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  1. Content type: Research article

    The Global Burden of Disease 2000 (GBD 2000) study starts from an analysis of the overall mortality envelope in order to ensure that the cause-specific estimates add to the total all cause mortality by age and...

    Authors: Colin D Mathers, Kenji Shibuya, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray

    Citation: BMC Cancer 2002 2:36

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  2. Content type: Research article

    Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers...

    Authors: Eusebio Chiefari, Antonio Brunetti, Franco Arturi, Jean-Michel Bidart, Diego Russo, Martin Schlumberger and Sebastiano Filetti

    Citation: BMC Cancer 2002 2:35

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  3. Content type: Case report

    A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosa...

    Authors: Vladimir Osipov, Khang-Che Ho, Hendrikus G Krouwer, Glenn Meyer and Vinod B Shidham

    Citation: BMC Cancer 2002 2:34

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  4. Content type: Research article

    Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling. To determine whether increased Wnt signaling in the adult CNS is sufficient to induce tumor...

    Authors: John E Kratz, Duncan Stearns, David L Huso, Hilda H Slunt, Donald L Price, David R Borchelt and Charles G Eberhart

    Citation: BMC Cancer 2002 2:33

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  5. Content type: Research article

    The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catal...

    Authors: Mark Schrader, Angelika M Burger, Markus Müller, Hans Krause, Bernd Straub, Martin Schostak, Wolfgang Schulze, Heidrun Lauke and Kurt Miller

    Citation: BMC Cancer 2002 2:32

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  6. Content type: Research article

    Although a large number of epidemiological studies have examined the role of aspirin in the chemoprevention of colon cancer and other solid tumors, there is a limited body of research focusing on the associati...

    Authors: Kirsten B Moysich, Ravi J Menezes, Adrienne Ronsani, Helen Swede, Mary E Reid, K Michael Cummings, Karen L Falkner, Gregory M Loewen and Gerold Bepler

    Citation: BMC Cancer 2002 2:31

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  7. Content type: Research article

    Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to succes...

    Authors: Jian Yu, Min Ni, Jian Xu, Hongyu Zhang, Baomei Gao, Jianren Gu, Jianguo Chen, Lisheng Zhang, Mengchao Wu, Sushen Zhen and Jingde Zhu

    Citation: BMC Cancer 2002 2:29

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  8. Content type: Research article

    Psoriasin has been identified as a gene that is highly expressed in pre-invasive breast cancer, but is often downregulated with breast cancer progression. It is currently unknown whether psoriasin influences e...

    Authors: Ethan D Emberley, R Daniel Gietz, J Darren Campbell, Kent T HayGlass, Leigh C Murphy and Peter H Watson

    Citation: BMC Cancer 2002 2:28

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  9. Content type: Research article

    In cervical tumours the integration of human papilloma viruses (HPV) transcripts often results in the generation of transcripts that consist of hybrids of viral and cellular sequences. Mapping data using a var...

    Authors: Eugene Klimov, Svetlana Vinokourova, Elena Moisjak, Elian Rakhmanaliev, Vera Kobseva, Laimonis Laimins, Fjodor Kisseljov and Galina Sulimova

    Citation: BMC Cancer 2002 2:24

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  10. Content type: Research article

    This study was designed to evaluate if erythropoietin (EPO) is effective in the treatment of cancer related anemia, and if its effect remains unchanged when data are analyzed according to various clinical and ...

    Authors: Otavio Clark, Jared R Adams, Charles L Bennett and Benjamin Djulbegovic

    Citation: BMC Cancer 2002 2:23

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  11. Content type: Research article

    Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has become clear that these drugs can affect specific genes, as well...

    Authors: Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, John T Dekker, Jolanda Maas, Carel JM van Noesel, Jaap Goudsmit and Marion Cornelissen

    Citation: BMC Cancer 2002 2:21

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  12. Content type: Research article

    Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contrib...

    Authors: Zhihong Chen, Yinlin Ge, Natalie Landman and Jing X Kang

    Citation: BMC Cancer 2002 2:18

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  13. Content type: Research article

    Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the androgen effects on prostate cells.

    Authors: Ming-tang Li, Frank Richter, Chawnshang Chang, Robert J Irwin and Hosea FS Huang

    Citation: BMC Cancer 2002 2:16

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  14. Content type: Research article

    Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt, a kinase involved in cell survival...

    Authors: B Lynn Seely, Goli Samimi and Nicholas JG Webster

    Citation: BMC Cancer 2002 2:15

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  15. Content type: Research article

    Immunomagnetic enrichment followed by RT-PCR (immunobead RT-PCR) is an efficient methodology to identify disseminated carcinoma cells in the blood and bone marrow. The RT-PCR assays must be both specific for t...

    Authors: Michael Raynor, Sally-Anne Stephenson, David CA Walsh, Kenneth B Pittman and Alexander Dobrovic

    Citation: BMC Cancer 2002 2:14

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  16. Content type: Research article

    Surgical treatment of hypopharyngeal cancers with extension to the retrocricoid region generally requires a circumferential pharyngolaryngectomy followed by a reconstruction of the removed segment of the upper...

    Authors: Marco Benazzo, Antonio Occhini, Vanessa Rossi, Giuseppe Aresi and Mario Alessiani

    Citation: BMC Cancer 2002 2:13

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  17. Content type: Research article

    The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that gran...

    Authors: Xing-Yue He, Paul Elson, Brad Pohlman, Alan Lichtin, Mohamad Hussein, Steve Andresen and Matt Kalaycio

    Citation: BMC Cancer 2002 2:12

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  18. Content type: Research article

    5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leuco...

    Authors: Shannon K Tomlinson, Susan A Melin, Vetta Higgs, Douglas R White, Paul Savage, Douglas Case and A William Blackstock

    Citation: BMC Cancer 2002 2:9

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  19. Content type: Research article

    The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth ...

    Authors: Chang Wei Feng, Li Dong Wang, Lian Hua Jiao, Bin Liu, Shu Zheng and Xin Ji Xie

    Citation: BMC Cancer 2002 2:8

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  20. Content type: Research article

    Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, δ-aminolevulinic acid (ALA) and porphobilinogen (PBG). ALA has been reported to...

    Authors: Adriana De Siervi, Elba S Vazquez, Carolina Rezaval, María V Rossetti and Alcira M del Batlle

    Citation: BMC Cancer 2002 2:6

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  21. Content type: Research article

    Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance our understan...

    Authors: Imad Fadl-Elmula, Soili Kytola, Mona EL Leithy, Mohamed Abdel-Hameed, Nils Mandahl, Atif Elagib, Muntaser Ibrahim, Catharina Larsson and Sverre Heim

    Citation: BMC Cancer 2002 2:5

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  22. Content type: Research article

    Expression of the retinoic acid receptor β2 (RAR-β2), a putative tumor suppressor gene, is reduced in various human cancers, including squamous cell carcinomas (SCC) of the uterine cervix. The mechanism of the...

    Authors: Tatyana Ivanova, Anatolii Petrenko, Tatyana Gritsko, Svetlana Vinokourova, Ernest Eshilev, Vera Kobzeva, Fjodor Kisseljov and Natalia Kisseljova

    Citation: BMC Cancer 2002 2:4

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  23. Content type: Research article

    The present study aimed at evaluating the efficacy of Raltitrexed, a specific thymidilate synthase inhibitor, in patients with advanced colorectal cancer (ACC) in relapse (>8 weeks) after a prior response or d...

    Authors: Nicolas Tsavaris, Christos Kosmas, Maria Vadiaka and Christos Koufos

    Citation: BMC Cancer 2002 2:2

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  24. Content type: Research article

    Intraoperative radiation therapy (IORT) is one of the methods used to deliver a large single dose to the tumor tissue while reducing the exposure of normal surrounding tissue. However, the usefulness of intrao...

    Authors: Kenji Nemoto, Yoshihiro Ogawa, Haruo Matsushita, Ken Takeda, Yoshihiro Takai, Shogo Yamada and Toshihiro Kumabe

    Citation: BMC Cancer 2002 2:1

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  25. Content type: Research article

    The effectiveness of neoadjuvant treatment (NT) prior to resection of squamous cell carcinoma of the esophagus (SCCE) in terms of prolonged survival has not been proven by randomized trials. Facing considerabl...

    Authors: Joachim W Heise, Hansjörg Heep, Thomas Frieling, Mario Sarbia, Karl A Hartmann and Hans-Dietrich Röher

    Citation: BMC Cancer 2001 1:20

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  26. Content type: Research article

    STAT3 phosphorylation is associated with the neoplastic state in many types of cancer, including prostate cancer. We investigated the role of IL-6 signaling and phosphorylation of STAT3 in 2 rat prostatic epit...

    Authors: Beverly E Barton, Thomas F Murphy, Patricia Adem, Richard A Watson, Robert J Irwin and Hosea F Huang

    Citation: BMC Cancer 2001 1:19

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  27. Content type: Research article

    We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine if t...

    Authors: Matthew Pavao, Yue-Hua Huang, Laurie J Hafer, Robert B Moreland and Abdulmaged M Traish

    Citation: BMC Cancer 2001 1:15

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  28. Content type: Research article

    We previously reported that the α-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline...

    Authors: Heléne Fischer, Sima Salahshor, Roger Stenling, Jan Björk, Gudrun Lindmark, Lennart Iselius, Carlos Rubio and Annika Lindblom

    Citation: BMC Cancer 2001 1:17

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  29. Content type: Research article

    Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was,...

    Authors: Janusz W Kostanski, Ge Jiang, Bhas A Dani, Santos B Murty, Wei Qiu, Bruce Schrier, B C Thanoo and Patrick P DeLuca

    Citation: BMC Cancer 2001 1:18

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  30. Content type: Research article

    The E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the expression or function of this complex results in loss of...

    Authors: Chen Huiping, Sigrun Kristjansdottir, Jon G Jonasson, Jonas Magnusson, Valgardur Egilsson and Sigurdur Ingvarsson

    Citation: BMC Cancer 2001 1:16

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  31. Content type: Research article

    Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the assoc...

    Authors: Shigeyuki Nakaji, Tadashi Shimoyama, Takashi Umeda, Juichi Sakamoto, Shuji Katsura, Kazuo Sugawara and David Baxter

    Citation: BMC Cancer 2001 1:14

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  32. Content type: Research article

    Loss of activity of tumor suppressor genes is considered a fundamental step in a genetic model of carcinogenesis. Altered expression of the p53 and the Deleted in Colon Cancer (DCC) proteins has been described...

    Authors: Francesco Graziano, Stefano Cascinu, Maria Pia Staccioli, Vincenzo Catalano, Maria Cristina Rossi, Anna Maria Baldelli, Paolo Giordani, Pietro Muretto and Giuseppina Catalano

    Citation: BMC Cancer 2001 1:9

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  33. Content type: Research article

    The role of telomerase activation in the expression and/or maintenance of drug resistance is not clearly understood. Therefore, we investigated the relationships, among the telomerase activity, telomere length...

    Authors: Noritsugu Kuranaga, Nariyoshi Shinomiya and Hidetaka Mochizuki

    Citation: BMC Cancer 2001 1:10

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  34. Content type: Research article

    The relationship between breast cancer and organochlorine exposure is controversial and complex. As estrogen receptor positive and negative breast cancer may represent different entities of the disease, this s...

    Authors: Annette P Høyer, Torben Jørgensen, Fritz Rank and Philippe Grandjean

    Citation: BMC Cancer 2001 1:8

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  35. Content type: Research article

    Invasion and metastasis is a complex process governed by the interaction of genetically altered tumor cells and the immunological and inflammatory host reponse. Specific T-cells directed against tumor cells an...

    Authors: Iris D Nagtegaal, Corrie AM Marijnen, Elma Klein Kranenbarg, Adri Mulder-Stapel, Jo Hermans, Cornelis JH van de Velde and J Han JM van Krieken

    Citation: BMC Cancer 2001 1:7

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