: Research article Published on:

  30. Anemia is a major cause of morbidity in patients with cancer resulting in poor physical performance, prognosis and therapy outcome. The aim of this study is to assess the efficacy of intravenous (iv) iron admi...

    Authors: Cengiz Gemici, Ozlem Yetmen, Gokhan Yaprak, Sevgi Ozden, Huseyin Tepetam, Hazan Ozyurt and Alpaslan Mayadagli
    Citation: BMC Cancer 2016 16:661
    Content type: Research article Published on:

  31. The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported th...

    Authors: Trinidad Dierssen-Sotos, Inés Gómez-Acebo, María de Pedro, Beatriz Pérez-Gómez, Sonia Servitja, Víctor Moreno, Pilar Amiano, Tania Fernandez-Villa, Aurelio Barricarte, Adonina Tardon, Marian Diaz-Santos, Rosana Peiro-Perez, Rafael Marcos-Gragera, Virginia Lope, Esther Gracia-Lavedan, M. Henar Alonso…
    Citation: BMC Cancer 2016 16:660
    Content type: Research article Published on:

  32. To investigate the prognostic value of oligo-recurrence in patients with brain-only oligometastases of non-small cell lung cancer (NSCLC) treated with stereotactic radiosurgery (SRS) or stereotactic radiothera...

    Authors: Yuzuru Niibe, Tetsuo Nishimura, Tetsuya Inoue, Katsuyuki Karasawa, Yoshiyuki Shioyama, Keiichi Jingu and Hiroki Shirato
    Citation: BMC Cancer 2016 16:659
    Content type: Research article Published on:

  33. The predictive accuracy of the American Joint Committee on Cancer (AJCC) stages of colorectal cancer (CRC) is mediocre. This study aimed to develop postoperative nomograms to predict cancer-specific survival (...

    Authors: Zhen-yu Zhang, Qi-feng Luo, Xiao-wei Yin, Zhen-ling Dai, Shiva Basnet and Hai-yan Ge
    Citation: BMC Cancer 2016 16:658
    Content type: Research article Published on:

  34. Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target fo...

    Authors: I. A. Netland, H. E. Førde, L. Sleire, L. Leiss, M. A. Rahman, B. S. Skeie, C. H. Gjerde, P. Ø. Enger and D. Goplen
    Citation: BMC Cancer 2016 16:657
    Content type: Research article Published on:

  37. Intraperitoneal chemotherapy is used to treat peritoneal cancer. The pattern of gene expression changes of peritoneal cancer during intraperitoneal chemotherapy has not been studied before. Pressurized intrape...

    Authors: Günther A. Rezniczek, Friederike Jüngst, Hendrik Jütte, Andrea Tannapfel, Ziad Hilal, Lukas A. Hefler, Marc-André Reymond and Clemens B. Tempfer
    Citation: BMC Cancer 2016 16:654
    Content type: Research article Published on:

  38. Her2/neu is an oncogene that plays an important role in the pathogenesis of many cancer types. In bladder carcinoma (BC), the clinical significance of Her2/neu status remains under-investigated and poorly linked ...

    Authors: Taoufik Nedjadi, Jaudah Al-Maghrabi, Mourad Assidi, Ashraf Dallol, Heba Al-Kattabi, Adeel Chaudhary, Ahmed Al-Sayyad, Adel Al-Ammari, Adel Abuzenadah, Abdelbaset Buhmeida and Mohammed Al-Qahtani
    Citation: BMC Cancer 2016 16:653
    Content type: Research article Published on:

  39. Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are myeloid neoplasms in which outgrowth of neoplastic clones disrupts normal hematopoiesis. Some patients with unexplained persistent cytopenia...

    Authors: David P. Steensma, Medrdad Abedi, Rafael Bejar, Christopher R. Cogle, Kathryn Foucar, Guillermo Garcia-Manero, Tracy I. George, David Grinblatt, Rami Komrokji, Xiaomei Ma, Jaroslaw Maciejewski, Daniel A. Pollyea, Michael R. Savona, Bart Scott, Mikkael A. Sekeres, Michael A. Thompson…
    Citation: BMC Cancer 2016 16:652
    Content type: Study protocol Published on:

  40. We report on the results of a phase II clinical trial of Panagen (tablet form of fragmented human DNA preparation) in breast cancer patients (placebo group n = 23, Panagen n = 57). Panagen was administered as an ...

    Authors: Anastasia S. Proskurina, Tatiana S. Gvozdeva, Ekaterina A. Potter, Evgenia V. Dolgova, Konstantin E. Orishchenko, Valeriy P. Nikolin, Nelly A. Popova, Sergey V. Sidorov, Elena R. Chernykh, Alexandr A. Ostanin, Olga Y. Leplina, Victoria V. Dvornichenko, Dmitriy M. Ponomarenko, Galina S. Soldatova, Nikolay A. Varaksin, Tatiana G. Ryabicheva…
    Citation: BMC Cancer 2016 16:651
    Content type: Research article Published on:

  41. Multimodal treatment strategies – perioperative chemotherapy (CTx) and radical surgery – are currently accepted as treatment standard for locally advanced gastric cancer. However, the role of adjuvant postoper...

    Authors: Sven Lichthardt, Alexander Kerscher, Ulrich A. Dietz, Christian Jurowich, Volker Kunzmann, Burkhard H. A. von Rahden, Christoph-Thomas Germer and Armin Wiegering
    Citation: BMC Cancer 2016 16:650
    Content type: Research article Published on:

  42. Traditional prognostic indicators of breast cancer, i.e. lymph node diffusion, tumor size, grading and estrogen receptor expression, are inadequate predictors of metastatic relapse. Thus, additional prognostic...

    Authors: Emanuela Guerra, Alessia Cimadamore, Pasquale Simeone, Giovanna Vacca, Rossano Lattanzio, Gerardo Botti, Valentina Gatta, Marco D’Aurora, Barbara Simionati, Mauro Piantelli and Saverio Alberti
    Citation: BMC Cancer 2016 16:649
    Content type: Research article Published on:

  43. Solid pseudopapillary neoplasms of the pancreas (SPN) are rare tumors affecting mainly women. They show an activating mutation in CTNNB1, the gene for β-catenin, and consequently an overactivation of the Wnt/β...

    Authors: Cora Hallas, Julia Phillipp, Lukas Domanowsky, Bettina Kah and Katharina Tiemann
    Citation: BMC Cancer 2016 16:648
    Content type: Research article Published on:

  44. Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive, fatal, childhood tumors that arise in the brainstem. DIPGs have no effective treatment, and their location and diffuse nature render them inoper...

    Authors: Vladimir Amani, Eric W Prince, Irina Alimova, Ilango Balakrishnan, Diane Birks, Andrew M. Donson, Peter Harris, Jean M. Mulcahy Levy, Michael Handler, Nicholas K. Foreman, Sujatha Venkataraman and Rajeev Vibhakar
    Citation: BMC Cancer 2016 16:647
    Content type: Research article Published on:

  45. Cancer is increasingly understood to arise in the context of dynamically evolving genomes with continuously generated variants subject to selective pressures. Diverse mutations have been identified in papillar...

    Authors: Jill C. Rubinstein, Taylor C. Brown, Emily R. Christison-Lagay, Yawei Zhang, John W. Kunstman, C. Christofer Juhlin, Carol Nelson-Williams, Gerald Goh, Courtney E. Quinn, Glenda G. Callender, Robert Udelsman, Richard P. Lifton, Reju Korah and Tobias Carling
    Citation: BMC Cancer 2016 16:646
    Content type: Research article Published on:

  46. Streptozocin (STZ) based chemotherapy is recommended for patients with metastatic pancreatic neuroendocrine tumors (pNET). Temozolomide as mono- or combination therapy has been suggested to be a promising alte...

    Authors: Daniela Mueller, Sebastian Krug, Moushumee Majumder, Anja Rinke and Thomas Matthias Gress
    Citation: BMC Cancer 2016 16:645
    Content type: Research article Published on:

  48. TMPRSS2:ERG fusions are frequent in prostate cancer, and occur predominantly in young patients. Several studies had proposed intratumoral heterogeneity of these fusions. This study was designed to determine fr...

    Authors: Maria-Christina Tsourlakis, Annegret Stender, Alexander Quaas, Martina Kluth, Corinna Wittmer, Alexander Haese, Markus Graefen, Stefan Steurer, Ronald Simon, Jan Korbel, Joachim Weischenfeldt, Hartwig Huland, Guido Sauter, Thorsten Schlomm and Sarah Minner
    Citation: BMC Cancer 2016 16:641
    Content type: Research article Published on:

  49. This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for ...

    Authors: Naoya Murakami, Shingo Kato, Takashi Nakano, Takashi Uno, Takeharu Yamanaka, Hideyuki Sakurai, Ryoichi Yoshimura, Junichi Hiratsuka, Yuki Kuroda, Kotaro Yoshio and Jun Itami
    Citation: BMC Cancer 2016 16:640
    Content type: Study protocol Published on:

  50. Cancer of the ovary is mostly discovered at a late stage and cannot be removed by surgery alone. Therefore surgery is usually followed by adjuvant chemotherapy. However, few reliable biomarkers exist to predic...

    Authors: Raoul A. Droeser, Robert Mechera, Silvio Däster, Benjamin Weixler, Marko Kraljević, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano and Gad Singer
    Citation: BMC Cancer 2016 16:639
    Content type: Research article Published on:

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