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  1. Renal cell carcinoma (RCC) is one of the tumors most refractory to chemotherapy to date. Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin (CPS), a natural active ingredient o...

    Authors: Tao Liu, Gang Wang, Huangheng Tao, Zhonghua Yang, Yongzhi Wang, Zhe Meng, Rui Cao, Yu Xiao, Xinghuan Wang and Jiajie Zhou
    Citation: BMC Cancer 2016 16:790
    Content type: Research article Published on:

  2. The extracellular matrix (ECM), one of the key components of tumor microenvironment, has a tremendous impact on cancer development and highly influences tumor cell features. ECM affects vital cellular function...

    Authors: Vaidotas Stankevicius, Gintautas Vasauskas, Danute Bulotiene, Stase Butkyte, Sonata Jarmalaite, Ricardas Rotomskis and Kestutis Suziedelis
    Citation: BMC Cancer 2016 16:789
    Content type: Research article Published on:

  3. Claudin-4 is a transmembrane protein expressed at high levels in the majority of epithelial ovarian tumors, irrespective of subtype, and has been associated with tumor cells that are both chemoresistant and hi...

    Authors: Douglas A. Hicks, Carly E. Galimanis, Patricia G. Webb, Monique A. Spillman, Kian Behbakht, Margaret C. Neville and Heidi K. Baumgartner
    Citation: BMC Cancer 2016 16:788
    Content type: Research article Published on:

  4. Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quali...

    Authors: Elisabeth Peters, Laura Mendoza Schulz and Monika Reuss-Borst
    Citation: BMC Cancer 2016 16:787
    Content type: Research article Published on:

  5. Pancreatic cancer is among the top 5 most common cancers worldwide, but is particularly devastating due to its insidious nature. Complete surgical resection remains the only potential curative treatment, altho...

    Authors: Mišo Gostimir, Sean Bennett, Terence Moyana, Harman Sekhon and Guillaume Martel
    Citation: BMC Cancer 2016 16:786
    Content type: Case report Published on:

  6. The risk of several types of cancer is increased in type 2 diabetes mellitus. The earliest possible diagnosis of cancer – difficult within regular outpatient diabetes care - is of utmost importance for patient...

    Authors: Mariusz Dąbrowski, Elektra Szymańska-Garbacz, Zofia Miszczyszyn, Tadeusz Dereziński and Leszek Czupryniak
    Citation: BMC Cancer 2016 16:785
    Content type: Research article Published on:

  7. MicroRNAs (miRNAs) regulate the expression of networks of genes and their dysregulation is well documented in human malignancies; however, limited information exists regarding the impact of miRNAs on the devel...

    Authors: Joelle M. Fenger, Ryan D. Roberts, O. Hans Iwenofu, Misty D. Bear, Xiaoli Zhang, Jason I. Couto, Jaime F. Modiano, William C. Kisseberth and Cheryl A. London
    Citation: BMC Cancer 2016 16:784
    Content type: Research article Published on:

  9. p63, a member of the p53 protein family, plays key roles in epithelial development and carcinogenesis. In breast cancer, p63 expression has been found predominantly in basal-A (epithelial-type) triple-negative...

    Authors: Marta Nekulova, Jitka Holcakova, Xiaolian Gu, Vaclav Hrabal, Sotiris Galtsidis, Paulina Orzol, Yajing Liu, Stella Logotheti, Vassilis Zoumpourlis, Karin Nylander, Philip J Coates and Borivoj Vojtesek
    Citation: BMC Cancer 2016 16:782
    Content type: Research article Published on:

  10. The successful targeting of neuroblastoma (NB) by associating tumor-initiating cells (TICs) is a major challenge in the development of new therapeutic strategies. The subfamily of aldehyde dehydrogenases 1 (AL...

    Authors: Marjorie Flahaut, Nicolas Jauquier, Nadja Chevalier, Katya Nardou, Katia Balmas Bourloud, Jean-Marc Joseph, David Barras, Christian Widmann, Nicole Gross, Raffaele Renella and Annick Mühlethaler-Mottet
    Citation: BMC Cancer 2016 16:781
    Content type: Research article Published on:

  11. Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevaciz...

    Authors: Christoph Rochlitz, Martin Bigler, Roger von Moos, Jürg Bernhard, Klazien Matter-Walstra, Andreas Wicki, Khalil Zaman, Sandro Anchisi, Marc Küng, Kyung-Jae Na, Daniela Bärtschi, Markus Borner, Tamara Rordorf, Daniel Rauch, Andreas Müller, Thomas Ruhstaller…
    Citation: BMC Cancer 2016 16:780
    Content type: Research article Published on:

  12. TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesopha...

    Authors: David Propper, Keith Jones, D. Alan Anthoney, Wasat Mansoor, Daniel Ford, Martin Eatock, Roshan Agarwal, Michiyasu Inatani, Tomohisa Saito, Masaichi Abe and T. R. Jeffry Evans
    Citation: BMC Cancer 2016 16:779
    Content type: Research article Published on:

  13. Inhaled corticosteroids (ICS) have been associated with decreased lung cancer risk. However, they have been associated with pulmonary infections (tuberculosis [TB] and pneumonia) in patients with chronic obstr...

    Authors: Ming-Fang Wu, Zhi-Hong Jian, Jing-Yang Huang, Cheng-Feng Jan, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Chien-Chang Ho, Chia-Chi Lung, Hui-Hsien Pan, Min-Chen Wu and Yung-Po Liaw
    Citation: BMC Cancer 2016 16:778
    Content type: Research article Published on:

  14. Extramedullary plasmacytoma (EMP) is a rare malignant disease that lacks a unique clinical staging system to predict the survival of EMP patients and to design individualized treatment. Instead, clinicians hav...

    Authors: Qian Zhu, Xiong Zou, Rui You, Rou Jiang, Meng-Xia Zhang, You-Ping Liu, Chao-Nan Qian, Hai-Qiang Mai, Ming-Huang Hong, Ling Guo and Ming-Yuan Chen
    Citation: BMC Cancer 2016 16:777
    Content type: Research article Published on:

  15. Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an estab...

    Authors: F. N. Fjeldheim, H. Frydenberg, V. G. Flote, A. McTiernan, A-S Furberg, P. T. Ellison, E. S. Barrett, T. Wilsgaard, G. Jasienska, G. Ursin, E. A. Wist and I. Thune
    Citation: BMC Cancer 2016 16:776
    Content type: Research article Published on:

  16. Concurrent chemotherapy and radiation is the standard treatment for unresectable stage III Lung adenocarcinoma. However, no optimal concurrent chemotherapeutic regimen has been described. This study aimed to a...

    Authors: Yiyu Lu, Weiguang Gu, Jin Deng, Hua Yang and Wen Yang
    Citation: BMC Cancer 2016 16:775
    Content type: Research article Published on:

  17. The study aimed to evaluate the long-term outcome in patients with advanced local recurrent nasopharyngeal carcinoma (NPC) treated with or without reirradiation.

    Authors: Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Lu Zhang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ming-Yuan Chen, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma…
    Citation: BMC Cancer 2016 16:774
    Content type: Research article Published on:

  18. The epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and several other human cancers. Monoclonal antibodies, such as cetuximab that block EGF...

    Authors: Gopal Iyer, James Price, Shay Bourgeois, Eric Armstrong, Shyhmin Huang and Paul M. Harari
    Citation: BMC Cancer 2016 16:773
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:928

  19. The related tumour suppressor proteins Deleted in Colorectal Cancer (DCC) and neogenin are absent or weakly expressed in many cancers, whereas their insertion into cells suppresses oncogenic behaviour. Serine ...

    Authors: Caroline M. Forrest, Kara McNair, Maria C. J. Vincenten, L. Gail Darlington and Trevor W. Stone
    Citation: BMC Cancer 2016 16:772
    Content type: Research article Published on:

  20. Given the prevalence of untreated pain among cancer patients, there have been calls for more and better research in the domain. Increasingly, calls for less waste and more optimal use of trial data collected a...

    Authors: Odile Sauzet, Maren Kleine and John E. Williams
    Citation: BMC Cancer 2016 16:771
    Content type: Research article Published on:

  21. Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients’ quality of life. Single arm studies have shown that the dosimetric sparing of cr...

    Authors: Imran Petkar, Keith Rooney, Justin W. G. Roe, Joanne M. Patterson, David Bernstein, Justine M. Tyler, Marie A. Emson, James P. Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A. Bhide, Kate L. Newbold, Kevin J. Harrington, Emma Hall…
    Citation: BMC Cancer 2016 16:770
    Content type: Study protocol Published on:

  22. The higher specificity of amino-acid positron emission tomography (AA-PET) in the diagnosis of gliomas, as well as in the differentiation between recurrence and treatment-related alterations, in comparison to ...

    Authors: Oliver Oehlke, Michael Mix, Erika Graf, Tanja Schimek-Jasch, Ursula Nestle, Irina Götz, Sabine Schneider-Fuchs, Astrid Weyerbrock, Irina Mader, Brigitta G. Baumert, Susan C. Short, Philipp T. Meyer, Wolfgang A. Weber and Anca-Ligia Grosu
    Citation: BMC Cancer 2016 16:769
    Content type: Study protocol Published on:

  23. Optimizing patient selection is a necessary step to design better clinical trials. ‘Life expectancy’ is a frequent inclusion criterion in phase II trial protocols, a measure that is subjective and often diffic...

    Authors: Thomas Grellety, Sophie Cousin, Louis Letinier, Pauline Bosco-Lévy, Stéphanie Hoppe, Damien Joly, Nicolas Penel, Simone Mathoulin-Pelissier and Antoine Italiano
    Citation: BMC Cancer 2016 16:768
    Content type: Research article Published on:

  24. Prostate cancer is the most common non-cutaneous malignancy in men. Today most patients may expect to live years following the diagnosis and may thus experience significant morbidity due to disease progression...

    Authors: Eik Bjerre, Ditte Marie Bruun, Anders Tolver, Klaus Brasso, Peter Krustrup, Christoffer Johansen, Robin Christensen, Mikael Rørth and Julie Midtgaard
    Citation: BMC Cancer 2016 16:767
    Content type: Study protocol Published on:

  25. We sought to assess physician interest in molecular prognosic testing for patients with early stage colon cancer, and identify factors associated with the likelihood of test adoption.

    Authors: Ronald E. Myers, Thomas Wolf, Phillip Shwae, Sarah Hegarty, Stephen C. Peiper and Scott A. Waldman
    Citation: BMC Cancer 2016 16:766
    Content type: Research article Published on:

  26. Surgery for advanced gastric cancer (AGC) often includes dissection of splenic hilar lymph nodes (SHLNs). This study compared the safety and effectiveness of different approaches to SHLN dissection for upper- ...

    Authors: Xin Ji, Tao Fu, Zhao-De Bu, Ji Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Zi-Yu Jia, Biao Fan, Yi-Nan Zhang and Jia-Fu Ji
    Citation: BMC Cancer 2016 16:765
    Content type: Research article Published on:

  27. Cachexia is one of the most important causes of cancer-related death. Supplementation with branched-chain amino acids, particularly leucine, has been used to minimise loss of muscle tissue, although few studie...

    Authors: Laís Rosa Viana, Rafael Canevarolo, Anna Caroline Perina Luiz, Raquel Frias Soares, Camila Lubaczeuski, Ana Carolina de Mattos Zeri and Maria Cristina Cintra Gomes-Marcondes
    Citation: BMC Cancer 2016 16:764
    Content type: Research article Published on:

  28. The formation of new lymphatic vessels provides an additional route for tumour cells to metastasize. Therefore, inhibiting lymphangiogenesis represents an interesting target in cancer therapy. First evidence s...

    Authors: Igor Hrgovic, Monika Doll, Johannes Kleemann, Xiao-Fan Wang, Nadja Zoeller, Andreas Pinter, Stefan Kippenberger, Roland Kaufmann and Markus Meissner
    Citation: BMC Cancer 2016 16:763
    Content type: Research article Published on:

  29. Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC is lethal at metastatic stage as it does not respond to conventional systemic treatments, and there is an urgent need to find ...

    Authors: Sajjad Karim, Jaudah A. Al-Maghrabi, Hasan M. A. Farsi, Ahmad J. Al-Sayyad, Hans-Juergen Schulten, Abdelbaset Buhmeida, Zeenat Mirza, Alaa A. Al-boogmi, Fai T. Ashgan, Manal M. Shabaad, Hend F. NourEldin, Khalid B. M. Al-Ghamdi, Adel Abuzenadah, Adeel G. A. Chaudhary and Mohammed H. Al-Qahtani
    Citation: BMC Cancer 2016 16(Suppl 2):741
    Content type: Research article Published on:

    This article is part of a Supplement: Volume 16 Supplement 2

  30. Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that ...

    Authors: Sara S. Franco, Karolina Szczesna, Maria S. Iliou, Mohammed Al-Qahtani, Ali Mobasheri, Julianna Kobolák and András Dinnyés
    Citation: BMC Cancer 2016 16(Suppl 2):738
    Content type: Review Published on:

    This article is part of a Supplement: Volume 16 Supplement 2

  31. The roles and mechanisms involved in starvation-induced autophagy in mammalian cells have been extensively studied. However, less is known about the potential role for autophagy as a survival pathway in acquir...

    Authors: Baoqing Guo, Adam Tam, Stacey A. Santi and Amadeo M. Parissenti
    Citation: BMC Cancer 2016 16:762
    Content type: Research article Published on:

  32. Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain o...

    Authors: Emilie Cordina-Duverger, Thérèse Truong, Antoinette Anger, Marie Sanchez, Patrick Arveux, Pierre Kerbrat and Pascal Guénel
    Citation: BMC Cancer 2016 16:761
    Content type: Research article Published on:

  33. Targeted therapies based on the molecular and histological features of cancer types are becoming standard practice. The most effective regimen in lung cancers is different between squamous cell carcinoma (SCC)...

    Authors: Kazuya Takamochi, Hiroko Ohmiya, Masayoshi Itoh, Kaoru Mogushi, Tsuyoshi Saito, Kieko Hara, Keiko Mitani, Yasushi Kogo, Yasunari Yamanaka, Jun Kawai, Yoshihide Hayashizaki, Shiaki Oh, Kenji Suzuki and Hideya Kawaji
    Citation: BMC Cancer 2016 16:760
    Content type: Research article Published on:

  34. Curcuminoids of the spice turmeric and their enhanced derivatives have much potential as cancer treatments. They act on a wide variety of biological pathways, including those regulating cell division and circa...

    Authors: Ashapurna Sarma, Vishal P. Sharma, Arindam B. Sarkar, M. Chandra Sekar, Karunakar Samuel and Michael E. Geusz
    Citation: BMC Cancer 2016 16:759
    Content type: Research article Published on:

  35. Arterial hyperenhancement and washout on computed tomography and magnetic resonance imaging (MRI) are described by all major guidelines as specific criteria for non-invasive diagnosis of hepatocellular carcino...

    Authors: Roman Kloeckner, Daniel Pinto dos Santos, Karl-Friedrich Kreitner, Anne Leicher-Düber, Arndt Weinmann, Jens Mittler and Christoph Düber
    Citation: BMC Cancer 2016 16:758
    Content type: Research article Published on:

  36. This prospective study aimed to compare dose volume histograms (DVH) of the breasts and organs at risk (OARs) of whole breast radiotherapy in the supine and prone positions, and frequency and severity of acute...

    Authors: Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno and Jun Itami
    Citation: BMC Cancer 2016 16:757
    Content type: Research article Published on:

  37. Although cis-diamminedichloro-platinum (CDDP) exhibits strong therapeutic effects in cancer chemotherapy, its adverse effects such as peripheral neuropathy, nephropathy, and vomiting are dose-limiting factors. Pr...

    Authors: Yoshihiro Seto, Fumiyasu Okazaki, Keiji Horikawa, Jing Zhang, Hitoshi Sasaki and Hideto To
    Citation: BMC Cancer 2016 16:756
    Content type: Research article Published on:

  38. Cancer makes up a large and increasing proportion of excess mortality for indigenous, marginalised and socioeconomically deprived populations, and much of this inequality is preventable. This study aimed to de...

    Authors: Andrea M. Teng, June Atkinson, George Disney, Nick Wilson, Diana Sarfati, Melissa McLeod and Tony Blakely
    Citation: BMC Cancer 2016 16:755
    Content type: Research article Published on:

  39. Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but implants have also caused some complications.

    Authors: Yang-Yang Shen, Hong-Wei Qin, Jian-Bo Zhang, Zhen-Dan Wang, Pang Li, Kai Pang, Bo Zhang, Sheng Li and Kai Cui
    Citation: BMC Cancer 2016 16:754
    Content type: Case report Published on:

  40. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, can be secreted by most cell types and released in perhaps all biological fluids. EVs contain multiple proteins, specific ...

    Authors: Yang Jin, Keyan Chen, Zongying Wang, Yan Wang, Jianzhi Liu, Li Lin, Yong Shao, Lihua Gao, Huihui Yin, Cong Cui, Zhaoli Tan, Liejun Liu, Chuanhua Zhao, Gairong Zhang, Ru Jia, Lijuan Du…
    Citation: BMC Cancer 2016 16:753
    Content type: Research article Published on:

  41. Platinum-based systemic chemotherapy is considered the backbone for management of advanced urothelial carcinomas. However there is a lack of real world data on the use of such chemotherapy regimens, on patient...

    Authors: N. Houédé, G. Locker, C. Lucas, H. Soto Parra, U. Basso, D. Spaeth, R. Tambaro, L. Basterretxea, F. Morelli, C. Theodore, L. Lusuardi, N. Lainez, A. Guillot, G. Tonini, J. Bielle and X. Garcia Del Muro
    Citation: BMC Cancer 2016 16:752
    Content type: Research article Published on:

  42. The associations between microRNAs and lung cancer have received increasing attention. This study assess the association between polymorphisms in miR-135a-2, miR-219-2 and miR-211 genes and the risk of lung ca...

    Authors: Zhihua Yin, Zhigang Cui, Hang li, Yangwu Ren, Biyun Qian, Nathaniel Rothman, Qing Lan and Baosen Zhou
    Citation: BMC Cancer 2016 16:751
    Content type: Research article Published on:

  43. After the approval of pazopanib for the treatment of soft tissue sarcoma (STS), pneumothorax was reported as an unexpected adverse event during pazopanib treatment. The incidence and risk factors of pneumothor...

    Authors: Kenji Nakano, Noriko Motoi, Junichi Tomomatsu, Tabu Gokita, Keisuke Ae, Taisuke Tanizawa, Seiichi Matsumoto and Shunji Takahashi
    Citation: BMC Cancer 2016 16:750
    Content type: Research article Published on:

  44. Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumours with a typical 5 year survival rate of <40 %. DNA methylation in tumour-suppressor genes often occurs at an early stage of tumo...

    Authors: Yenkai Lim, Yunxia Wan, Dimitrios Vagenas, Dmitry A. Ovchinnikov, Chris F. L. Perry, Melissa J. Davis and Chamindie Punyadeera
    Citation: BMC Cancer 2016 16:749
    Content type: Research article Published on:

  45. Chromosome 7 open reading frame 24 (C7orf24) was originally identified as a highly expressed protein in various types of cancer, and later shown to be a γ-glutamylcyclotransferase (GGCT). GGCT depletion in can...

    Authors: Kengo Matsumura, Susumu Nakata, Keiko Taniguchi, Hiromi Ii, Eishi Ashihara, Susumu Kageyama, Akihiro Kawauchi and Tatsuhiro Yoshiki
    Citation: BMC Cancer 2016 16:748
    Content type: Research article Published on:

  46. A totally implantable venous access device (TIVAD) provides reliable, long-term vascular access and improves patients’ quality of life. The wide use of TIVADs is associated with important complications. A meta...

    Authors: Shaoyong Wu, Jingxiu Huang, Zongming Jiang, Zhimei Huang, Handong Ouyang, Li Deng, Wenqian Lin, Jin Guo and Weian Zeng
    Citation: BMC Cancer 2016 16:747
    Content type: Research article Published on:

  47. Several studies show that bone marrow (BM) microenvironment and hypoxia condition can promote the survival of leukemic cells and induce resistance to anti-leukemic drugs. However, the molecular mechanism for c...

    Authors: C. Petit, F. Gouel, I. Dubus, C. Heuclin, K. Roget and J. P. Vannier
    Citation: BMC Cancer 2016 16:746
    Content type: Research article Published on:

  48. Sequential biopsy of breast cancer is used to assess biomarker effects and drug efficacy. The preoperative “window of opportunity” setting is advantageous to test biomarker changes in response to therapeutic a...

    Authors: Sirwan M. Hadad, Lee B. Jordan, Pankaj G. Roy, Colin A. Purdie, Takayuki Iwamoto, Lajos Pusztai, Stacy L. Moulder-Thompson and Alastair M. Thompson
    Citation: BMC Cancer 2016 16:745
    Content type: Research article Published on:

  49. While programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive and prognostic biomarkers...

    Authors: Archana Anantharaman, Terence Friedlander, David Lu, Rachel Krupa, Gayatri Premasekharan, Jeffrey Hough, Matthew Edwards, Rosa Paz, Karla Lindquist, Ryon Graf, Adam Jendrisak, Jessica Louw, Lyndsey Dugan, Sarah Baird, Yipeng Wang, Ryan Dittamore…
    Citation: BMC Cancer 2016 16:744
    Content type: Research article Published on:

  50. The incidence rate has been increasing for superficial head and neck squamous cell carcinoma (HNSCC) discovered through surveillance endoscopic study using narrow band imaging (NBI), a procedure mainly used fo...

    Authors: Hiroshi Nakamura, Tomonori Yano, Satoshi Fujii, Tomohiro Kadota, Toshifumi Tomioka, Takeshi Shinozaki, Ryuichi Hayashi and Kazuhiro Kaneko
    Citation: BMC Cancer 2016 16:743
    Content type: Research article Published on:

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